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Article ; Online: Muscle Protein Synthesis with a Hybrid Dairy and Plant-Based Protein Blend (P4) Is Equal to Whey Protein in a Murine Ageing Model after Fasting.

Dijk, Francina J / Hofman, Zandrie / Luiking, Yvette C / Furber, Matthew J W / Roberts, Justin D / van Helvoort, Ardy / van Dijk, Miriam

Nutrients

2023 Volume 15, Issue 11

Abstract: P4, a specific combination of dairy proteins (whey and casein) and plant-based protein isolates (pea and soy), has been shown to provide a more balanced amino acid (AA) profile than its single constituent proteins; however, less is known about how this ... ...

Abstract	P4, a specific combination of dairy proteins (whey and casein) and plant-based protein isolates (pea and soy), has been shown to provide a more balanced amino acid (AA) profile than its single constituent proteins; however, less is known about how this translates to muscle protein synthesis (MPS). The aim of this study was to investigate the effect of P4 compared to whey or casein against fasted control on MPS. C57BL/6J mice, aged 25 months, were fasted overnight, followed by oral gavage of either whey, P4, casein, or water as a fasted control. Thirty minutes after ingestion, puromycin (0.04 µmol∙g
MeSH term(s)	Mice ; Animals ; Whey Proteins/pharmacology ; Leucine/pharmacology ; Caseins/metabolism ; Muscle Proteins/metabolism ; Plant Proteins/pharmacology ; Mice, Inbred C57BL ; Amino Acids ; Muscle, Skeletal/metabolism ; Fasting ; Milk Proteins/metabolism
Chemical Substances	Whey Proteins ; Leucine (GMW67QNF9C) ; Caseins ; Muscle Proteins ; Plant Proteins ; Amino Acids ; Milk Proteins
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15112569
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A randomized-controlled trial of arginine infusion in severe sepsis on microcirculation and metabolism

Luiking, Yvette C / Poeze, Martijn / Deutz, Nicolaas E

Clinical nutrition. 2020 June, v. 39, no. 6

2020

Abstract: Sepsis is hypothesized as an arginine deficient state, with lack of nitric oxide (NO) for adequate microcirculation and local perfusion. This study aimed to investigate if prolonged (72-h) intravenous l-arginine administration in sepsis patients improves ...

Abstract	Sepsis is hypothesized as an arginine deficient state, with lack of nitric oxide (NO) for adequate microcirculation and local perfusion. This study aimed to investigate if prolonged (72-h) intravenous l-arginine administration in sepsis patients improves microcirculation. Secondly, effects on arginine and protein metabolism, and organ function were studied.Critically ill patients with a diagnosis of septic shock participated in a long-term (72 h) randomized double-blind placebo-controlled parallel-group study. l-arginine-HCl (1.2 μmol kg⁻¹ min⁻¹; n = 9) or l-alanine (isocaloric control: 2.4 μmol kg⁻¹ min⁻¹; n = 9) was continuously infused. Primary study outcome was microcirculation, assessed as gastric mucosal perfusion by gastric tonometry (Pᵣ₋ₐCO₂ gap) and skin perfusion by Laser Doppler flowmetry. Secondary endpoints were whole body (WB) arginine and protein metabolism, organ function and clinical outcomes. We measured global hemodynamics continuously for safety monitoring. Statistical analyses were performed by mixed model for repeated measures with treatment by time interaction as estimate for between-group difference.Pᵣ₋ₐCO₂ increased only in the l-arginine group (p = 0.006), without a significant between-group difference (p = 0.17). We found no significant differences in skin perfusion parameters. l-arginine infusion resulted in a larger increase of plasma arginine and ornithine concentrations (p < 0.01), WB (endogenous) arginine appearance (p < 0.001), WB NO synthesis (p = 0.027) and WB arginine to urea conversion (p < 0.001) than infusion of l-alanine. We found no effect on global hemodynamics, and protein metabolism by l-arginine infusion. Organ function parameters were unaffected, except for a significant difference between groups in intra-abdominal pressure over time (p = 0.029).Prolonged intravenous l-arginine administration does not improve local perfusion and organ function despite an increase in WB NO synthesis. Administration is safe with regard to global hemodynamics, but the observed increase in Pᵣ₋ₐCO₂ and intra-abdominal pressure warrants careful application of l-arginine infusion and further research, especially in the early stage of septic shock.
Keywords	alanine ; arginine ; hemodynamics ; intravenous injection ; monitoring ; nitric oxide ; ornithine ; patients ; protein metabolism ; randomized clinical trials ; septic shock ; statistical analysis ; statistical models ; urea
Language	English
Dates of publication	2020-06
Size	p. 1764-1773.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2019.08.013
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A randomized-controlled trial of arginine infusion in severe sepsis on microcirculation and metabolism.

Luiking, Yvette C / Poeze, Martijn / Deutz, Nicolaas E

Clinical nutrition (Edinburgh, Scotland)

2019 Volume 39, Issue 6, Page(s) 1764–1773

Abstract: Background & aims: Sepsis is hypothesized as an arginine deficient state, with lack of nitric oxide (NO) for adequate microcirculation and local perfusion. This study aimed to investigate if prolonged (72-h) intravenous l-arginine administration in ... ...

Abstract	Background & aims: Sepsis is hypothesized as an arginine deficient state, with lack of nitric oxide (NO) for adequate microcirculation and local perfusion. This study aimed to investigate if prolonged (72-h) intravenous l-arginine administration in sepsis patients improves microcirculation. Secondly, effects on arginine and protein metabolism, and organ function were studied. Methods: Critically ill patients with a diagnosis of septic shock participated in a long-term (72 h) randomized double-blind placebo-controlled parallel-group study. l-arginine-HCl (1.2 μmol kg Results: P Conclusions: Prolonged intravenous l-arginine administration does not improve local perfusion and organ function despite an increase in WB NO synthesis. Administration is safe with regard to global hemodynamics, but the observed increase in P
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Arginine/administration & dosage ; Arginine/adverse effects ; Arginine/metabolism ; Critical Illness ; Double-Blind Method ; Female ; Gastric Mucosa/blood supply ; Hemodynamics/drug effects ; Humans ; Infusions, Intravenous ; Male ; Microcirculation/drug effects ; Middle Aged ; Netherlands ; Nitric Oxide/blood ; Proteins/metabolism ; Sepsis/blood ; Sepsis/diagnosis ; Sepsis/drug therapy ; Sepsis/physiopathology ; Severity of Illness Index ; Skin/blood supply ; Time Factors ; Treatment Outcome
Chemical Substances	Proteins ; Nitric Oxide (31C4KY9ESH) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2019-08-27
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2019.08.013
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Article: A randomized-controlled trial of arginine infusion in severe sepsis on microcirculation and metabolism

Luiking, Yvette C / Deutz, Nicolaas E / Poeze, Martijn

Clinical nutrition. 2019 Aug. 13,

2019

Abstract	Sepsis is hypothesized as an arginine deficient state, with lack of nitric oxide (NO) for adequate microcirculation and local perfusion. This study aimed to investigate if prolonged (72-h) intravenous l-arginine administration in sepsis patients improves microcirculation. Secondly, effects on arginine and protein metabolism, and organ function were studied.Critically ill patients with a diagnosis of septic shock participated in a long-term (72 h) randomized double-blind placebo-controlled parallel-group study. l-arginine-HCl (1.2 μmol kg−1 min−1; n = 9) or l-alanine (isocaloric control: 2.4 μmol kg−1 min−1; n = 9) was continuously infused. Primary study outcome was microcirculation, assessed as gastric mucosal perfusion by gastric tonometry (Pr-aCO2 gap) and skin perfusion by Laser Doppler flowmetry. Secondary endpoints were whole body (WB) arginine and protein metabolism, organ function and clinical outcomes. We measured global hemodynamics continuously for safety monitoring. Statistical analyses were performed by mixed model for repeated measures with treatment by time interaction as estimate for between-group difference.Pr-aCO2 increased only in the l-arginine group (p = 0.006), without a significant between-group difference (p = 0.17). We found no significant differences in skin perfusion parameters. l-arginine infusion resulted in a larger increase of plasma arginine and ornithine concentrations (p < 0.01), WB (endogenous) arginine appearance (p < 0.001), WB NO synthesis (p = 0.027) and WB arginine to urea conversion (p < 0.001) than infusion of l-alanine. We found no effect on global hemodynamics, and protein metabolism by l-arginine infusion. Organ function parameters were unaffected, except for a significant difference between groups in intra-abdominal pressure over time (p = 0.029).Prolonged intravenous l-arginine administration does not improve local perfusion and organ function despite an increase in WB NO synthesis. Administration is safe with regard to global hemodynamics, but the observed increase in Pr-aCO2 and intra-abdominal pressure warrants careful application of l-arginine infusion and further research, especially in the early stage of septic shock.
Keywords	alanine ; arginine ; hemodynamics ; intravenous injection ; monitoring ; nitric oxide ; ornithine ; patients ; protein metabolism ; randomized clinical trials ; septic shock ; statistical analysis ; statistical models ; urea
Language	English
Dates of publication	2019-0813
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2019.08.013
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Frailty, Sarcopenia, and Malnutrition Frequently (Co-)occur in Hospitalized Older Adults: A Systematic Review and Meta-analysis.

Ligthart-Melis, Gerdien C / Luiking, Yvette C / Kakourou, Alexia / Cederholm, Tommy / Maier, Andrea B / de van der Schueren, Marian A E

Journal of the American Medical Directors Association

2020 Volume 21, Issue 9, Page(s) 1216–1228

Abstract: Objectives: The purpose of this systematic review and meta-analysis was to summarize the prevalence of, and association between, physical frailty or sarcopenia and malnutrition in older hospitalized adults.: Design: A systematic literature search was ...

Abstract	Objectives: The purpose of this systematic review and meta-analysis was to summarize the prevalence of, and association between, physical frailty or sarcopenia and malnutrition in older hospitalized adults. Design: A systematic literature search was performed in 10 databases. Setting and participants: Articles were selected that evaluated physical frailty or sarcopenia and malnutrition according to predefined criteria and cutoffs in older hospitalized patients. Measures: Data were pooled in a meta-analysis to evaluate the prevalence of prefrailty and frailty [together (pre-)frailty], sarcopenia, and risk of malnutrition and malnutrition [together (risk of) malnutrition], and the association between either (pre-)frailty or sarcopenia and (risk of) malnutrition. Results: Forty-seven articles with 18,039 patients (55% female) were included in the systematic review, and 39 articles (8868 patients, 62% female) were eligible for the meta-analysis. Pooling 11 studies (2725 patients) revealed that 84% [95% confidence interval (CI): 77%, 91%, I Conclusions and implications: The association between and prevalence of (pre-)frailty or sarcopenia and (risk of) malnutrition in older hospitalized adults is substantial. About half of the hospitalized older adults suffer from 2 and perhaps 3 of these debilitating conditions. Therefore, standardized screening for these conditions at hospital admission is highly warranted to guide targeted nutritional and physical interventions.
MeSH term(s)	Aged ; Cross-Sectional Studies ; Female ; Frail Elderly ; Frailty/epidemiology ; Humans ; Male ; Malnutrition/epidemiology ; Prevalence ; Sarcopenia/epidemiology
Language	English
Publishing date	2020-04-21
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2020.03.006
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Article ; Online: Effects of Nutritional Interventions on Nutritional and Functional Outcomes in Geriatric Rehabilitation Patients: A Systematic Review and Meta-Analysis.

van Wijngaarden, Janneke P / Wojzischke, Julia / van den Berg, Claudia / Cetinyurek-Yavuz, Aysun / Diekmann, Rebecca / Luiking, Yvette C / Bauer, Jürgen M

Journal of the American Medical Directors Association

2020 Volume 21, Issue 9, Page(s) 1207–1215.e9

Abstract: Objectives: It has been recognized that nutritional interventions play a role in improving the nutritional and functional status of older persons. This systematic review summarizes the evidence on nutritional and functional outcomes of nutritional ... ...

Abstract	Objectives: It has been recognized that nutritional interventions play a role in improving the nutritional and functional status of older persons. This systematic review summarizes the evidence on nutritional and functional outcomes of nutritional interventions alone or in combination with physical exercise in geriatric rehabilitation patients. Design: Eight electronic databases were searched until July 1, 2019 to identify nutritional intervention studies in patients aged ≥60 years who were admitted to geriatric rehabilitation. A meta-analysis was performed to quantify intervention effects on serum albumin, muscle mass, and hand grip strength (HGS). Results: A total of 1962 studies were screened and 13 included in the systematic review. Studies were heterogeneous in interventions (4 nutritional interventions, 6 physical exercise + nutritional intervention, 1 timing of protein provision, 1 exercise + dietary advice, 1 nutrition-related nursing care) and outcomes. Among the 9 interventions that tested oral nutritional supplements (ONS) with protein, with or without exercise, 7 studies reported protein intake and 6 showed increased protein intakes, 2 of 5 studies showed increased albumin levels, and 5 of 9 reported an improvement in functional outcomes (BI, Functional Independence Measure, mobility). Meta-analyses showed no significant intervention effects on albumin [standardized mean difference (SMD) 0.45, 95% confidence interval (CI) -0.14, 1.04 (4 studies)], muscle mass [mean difference (MD) 2.14 kg, 95% CI -2.17, 6.45 (3 studies)], and HGS [SMD -0.04, 95% CI -0.55, 0.63 (3 studies)], but was based on a very limited number of studies. Conclusions and implications: Only a limited number of studies with heterogeneous nutritional interventions and outcomes were available in the geriatric rehabilitation population. Studies that included ONS improved nutritional outcomes, especially protein intake and albumin levels. Functional outcomes improved in the majority of reporting studies. This indicates benefits of protein supplementation, with or without exercise, in this population. Future well-designed and well-powered clinical trials are needed to clarify existing controversial aspects.
MeSH term(s)	Aged ; Aged, 80 and over ; Diet ; Exercise ; Hand Strength ; Humans ; Nutrition Therapy ; Nutritional Status
Language	English
Publishing date	2020-07-25
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2020.04.012
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Article ; Online: Effect of Sit-to-Stand Exercises Combined With Protein-Rich Oral Supplementation in Older Persons: The Older Person's Exercise and Nutrition Study.

Grönstedt, Helena / Vikström, Sofia / Cederholm, Tommy / Franzén, Erika / Luiking, Yvette C / Seiger, Åke / Wimo, Anders / Faxén-Irving, Gerd / Boström, Anne-Marie

Journal of the American Medical Directors Association

2020 Volume 21, Issue 9, Page(s) 1229–1237

Abstract: Objectives: Nursing home (NH) residents are often undernourished and physically inactive, which contributes to sarcopenia and frailty. The Older Person's Exercise and Nutrition Study aimed to investigate the effects of sit-to-stand exercises (STS) ... ...

Abstract	Objectives: Nursing home (NH) residents are often undernourished and physically inactive, which contributes to sarcopenia and frailty. The Older Person's Exercise and Nutrition Study aimed to investigate the effects of sit-to-stand exercises (STS) integrated into daily care, combined with a protein-rich oral nutritional supplement (ONS), on physical function, nutritional status, body composition, health-related quality of life, and resource use. Design: Residents in 8 NHs were randomized by NH units into an intervention group (IG) or a control group (CG) (n = 60/group). The IG was a combination of STS (4 times/day) and ONS (2 bottles/day providing 600 kcal and 36 g protein) for 12 weeks. Setting and participants: The participants resided in NH units (dementia and somatic care), were ≥75 years of age, and able to rise from a seated position. Methods: The 30-second Chair Stand Test was the primary outcome. Secondary outcomes were balance, walking speed, dependence in activities of daily living, nutritional status and body composition, health-related quality of life, and resource use. Results: Altogether, 102 residents (age 86 ± 5 years, 62% female) completed the study. No improvement in the physical function assessments was observed in the IG, whereas body weight increased significantly (2.05 ± 3.5 kg, P = .013) vs the CG. Twenty-one (of 52) participants with high adherence to the intervention (ie, at least 40% compliance to the combined intervention) increased their fat free mass (2.12 kg (0.13, 4.26 interquartile range), P = .007 vs CG). Logistic regression analyses indicated that the odds ratio for maintained/improved 30-second Chair Stand Test was 3.5 (confidence interval 1.1, 10.9, P = .034) among the participants with high adherence compared with the CG. Conclusions/implications: Twelve-week intervention of daily STS combined with ONS in NH residents did not improve physical function, but increased body weight. Subgroup analyses indicated that high adherence to the combined intervention was associated with maintained or improved physical function and a gain of fat free mass.
MeSH term(s)	Activities of Daily Living ; Aged ; Aged, 80 and over ; Dietary Supplements ; Exercise ; Exercise Therapy ; Female ; Humans ; Male ; Quality of Life
Language	English
Publishing date	2020-05-26
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2020.03.030
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Article ; Online: Arginine infusion in patients with septic shock increases nitric oxide production without haemodynamic instability.

Luiking, Yvette C / Poeze, Martijn / Deutz, Nicolaas E

Clinical science (London, England : 1979)

2015 Volume 128, Issue 1, Page(s) 57–67

Abstract: Arginine deficiency in sepsis may impair nitric oxide (NO) production for local perfusion and add to the catabolic state. In contrast, excessive NO production has been related to global haemodynamic instability. Therefore, the aim of the present study ... ...

Abstract	Arginine deficiency in sepsis may impair nitric oxide (NO) production for local perfusion and add to the catabolic state. In contrast, excessive NO production has been related to global haemodynamic instability. Therefore, the aim of the present study was to investigate the dose-response effect of intravenous arginine supplementation in post-absorptive patients with septic shock on arginine-NO and protein metabolism and on global and regional haemodynamics. Eight critically ill patients with a diagnosis of septic shock participated in this short-term (8 h) dose-response study. L-Arginine-HCl was continuously infused [intravenously (IV)] in three stepwise-increasing doses (33, 66 and 99 μmol·kg-1·h-1). Whole-body arginine-NO and protein metabolism were measured using stable isotope techniques, and baseline values were compared with healthy controls. Global and regional haemodynamic parameters were continuously recorded during the study. Upon infusion, plasma arginine increased from 48±7 to 189±23 μmol·l-1 (means±S.D.; P<0.0001). This coincided with increased de novo arginine (P<0.0001) and increased NO production (P<0.05). Sepsis patients demonstrated elevated protein breakdown at baseline (P<0.001 compared with healthy controls), whereas protein breakdown and synthesis both decreased during arginine infusion (P<0.0001). Mean arterial and pulmonary pressure and gastric mucosal-arterial partial pressure of carbon dioxide difference (Pr-aCO2) gap did not alter during arginine infusion (P>0.05), whereas stroke volume (SV) increased (P<0.05) and arterial lactate decreased (P<0.05). In conclusion, a 4-fold increase in plasma arginine with intravenous arginine infusion in sepsis stimulates de novo arginine and NO production and reduces whole-body protein breakdown. These potential beneficial metabolic effects occurred without negative alterations in haemodynamic parameters, although improvement in regional perfusion could not be demonstrated in the eight patients with septic shock who were studied.
MeSH term(s)	Aged ; Arginine/administration & dosage ; Arginine/blood ; Arginine/therapeutic use ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Case-Control Studies ; Citrulline/blood ; Dose-Response Relationship, Drug ; Female ; Hemodynamics/drug effects ; Hemodynamics/physiology ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Nitric Oxide/blood ; Shock, Septic/drug therapy ; Shock, Septic/enzymology ; Shock, Septic/physiopathology ; Urea/blood
Chemical Substances	Citrulline (29VT07BGDA) ; Nitric Oxide (31C4KY9ESH) ; Urea (8W8T17847W) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2015-01
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	206835-7
ISSN	1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
ISSN (online)	1470-8736
ISSN	0301-0538 ; 0009-0360 ; 0143-5221
DOI	10.1042/CS20140343
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Article ; Online: Correction to: The prevalence and health burden of malnutrition in Belgian older people in the community or residing in nursing homes: results of the NutriAction II study.

Vandewoude, Maurits F J / van Wijngaarden, Janneke P / De Maesschalck, Lieven / Luiking, Yvette C / Van Gossum, André

Aging clinical and experimental research

2018 Volume 31, Issue 2, Page(s) 295–298

Abstract: In the original publication, table row alignment was incorrectly formatted for all the tables. The corrected tables are given below. ...

Abstract	In the original publication, table row alignment was incorrectly formatted for all the tables. The corrected tables are given below.
Language	English
Publishing date	2018-06-22
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-018-0979-9
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Article ; Online: Response and Adherence of Nursing Home Residents to a Nutrition/Exercise Intervention.

Karlsson, Emelie S / Grönstedt, Helena K / Faxén-Irving, Gerd / Franzén, Erika / Luiking, Yvette C / Seiger, Åke / Vikström, Sofia / Wimo, Anders / Cederholm, Tommy E / Boström, Anne-Marie

Journal of the American Medical Directors Association

2021 Volume 22, Issue 9, Page(s) 1939–1945.e3

Abstract: Objectives: Interindividual response variability to nutrition and exercise interventions is extensive in older adults. A group of nursing home (NH) residents participated in a combined intervention. The objective of this post-hoc analysis was to ... ...

Abstract	Objectives: Interindividual response variability to nutrition and exercise interventions is extensive in older adults. A group of nursing home (NH) residents participated in a combined intervention. The objective of this post-hoc analysis was to identify factors associated with intervention response measured by change in physical function and body composition. Design: Post-hoc analyses in the Older Person's Exercise and Nutrition study, a 2-arm randomized trial. The primary outcomes were 30-second Chair Stand Test and composite scores combining physical function and fat-free mass. A secondary outcome was intervention adherence. A 12-week intervention of sit-to-stand exercises and protein-rich nutritional supplements did not improve chair-stand capacity vs control on intention-to-treat basis. Setting and participants: Residents ≥75 years of age from dementia and somatic units in eight NHs in Sweden. Methods: Logistic regressions were performed to define factors associated with response (maintenance/improvement) or nonresponse (deterioration) in 30-second Chair Stand Test, and with intervention adherence. Linear regressions were performed to explore factors associated with response in composite scores. Results: Mean age of participants (n = 52 intervention, n = 49 control) was 85.8 years. Sarcopenia was occurring in 74%. Sarcopenia at baseline (P = .005) and high adherence to nutritional supplements (P = .002) increased the odds of response. Higher independence in daily activities increased the odds of adherence to sit-to-stand exercises (P = .027) and the combined intervention (P = .020). Allocation to the intervention group and higher self-perceived health were associated with higher composite scores. Conclusions and implications: NH residents with baseline sarcopenia, better self-perceived health, and high adherence to nutritional supplements benefitted most from a combined nutrition and exercise intervention regarding chair-stand capacity and composite scores of function and fat-free mass. Adherence was related to higher grade of independence. Understanding factors associated with response and adherence to an intervention will help target susceptible residents in most need of support and to optimize the outcome.
MeSH term(s)	Aged ; Aged, 80 and over ; Exercise ; Exercise Therapy ; Humans ; Nursing Homes ; Nutritional Status ; Sarcopenia/prevention & control
Language	English
Publishing date	2021-05-04
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2021.04.001
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