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  1. Article ; Online: Transcription factor networks in trophoblast development.

    Papuchova, Henrieta / Latos, Paulina A

    Cellular and molecular life sciences : CMLS

    2022  Volume 79, Issue 6, Page(s) 337

    Abstract: The placenta sustains embryonic development and is critical for a successful pregnancy outcome. It provides the site of exchange between the mother and the embryo, has immunological functions and is a vital endocrine organ. To perform these diverse roles, ...

    Abstract The placenta sustains embryonic development and is critical for a successful pregnancy outcome. It provides the site of exchange between the mother and the embryo, has immunological functions and is a vital endocrine organ. To perform these diverse roles, the placenta comprises highly specialized trophoblast cell types, including syncytiotrophoblast and extravillous trophoblast. The coordinated actions of transcription factors (TFs) regulate their emergence during development, subsequent specialization, and identity. These TFs integrate diverse signaling cues, form TF networks, associate with chromatin remodeling and modifying factors, and collectively determine the cell type-specific characteristics. Here, we summarize the general properties of TFs, provide an overview of TFs involved in the development and function of the human trophoblast, and address similarities and differences to their murine orthologs. In addition, we discuss how the recent establishment of human in vitro models combined with -omics approaches propel our knowledge and transform the human trophoblast field.
    MeSH term(s) Animals ; Cell Differentiation/physiology ; Female ; Gene Expression Regulation ; Humans ; Mice ; Placenta/metabolism ; Pregnancy ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Trophoblasts/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2022-06-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04363-6
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  2. Article ; Online: Trophoblast Organoids as a Novel Tool to Study Human Placental Development and Function.

    Haider, Sandra / Knöfler, Martin / Latos, Paulina A

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2728, Page(s) 195–222

    Abstract: The human placenta provides the site of exchange between the maternal and fetal bloodstreams, acts as an endocrine organ, and has immunological functions. The majority of pregnancy disorders including preeclampsia and fetal growth restriction have their ... ...

    Abstract The human placenta provides the site of exchange between the maternal and fetal bloodstreams, acts as an endocrine organ, and has immunological functions. The majority of pregnancy disorders including preeclampsia and fetal growth restriction have their roots in pathological placentation. Yet, the underlying molecular causes of these complications remain largely unknown, not least due to the lack of reliable in vitro models. Recent establishment of 2D human trophoblast stem cells and 3D trophoblast organoids has been a major advancement that opened new avenues for trophoblast research. Here we provide a protocol detailing isolation of cytotrophoblast from the first trimester human placenta, establishment of trophoblast organoids, their culture and differentiation conditions. Overall, we describe an in vitro system that offers an excellent model to study the molecular basis of placental development and disease.
    MeSH term(s) Pregnancy ; Humans ; Female ; Placenta ; Placentation ; Trophoblasts ; Cell Differentiation ; Organoids
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3495-0_17
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  3. Article: Transcription factor networks in trophoblast development

    Papuchova, Henrieta / Latos, Paulina A.

    Cellular and molecular life sciences. 2022 June, v. 79, no. 6

    2022  

    Abstract: The placenta sustains embryonic development and is critical for a successful pregnancy outcome. It provides the site of exchange between the mother and the embryo, has immunological functions and is a vital endocrine organ. To perform these diverse roles, ...

    Abstract The placenta sustains embryonic development and is critical for a successful pregnancy outcome. It provides the site of exchange between the mother and the embryo, has immunological functions and is a vital endocrine organ. To perform these diverse roles, the placenta comprises highly specialized trophoblast cell types, including syncytiotrophoblast and extravillous trophoblast. The coordinated actions of transcription factors (TFs) regulate their emergence during development, subsequent specialization, and identity. These TFs integrate diverse signaling cues, form TF networks, associate with chromatin remodeling and modifying factors, and collectively determine the cell type-specific characteristics. Here, we summarize the general properties of TFs, provide an overview of TFs involved in the development and function of the human trophoblast, and address similarities and differences to their murine orthologs. In addition, we discuss how the recent establishment of human in vitro models combined with -omics approaches propel our knowledge and transform the human trophoblast field.
    Keywords chromatin ; embryogenesis ; humans ; mice ; pregnancy outcome ; transcription factors ; trophoblast
    Language English
    Dates of publication 2022-06
    Size p. 337.
    Publishing place Springer International Publishing
    Document type Article
    Note Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04363-6
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  4. Article ; Online: 21-Carba-23-selenaporphyrinoid Dyads-An Azepine Unit as a Merging Motif.

    Berlicka, Anna / Foryś-Martowłos, Paulina / Białek, Michał J / Stasiak, Katarzyna / Walczak, Aleksandra / Wójcik, Agnieszka / Białońska, Agata / Latos-Grażyński, Lechosław

    Angewandte Chemie (International ed. in English)

    2023  Volume 63, Issue 3, Page(s) e202314925

    Abstract: The oxidation of 10,15-diaryl-21-carba-23-selenaporphyrinoids resulted in the creation of dyads. The dimerization process follows a [5+2] cycloaddition path with the formation of an azepine unit. The arrays display two direct bonds between the peripheral ...

    Abstract The oxidation of 10,15-diaryl-21-carba-23-selenaporphyrinoids resulted in the creation of dyads. The dimerization process follows a [5+2] cycloaddition path with the formation of an azepine unit. The arrays display two direct bonds between the peripheral carbocyclic carbon atoms of one carbaselenaporphyrinic subunit and the central carbon and nitrogen atoms of the second subunit. This results in a unique canted arrangement of two carbaporphyrinoid planes resembling an open seashell-like motif.
    Language English
    Publishing date 2023-11-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202314925
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  5. Article: Ciliary phenotyping in renal epithelial cells in a cranioectodermal dysplasia patient with

    Walczak-Sztulpa, Joanna / Wawrocka, Anna / Kuszel, Łukasz / Pietras, Paulina / Leśniczak-Staszak, Marta / Andrusiewicz, Mirosław / Krawczyński, Maciej R / Latos-Bieleńska, Anna / Pawlak, Marta / Grenda, Ryszard / Materna-Kiryluk, Anna / Oud, Machteld M / Szaflarski, Witold

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1285790

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1285790
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  6. Article ; Online: Lung Transplant as a Treatment for Patients with End-Stage Respiratory Failure Due to COVID-19.

    Urlik, Maciej / Stącel, Tomasz / Latos, Magdalena / Pasek, Piotr / Pióro, Anna / Zawadzki, Fryderyk / Gmerek, Marta / Księżopolska, Paulina / Przybyłowski, Piotr / Ochman, Marek

    Transplantation proceedings

    2022  Volume 54, Issue 4, Page(s) 908–912

    Abstract: Background: COVID-19 may lead to development of irreversible acute respiratory distress syndrome. Some patients sustain severe respiratory failure after infection subsides. They may require lung transplant as a last resort treatment. The aim of the ... ...

    Abstract Background: COVID-19 may lead to development of irreversible acute respiratory distress syndrome. Some patients sustain severe respiratory failure after infection subsides. They may require lung transplant as a last resort treatment. The aim of the study is to assess the effect and feasibility of lung transplant as a treatment for patients with severe irreversible respiratory failure due to COVID-19.
    Methods: This retrospective study pertains to analysis of 119 patients in critical condition who were referred to Lung Transplant Ward (Zabrze, Poland). between July 2020 and June 2021 after developing respiratory failure requiring extracorporeal membrane oxygenation, invasive ventilation, or both, as well as a few patients on high-flow oxygen therapy. Inclusion criteria for referral were confirmed lack of viral disease and exhaustion of other therapeutic options.
    Results: Of the referred patients, 21.84% were disqualified from such treatment owing to existing contraindications. Among the suitable patients, 75.8% died without transplant. Among all patients who were qualified for lung transplant, only 9 patients became double lung transplant recipients. Intraoperative mortality for this procedure was 33%. Four patients were discharged after the procedure and are currently self-reliant with full respiratory capacity.
    Conclusions: Patients with severe irreversible respiratory failure after COVID-19 present significantly high mortality without lung transplant. This procedure may present satisfactory results but must be performed in a timely fashion owing to critical condition and scarcity of lung donors, only aggravated around the time of peak infection waves.
    MeSH term(s) COVID-19 ; Humans ; Lung Transplantation/adverse effects ; Respiratory Distress Syndrome ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/surgery ; Retrospective Studies
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2022.03.017
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 835: Show issues Location:
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  7. Article ; Online: The human placenta shapes the phenotype of decidual macrophages.

    Vondra, Sigrid / Höbler, Anna-Lena / Lackner, Andreas Ian / Raffetseder, Johanna / Mihalic, Zala Nikita / Vogel, Andrea / Saleh, Leila / Kunihs, Victoria / Haslinger, Peter / Wahrmann, Markus / Husslein, Heinrich / Oberle, Raimund / Kargl, Julia / Haider, Sandra / Latos, Paulina / Schabbauer, Gernot / Knöfler, Martin / Ernerudh, Jan / Pollheimer, Jürgen

    Cell reports

    2023  Volume 42, Issue 3, Page(s) 112285

    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112285
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  8. Article ; Online: The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate.

    Lackner, Andreas / Müller, Michael / Gamperl, Magdalena / Stoeva, Delyana / Langmann, Olivia / Papuchova, Henrieta / Roitinger, Elisabeth / Dürnberger, Gerhard / Imre, Richard / Mechtler, Karl / Latos, Paulina A

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2559

    Abstract: Placental development relies on coordinated cell fate decisions governed by signalling inputs. However, little is known about how signalling cues are transformed into repressive mechanisms triggering lineage-specific transcriptional signatures. Here, we ... ...

    Abstract Placental development relies on coordinated cell fate decisions governed by signalling inputs. However, little is known about how signalling cues are transformed into repressive mechanisms triggering lineage-specific transcriptional signatures. Here, we demonstrate that upon inhibition of the Fgf/Erk pathway in mouse trophoblast stem cells (TSCs), the Ets2 repressor factor (Erf) interacts with the Nuclear Receptor Co-Repressor Complex 1 and 2 (NCoR1/2) and recruits it to key trophoblast genes. Genetic ablation of Erf or Tbl1x (a component of the NCoR1/2 complex) abrogates the Erf/NCoR1/2 interaction. This leads to mis-expression of Erf/NCoR1/2 target genes, resulting in a TSC differentiation defect. Mechanistically, Erf regulates expression of these genes by recruiting the NCoR1/2 complex and decommissioning their H3K27ac-dependent enhancers. Our findings uncover how the Fgf/Erf/NCoR1/2 repressive axis governs cell fate and placental development, providing a paradigm for Fgf-mediated transcriptional control.
    MeSH term(s) Mice ; Animals ; Female ; Pregnancy ; Trophoblasts ; Fibroblast Growth Factor 2 ; Placenta ; Cell Differentiation/physiology ; Gene Expression Regulation ; Nuclear Receptor Co-Repressor 1 ; Nuclear Receptor Co-Repressor 2
    Chemical Substances Fibroblast Growth Factor 2 (103107-01-3) ; Nuclear Receptor Co-Repressor 1 ; Nuclear Receptor Co-Repressor 2 ; Ncor1 protein, mouse
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38101-8
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  9. Article ; Online: The human placenta shapes the phenotype of decidual macrophages.

    Vondra, Sigrid / Höbler, Anna-Lena / Lackner, Andreas Ian / Raffetseder, Johanna / Mihalic, Zala Nikita / Vogel, Andrea / Saleh, Leila / Kunihs, Victoria / Haslinger, Peter / Wahrmann, Markus / Husslein, Heinrich / Oberle, Raimund / Kargl, Julia / Haider, Sandra / Latos, Paulina / Schabbauer, Gernot / Knöfler, Martin / Ernerudh, Jan / Pollheimer, Jürgen

    Cell reports

    2023  Volume 42, Issue 1, Page(s) 111977

    Abstract: During human pregnancy, placenta-derived extravillous trophoblasts (EVTs) invade the decidua and communicate with maternal immune cells. The decidua distinguishes into basalis (decB) and parietalis (decP). The latter remains unaffected by EVT invasion. ... ...

    Abstract During human pregnancy, placenta-derived extravillous trophoblasts (EVTs) invade the decidua and communicate with maternal immune cells. The decidua distinguishes into basalis (decB) and parietalis (decP). The latter remains unaffected by EVT invasion. By defining a specific gating strategy, we report the accumulation of macrophages in decB. We describe a decidua basalis-associated macrophage (decBAM) population with a differential transcriptome and secretome compared with decidua parietalis-associated macrophages (decPAMs). decBAMs are CD11c
    MeSH term(s) Pregnancy ; Female ; Humans ; Pregnancy Trimester, First/physiology ; Decidua/metabolism ; Trophoblasts/metabolism ; Phenotype ; Macrophages/metabolism
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.111977
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  10. Article ; Online: MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells.

    Hornbachner, Ruth / Lackner, Andreas / Papuchova, Henrieta / Haider, Sandra / Knöfler, Martin / Mechtler, Karl / Latos, Paulina A

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 37

    Abstract: Multiple placental pathologies are associated with failures in trophoblast differentiation, yet the underlying transcriptional regulation is poorly understood. Here, we discovered msh homeobox 2 (MSX2) as a key transcriptional regulator of trophoblast ... ...

    Abstract Multiple placental pathologies are associated with failures in trophoblast differentiation, yet the underlying transcriptional regulation is poorly understood. Here, we discovered msh homeobox 2 (MSX2) as a key transcriptional regulator of trophoblast identity using the human trophoblast stem cell model. Depletion of MSX2 resulted in activation of the syncytiotrophoblast transcriptional program, while forced expression of MSX2 blocked it. We demonstrated that a large proportion of the affected genes were directly bound and regulated by MSX2 and identified components of the SWItch/Sucrose nonfermentable (SWI/SNF) complex as strong MSX2 interactors and target gene cobinders. MSX2 cooperated specifically with the SWI/SNF canonical BAF (cBAF) subcomplex and cooccupied, together with H3K27ac, a number of differentiation genes. Increased H3K27ac and cBAF occupancy upon MSX2 depletion imply that MSX2 prevents premature syncytiotrophoblast differentiation. Our findings established MSX2 as a repressor of the syncytiotrophoblast lineage and demonstrated its pivotal role in cell fate decisions that govern human placental development and disease.
    MeSH term(s) Cell Differentiation ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; Female ; Histones/genetics ; Histones/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Placenta/cytology ; Placenta/metabolism ; Placentation ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; Pregnancy ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Trophoblasts/cytology ; Trophoblasts/metabolism
    Chemical Substances Chromosomal Proteins, Non-Histone ; Histones ; Homeodomain Proteins ; MSX2 protein ; SWI-SNF-B chromatin-remodeling complex ; Transcription Factors
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2105130118
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