LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 81

Search options

  1. Book ; Online: Methods in kidney cell biology

    Weimbs, Thomas

    (Methods in cell biology)

    2019  

    Author's details edited by Thomas Weimbs
    Series title Methods in cell biology
    Language English
    Dates of publication 2019-9999
    Size Online-Ressource
    Edition First edition
    Publisher Academic Press, an imprint of Elsevier
    Publishing place Cambridge, MA
    Publishing country United States
    Document type Book ; Online
    HBZ-ID HT020233289
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Book ; Online ; E-Book: Methods in kidney cell biology / Part B

    Weimbs, Thomas

    (Methods in cell biology ; 154)

    2019  

    Author's details edited by Thomas Weimbs
    Series title Methods in cell biology ; 154
    Methods in kidney cell biology
    Collection Methods in kidney cell biology
    Language English
    Size 1 Online-Ressource (xiv, 240 Seiten), Illustrationen, Diagramme
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020275074
    ISBN 978-0-12-820336-1 ; 9780128203354 ; 0-12-820336-6 ; 0128203358
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book ; Online ; E-Book: Methods in kidney cell biology / Part A

    Weimbs, Thomas

    (Methods in cell biology ; 153)

    2019  

    Author's details edited by Thomas Weimbs
    Series title Methods in cell biology ; 153
    Methods in kidney cell biology
    Collection Methods in kidney cell biology
    Language English
    Size 1 Online-Ressource (xiv, 278 Seiten), Illustrationen, Diagramme
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020233306
    ISBN 978-0-12-817083-0 ; 9780128170823 ; 0-12-817083-2 ; 0128170824
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Preface.

    Weimbs, Thomas

    Methods in cell biology

    2019  Volume 153, Page(s) xiii–xiv

    Language English
    Publishing date 2019-06-13
    Publishing country United States
    Document type Editorial
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/S0091-679X(19)30104-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Preface.

    Weimbs, Thomas

    Methods in cell biology

    2019  Volume 154, Page(s) xiii–xiv

    Language English
    Publishing date 2019-05-17
    Publishing country United States
    Document type Editorial
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/S0091-679X(19)30115-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Are Cyst-Associated Macrophages in Polycystic Kidney Disease the Equivalent to TAMs in Cancer?

    Weimbs, Thomas

    Journal of the American Society of Nephrology : JASN

    2018  Volume 29, Issue 10, Page(s) 2447–2448

    MeSH term(s) Cysts ; Humans ; Macrophages ; Polycystic Kidney Diseases ; Polycystic Kidney, Autosomal Dominant
    Language English
    Publishing date 2018-09-12
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2018080846
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Ketogenic metabolic therapy for chronic kidney disease - the pro part.

    Weimbs, Thomas / Saville, Jessianna / Kalantar-Zadeh, Kamyar

    Clinical kidney journal

    2023  Volume 17, Issue 1, Page(s) sfad273

    Abstract: Ketogenic metabolic therapy (KMT) is a medical nutrition therapy to address certain health and disease conditions. It is increasingly used for many non-communicable diseases that are rooted in abnormal metabolic health. Since chronic kidney disease (CKD) ...

    Abstract Ketogenic metabolic therapy (KMT) is a medical nutrition therapy to address certain health and disease conditions. It is increasingly used for many non-communicable diseases that are rooted in abnormal metabolic health. Since chronic kidney disease (CKD) is commonly caused by overnutrition leading to hyperglycemia, insulin resistance and diabetes mellitus, the carbohydrate restriction inherent in KMT may offer a therapeutic option. Numerous studies have found that various forms of KMT are safe for individuals with CKD and may lead to improvement of renal function. This is in contrast to the current standard pharmacological approach to CKD that only slows the relentless progression towards renal failure. Kidney care providers, including physicians and dietitians, are usually not aware of non-standard dietary interventions, including KMT, and often criticize KMT due to common misconceptions and uncertainty about the underlying science, including the common misconception that KMT must involve high protein or meat consumption. This review article discusses the rationales for using KMT, including plant-dominant KMT, for treatment of CKD, clarifies common misconceptions, summarizes the results of clinical studies and discusses why KMT is emerging as an effective medical nutrition therapy (MNT) to consider for patients with kidney disease. KMT, including its plant-dominant versions, can expand a practitioner's kidney health toolbox and will likely become a first-line therapy for CKD in certain CKD-associated conditions such as obesity, metabolic syndrome and polycystic kidney disease.
    Language English
    Publishing date 2023-11-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfad273
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6587: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: The case for a ketogenic diet in the management of kidney disease.

    Athinarayanan, Shaminie J / Roberts, Caroline G P / Vangala, Chandan / Shetty, Greeshma K / McKenzie, Amy L / Weimbs, Thomas / Volek, Jeff S

    BMJ open diabetes research & care

    2024  Volume 12, Issue 2

    Abstract: Ketogenic diets have been widely used for weight loss and are increasingly used in the management of type 2 diabetes. Despite evidence that ketones have multiple positive effects on kidney function, common misconceptions about ketogenic diets, such as ... ...

    Abstract Ketogenic diets have been widely used for weight loss and are increasingly used in the management of type 2 diabetes. Despite evidence that ketones have multiple positive effects on kidney function, common misconceptions about ketogenic diets, such as high protein content and acid load, have prevented their widespread use in individuals with impaired kidney function. Clinical trial evidence focusing on major adverse kidney events is sparse. The aim of this review is to explore the effects of a ketogenic diet, with an emphasis on the pleiotropic actions of ketones, on kidney health. Given the minimal concerns in relation to the potential renoprotective effects of a ketogenic diet, future studies should evaluate the safety and efficacy of ketogenic interventions in kidney disease.
    MeSH term(s) Diet, Ketogenic/methods ; Humans ; Diabetes Mellitus, Type 2/diet therapy ; Diabetic Nephropathies/diet therapy ; Ketones ; Kidney Diseases/diet therapy
    Chemical Substances Ketones
    Language English
    Publishing date 2024-04-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2732918-5
    ISSN 2052-4897 ; 2052-4897
    ISSN (online) 2052-4897
    ISSN 2052-4897
    DOI 10.1136/bmjdrc-2024-004101
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Third-hit signaling in renal cyst formation.

    Weimbs, Thomas

    Journal of the American Society of Nephrology : JASN

    2011  Volume 22, Issue 5, Page(s) 793–795

    MeSH term(s) Animals ; Cilia/physiology ; Humans ; Kidney Diseases, Cystic/etiology ; Mice ; Polycystic Kidney, Autosomal Dominant/etiology ; Signal Transduction/physiology ; TOR Serine-Threonine Kinases/physiology ; TRPP Cation Channels/physiology
    Chemical Substances TRPP Cation Channels ; polycystic kidney disease 1 protein ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
    Language English
    Publishing date 2011-04-14
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2011030284
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Cleavage fragments of the C-terminal tail of polycystin-1 are regulated by oxidative stress and induce mitochondrial dysfunction.

    Pellegrini, Hannah / Sharpe, Elizabeth H / Liu, Guangyi / Nishiuchi, Eiko / Doerr, Nicholas / Kipp, Kevin R / Chin, Tiffany / Schimmel, Margaret F / Weimbs, Thomas

    The Journal of biological chemistry

    2023  Volume 299, Issue 9, Page(s) 105158

    Abstract: Mutations in the gene encoding polycystin-1 (PC1) are the most common cause of autosomal dominant polycystic kidney disease (ADPKD). Cysts in ADPKD exhibit a Warburg-like metabolism characterized by dysfunctional mitochondria and aerobic glycolysis. PC1 ... ...

    Abstract Mutations in the gene encoding polycystin-1 (PC1) are the most common cause of autosomal dominant polycystic kidney disease (ADPKD). Cysts in ADPKD exhibit a Warburg-like metabolism characterized by dysfunctional mitochondria and aerobic glycolysis. PC1 is an integral membrane protein with a large extracellular domain, a short C-terminal cytoplasmic tail and shares structural and functional similarities with G protein-coupled receptors. Its exact function remains unclear. The C-terminal cytoplasmic tail of PC1 undergoes proteolytic cleavage, generating soluble fragments that are overexpressed in ADPKD kidneys. The regulation, localization, and function of these fragments is poorly understood. Here, we show that a ∼30 kDa cleavage fragment (PC1-p30), comprising the entire C-terminal tail, undergoes rapid proteasomal degradation by a mechanism involving the von Hippel-Lindau tumor suppressor protein. PC1-p30 is stabilized by reactive oxygen species, and the subcellular localization is regulated by reactive oxygen species in a dose-dependent manner. We found that a second, ∼15 kDa fragment (PC1-p15), is generated by caspase cleavage at a conserved site (Asp-4195) on the PC1 C-terminal tail. PC1-p15 is not subject to degradation and constitutively localizes to the mitochondrial matrix. Both cleavage fragments induce mitochondrial fragmentation, and PC1-p15 expression causes impaired fatty acid oxidation and increased lactate production, indicative of a Warburg-like phenotype. Endogenous PC1 tail fragments accumulate in renal cyst-lining cells in a mouse model of PKD. Collectively, these results identify novel mechanisms regarding the regulation and function of PC1 and suggest that C-terminal PC1 fragments may be involved in the mitochondrial and metabolic abnormalities observed in ADPKD.
    MeSH term(s) Animals ; Mice ; Mitochondrial Diseases ; Oxidative Stress ; Polycystic Kidney, Autosomal Dominant/metabolism ; Reactive Oxygen Species/metabolism ; TRPP Cation Channels/genetics ; TRPP Cation Channels/metabolism
    Chemical Substances Reactive Oxygen Species ; TRPP Cation Channels ; polycystic kidney disease 1 protein
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105158
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top