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  1. Book: Tumour associated macrophages

    Hagemann, Thorsten / Lawrence, Toby

    2012  

    Title variant Tumour-associated macrophages
    Author's details Toby Lawrence ; Thorsten Hagemann ed
    Language English
    Size XI, 187 S. : Ill., 24 cm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017030066
    ISBN 978-1-4614-0661-7 ; 1-4614-0661-7 ; 9781461406624 ; 1461406625
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 4622 order for loan Magazin

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  2. Book ; Thesis: Untersuchung der mRNA-Expression von Mitgliedern der Bcl-2-Familie in Mamma-Karzinomen und ihres Bezuges zu weiteren prognostischen Parametern

    Hagemann, Thorsten

    2002  

    Author's details vorgelegt von Thorsten Hagemann
    Language German
    Size 117 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Göttingen, Univ., Diss., 2002
    HBZ-ID HT013551280
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 MB 4563 order for loan Magazin

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  3. Article: Immune monitoring technology primer: immunoprofiling of antigen-stimulated blood.

    Brunet, Laura Rosa / LaBrie, Samuel / Hagemann, Thorsten

    Journal for immunotherapy of cancer

    2016  Volume 4, Page(s) 18

    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article
    ZDB-ID 2719863-7
    ISSN 2051-1426
    ISSN 2051-1426
    DOI 10.1186/s40425-016-0122-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  4. Book: Tumour-associated macrophages

    Lawrence, Toby / Hagemann, Thorsten

    2012  

    Author's details Toby Lawrence, Thorsten Hagemann, editors
    MeSH term(s) Macrophages/physiology ; Neoplasms/etiology ; Disease Progression
    Language English
    Size xi, 187 p. :, ill.
    Publisher Springer
    Publishing place New York
    Document type Book
    ISBN 9781461406617 ; 9781461406624 ; 1461406617 ; 1461406625
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article ; Online: Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages.

    Yin, Dongpei / Wang, Chen / Qi, Yachao / Wang, Ya-Chao / Hagemann, Nina / Mohamud Yusuf, Ayan / Dzyubenko, Egor / Kaltwasser, Britta / Tertel, Tobias / Giebel, Bernd / Gunzer, Matthias / Popa-Wagner, Aurel / Doeppner, Thorsten R / Hermann, Dirk M

    Journal of neuroinflammation

    2023  Volume 20, Issue 1, Page(s) 210

    Abstract: Background: The intravenous delivery of adult neural precursor cells (NPC) has shown promising results in enabling cerebroprotection, brain tissue remodeling, and neurological recovery in young, healthy stroke mice. However, the translation of cell- ... ...

    Abstract Background: The intravenous delivery of adult neural precursor cells (NPC) has shown promising results in enabling cerebroprotection, brain tissue remodeling, and neurological recovery in young, healthy stroke mice. However, the translation of cell-based therapies to clinical settings has encountered challenges. It remained unclear if adult NPCs could induce brain tissue remodeling and recovery in mice with hyperlipidemia, a prevalent vascular risk factor in stroke patients.
    Methods: Male mice on a normal (regular) diet or on cholesterol-rich Western diet were exposed to 30 min intraluminal middle cerebral artery occlusion (MCAO). Vehicle or 10
    Results: NPC administration reduced infarct volume, blood-brain barrier permeability and the brain infiltration of neutrophils, monocytes, T cells and NK cells in the acute stroke phase in both normolipidemic and hyperlipidemic mice, but increased brain hemorrhage formation and neutrophil, monocyte and CD4
    Conclusions: Intravenously administered NPCs did not have persistent effects on post-ischemic neurological recovery and brain remodeling in hyperlipidemic mice. These findings highlight the necessity of rigorous investigations in vascular risk factor models to fully assess the long-term restorative effects of cell-based therapies. Without comprehensive studies in such models, the clinical potential of cell-based therapies cannot be definitely determined.
    MeSH term(s) Male ; Animals ; Mice ; Neural Stem Cells ; Stroke ; Neurons ; Intracranial Hemorrhages ; Brain
    Language English
    Publishing date 2023-09-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-023-02894-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Einflüsse von Ballaststoffen auf das Syndrom des Irritablen Darms (Reizdarmsyndrom)

    Hagemann, Thorsten

    2006  

    Author's details vorgelegt von Thorsten Hagemann
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Düsseldorf, 2006
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  7. Article ; Online: Targeting immunosuppression for cancer therapy.

    Ghirelli, Cristina / Hagemann, Thorsten

    The Journal of clinical investigation

    2013  Volume 123, Issue 6, Page(s) 2355–2357

    Abstract: Failing immunity has been acknowledged for its contribution to cancer development and progression. Recent clinical findings have provided payoffs for significant preclinical evaluation and refinement over the last 20 years, but many questions remain to ... ...

    Abstract Failing immunity has been acknowledged for its contribution to cancer development and progression. Recent clinical findings have provided payoffs for significant preclinical evaluation and refinement over the last 20 years, but many questions remain to be answered. In this issue of the JCI, Marabelle et al. describe a novel method for targeting the Tregs that infiltrate tumors, demonstrating that dampening the tumor immunosuppressive environment while activating innate antitumor immunity may be an effective approach to cancer treatment.
    MeSH term(s) Animals ; Brain Neoplasms/therapy ; Female ; Humans ; Lymphoma/therapy ; Meningeal Neoplasms/therapy ; T-Lymphocytes, Regulatory/immunology
    Language English
    Publishing date 2013-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI69999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: IL-17 mediates resistance to anti-VEGF therapy.

    Maniati, Eleni / Hagemann, Thorsten

    Nature medicine

    2013  Volume 19, Issue 9, Page(s) 1092–1094

    Abstract: Interleukin-17 (IL-17) released in the tumor microenvironment in response to drugs blocking vascular endothelial growth factor (VEGF) triggers stromal-derived inflammatory and VEGF-independent angiogenic programs that induce the drug refractoriness found ...

    Abstract Interleukin-17 (IL-17) released in the tumor microenvironment in response to drugs blocking vascular endothelial growth factor (VEGF) triggers stromal-derived inflammatory and VEGF-independent angiogenic programs that induce the drug refractoriness found in cancers resistant to anti-angiogenic therapy.
    MeSH term(s) Angiogenesis Inhibitors/pharmacology ; Animals ; Drug Resistance, Neoplasm ; Female ; Humans ; Interleukin-17/metabolism ; Male ; Neoplasms/drug therapy ; Neovascularization, Pathologic/immunology ; Th17 Cells/immunology ; Vascular Endothelial Growth Factor A/antagonists & inhibitors
    Chemical Substances Angiogenesis Inhibitors ; Interleukin-17 ; Vascular Endothelial Growth Factor A ; vascular endothelial growth factor A, mouse
    Language English
    Publishing date 2013-09-07
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm.3333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 39: Show issues

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  9. Article ; Online: Tumour-associated macrophages and cancer.

    Cook, Jenny / Hagemann, Thorsten

    Current opinion in pharmacology

    2013  Volume 13, Issue 4, Page(s) 595–601

    Abstract: Our understanding of the complex roles and functions of tumour-associated myeloid cells has improved vastly over the last few years. Alternatively activated macrophages, TAMs, are an abundant part of solid and haematological malignancies and have been ... ...

    Abstract Our understanding of the complex roles and functions of tumour-associated myeloid cells has improved vastly over the last few years. Alternatively activated macrophages, TAMs, are an abundant part of solid and haematological malignancies and have been linked with progression, metastasis and resistance to therapy. Still, characterisation and TAM targeting is hindered by a lack of TAM specific markers, but advances in next generation technologies are rapidly increasing our understanding of the sheer diversity of myeloid differentiation and phenotypic regulation. These technologies help to shed light on the heterogeneous phenotypic states of myeloid cells within the tumour. Alternative approaches to influence the myeloid compartment within cancers surround inhibition of myeloid recruitment or 're-education' of the plastic TAM phenotype. Our knowledge continuously grows on how even 'established' therapies might influence the myeloid compartment within tumours. Now the promising results from elegant pre-clinical studies at first translate into the clinic and use combination therapies with myeloid inhibitors and standard chemotherapy.
    MeSH term(s) Animals ; Humans ; Inflammation/microbiology ; Macrophages/immunology ; Neoplasms/immunology ; Phenotype
    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2013.05.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Resistance--the true face of biological defiance.

    Emami-Shahri, Nia / Hagemann, Thorsten

    Rheumatology (Oxford, England)

    2012  Volume 51, Issue 3, Page(s) 413–422

    Abstract: Biological therapeutics are widely used in chronic inflammatory and malignant disease. The underlying mechanisms of treatment failure for these drugs are poorly understood. Resistance to these biological agents and the further subdivision into intrinsic ... ...

    Abstract Biological therapeutics are widely used in chronic inflammatory and malignant disease. The underlying mechanisms of treatment failure for these drugs are poorly understood. Resistance to these biological agents and the further subdivision into intrinsic and acquired resistance are not clearly defined. In this review, we explore the current understanding of the mechanisms of action of several biological agents as well as the complex biological processes that underlie resistance. A better understanding of why biologicals fail might help to improve their single or combinational use and will ultimately help to alleviate disease burden more efficiently.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Antirheumatic Agents/therapeutic use ; Drug Resistance ; Humans ; Immunosuppressive Agents/therapeutic use ; Treatment Failure
    Chemical Substances Anti-Inflammatory Agents ; Antirheumatic Agents ; Immunosuppressive Agents
    Language English
    Publishing date 2012-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/ker326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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