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Article ; Online: Load Monitoring Practice in Elite Women Association Football.

Luteberget, Live S / Houtmeyers, Kobe C / Vanrenterghem, Jos / Jaspers, Arne / Brink, Michel S / Helsen, Werner F

Frontiers in sports and active living

2021 Volume 3, Page(s) 715122

Abstract: ... Given the clear organizational differences (i.e., professionalization and infrastructure) between men's and ...

Abstract	The description of current load monitoring practices may serve to highlight developmental needs for both the training ground, academia and related industries. While previous studies described these practices in elite men's football, no study has provided an overview of load monitoring practices in elite women's football. Given the clear organizational differences (i.e., professionalization and infrastructure) between men's and women's clubs, making inferences based on men's data is not appropriate. Therefore, this study aims to provide a first overview of the current load monitoring practices in elite women's football. Twenty-two elite European women's football clubs participated in a closed online survey (40% response rate). The survey consisted of 33 questions using multiple choice or Likert scales. The questions covered three topics; type of data collected and collection purpose, analysis methods, and staff member involvement. All 22 clubs collected data related to different load monitoring purposes, with 18 (82%), 21 (95%), and 22 (100%) clubs collecting external load, internal load, and training outcome data, respectively. Most respondents indicated that their club use training models and take into account multiple indicators to analyse and interpret the data. While sports-science staff members were most involved in the monitoring process, coaching, and sports-medicine staff members also contributed to the discussion of the data. Overall, the results of this study show that most elite women's clubs apply load monitoring practices extensively. Despite the organizational challenges compared to men's football, these observations indicate that women's clubs have a vested interest in load monitoring. We hope these findings encourage future developments within women's football.
Language	English
Publishing date	2021-08-27
Publishing country	Switzerland
Document type	Journal Article
ISSN	2624-9367
ISSN (online)	2624-9367
DOI	10.3389/fspor.2021.715122
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Article ; Online: Load Monitoring Practice in European Elite Football and the Impact of Club Culture and Financial Resources

Kobe C. Houtmeyers / Jos Vanrenterghem / Arne Jaspers / Ludwig Ruf / Michel S. Brink / Werner F. Helsen

Frontiers in Sports and Active Living, Vol

2021 Volume 3

Abstract: ... indicated that external load data (e.g., global navigation satellite system, accelerometer…) was collected ... the most whilst respondents also indicated to collect internal load (e.g., heart rate, rating of perceived ... exertion…) and training outcome data (e.g., aerobic fitness, neuromuscular fatigue…) for multiple purposes ...

Abstract	Load monitoring is considered important to manage the physical training process in team sports such as Association Football. Previous studies have described the load monitoring practices of elite English football clubs and clubs with an established sports-science department. An examination of a broader international sample is currently not available. In addition, previous research has suggested factors that may improve the implementation of load monitoring practices, such as a strong club belief on the benefit of evidence-based practice (EBP) and high club financial resources. However, no study has examined yet the actual impact of these factors on the monitoring practices. Therefore, this study aims (1) to provide an overview of load monitoring practices in European elite football and (2) to provide insight into the differences in implementation between clubs by examining the impact of the club beliefs on the benefit of EBP and the club financial resources. An online survey, consisting of multiple choice and Likert scale questions, was distributed among sports-science and sports-medicine staff (n = 99, 50% response rate). Information was asked about the types of data collected, collection purposes, analysis methods, and staff involvement. The results indicated that external load data (e.g., global navigation satellite system, accelerometer…) was collected the most whilst respondents also indicated to collect internal load (e.g., heart rate, rating of perceived exertion…) and training outcome data (e.g., aerobic fitness, neuromuscular fatigue…) for multiple purposes. Considerable diversity in data analysis was observed suggesting that analysis is often limited to reporting the gathered data. Sports-science staff were responsible for data collection and analysis. Other staff were involved in data discussion to share decision-making. These practices were positively impacted by a stronger club belief on the benefit of EBP and greater financial resources. Creating an organizational culture, characterized by a strong ...
Keywords	soccer ; physical training ; team sport ; technology ; sports science ; analysis ; Sports ; GV557-1198.995
Subject code	796
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preoperative planning of a pedicled anterolateral thigh (ALT) flap for penile reconstruction with the multidetector CT scan.

Sinove, Y / Kyriopoulos, E / Ceulemans, P / Houtmeyers, P / Hoebeke, P / Monstrey, S

Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...

2013 Volume 45, Issue 4, Page(s) 217–222

Abstract: Introduction: Recently, perforator flap surgery has been introduced in phalloplasty procedures. Especially the anterolateral thigh (ALT) flap has found its application as a pedicled flap for the penile reconstruction. Adequate shaping of the flap and ... ...

Abstract	Introduction: Recently, perforator flap surgery has been introduced in phalloplasty procedures. Especially the anterolateral thigh (ALT) flap has found its application as a pedicled flap for the penile reconstruction. Adequate shaping of the flap and the need of transferring the shaped flap on its pedicle to the pubic area requires precise localisation and preoperative evaluation of the perforators. Also preoperative measurement of the subcutaneous fat tissue is necessary to allow adequate patient selection and optimal shaping of the phallus. The objective of this report is to demonstrate the usefulness of a multidetector CT scan (MDCT) in the preoperative planning of patients undergoing an ALT flap phalloplasty. Methods: Between September 2009 and July 2011, 13 patients were operated for ALT phalloplasty and had preoperative perforator mapping with the MDCT. An algorithm was set up to select the best perforator. Indocyanine green angiography was used in 5 patients to confirm the perforator selection. A mathematical formula was developed to calculate the necessary flap width from the flap thickness. Results: Accurate identification of the main perforators was achieved in all patients with a very satisfactory concordance between the MDCT scan and surgical findings. Indocyanine green angiography confirmed the MDCT perforator selection in all cases. The flap size could be determined preoperatively in all patients by measuring the thickness of the subcutaneous fat layer. Conclusions: Preoperative evaluation of ALT perforators and the subcutaneous fat tissue layer is feasible with an MDCT scan and provides precise data to make an adequate patient and perforator selection and determine the exact flap size.
MeSH term(s)	Adult ; Algorithms ; Angiography ; Cooperative Behavior ; Female ; Humans ; Image Interpretation, Computer-Assisted ; Imaging, Three-Dimensional ; Indocyanine Green ; Interdisciplinary Communication ; Iopamidol/analogs & derivatives ; Microsurgery/methods ; Models, Theoretical ; Multidetector Computed Tomography ; Patient Care Planning ; Patient Satisfaction ; Patient Selection ; Perforator Flap/blood supply ; Perforator Flap/surgery ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Sex Reassignment Surgery/methods ; Tissue and Organ Harvesting/methods
Chemical Substances	iomeprol (17E17JBP8L) ; Indocyanine Green (IX6J1063HV) ; Iopamidol (JR13W81H44)
Language	English
Publishing date	2013-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392414-2
ISSN	1439-3980 ; 0722-1819
ISSN (online)	1439-3980
ISSN	0722-1819
DOI	10.1055/s-0032-1333271
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Article: Preoperative Planning of a Pedicled Anterolateral Thigh (ALT) Flap for Penile Reconstruction with the Multidetector CT Scan

Sinove, Y. / Kyriopoulos, E. / Ceulemans, P. / Houtmeyers, P. / Hoebeke, P. / Monstrey, S.

Handchirurgie · Mikrochirurgie · Plastische Chirurgie

2013 Volume 45, Issue 04, Page(s) 217–222

Abstract: Recently, perforator flap surgery has been introduced in phalloplasty procedures. Especially the anterolateral thigh (ALT) flap has found its application as a pedicled flap for the penile reconstruction. Adequate shaping of the flap and the need of ... ...

Abstract	Recently, perforator flap surgery has been introduced in phalloplasty procedures. Especially the anterolateral thigh (ALT) flap has found its application as a pedicled flap for the penile reconstruction. Adequate shaping of the flap and the need of transferring the shaped flap on its pedicle to the pubic area requires precise localisation and preoperative evaluation of the perforators. Also preoperative measurement of the subcutaneous fat tissue is necessary to allow adequate patient selection and optimal shaping of the phallus. The objective of this report is to demonstrate the usefulness of a multidetector CT scan (MDCT) in the preoperative planning of patients undergoing an ALT flap phalloplasty. Between September 2009 and July 2011, 13 patients were operated for ALT phalloplasty and had preoperative perforator mapping with the MDCT. An algorithm was set up to select the best perforator. Indocyanine green angiography was used in 5 patients to confirm the perforator selection. A mathematical formula was developed to calculate the necessary flap width from the flap thickness. Accurate identification of the main perforators was achieved in all patients with a very satisfactory concordance between the MDCT scan and surgical findings. Indocyanine green angiography confirmed the MDCT perforator selection in all cases. The flap size could be determined preoperatively in all patients by measuring the thickness of the subcutaneous fat layer. Preoperative evaluation of ALT perforators and the subcutaneous fat tissue layer is feasible with an MDCT scan and provides precise data to make an adequate patient and perforator selection and determine the exact flap size.
Keywords	interdisciplinary plastic surgery ; transsexualism ; urological plastic surgery ; genital organs ; pedicled flap ; perforator flap ; interdisziplinäre plastische Chirurgie ; Transsexualität ; urologische plastische Chirurgie ; Genitalorgane ; gestielter Lappen ; Perforator-Lappen
Language	English
Publishing date	2013-03-06
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	392414-2
ISSN	1439-3980 ; 0722-1819
ISSN (online)	1439-3980
ISSN	0722-1819
DOI	10.1055/s-0032-1333271
Database	Thieme publisher's database

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Article ; Online: Titration efficacy of two auto-adjustable continuous positive airway pressure devices using different flow limitation-based algorithms.

Hertegonne, Katrien B / Rombaut, Bart / Houtmeyers, Philippe / Van Maele, Georges / Pevernagie, Dirk A

Respiration; international review of thoracic diseases

2008 Volume 75, Issue 1, Page(s) 48–54

Abstract: ... limitation, i.e. the Respironics REMstar Auto (RR) and the ResMed Spirit (RS).: Methods: Fifty ...

Abstract	Background: Auto-adjustable continuous positive airway pressure devices are widely used in titration procedures to determine therapeutic pressure levels in obstructive sleep apnea patients. However, differences in operational characteristics may influence the effect on the apnea-hypopnea index (AHI). Objectives: We compared the titration performance of two devices based on detection of inspiratory flow limitation, i.e. the Respironics REMstar Auto (RR) and the ResMed Spirit (RS). Methods: Fifty obstructive sleep apnea patients were recruited for a double-blind randomized crossover trial. Both devices were employed overnight by means of split-night polysomnography. The primary outcome was the AHI. Secondary outcome measures were the snoring index, pressure profiles and subjective appraisal of sleep quality assessed the morning after the sleep study. The Wilcoxon signed rank test for matched pairs was applied to assess differences between treatment conditions. Results: No significant differences were found in sleep parameters, subjective sleep quality and snoring index. The use of the RR was associated with a significantly lower AHI in comparison with the RS [mean (SD) 6.9 (11.6)/h vs. 9.4 (9.2)/h, p = 0.004]. This result was obtained at significantly lower pressure levels [P95 9.2 (2.3) cm H(2)O vs. 10.2 (1.5) cm H(2)O, p = 0.001]. Conclusion: While the RR provided a lower AHI than the RS at lower pressure levels, it could not be assessed whether this difference was relevant for clinical outcomes. However, this face-to-face comparison of Auto-adjustable continuous positive airway pressure devices seems useful for the assessment of titration efficacy.
MeSH term(s)	Adult ; Airway Resistance ; Analysis of Variance ; Automation ; Blood Gas Analysis ; Continuous Positive Airway Pressure/instrumentation ; Continuous Positive Airway Pressure/methods ; Cross-Over Studies ; Double-Blind Method ; Equipment Design ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Oxygen Consumption/physiology ; Polysomnography ; Probability ; Pulmonary Gas Exchange ; Risk Assessment ; Severity of Illness Index ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/therapy ; Statistics, Nonparametric ; Titrimetry ; Treatment Outcome ; Ventilators, Mechanical/standards
Language	English
Publishing date	2008
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	206674-9
ISSN	1423-0356 ; 0025-7931
ISSN (online)	1423-0356
ISSN	0025-7931
DOI	10.1159/000103515
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Article: High-dose lidocaine reduces airway mucus transport velocity in intubated anesthetized dogs.

Gosselink, Rik / Gayan-Ramirez, Ghislaine / Houtmeyers, Els / de Paepe, Kristel / Decramer, Marc

Respiratory medicine

2006 Volume 100, Issue 2, Page(s) 258–263

Abstract: Background: Assessment of mucociliary clearance with displacement of charcoal markers in the central airways needs a bronchoscopic procedure and thus local anesthesia of the upper airways. However, the effects of lidocaine administration on mucus ... ...

Abstract	Background: Assessment of mucociliary clearance with displacement of charcoal markers in the central airways needs a bronchoscopic procedure and thus local anesthesia of the upper airways. However, the effects of lidocaine administration on mucus transport in airways are inconclusive. Therefore, detailed information is needed to establish the effects of high- and low-dose lidocaine administration. Objectives: To study the dose-dependent effect of instillation of lidocaine on mucus transport velocity (MTV) in intubated, anaesthetized dogs. Methods: Displacement of a charcoal spot in time was studied with a bronchoscope in 10 anaesthetized dogs before and after administration of respectively 5 and 10 ml of either 2% lidocaine (n=5) or NaCl 0.9% (n=5). In addition, mucus viscoelastic properties were determined. Results: No significant differences in MTV were observed after administration of 5 ml of NaCl (8.2+/-3.2 mm/min) or 2% lidocaine (6.7+/-3.8 mm/min) compared to baseline values. By contrast, MTV was reduced after administration of 10 ml of 2% lidocaine (1.9+/-1.0 mm/min; P<0.05 vs. baseline and 5 ml of 2% lidocaine vs. controls, P=0.0035), but not after 10 ml of NaCl (6.2+/-2.1 mm/min). A trend towards an increased mucociliary clearability index was observed for the lidocaine-treated group as compared to the control group (P=0.07). The cough clearability index was not different between groups (P=0.89). Conclusions: High-dose lidocaine reduces MTV. Therefore, only low-dose lidocaine administration should be applied in the bronchoscopic procedure for assessment of MTV.
MeSH term(s)	Anesthetics, Local/administration & dosage ; Anesthetics, Local/pharmacology ; Animals ; Bronchi/drug effects ; Dogs ; Dose-Response Relationship, Drug ; Elasticity/drug effects ; Intubation, Intratracheal ; Lidocaine/administration & dosage ; Lidocaine/pharmacology ; Mucus/drug effects ; Viscosity/drug effects
Chemical Substances	Anesthetics, Local ; Lidocaine (98PI200987)
Language	English
Publishing date	2006-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2005.04.028
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Article: Regulation of mucociliary clearance in health and disease.

Houtmeyers, E / Gosselink, R / Gayan-Ramirez, G / Decramer, M

The European respiratory journal

1999 Volume 13, Issue 5, Page(s) 1177–1188

Abstract: Airway secretions are cleared by mucociliary clearance (MCC), in addition to other mechanisms such as cough, peristalsis, two-phase gas-liquid flow and alveolar clearance. MCC comprises the cephalad movement of mucus caused by the cilia lining the ... ...

Abstract	Airway secretions are cleared by mucociliary clearance (MCC), in addition to other mechanisms such as cough, peristalsis, two-phase gas-liquid flow and alveolar clearance. MCC comprises the cephalad movement of mucus caused by the cilia lining the conducting airways until it can be swallowed or expectorated. MCC is a very complex process in which many variables are involved, all of which may modify the final outcome. The structure, number, movement and co-ordination of the cilia present in the airways as well as the amount, composition and rheological properties of the periciliary and mucus layers are determinants of MCC. Physiological factors such as age, sex, posture, sleep and exercise are reported to influence MCC due to a change in the cilia, the mucus or the periciliary layer, or a combination of these. Environmental pollution is suspected to have a depressant effect on MCC dependent on different factors such as pollutant concentration and the duration of exposure. Most studies focus on sulphur dioxide, sulphuric acid, nitrogen dioxide and ozone. Tobacco smoke and hairspray have been noted to have a negative influence on MCC. Some diseases are known to affect MCC, mostly negatively. The underlying mechanism differs from one illness to another. Immotile cilia syndrome, asthma, bronchiectasis, chronic bronchitis, cystic fibrosis and some acute respiratory tract infections are among the most frequently reported. The present paper reviews normal mucociliary clearance and the effects of diseases on this process.
MeSH term(s)	Ciliary Motility Disorders/physiopathology ; Environmental Pollutants/adverse effects ; Humans ; Lung Diseases/physiopathology ; Mucociliary Clearance/physiology ; Mucus/chemistry
Chemical Substances	Environmental Pollutants
Language	English
Publishing date	1999-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1034/j.1399-3003.1999.13e39.x
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Article: Effects of drugs on mucus clearance.

Houtmeyers, E / Gosselink, R / Gayan-Ramirez, G / Decramer, M

The European respiratory journal

1999 Volume 14, Issue 2, Page(s) 452–467

Abstract: Mucociliary clearance (MCC), the process in which airway mucus together with substances trapped within are moved out of the lungs, is an important defence mechanism of the human body. Drugs may alter this process, such that it is necessary to know the ... ...

Abstract	Mucociliary clearance (MCC), the process in which airway mucus together with substances trapped within are moved out of the lungs, is an important defence mechanism of the human body. Drugs may alter this process, such that it is necessary to know the effect of the drugs on MCC. Indeed, agents stimulating MCC may be used therapeutically in respiratory medicine, especially in patients suspected of having an impairment of their mucociliary transport system. In contrast, caution should be taken with drugs depressing MCC as an undesired side-effect, independently of their therapeutic indication. Since cough clearance (CC) serves as a back-up system when MCC fails, the influence of drugs must be examined not only on MCC but also on CC. Ultimately, the clinical repercussions of alterations in mucus transport induced by drug administration must be studied. Tertiary ammonium compounds (anticholinergics), aspirin, anaesthetic agents and benzodiazepines have been shown to be capable of depressing the mucociliary transport system. Cholinergics, methylxanthines, sodium cromoglycate, hypertonic saline, saline as well as water aerosol have been shown to increase MCC. Adrenergic antagonists, guaifenesin, S-carboxymethylcysteine, sodium 2-mercapto-ethane sulphonate and frusemide have been reported not to alter the mucociliary transport significantly. Amiloride, uridine 5'-triphosphate (UTP), quaternary ammonium compounds (anticholinergics), adrenergic agonists, corticosteroids, recombinant human deoxyribonuclease (rhDNase), N-acetylcysteine, bromhexine and ambroxol have been reported either not to change or to augment MCC. Indirect data suggest that surfactant as well as antibiotics may improve the mucociliary transport system. As for the influence of drugs on CC, amiloride and rhDNase have been demonstrated to increase the effectiveness of cough. A trend towards an improved CC was noted after treatment with adrenergic agonists. The anticholinergic agent ipratropium bromide, which is a quaternary ammonium compound, has been suggested to decrease CC significantly. Bromhexine, ambroxol and neutral saline seemed not to alter CC, either positively or negatively. Finally, treatment with either amiloride, recombinant human deoxyribonuclease, bromhexine, ambroxol, N-acetylcysteine, S-carboxymethylcysteine or hypertonic saline has been suggested as a possible cause of clinical improvement in patients, such as the experience of dyspnoea, the case of expectoration or the frequency of infective exacerbations. Other agents did not show a clinical benefit.
MeSH term(s)	Animals ; Ciliary Motility Disorders/chemically induced ; Ciliary Motility Disorders/drug therapy ; Ciliary Motility Disorders/physiopathology ; Cough/physiopathology ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Mucociliary Clearance/drug effects ; Mucociliary Clearance/physiology ; Mucus/drug effects ; Mucus/physiology
Language	English
Publishing date	1999-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1034/j.1399-3003.1999.14b35.x
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Article ; Online: Transcription factor Zic2 inhibits Wnt/β-catenin protein signaling.

Pourebrahim, Rasoul / Houtmeyers, Rob / Ghogomu, Stephen / Janssens, Sylvie / Thelie, Aurore / Tran, Hong Thi / Langenberg, Tobias / Vleminckx, Kris / Bellefroid, Eric / Cassiman, Jean-Jacques / Tejpar, Sabine

The Journal of biological chemistry

2011 Volume 286, Issue 43, Page(s) 37732–37740

Abstract: The Zic transcription factors play critical roles during embryonic development. Mutations in the ZIC2 gene are associated with human holoprosencephaly, but the etiology is still unclear. Here, we report a novel function for ZIC2 as a regulator of β- ... ...

Abstract	The Zic transcription factors play critical roles during embryonic development. Mutations in the ZIC2 gene are associated with human holoprosencephaly, but the etiology is still unclear. Here, we report a novel function for ZIC2 as a regulator of β-catenin·TCF4-mediated transcription. We show that ZIC2 can bind directly to the DNA-binding high mobility group box of TCF4 via its zinc finger domain and inhibit the transcriptional activity of the β-catenin·TCF4 complex. However, the binding of TCF4 to DNA was not affected by ZIC2. Zic2 RNA injection completely inhibited β-catenin-induced axis duplication in Xenopus embryos and strongly blocked the ability of β-catenin to induce expression of known Wnt targets in animal caps. Moreover, Zic2 knockdown in transgenic Xenopus Wnt reporter embryos led to ectopic Wnt signaling activity mainly at the midbrain-hindbrain boundary. Together, our results demonstrate a previously unknown role for ZIC2 as a transcriptional regulator of the β-catenin·TCF4 complex.
MeSH term(s)	Animals ; Animals, Genetically Modified/genetics ; Animals, Genetically Modified/microbiology ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Embryo, Nonmammalian/metabolism ; HEK293 Cells ; Humans ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Signal Transduction/physiology ; Transcription Factor 4 ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic/physiology ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Xenopus laevis ; beta Catenin/genetics ; beta Catenin/metabolism
Chemical Substances	Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Multiprotein Complexes ; Nuclear Proteins ; TCF4 protein, human ; Transcription Factor 4 ; Transcription Factors ; Wnt Proteins ; ZIC2 protein, human ; beta Catenin
Language	English
Publishing date	2011-09-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M111.242826
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Article: Titration Efficacy of Two Auto-Adjustable Continuous Positive Airway Pressure Devices Using Different Flow Limitation-Based Algorithms

Hertegonne, Katrien B. / Rombaut, Bart / Houtmeyers, Philippe / Van Maele, Georges / Pevernagie, Dirk A.

Respiration

2007 Volume 75, Issue 1, Page(s) 48–54

Abstract: ... limitation, i.e. the Respironics REMstar Auto™ (RR) and the ResMed Spirit™ (RS). Methods: Fifty ...

Institution	Department of Respiratory Diseases and Medical Statistics, Ghent University Hospital Ghent University, Ghent, and Department of Respiratory Diseases, Stedelijk Ziekenhuis, Aalst, Belgium
Abstract	Background: Auto-adjustable continuous positive airway pressure devices are widely used in titration procedures to determine therapeutic pressure levels in obstructive sleep apnea patients. However, differences in operational characteristics may influence the effect on the apnea-hypopnea index (AHI). Objectives: We compared the titration performance of two devices based on detection of inspiratory flow limitation, i.e. the Respironics REMstar Auto™ (RR) and the ResMed Spirit™ (RS). Methods: Fifty obstructive sleep apnea patients were recruited for a double-blind randomized crossover trial. Both devices were employed overnight by means of split-night polysomnography. The primary outcome was the AHI. Secondary outcome measures were the snoring index, pressure profiles and subjective appraisal of sleep quality assessed the morning after the sleep study. The Wilcoxon signed rank test for matched pairs was applied to assess differences between treatment conditions. Results: No significant differences were found in sleep parameters, subjective sleep quality and snoring index. The use of the RR was associated with a significantly lower AHI in comparison with the RS [mean (SD) 6.9 (11.6)/h vs. 9.4 (9.2)/h, p = 0.004]. This result was obtained at significantly lower pressure levels [P95 9.2 (2.3) cm H2O vs. 10.2 (1.5) cm H2O, p = 0.001]. Conclusion: While the RR provided a lower AHI than the RS at lower pressure levels, it could not be assessed whether this difference was relevant for clinical outcomes. However, this face-to-face comparison of Auto-adjustable continuous positive airway pressure devices seems useful for the assessment of titration efficacy.
Keywords	Respironics REMstar Auto™ ; Continuous positive airway pressure ; Obstructive sleep apnea ; Snoring ; ResMed Spirit™
Language	English
Publishing date	2007-06-01
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Clinical Investigations
ZDB-ID	206674-9
ISSN	1423-0356 ; 0025-7931
ISSN (online)	1423-0356
ISSN	0025-7931
DOI	10.1159/000103515
Database	Karger publisher's database

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