LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 16581

Search options

  1. Article ; Online: R-type voltage-gated Ca

    Murphy, Jonathan G / Gutzmann, Jakob J / Lin, Lin / Hu, Jiahua / Petralia, Ronald S / Wang, Ya-Xian / Hoffman, Dax A

    Cell reports

    2022  Volume 38, Issue 3, Page(s) 110264

    Abstract: The subthreshold voltage-gated transient ... ...

    Abstract The subthreshold voltage-gated transient K
    MeSH term(s) Animals ; Calcium Channels, R-Type/metabolism ; Dendrites/metabolism ; HEK293 Cells ; Hippocampus/metabolism ; Humans ; Mice ; Mice, Inbred C57BL ; Neuronal Plasticity/physiology ; Rats ; Rats, Sprague-Dawley ; Shal Potassium Channels/metabolism ; Synaptic Transmission/physiology
    Chemical Substances Calcium Channels, R-Type ; Shal Potassium Channels
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2021.110264
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: A Career in Cytometry R&D.

    Hoffman, Robert A Bob

    Cytometry. Part A : the journal of the International Society for Analytical Cytology

    2020  Volume 97, Issue 6, Page(s) 563–565

    MeSH term(s) Humans ; Surveys and Questionnaires
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 2099868-5
    ISSN 1552-4930 ; 0196-4763 ; 1552-4922
    ISSN (online) 1552-4930
    ISSN 0196-4763 ; 1552-4922
    DOI 10.1002/cyto.a.24157
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1688: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 68: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: GOES-R land surface products at Western Hemisphere eddy covariance tower locations.

    Losos, Danielle / Hoffman, Sophie / Stoy, Paul C

    Scientific data

    2024  Volume 11, Issue 1, Page(s) 277

    Abstract: ... R Series (GOES-R) deliver near-hemispheric imagery at a ten-minute cadence. The Advanced Baseline ... Imager (ABI) aboard GOES-R measures visible and near-infrared spectral bands that can be used to estimate ... land surface properties and carbon dioxide flux. However, GOES-R data are designed for real-time ...

    Abstract The terrestrial carbon cycle varies dynamically on hourly to weekly scales, making it difficult to observe. Geostationary ("weather") satellites like the Geostationary Environmental Operational Satellite - R Series (GOES-R) deliver near-hemispheric imagery at a ten-minute cadence. The Advanced Baseline Imager (ABI) aboard GOES-R measures visible and near-infrared spectral bands that can be used to estimate land surface properties and carbon dioxide flux. However, GOES-R data are designed for real-time dissemination and are difficult to link with eddy covariance time series of land-atmosphere carbon dioxide exchange. We compiled three-year time series of GOES-R land surface attributes including visible and near-infrared reflectances, land surface temperature (LST), and downwelling shortwave radiation (DSR) at 314 ABI fixed grid pixels containing eddy covariance towers. We demonstrate how to best combine satellite and in-situ datasets and show how ABI attributes useful for ecosystem monitoring vary across space and time. By connecting observation networks that infer rapid changes to the carbon cycle, we can gain a richer understanding of the processes that control it.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Dataset ; Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-024-03071-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Using the International Pandemic Instrument to Revitalize the Innovation Ecosystem for Antimicrobial R&D.

    Caceres, Andrea Morales / Singh, Kshitij Kumar / Minssen, Timo / Van Katwyk, Susan Rogers / Hoffman, Steven J

    The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics

    2023  Volume 50, Issue S2, Page(s) 47–54

    Abstract: The inclusion of antimicrobial resistance (AMR) and increased research and development (R&D ... instrument signals an opportunity to reshape pharmaceutical R&D system in favour of antimicrobial ... stimulate international cooperation to implement innovative R&D incentives to bring new, life-saving ...

    Abstract The inclusion of antimicrobial resistance (AMR) and increased research and development (R&D) capabilities in the most recent outline of the World Health Organization's (WHO's) international pandemic instrument signals an opportunity to reshape pharmaceutical R&D system in favour of antimicrobial product development. This article explains why the current innovation ecosystem has disadvantaged the creation of antimicrobial products for human use. It also highlights how the COVID-19 pandemic experience can inform and stimulate international cooperation to implement innovative R&D incentives to bring new, life-saving antimicrobial products to the market.
    MeSH term(s) Humans ; Pandemics ; Ecosystem ; COVID-19 ; Anti-Infective Agents/therapeutic use ; Research
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1168812-9
    ISSN 1748-720X ; 1073-1105 ; 0277-8459
    ISSN (online) 1748-720X
    ISSN 1073-1105 ; 0277-8459
    DOI 10.1017/jme.2022.79
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2075: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: covidscreen: a web app and R Package for assessing asymptomatic COVID-19 testing strategies.

    Smith, Jesse / Sun, Yilun / Hijano, Diego R / Hoffman, James M / Hakim, Hana / Webby, Richard J / Hayden, Randall T / Gaur, Aditya H / Armstrong, Gregory T / Mori, Motomi / Tang, Li

    BMC public health

    2022  Volume 22, Issue 1, Page(s) 1361

    Abstract: ... and R package that provides estimates and visualizations to aid the assessment of organizational ... of their on-campus risk-mitigation strategy. The web application, R package, and source code are freely available ...

    Abstract Background: COVID-19 has caused over 305 million infections and nearly 5.5 million deaths globally. With complete eradication unlikely, organizations will need to evaluate their risk and the benefits of mitigation strategies, including the effects of regular asymptomatic testing. We developed a web application and R package that provides estimates and visualizations to aid the assessment of organizational infection risk and testing benefits to facilitate decision-making, which combines internal and community information with malleable assumptions.
    Results: Our web application, covidscreen, presents estimated values of risk metrics in an intuitive graphical format. It shows the current expected number of active, primarily community-acquired infections among employees in an organization. It calculates and explains the absolute and relative risk reduction of an intervention, relative to the baseline scenario, and shows the value of testing vaccinated and unvaccinated employees. In addition, the web interface allows users to profile risk over a chosen range of input values. The performance and output are illustrated using simulations and a real-world example from the employee testing program of a pediatric oncology specialty hospital.
    Conclusions: As the COVID-19 pandemic continues to evolve, covidscreen can assist organizations in making informed decisions about whether to incorporate covid test based screening as part of their on-campus risk-mitigation strategy. The web application, R package, and source code are freely available online (see "Availability of data and materials").
    MeSH term(s) COVID-19/diagnosis ; COVID-19/prevention & control ; COVID-19 Testing ; Child ; Humans ; Mass Screening ; Mobile Applications ; Pandemics/prevention & control
    Language English
    Publishing date 2022-07-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-022-13718-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Long Vibrational Lifetime R-Selenocyanate Probes for Ultrafast Infrared Spectroscopy: Properties and Synthesis.

    Fica-Contreras, Sebastian M / Daniels, Robert / Yassin, Omer / Hoffman, David J / Pan, Junkun / Sotzing, Gregory / Fayer, Michael D

    The journal of physical chemistry. B

    2021  Volume 125, Issue 31, Page(s) 8907–8918

    Abstract: Ultrafast infrared vibrational spectroscopy is widely used for the investigation of dynamics in systems from water to model membranes. Because the experimental observation window is limited to a few times the probe's vibrational lifetime, a frequent ... ...

    Abstract Ultrafast infrared vibrational spectroscopy is widely used for the investigation of dynamics in systems from water to model membranes. Because the experimental observation window is limited to a few times the probe's vibrational lifetime, a frequent obstacle for the measurement of a broad time range is short molecular vibrational lifetimes (typically a few to tens of picoseconds). Five new long-lifetime aromatic selenocyanate vibrational probes have been synthesized and their vibrational properties characterized. These probes are compared to commercial phenyl selenocyanate. The vibrational lifetimes range between ∼400 and 500 ps in complex solvents, which are some of the longest room-temperature vibrational lifetimes reported to date. In contrast to vibrations that are long-lived in simple solvents such as CCl
    MeSH term(s) Cyanates ; Selenium Compounds ; Spectrophotometry, Infrared ; Vibration
    Chemical Substances Cyanates ; Selenium Compounds ; selenocyanic acid (5749-48-4)
    Language English
    Publishing date 2021-08-02
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.1c04939
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Reply to F. Muntoni et al.: "In response to P.R. Clemens et al., Efficacy and Safety of Viltolarsen in Boys with Duchenne Muscular Dystrophy: Results From the Phase 2, Open-Label, 4-Year Extension Study, and Long-Term Functional Efficacy and Safety of Viltolarsen in Patients with Duchenne Muscular Dystrophy.

    Clemens, Paula R / Hoffman, Eric P

    Journal of neuromuscular diseases

    2023  Volume 10, Issue 6, Page(s) 1155–1157

    Language English
    Publishing date 2023-11-13
    Publishing country Netherlands
    Document type Clinical Trial, Phase II ; Letter
    ISSN 2214-3602
    ISSN (online) 2214-3602
    DOI 10.3233/JND-239005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: regentrans: a framework and R package for using genomics to study regional pathogen transmission.

    Hoffman, Sophie / Lapp, Zena / Wang, Joyce / Snitkin, Evan S

    Microbial genomics

    2022  Volume 8, Issue 1

    Abstract: ... to-use, open source R package that implements these methods (https://github.com/Snitkin-Lab-Umich ...

    Abstract Increasing evidence of regional pathogen transmission networks highlights the importance of investigating the dissemination of multidrug-resistant organisms (MDROs) across a region to identify where transmission is occurring and how pathogens move across regions. We developed a framework for investigating MDRO regional transmission dynamics using whole-genome sequencing data and created regentrans, an easy-to-use, open source R package that implements these methods (https://github.com/Snitkin-Lab-Umich/regentrans). Using a dataset of over 400 carbapenem-resistant isolates of
    MeSH term(s) Carbapenems/pharmacology ; Cross Infection/microbiology ; Cross Infection/transmission ; Databases, Genetic ; Drug Resistance, Multiple, Bacterial ; Genomics/methods ; Humans ; Klebsiella Infections/transmission ; Klebsiella pneumoniae/classification ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/genetics ; Klebsiella pneumoniae/isolation & purification ; Phylogeny ; Software ; Whole Genome Sequencing
    Chemical Substances Carbapenems
    Language English
    Publishing date 2022-01-11
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000747
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Tumor-Targeting Salmonella typhimurium A1-R Promotes Tumoricidal CD8

    Murakami, Takashi / Hiroshima, Yukihiko / Zhang, Yong / Zhao, Ming / Kiyuna, Tasuku / Hwang, Ho Kyoung / Miyake, Kentaro / Homma, Yuki / Mori, Ryutaro / Matsuyama, Ryusei / Chishima, Takashi / Ichikawa, Yasushi / Tanaka, Kuniya / Bouvet, Michael / Endo, Itaru / Hoffman, Robert M

    Journal of cellular biochemistry

    2017  

    Abstract: The present study determined the effect of the tumor-targeting strain Salmonella typhimurium A1-R ... S. typhimurium A1-R) on CD8 ...

    Abstract The present study determined the effect of the tumor-targeting strain Salmonella typhimurium A1-R (S. typhimurium A1-R) on CD8
    Language English
    Publishing date 2017-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392402-6
    ISSN 1097-4644 ; 0730-2312
    ISSN (online) 1097-4644
    ISSN 0730-2312
    DOI 10.1002/jcb.26224
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1114: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Tumor-Targeting Salmonella typhimurium A1-R: An Overview.

    Hoffman, Robert M

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1409, Page(s) 1–8

    Abstract: ... typhimurium A1-R. Efficacy of S. typhimurium A1-R in nude-mouse models of prostate, breast, pancreatic, and ... of S. typhimurium A1-R targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma ... The efficacy of S. typhimurium A1-R on pancreatic cancer stem cells, on pancreatic cancer in combination ...

    Abstract The present chapter reviews the development of the tumor-targeting amino-acid auxotrophic strain S. typhimurium A1 and the in vivo selection and characterization of the high-tumor-targeting strain S. typhimurium A1-R. Efficacy of S. typhimurium A1-R in nude-mouse models of prostate, breast, pancreatic, and ovarian cancer, as well as sarcoma and glioma in orthotopic mouse models is described. Also reviewed is efficacy of S. typhimurium A1-R targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma, breast-cancer brain metastasis, and experimental breast-cancer bone metastasis in orthotopic mouse models. The efficacy of S. typhimurium A1-R on pancreatic cancer stem cells, on pancreatic cancer in combination with anti-angiogenic agents, as well as on cervical cancer, soft-tissue sarcoma, and pancreatic cancer patient-derived orthotopic xenograft (PDOX) mouse models, is also described.
    MeSH term(s) Amino Acids/metabolism ; Animals ; Disease Models, Animal ; Humans ; Mice ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Nitric Oxide/metabolism ; Nitroglycerin/metabolism ; Permeability ; Salmonella typhimurium/classification ; Salmonella typhimurium/genetics ; Salmonella typhimurium/metabolism ; Xenograft Model Antitumor Assays
    Chemical Substances Amino Acids ; Nitric Oxide (31C4KY9ESH) ; Nitroglycerin (G59M7S0WS3)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-3515-4_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top