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  1. Article ; Online: Fetal Eosinophils Get on the Nerves of Airways. Early Origins of Bronchoconstriction.

    Mattes, Joerg / Collison, Adam

    American journal of respiratory cell and molecular biology

    2020  Volume 62, Issue 4, Page(s) 407–408

    MeSH term(s) Asthma ; Bronchoconstriction ; Eosinophils ; Humans ; Interleukin-5 ; Respiratory System
    Chemical Substances Interleukin-5
    Language English
    Publishing date 2020-01-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2019-0438ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Aussagewert der Technetium-99m-Sestamibi-SPECT- Myokardszintigraphie für die Erkennung von Koronarstenosen bei Patienten mit Zustand nach Myokardinfarkt

    Mattes, Jörg

    1998  

    Author's details vorgelegt von Jörg Mattes
    Language German
    Size 87 Bl., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hamburg, Univ., Diss., 1998
    HBZ-ID HT013104924
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Effect of fractional exhaled nitric oxide (F

    Whalen, Olivia M / Campbell, Linda E / Lane, Alison E / Karayanidis, Frini / Mallise, Carly A / Woolard, Alix J / Holliday, Elizabeth G / Mattes, Joerg / Collison, Adam / Gibson, Peter G / Murphy, Vanessa E

    European journal of pediatrics

    2024  

    Abstract: Asthma during pregnancy is associated with a range of adverse perinatal outcomes. It is also linked to increased rates of neurodevelopmental conditions in the offspring. We aimed to assess whether fractional exhaled nitric oxide (F: Conclusion:  In ... ...

    Abstract Asthma during pregnancy is associated with a range of adverse perinatal outcomes. It is also linked to increased rates of neurodevelopmental conditions in the offspring. We aimed to assess whether fractional exhaled nitric oxide (F
    Conclusion:  In this sample, F
    Trial registration: ClinicalTrials.gov Identifier: ACTRN12613000202763.
    What is known: • Maternal asthma during pregnancy has been associated with increased rates of neurodevelopmental conditions in offspring, including intellectual disability and autism.
    What is new: • This is the first study to examine how managing asthma during pregnancy via a F
    Language English
    Publishing date 2024-05-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-024-05578-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A unique role for IL-13 in inducing esophageal eosinophilia through MID-1 and STAT6.

    Girkin, Jason L N / Sokulsky, Leon A / Starkey, Malcolm R / Hansbro, Philip M / Foster, Paul S / Collison, Adam M / Mattes, Joerg

    Frontiers in allergy

    2023  Volume 4, Page(s) 1248432

    Abstract: Introduction: Eosinophilic esophagitis (EoE) is associated with allergen-driven inflammation of the esophagus and an upregulated Th2 cytokine signature. Recombinant interleukin (IL)-13 (rIL-13) administration to mice induces some of the hallmark ... ...

    Abstract Introduction: Eosinophilic esophagitis (EoE) is associated with allergen-driven inflammation of the esophagus and an upregulated Th2 cytokine signature. Recombinant interleukin (IL)-13 (rIL-13) administration to mice induces some of the hallmark features of EoE, including increased eotaxin expression and eosinophil recruitment. Inflammation in EoE has previously been shown to depend on the expression of TRAIL and MID-1, which reduced protein phosphatase 2A (PP2A) activity. The relationship between IL-13 and TRAIL signalling in esophageal eosinophilia is currently unknown.
    Objective: To investigate the interaction between IL-13-driven eosinophil infiltration and TRAIL or MID-1 in the esophagus.
    Method: We administered rIL-13 to wild type (WT), TRAIL-deficient (
    Results: rIL-13 administration to mice increased TRAIL and MID-1 expression in the esophagus while reducing PP2A activity. TRAIL deficient, but not STAT6 deficient mice demonstrated increased MID-1 expression and PP2A reduction upon IL-13 challenge which correlated with eosinophil infiltration into the esophagus. Silencing MID-1 expression with siRNA completely ablated IL-13 induced eosinophil infiltration of the esophagus, restored PP2A activity, and reduced eotaxin-1 expression.
    Conclusion: IL-13-driven eosinophil infiltration of the esophagus induced eosinophilia and eotaxin-1 expression in a STAT6-dependent and MID-1-dependent manner. This study highlights a novel mechanism employed by IL-13 to perpetuate eosinophil infiltration.
    Language English
    Publishing date 2023-11-06
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-6101
    ISSN (online) 2673-6101
    DOI 10.3389/falgy.2023.1248432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In utero smoking exposure induces changes to lung clearance index and modifies risk of wheeze in infants.

    De Queiroz Andrade, Ediane / Sena, Carla Rebeca Da Silva / de Gouveia Belinelo, Patricia / Robinson, Paul D / Blaxland, Anneliese / Sly, Peter D / Murphy, Vanessa E / Gibson, Peter G / Collison, Adam M / Mattes, Joerg

    Pediatric pulmonology

    2024  

    Abstract: Background: Fetal exposure to tobacco smoking throughout pregnancy is associated with wheezing in infancy. We investigated the influence of in utero smoking exposure on lung ventilation homogeneity and the relationship between lung ventilation ... ...

    Abstract Background: Fetal exposure to tobacco smoking throughout pregnancy is associated with wheezing in infancy. We investigated the influence of in utero smoking exposure on lung ventilation homogeneity and the relationship between lung ventilation inhomogeneity at 7 weeks of age and wheezing in the first year of life.
    Methods: Maternal smoking was defined as self-reported smoking of tobacco or validated by exhaled (e)CO > 6 ppm. Lung function data from healthy infants (age 5-9 weeks) born to asthmatic mothers and parent-reported respiratory questionnaire data aged 12 months were collected in the Breathing for Life Trial (BLT) birth cohort. Tidal breathing analysis and SF
    Results: Data were collected on 423 participants. Infants born to women who self-reported smoking during pregnancy (n = 42) had higher lung clearance index (LCI) than those born to nonsmoking mothers (7.90 vs. 7.64; p = .030). Adjusted regression analyzes revealed interactions between self-reported smoking and LCI (RR: 1.98, 95% CI: 1.07-3.63, 0.028, for each unit increase in LCI) and between eCO > 6 ppm and LCI (RR: 2.25, 95% CI: 1.13-4.50, 0.022) for the risk of wheeze in the first year of life.
    Conclusion: In utero tobacco smoke exposure induces lung ventilation inhomogeneities. Furthermore, an interaction between smoke exposure and lung ventilation inhomogeneities increases the risk of having a wheeze in the first year of life.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Newcastle 1000 (NEW1000) Study: an Australian population-based prospective pregnancy cohort study design and protocol.

    Grace, Tegan / Fisher, Joshua / Wang, Carol / Valkenborghs, Sarah R / Smith, Roger / Hirst, Jonathan J / Mattes, Joerg / Murphy, Vanessa E / Pennell, Craig E

    BMJ open

    2023  Volume 13, Issue 7, Page(s) e072205

    Abstract: Introduction: Multiple cohort studies have been established to investigate the impact of early life factors on development and health outcomes. In Australia the majority of these studies were established more than 20 years ago and, although longitudinal ...

    Abstract Introduction: Multiple cohort studies have been established to investigate the impact of early life factors on development and health outcomes. In Australia the majority of these studies were established more than 20 years ago and, although longitudinal in nature, are inherently susceptible to socioeconomic, environmental and cultural influences which change over time. Additionally, rapid leaps in technology have increased our understanding of the complex role of gene-environment interactions in life course health, highlighting the need for new cohort studies with repeated biological sampling and in-depth phenotype data across the first 1000 days of life from conception.
    Methods and analysis: The Newcastle 1000 (NEW1000) Study, based in the regional city of Newcastle, New South Wales, was developed after an extensive consultation process involving 3 years of discussion with key stakeholders and healthcare consumer organisations and seven healthcare consumer workshops. This prospective population-based pregnancy cohort study will recruit 500 families per year for 5 years, providing detailed, longitudinal, multisystem phenotyping, repeated ultrasound measures and serial sample collection to investigate healthcare consumer identified health outcomes of priority. Stage 1 will involve recruitment of pregnant participants and their partners at 14 weeks gestation, with dense phenotype data and biological samples collected at 14, 20, 28 and 36 weeks gestation and serial ultrasound measures at 20, 28, 36 and 40 weeks, with postpartum follow-up at 6 weeks and 6 months. Biological samples will be used for biomarker discovery and sequencing of the genome, transcriptome, epigenome, microbiome and metabolome.
    Ethics and dissemination: Ethics approval was obtained from Hunter New England Local Health District Ethics Committee (2020/ETH02881). Outcomes will be published in peer-reviewed journals, disseminated to participants through the NEW1000 website, presented at scientific conferences, and written reports to local, state and national government bodies and key stakeholders in the healthcare system to inform policy and evidence-based practice.
    MeSH term(s) Pregnancy ; Female ; Humans ; Cohort Studies ; Australia ; Prospective Studies ; New South Wales/epidemiology ; Research Design
    Language English
    Publishing date 2023-07-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-072205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluation of an mHealth Intervention (Growin' Up Healthy Jarjums) Designed With and for Aboriginal and Torres Strait Islander Mothers: Engagement and Acceptability Study.

    Perkes, Sarah Jane / Huntriss, Belinda / Skinner, Noelene / Leece, Bernise / Dobson, Rosie / Mattes, Joerg / Hall, Kerry / Bonevski, Billie

    JMIR pediatrics and parenting

    2023  Volume 6, Page(s) e43673

    Abstract: Background: Aboriginal and Torres Strait Islander women have access to and interest in mobile health (mHealth), although few culturally relevant, evidence-based mHealth programs are available. We codeveloped an mHealth program in New South Wales with ... ...

    Abstract Background: Aboriginal and Torres Strait Islander women have access to and interest in mobile health (mHealth), although few culturally relevant, evidence-based mHealth programs are available. We codeveloped an mHealth program in New South Wales with Aboriginal and Torres Strait Islander women, focusing on women's and children's health and well-being.
    Objective: This study aims to assess the engagement with and acceptability of the Growin' Up Healthy Jarjums program among mothers caring for Aboriginal and Torres Strait Islander children aged <5 years and assess the acceptability of the program among professionals.
    Methods: Women were given access to Growin' Up Healthy Jarjums-a web-based application, a Facebook (Meta Platforms, Inc) page, and SMS text messages-for 4 weeks. Short videos of health professionals presenting health information were tested within the application and on the Facebook page. Engagement with the application was examined through the number of log-ins, page views, and links used on the application. Engagement with the Facebook page was examined through likes, follows, comments, and the reach of posts. Engagement with the SMS text messages was examined through the number of mothers who opted out, and engagement with the videos was examined through the number of plays and videos watched and duration of the video watched. The acceptability of the program was examined through posttest interviews with mothers and focus groups with professionals.
    Results: A total of 47 participants joined the study (n=41, 87%, mothers and n=6, 13%, health professionals). Interviews were completed by 78% (32/41) of the women and 100% (6/6) health professionals. Of the 41 mothers, 31 (76%) women accessed the application, 13 (42%) scrolled the main page only, and 18 (58%) clicked on other pages. There were 48 plays and 6 completions of the 12 videos. The Facebook page received 49 page likes and 51 followers. The post with the most reach was a supportive and affirming cultural post. No participants opted out of the SMS text messages. Almost all mothers (30/32, 94%) reported that Growin' Up Healthy Jarjums was useful, and all mothers reported that the program was culturally appropriate and easy to use. Of the 32 mothers, 6 (19%) mothers reported technical problems with accessing the application. Moreover, 44% (14/32) of mothers suggested improvements to the application. All the women reported that they would recommend the program to other families.
    Conclusions: This study demonstrated that the Growin' Up Healthy Jarjums program was perceived useful and culturally appropriate. SMS text messages had the highest engagement, followed by the Facebook page and then the application. This study identified areas for technical and engagement-related improvements to the application. A trial is needed to assess the effectiveness of the Growin' Up Healthy Jarjums program at improving health outcomes.
    Language English
    Publishing date 2023-05-26
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-6722
    ISSN (online) 2561-6722
    DOI 10.2196/43673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The microbiota in eosinophilic esophagitis: A systematic review.

    Angerami Almeida, Kaylani / de Queiroz Andrade, Ediane / Burns, Grace / Hoedt, Emily C / Mattes, Joerg / Keely, Simon / Collison, Adam

    Journal of gastroenterology and hepatology

    2022  Volume 37, Issue 9, Page(s) 1673–1684

    Abstract: Eosinophilic esophagitis (EoE) is an atopic disease of the esophagus that has shown a significant increase in incidence and prevalence in the last 20 years. The etiology of EoE is unclear, and few studies explore the esophageal microbiota in EoE. The ... ...

    Abstract Eosinophilic esophagitis (EoE) is an atopic disease of the esophagus that has shown a significant increase in incidence and prevalence in the last 20 years. The etiology of EoE is unclear, and few studies explore the esophageal microbiota in EoE. The local microbiome has been implicated in the pathogenesis of several allergic and inflammatory diseases, such as asthma and eczema. In this study, we performed a systematic review to evaluate differences in the microbiota profile of patients with EoE compared with controls. MEDLINE, Embase, Cochrane Library, Scopus, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases were searched to identify studies investigating the microbiota composition in EoE. Three reviewers screened the articles for eligibility and quality. Seven articles underwent full-text review, and a narrative synthesis was undertaken. The microbiota of the mouth and esophagus are correlated. Patients with active EoE present increased esophageal microbial load and increased abundance in particular species, such as Haemophilus and Aggregatibacter. On the other hand, EoE patients present a decrease in Firmicutes. High microbial load and abundance of Haemophilus are observed in EoE patients, but little evidence exists to demonstrate their influence on inflammation and disease. Understanding microbial signatures in EoE might contribute to the development of novel therapeutic strategies.
    MeSH term(s) Eosinophilic Esophagitis/drug therapy ; Eosinophilic Esophagitis/etiology ; Humans ; Incidence ; Inflammation/complications ; Microbiota
    Language English
    Publishing date 2022-07-12
    Publishing country Australia
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.15921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Development of a Maternal and Child mHealth Intervention With Aboriginal and Torres Strait Islander Mothers: Co-design Approach.

    Perkes, Sarah Jane / Huntriss, Belinda / Skinner, Noelene / Leece, Bernise / Dobson, Rosie / Mattes, Joerg / Hall, Kerry / Bonevski, Billie

    JMIR formative research

    2022  Volume 6, Issue 7, Page(s) e33541

    Abstract: Background: Despite their growing popularity, there are very few mobile health (mHealth) interventions for Aboriginal and Torres Strait Islander people that are culturally safe and evidence based. A co-design approach is considered a suitable ... ...

    Abstract Background: Despite their growing popularity, there are very few mobile health (mHealth) interventions for Aboriginal and Torres Strait Islander people that are culturally safe and evidence based. A co-design approach is considered a suitable methodology for developing health interventions with Aboriginal and Torres Strait Islander people.
    Objective: The aim of this study was to co-design an mHealth intervention to improve health knowledge, health behaviors, and access to health services for women caring for young Aboriginal and Torres Strait Islander children.
    Methods: Aboriginal researchers led engagement and recruitment with health services and participants in 3 Aboriginal and Torres Strait Islander communities in New South Wales, Australia. Focus groups and interviews were facilitated by researchers and an app developer to gather information on 3 predetermined themes: design characteristics, content modules, and features and functions. Findings from the co-design led to the development of an intervention prototype. Theories of health behavior change were used to underpin intervention components. Existing publicly available evidence-based information was used to develop content. Governance was provided by an Aboriginal advisory group.
    Results: In total, 31 mothers and 11 health professionals participated in 8 co-design focus groups and 12 interviews from June 2019 to September 2019. The 6 design characteristics identified as important were credibility, Aboriginal and Torres Strait Islander designs and cultural safety, family centeredness, supportive, simple to use, and confidential. The content includes 6 modules for women's health: Smoke-free families, Safe drinking, Feeling good, Women's business, Eating, and Exercising. The content also includes 6 modules for children's health: Breathing well; Sleeping; Milestones; Feeding and eating; Vaccinations and medicines; and Ears, eyes, and teeth. In addition, 6 technology features and functions were identified: content feed, social connection, reminders, rewards, communication with health professionals, and use of videos.
    Conclusions: An mHealth intervention that included app, Facebook page, and SMS text messaging modalities was developed based on the co-design findings. The intervention incorporates health behavior change theory, evidence-based information, and the preferences of Aboriginal and Torres Strait Islander women and health professionals. A pilot study is now needed to assess the acceptability and feasibility of the intervention.
    Language English
    Publishing date 2022-07-08
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/33541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Exposure to 4% SF

    De Queiroz Andrade, Ediane / Bayfield, Katie J / Blaxland, Anneliese / Wong, Alexander / De Gouveia Belinelo, Patricia / Sly, Peter D / Collison, Adam / Murphy, Vanessa E / Gibson, Peter / Mattes, Joerg / Robinson, Paul D

    Pediatric pulmonology

    2022  Volume 57, Issue 4, Page(s) 1089–1091

    MeSH term(s) Humans ; Infant ; Respiration ; Respiratory Function Tests ; Tidal Volume
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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