LIVIVO - Search results -

Search results

Result 1 - 10 of total 88

Search options

Book: Down syndrome and related developmental disorders

Corbin, Joshua G. / Haydar, Tarik F.

5 tables

(Developmental neuroscience ; 33,5)

2011

Author's details	ed.: Tarik F. Haydar ; Joshua G. Corbin
Series title	Developmental neuroscience ; 33,5
Collection
Keywords	Fragiles-X-Syndrom ; Down-Syndrom ; Pathophysiologie
Subject	Fragile-X-Syndrome ; Marker-X-Syndrom ; Martin-Bell-Syndrom ; Fragile x chromosome ; Fragile-x-linked mentalretardation ; Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie ; Langdon-Down-Krankheit ; Mongolismus ; Mongoloidismus ; Morbus Down ; Morbus Langdon Down ; Trisomie 21 ; Down's Syndrome ; Downsyndrom
Language	English
Size	S. 337 - 467 : Ill., graph. Darst.
Publisher	Karger
Publishing place	Basel u.a.
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT017147355
ISBN	978-3-8055-9886-6 ; 9783805598873 ; 3-8055-9886-6 ; 3805598874
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Zs A 1438 -33-	not available for loan	Zeitschriften-Lesesaal

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Neuronal subtypes and connectivity of the adult mouse paralaminar amygdala.

Saxon, David / Alderman, Pia J / Sorrells, Shawn F / Vicini, Stefano / Corbin, Joshua G

bioRxiv : the preprint server for biology

2024

Abstract: The paralaminar nucleus of the amygdala (PL) is comprised of neurons which exhibit delayed maturation. PL neurons are born during gestation but mature during adolescent ages, differentiating into excitatory neurons. The PL is prominent in the adult ... ...

Abstract	The paralaminar nucleus of the amygdala (PL) is comprised of neurons which exhibit delayed maturation. PL neurons are born during gestation but mature during adolescent ages, differentiating into excitatory neurons. The PL is prominent in the adult amygdala, contributing to its increased neuron number and relative size compared to childhood. However, the function of the PL is unknown, as the region has only recently begun to be characterized in detail. In this study, we investigated key defining features of the adult PL; the intrinsic morpho-electric properties of its neurons, and its input and output connectivity. We identify two subtypes of excitatory neurons in the PL based on unsupervised clustering of electrophysiological properties. These subtypes are defined by differential action potential firing properties and dendritic architecture, suggesting divergent functional roles. We further uncover major axonal inputs to the adult PL from the main olfactory network and basolateral amygdala. We also find that axonal outputs from the PL project reciprocally to major inputs, and to diverse targets including the amygdala, frontal cortex, hippocampus, hypothalamus, and brainstem. Thus, the adult PL is centrally placed to play a major role in the integration of olfactory sensory information, likely coordinating affective and autonomic behavioral responses to salient odor stimuli. Significance statement: Mammalian amygdala development includes a growth period from childhood to adulthood, believed to support emotional and social learning. This amygdala growth is partly due to the maturation of neurons during adolescence in the paralaminar amygdala. However, the functional properties of these neurons are unknown. In our recent studies, we characterized the paralaminar amygdala in the mouse. Here, we investigate the properties of the adult PL in the mouse, revealing the existence of two neuronal subtypes that may play distinct functional roles in the adult brain. We further reveal the brain-wide input and output connectivity of the PL, indicating that the PL combines olfactory cues for emotional processing and delivers information to regions associated with reward and autonomic states.
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.11.575250
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Hardwired to attack: Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors.

Lischinsky, Julieta E / Yin, Luping / Shi, Chenxi / Prakash, Nandkishore / Burke, Jared / Shekaran, Govind / Grba, Maria / Corbin, Joshua G / Lin, Dayu

bioRxiv : the preprint server for biology

2023

Abstract: Social behaviors are innate and supported by dedicated neural circuits, but it remains unclear whether these circuits are developmentally hardwired or established through social experience. Here, we revealed distinct response patterns and functions in ... ...

Abstract	Social behaviors are innate and supported by dedicated neural circuits, but it remains unclear whether these circuits are developmentally hardwired or established through social experience. Here, we revealed distinct response patterns and functions in social behavior of medial amygdala (MeA) cells originating from two embryonically parcellated developmental lineages. MeA cells in male mice that express the transcription factor Foxp2 (MeA
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.16.532692
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors.

Lischinsky, Julieta E / Yin, Luping / Shi, Chenxi / Prakash, Nandkishore / Burke, Jared / Shekaran, Govind / Grba, Maria / Corbin, Joshua G / Lin, Dayu

Nature neuroscience

2023 Volume 26, Issue 12, Page(s) 2131–2146

Abstract: Social behaviors are innate and supported by dedicated neural circuits, but the molecular identities of these circuits and how they are established developmentally and shaped by experience remain unclear. Here we show that medial amygdala (MeA) cells ... ...

Abstract	Social behaviors are innate and supported by dedicated neural circuits, but the molecular identities of these circuits and how they are established developmentally and shaped by experience remain unclear. Here we show that medial amygdala (MeA) cells originating from two embryonically parcellated developmental lineages have distinct response patterns and functions in social behavior in male mice. MeA cells expressing the transcription factor Foxp2 (MeA
MeSH term(s)	Male ; Mice ; Animals ; Neurons/physiology ; Social Behavior ; Amygdala/physiology ; Corticomedial Nuclear Complex ; Transcription Factors/genetics ; Homeodomain Proteins/metabolism
Chemical Substances	Transcription Factors ; Dbx1 protein, mouse ; Homeodomain Proteins
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1420596-8
ISSN	1546-1726 ; 1097-6256
ISSN (online)	1546-1726
ISSN	1097-6256
DOI	10.1038/s41593-023-01475-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4891: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 67: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala.

Alderman, Pia J / Saxon, David / Torrijos-Saiz, Lucía I / Sharief, Malaz / Page, Chloe E / Baroudi, Jude K / Biagiotti, Sean W / Butyrkin, Vladimir A / Melamed, Anna / Kuo, Chay T / Vicini, Stefano / García-Verdugo, Jose M / Herranz-Pérez, Vicente / Corbin, Joshua G / Sorrells, Shawn F

Neuron

2023 Volume 112, Issue 4, Page(s) 574–592.e10

Abstract: The human amygdala paralaminar nucleus (PL) contains many immature excitatory neurons that undergo prolonged maturation from birth to adulthood. We describe a previously unidentified homologous PL region in mice that contains immature excitatory neurons ... ...

Abstract	The human amygdala paralaminar nucleus (PL) contains many immature excitatory neurons that undergo prolonged maturation from birth to adulthood. We describe a previously unidentified homologous PL region in mice that contains immature excitatory neurons and has previously been considered part of the amygdala intercalated cell clusters or ventral endopiriform cortex. Mouse PL neurons are born embryonically, not from postnatal neurogenesis, despite a subset retaining immature molecular and morphological features in adults. During juvenile-adolescent ages (P21-P35), the majority of PL neurons undergo molecular, structural, and physiological maturation, and a subset of excitatory PL neurons migrate into the adjacent endopiriform cortex. Alongside these changes, PL neurons develop responses to aversive and appetitive olfactory stimuli. The presence of this homologous region in both humans and mice points to the significance of this conserved mechanism of neuronal maturation and migration during adolescence, a key time period for amygdala circuit maturation and related behavioral changes.
MeSH term(s)	Adolescent ; Humans ; Adult ; Animals ; Mice ; Neurons ; Amygdala ; Neural Stem Cells ; Basolateral Nuclear Complex ; Affect
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2023.11.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 92: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Developmental changes in expression of inhibitory neuronal proteins in the Fragile X Syndrome mouse basolateral amygdala.

Kratovac, Sebila / Corbin, Joshua G

Brain research

2013 Volume 1537, Page(s) 69–78

Abstract: In humans, Fragile X Syndrome (FXS) is characterized by enhanced fear, hyperactivity, social anxiety, and, in a subset of individuals, autism. Many of the emotional and social deficits point to defects in the amygdala. We have previously shown defects in ...

Abstract	In humans, Fragile X Syndrome (FXS) is characterized by enhanced fear, hyperactivity, social anxiety, and, in a subset of individuals, autism. Many of the emotional and social deficits point to defects in the amygdala. We have previously shown defects in inhibitory neuron drive onto excitatory projection neurons in the basolateral amygdala (BLA) of juvenile Fmr1(-/y) knockout (KO) mice. Using pharmacological approaches, we have also previously revealed dynamic functional deficits in α1, α2, and α3 subunit-containing GABAA receptors (GABAARs α1, α2, and α3) during early postnatal development. In this study, we sought to determine whether these defects in GABAAR function are accompanied by changes in protein expression of GABAARs α1, α2, and α3 and the post-synaptic GABAAR-clustering protein gephyrin. Interestingly, we found that while the expression of these proteins did not significantly differ between wildtype (WT) and KO mice at each time point, the timing of developmental expression of GABAAR α1, α2, and gephyrin was altered. Collectively, these data reveal novel defects in inhibitory synapse protein expression during critical periods of early postnatal development that could contribute to observed inhibitory neurotransmission deficits in the KO mouse BLA.
MeSH term(s)	Amygdala/growth & development ; Amygdala/metabolism ; Amygdala/physiopathology ; Animals ; Disease Models, Animal ; Fragile X Mental Retardation Protein/genetics ; Fragile X Mental Retardation Protein/metabolism ; Fragile X Syndrome/metabolism ; Fragile X Syndrome/physiopathology ; Mice ; Mice, Knockout ; Neurons/metabolism ; Receptors, GABA-A/metabolism ; Synapses/metabolism ; Synaptic Transmission/physiology
Chemical Substances	Fmr1 protein, mouse ; Receptors, GABA-A ; Fragile X Mental Retardation Protein (139135-51-6)
Language	English
Publishing date	2013-11-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2013.08.052
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 161: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Sex Differences in Biophysical Signatures across Molecularly Defined Medial Amygdala Neuronal Subpopulations.

Matos, Heidi Y / Hernandez-Pineda, David / Charpentier, Claire M / Rusk, Allison / Corbin, Joshua G / Jones, Kevin S

eNeuro

2020 Volume 7, Issue 4

Abstract: The medial amygdala (MeA) is essential for processing innate social and non-social behaviors, such as territorial aggression and mating, which display in a sex-specific manner. While sex differences in cell numbers and neuronal morphology in the MeA are ... ...

Abstract	The medial amygdala (MeA) is essential for processing innate social and non-social behaviors, such as territorial aggression and mating, which display in a sex-specific manner. While sex differences in cell numbers and neuronal morphology in the MeA are well established, if and how these differences extend to the biophysical level remain unknown. Our previous studies revealed that expression of the transcription factors, Dbx1 and Foxp2, during embryogenesis defines separate progenitor pools destined to generate different subclasses of MEA inhibitory output neurons. We have also previously shown that
MeSH term(s)	Action Potentials ; Amygdala ; Corticomedial Nuclear Complex ; Female ; Humans ; Male ; Neurons ; Sex Characteristics
Language	English
Publishing date	2020-07-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2800598-3
ISSN	2373-2822 ; 2373-2822
ISSN (online)	2373-2822
ISSN	2373-2822
DOI	10.1523/ENEURO.0035-20.2020
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Sex-Specific Social Behavior and Amygdala Proteomic Deficits in

Herrero, Maria Jesus / Wang, Li / Hernandez-Pineda, David / Banerjee, Payal / Matos, Heidi Y / Goodrich, Meredith / Panigrahi, Aswini / Smith, Nathan Anthony / Corbin, Joshua G

Frontiers in behavioral neuroscience

2021 Volume 15, Page(s) 706079

Abstract: In humans, mutations in the transcription factor encoding gene, ...

Abstract	In humans, mutations in the transcription factor encoding gene,
Language	English
Publishing date	2021-08-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2021.706079
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Eukaryote-conserved histone post-translational modification landscape in Giardia duodenalis revealed by mass spectrometry

Emery-Corbin, Samantha J / Hamey, Joshua J / Balan, Balu / Rojas-López, Laura / Svärd, Staffan G / Jex, Aaron R

Australian Society for Parasitology International journal for parasitology. 2021 Mar., v. 51, no. 4

2021

Abstract: Diarrheal disease caused by Giardia duodenalis is highly prevalent, causing over 200 million cases globally each year. The processes that drive parasite virulence, host immune evasion and transmission involve coordinated gene expression and have been ... ...

Abstract	Diarrheal disease caused by Giardia duodenalis is highly prevalent, causing over 200 million cases globally each year. The processes that drive parasite virulence, host immune evasion and transmission involve coordinated gene expression and have been linked to epigenetic regulation. Epigenetic regulatory systems are eukaryote-conserved, including in deep branching excavates such as Giardia, with several studies already implicating histone post-translational modifications in regulation of its pathogenesis and life cycle. However, further insights into Giardia chromatin dynamics have been hindered by a lack of site-specific knowledge of histone modifications. Using mass spectrometry, we have provided the first known molecular map of histone methylation, acetylation and phosphorylation modifications in Giardia core histones. We have identified over 50 previously unreported histone modifications including sites with established roles in epigenetic regulation, and co-occurring modifications indicative of post-translational modification crosstalk. These demonstrate conserved histone modifications in Giardia which are equivalent to many other eukaryotes, and suggest that similar epigenetic mechanisms are in place in this parasite. Further, we used sequence, domain and structural homology to annotate putative histone enzyme networks in Giardia, highlighting representative chromatin modifiers which appear sufficient for identified sites, particularly those from H3 and H4 variants. This study is to our knowledge the first and most comprehensive, complete and accurate view of Giardia histone post-translational modifications to date, and a substantial step towards understanding their associations in parasite development and virulence.
Keywords	Giardia lamblia ; acetylation ; chromatin ; chromosome mapping ; conserved sequences ; epigenetics ; gene expression ; giardiasis ; histones ; immune evasion ; life cycle (organisms) ; mass spectrometry ; methylation ; modifiers (genes) ; pathogenesis ; post-translational modification ; protein phosphorylation ; sequence homology ; virulence
Language	English
Dates of publication	2021-03
Size	p. 225-239.
Publishing place	Elsevier Ltd
Document type	Article
Note	golden set
ZDB-ID	120518-3
ISSN	1879-0135 ; 0020-7519
ISSN (online)	1879-0135
ISSN	0020-7519
DOI	10.1016/j.ijpara.2020.09.006
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 789: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Eukaryote-conserved histone post-translational modification landscape in Giardia duodenalis revealed by mass spectrometry.

Emery-Corbin, Samantha J / Hamey, Joshua J / Balan, Balu / Rojas-López, Laura / Svärd, Staffan G / Jex, Aaron R

International journal for parasitology

2020 Volume 51, Issue 4, Page(s) 225–239

Abstract	Diarrheal disease caused by Giardia duodenalis is highly prevalent, causing over 200 million cases globally each year. The processes that drive parasite virulence, host immune evasion and transmission involve coordinated gene expression and have been linked to epigenetic regulation. Epigenetic regulatory systems are eukaryote-conserved, including in deep branching excavates such as Giardia, with several studies already implicating histone post-translational modifications in regulation of its pathogenesis and life cycle. However, further insights into Giardia chromatin dynamics have been hindered by a lack of site-specific knowledge of histone modifications. Using mass spectrometry, we have provided the first known molecular map of histone methylation, acetylation and phosphorylation modifications in Giardia core histones. We have identified over 50 previously unreported histone modifications including sites with established roles in epigenetic regulation, and co-occurring modifications indicative of post-translational modification crosstalk. These demonstrate conserved histone modifications in Giardia which are equivalent to many other eukaryotes, and suggest that similar epigenetic mechanisms are in place in this parasite. Further, we used sequence, domain and structural homology to annotate putative histone enzyme networks in Giardia, highlighting representative chromatin modifiers which appear sufficient for identified sites, particularly those from H3 and H4 variants. This study is to our knowledge the first and most comprehensive, complete and accurate view of Giardia histone post-translational modifications to date, and a substantial step towards understanding their associations in parasite development and virulence.
MeSH term(s)	Epigenesis, Genetic ; Eukaryota/metabolism ; Giardia lamblia/genetics ; Giardia lamblia/metabolism ; Histones/genetics ; Histones/metabolism ; Mass Spectrometry ; Protein Processing, Post-Translational
Chemical Substances	Histones
Language	English
Publishing date	2020-12-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120518-3
ISSN	1879-0135 ; 0020-7519
ISSN (online)	1879-0135
ISSN	0020-7519
DOI	10.1016/j.ijpara.2020.09.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 789: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito