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  1. Article: Insights from the molecular docking analysis of gambogic acid with the Chikungunya spike glycoprotein E2.

    Qamar, Sadia / Syeda, Amna / Amjad Beg, M / Irfan Qureshi, M

    Bioinformation

    2023  Volume 19, Issue 5, Page(s) 525–530

    Abstract: Chikungunya fever is a mosquito-borne disease caused by the chikungunya virus (CHIKV) and has drawn substantial attention in recent years. So far, no effective treatment is available in the form of drugs or vaccines. In this study, we aimed to screen ... ...

    Abstract Chikungunya fever is a mosquito-borne disease caused by the chikungunya virus (CHIKV) and has drawn substantial attention in recent years. So far, no effective treatment is available in the form of drugs or vaccines. In this study, we aimed to screen some drugs against the pathogenic Chikungunya virus through a molecular docking approach. As a fact, the spike E2 protein plays an important role in viral attachment to the human host cell, binding to a cell receptor MXRA8. The molecules screened for in-silico interaction against MXRA8 were selected with top hit based on binding affinity. The existing intermolecular bonds were investigated further in the active site of the protein that interacts with the top-hit ligands. Gambogic acid (guttic acid) was depicted as the furthermost potential inhibitor when compared to the others it had the lowest binding affinity (-10.9 kcal/mol). Gambogic acid, as a potential antiviral agent against the spike E2 protein, could be a promising candidate.
    Language English
    Publishing date 2023-05-31
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2203786-X
    ISSN 0973-2063
    ISSN 0973-2063
    DOI 10.6026/97320630019525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Biological Reconstruction of Posteromedial Tibial Defect with Autogenous Bone Graft in Complex Knee Arthroplasty.

    Khan, Muhammad Waqas / Rajput, Irfan Muhammad / Qamar, Javeria / Qureshi, Aurangzeb

    Indian journal of orthopaedics

    2023  Volume 57, Issue 6, Page(s) 856–862

    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 603194-8
    ISSN 0019-5413
    ISSN 0019-5413
    DOI 10.1007/s43465-023-00857-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1720: Show issues Location:
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  3. Article ; Online: Naproxen sodium nanoparticles are less toxic and gastroprotective agents than the conventional NSAID drug naproxen sodium in Balb/c mice.

    Razzaq, Ayesha / Qureshi, Irfan Zia

    Toxicology and applied pharmacology

    2022  Volume 452, Page(s) 116192

    Abstract: Use of non-steroidal anti-inflammatory drugs (NSAIDs) is one of the leading causes of gastric ulcers. Excellent therapeutic properties have made the use of NSAIDs widespread. Nano-drug delivery to reduce systemic toxicity through modulating drug ... ...

    Abstract Use of non-steroidal anti-inflammatory drugs (NSAIDs) is one of the leading causes of gastric ulcers. Excellent therapeutic properties have made the use of NSAIDs widespread. Nano-drug delivery to reduce systemic toxicity through modulating drug pharmacokinetics may be a better choice. Presently, we investigated if naproxen nanoformulation (PVA capped NPRS-MgO NPs) is less toxic to be used as an alternative drug. Groups of mice were assigned to control, NPRS-treated, CNF-treated, UNF-treated, and MgO NPs-treated groups. Analyses included gross examination of gastric mucosa, calculation of ulcer and inhibition indices, determination of tissue levels of reactive oxygen species (ROS), malondialdehyde (MDA), catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), and reduced glutathione (GSH), histological and immunohistochemical assessment of i-NOS, COX-2, and caspase-3 of stomach mucosa, q-PCR for the detection of mRNA expression of IL-1β, IL-6, and TNF-α. Results were compared statistically at P < 0.05. Compared to NPRS-treated mice which developed multiple ulcers, had elevated MDA and ROS levels, and deceased CAT, POD, SOD, and GSH levels, significantly increased expression of IL-1β, IL-6, and TNF-α mRNA, damaged surface epithelium with disrupted glandular architecture and leucocyte infiltration of lamina propria with a marked increase in mucosal COX-2, i-NOS, and caspase-3 expression, oral administration of coated and uncoated naproxen nanoformulations prevented the gross mucosal damage by a restoration of all biochemical, histological, and immunohistochemical alterations to near control levels. The present study demonstrates that naproxen sodium nanoformulation has a gastroprotective action and in the clinical setting can be a better alternative to conventional naproxen.
    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Caspase 3/genetics ; Caspase 3/metabolism ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Interleukin-6/metabolism ; Magnesium Oxide/metabolism ; Magnesium Oxide/therapeutic use ; Mice ; Mice, Inbred BALB C ; Nanoparticles/therapeutic use ; Naproxen/metabolism ; Naproxen/pharmacology ; Naproxen/therapeutic use ; Pharmaceutical Preparations/metabolism ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Stomach Ulcer/prevention & control ; Superoxide Dismutase/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Interleukin-6 ; Pharmaceutical Preparations ; RNA, Messenger ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha ; Magnesium Oxide (3A3U0GI71G) ; Naproxen (57Y76R9ATQ) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Superoxide Dismutase (EC 1.15.1.1) ; Caspase 3 (EC 3.4.22.-)
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2022.116192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 14: Show issues Location:
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  4. Article: Task Challenge and Employee Performance: A Moderated Mediation Model of Resilience and Digitalization.

    Saleem, Irfan / Qureshi, Tahir Masood / Verma, Amitabh

    Behavioral sciences (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Lately, organizations are giving attention to enhancing employee resilience due to turbulent economic times caused by lockdowns in the last couple of years. This explanatory research proposes and tests the mediating role of employee resilience to link ... ...

    Abstract Lately, organizations are giving attention to enhancing employee resilience due to turbulent economic times caused by lockdowns in the last couple of years. This explanatory research proposes and tests the mediating role of employee resilience to link task challenge and employee performance during the COVID-19 pandemic in government schools of Oman using the broaden-and-build theory. An explanatory research design was used for this empirical study. An Arabic-translated questionnaire version was designed to collect primary data online during the lockdown using simple random sampling. We used the Preacher and Hayes macro to analyze moderated mediation using cross-sectional data and analyzed 441 responses. The findings confirm the mediation roles of employee resilience and moderating roles of digitalization during unusual circumstances. The study has implications for the school administrators, Omani policymakers and schooling staff of the Middle Eastern educational industry.
    Language English
    Publishing date 2023-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs13020119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Frontiers in neuroepigenetics.

    Qureshi, Irfan A / Mehler, Mark F

    Neurobiology of disease

    2021  Volume 153, Page(s) 105333

    MeSH term(s) Brain/metabolism ; Brain Neoplasms/genetics ; Cellular Reprogramming/genetics ; Epigenesis, Genetic/genetics ; Epigenomics ; Epileptic Syndromes/genetics ; Gene Expression Profiling ; Histone Code ; Humans ; Mental Disorders/genetics ; Neurodegenerative Diseases/genetics ; RNA Processing, Post-Transcriptional/genetics
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2021.105333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4444: Show issues Location:
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  6. Article ; Online: Assessment of health risk, genotoxicity, and thiol compounds in Trigonella foenum-graecum (Fenugreek) under arsenic stress.

    Ahmad, Javed / Yasmeen, Rubina / Irfan, Mohammad / Al-Huqail, Asma A / Qureshi, Mohammad Irfan

    Environmental science and pollution research international

    2022  

    Abstract: Arsenic (As) traces have been reported worldwide in vegetables and crops cultivated in As-polluted soils. Being carcinogenic, the presence of As in edibles is of great concern as it ultimately reaches humans and animals through the food chain. Besides, ... ...

    Abstract Arsenic (As) traces have been reported worldwide in vegetables and crops cultivated in As-polluted soils. Being carcinogenic, the presence of As in edibles is of great concern as it ultimately reaches humans and animals through the food chain. Besides, As toxicity adversely affects the growth, physiology, metabolism, and productivity of crops. In the present study, Trigonella foenum-graecum (Fenugreek) was exposed to the As stress (0, 50, 100, and 150 μM sodium arsenate) for a week. Further, evaluation of As accumulation in roots and shoots, magnitude and visualization of oxyradicals, and thiol-based defence offered by Fenugreek was assessed. The root and leaf accumulated 258-453 μg g
    Language English
    Publishing date 2022-07-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-22269-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  7. Article ; Online: Assessment of health risk, genotoxicity, and thiol compounds in Trigonella foenum-graecum (Fenugreek) under arsenic stress

    Ahmad, Javed / Yasmeen, Rubina / Irfan, Mohammad / Al-Huqail, Asma A. / Qureshi, Mohammad Irfan

    Environ Sci Pollut Res. 2023 Jan., v. 30, no. 1 p.884-898

    2023  

    Abstract: Arsenic (As) traces have been reported worldwide in vegetables and crops cultivated in As-polluted soils. Being carcinogenic, the presence of As in edibles is of great concern as it ultimately reaches humans and animals through the food chain. Besides, ... ...

    Abstract Arsenic (As) traces have been reported worldwide in vegetables and crops cultivated in As-polluted soils. Being carcinogenic, the presence of As in edibles is of great concern as it ultimately reaches humans and animals through the food chain. Besides, As toxicity adversely affects the growth, physiology, metabolism, and productivity of crops. In the present study, Trigonella foenum-graecum (Fenugreek) was exposed to the As stress (0, 50, 100, and 150 μM sodium arsenate) for a week. Further, evaluation of As accumulation in roots and shoots, magnitude and visualization of oxyradicals, and thiol-based defence offered by Fenugreek was assessed. The root and leaf accumulated 258–453 μg g⁻¹ dry wt (DW) and 81.4–102.1 μg g⁻¹ DW of As, respectively. An arsenic-mediated decline in the growth index and increase in oxidative stress was noted. Arsenic stress modulated the content of thiol compounds; especially cysteine content increased from 0.36 to 0.43 µmole g⁻¹ FW protein was noted. Random Amplified Polymorphic DNA (RAPD)–based analysis showed DNA damage in As-treated plants. Health risk assessment parameters showed that As concentration in the consumable plant shoot was below the critical hazard level (hazard quotient < 1). Moreover, T. foenum-graecum showed varied responses to As-induced oxidative stress with applied concentrations (150 μM being more toxic than lower concentrations). In addition, the RAPD profile and level of thiol compounds were proved significant biomarkers to assess the As toxicity in plants. The conclusion of this study will help users of fenugreek to have a clue and create awareness regarding the consumption.
    Keywords DNA damage ; Trigonella foenum-graecum ; arsenic ; biomarkers ; carcinogenicity ; cysteine ; decline ; fenugreek ; food chain ; genotoxicity ; health effects assessments ; leaves ; metabolism ; oxidative stress ; random amplified polymorphic DNA technique ; risk ; sodium arsenate ; thiols
    Language English
    Dates of publication 2023-01
    Size p. 884-898.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-22269-5
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Ethno-Dentistry of Medicinal Plants Used in North Waziristan, Pakistan.

    Rehman, Sabith / Iqbal, Zafar / Qureshi, Rahmatullah / AlOmar, Taghrid S / Almasoud, Najla / Younas, Muhammad / Rauf, Abdur / Irfan, Muhammad

    International dental journal

    2023  Volume 74, Issue 2, Page(s) 310–320

    Abstract: Objective: This study aimed at recording therapeutic plant species used by inhabitants to treat dental disorders in the district of North Waziristan, Pakistan. The indigenous people of the studied area are dependent on medicinal plants for their basic ... ...

    Abstract Objective: This study aimed at recording therapeutic plant species used by inhabitants to treat dental disorders in the district of North Waziristan, Pakistan. The indigenous people of the studied area are dependent on medicinal plants for their basic health care needs including dental care.
    Methods: Ethnomedicinal data were collected using a semi-structured questionnaires, and in addition 130 local informants were interviewed. The collected data were evaluated using various quantitative indices, including use value (UV), relative frequency of citation (RFC), fidelity level (FL%), and Jaccard Index (JI).
    Results: A total of 69 plants belonging to 48 plant families used in dental disorders were identified. The Lamiaceae was the leading family that shared 7 species, followed by Solanaceae (4 spp).The dominant life form used was herbs (47.83%), folowed by leaves (43.90%) in preparing remedies for different dental disorders. Decoction was the most common mode of preparation (34.21%), followed by pastes (21.05%). The highest RFC (0.36) was reported for Bergenia ciliata, followed by Salvadora oleoides (0.35). The majority of the plants (36 spp) were utilised as herbal medicine to treat toothache, followed by 13 species for periodontal (gum) infections, 11 species used for teeth cleaning, and 9 species for halitosis (bad breath).
    Conclusions: This study is the first-ever record of ethnomedicinal applications for the treatment of dental diseases from Pakistan. Some of the forgeoing hebal medications should be further evalauted for the development of pahrmaceutical bio-products for the treatment of dental disorders.
    MeSH term(s) Humans ; Plants, Medicinal ; Phytotherapy ; Pakistan ; Medicine, Traditional ; Surveys and Questionnaires
    Language English
    Publishing date 2023-11-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 218262-2
    ISSN 1875-595X ; 0020-6539
    ISSN (online) 1875-595X
    ISSN 0020-6539
    DOI 10.1016/j.identj.2023.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 205: Show issues Location:
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  9. Article: Heartwood Extract of

    Dar, Mohammad Irfan / Rafat, Sahar / Dev, Kapil / Abass, Sageer / Khan, Mohammad Umar / Abualsunun, Walaa A / Murshid, Samar S / Ahmad, Sayeed / Qureshi, Mohammad Irfan

    Metabolites

    2022  Volume 12, Issue 10

    Abstract: Diabetes mellitus leads to cellular damage and causes apoptosis by oxidative stress. Heartwood extract ... ...

    Abstract Diabetes mellitus leads to cellular damage and causes apoptosis by oxidative stress. Heartwood extract of
    Language English
    Publishing date 2022-10-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12100947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Phytoremediation of Potentially Toxic Elements from Contaminated Saline Soils Using

    Mujeeb, Amtul / Abideen, Zainul / Aziz, Irfan / Sharif, Nadia / Hussain, Muhammad Iftikhar / Qureshi, Asad Sarwar / Yang, Hsi-Hsien

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Plants in coastal ecosystems are primarily known as natural sinks of trace metals and their importance for phytoremediation is well established. ...

    Abstract Plants in coastal ecosystems are primarily known as natural sinks of trace metals and their importance for phytoremediation is well established.
    Language English
    Publishing date 2023-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12030598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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