LIVIVO - Search results -

Search results

Result 1 - 10 of total 155

Search options

Article ; Online: Asymmetric cell division in the Drosophila bristle lineage: from the polarization of sensory organ precursor cells to Notch-mediated binary fate decision.

Schweisguth, François

Wiley interdisciplinary reviews. Developmental biology

2015 Volume 4, Issue 3, Page(s) 299–309

Abstract: Asymmetric cell division (ACD) is a simple and evolutionary conserved process whereby a mother divides to generate two daughter cells with distinct developmental potentials. This process can generate cell fate diversity during development. Fate asymmetry ...

Abstract	Asymmetric cell division (ACD) is a simple and evolutionary conserved process whereby a mother divides to generate two daughter cells with distinct developmental potentials. This process can generate cell fate diversity during development. Fate asymmetry may result from the unequal segregation of molecules and/or organelles between the two daughter cells. Here, I will review how fate asymmetry is regulated in the sensory bristle lineage in Drosophila and focus on the molecular mechanisms underlying ACD of the sensory organ precursor cells (SOPs). For further resources related to this article, please visit the WIREs website.
MeSH term(s)	Animals ; Asymmetric Cell Division/physiology ; Cell Differentiation/physiology ; Cell Lineage/physiology ; Cell Polarity/physiology ; Drosophila/growth & development ; Drosophila Proteins/metabolism ; Endocytosis/physiology ; Intracellular Signaling Peptides and Proteins/metabolism ; Juvenile Hormones/metabolism ; Membrane Proteins/metabolism ; Models, Biological ; Neural Stem Cells/physiology ; Receptors, Notch/metabolism ; Sense Organs/cytology ; Sense Organs/growth & development ; Spindle Apparatus/metabolism ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Drosophila Proteins ; Intracellular Signaling Peptides and Proteins ; Juvenile Hormones ; Membrane Proteins ; Receptors, Notch ; delta protein ; numb protein, Drosophila ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; neur protein, Drosophila (EC 2.3.2.27)
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1759-7692
ISSN (online)	1759-7692
DOI	10.1002/wdev.175
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: Self-Organization in Pattern Formation.

Schweisguth, François / Corson, Francis

Developmental cell

2019 Volume 49, Issue 5, Page(s) 659–677

Abstract: Self-organization is pervasive in development, from symmetry breaking in the early embryo to tissue patterning and morphogenesis. For a few model systems, the underlying molecular and cellular processes are now sufficiently characterized that ... ...

Abstract	Self-organization is pervasive in development, from symmetry breaking in the early embryo to tissue patterning and morphogenesis. For a few model systems, the underlying molecular and cellular processes are now sufficiently characterized that mathematical models can be confronted with experiments, to explore the dynamics of pattern formation. Here, we review selected systems, ranging from cyanobacteria to mammals, where different forms of cell-cell communication, acting alone or together with positional cues, drive the patterning of cell fates, highlighting the insights that even very simple models can provide as well as the challenges on the path to a predictive understanding of development.
MeSH term(s)	Animals ; Body Patterning ; Cell Communication ; Cell Differentiation ; Mammals ; Models, Biological ; Morphogenesis
Language	English
Publishing date	2019-06-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2019.05.019
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 76: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mechanisms of Notch signaling: a simple logic deployed in time and space.

Henrique, Domingos / Schweisguth, François

Development (Cambridge, England)

2019 Volume 146, Issue 3

Abstract: Most cells in our body communicate during development and throughout life via Notch receptors and their ligands. Notch receptors relay information from the cell surface to the genome via a very simple mechanism, yet Notch plays multiple roles in ... ...

Abstract	Most cells in our body communicate during development and throughout life via Notch receptors and their ligands. Notch receptors relay information from the cell surface to the genome via a very simple mechanism, yet Notch plays multiple roles in development and disease. Recent studies suggest that this versatility in Notch function may not necessarily arise from complex and context-dependent integration of Notch signaling with other developmental signals, but instead arises, in part, from signaling dynamics. Here, we review recent findings on the core Notch signaling mechanism and discuss how spatial-temporal dynamics contribute to Notch signaling output.
MeSH term(s)	Animals ; Humans ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Signal Transduction
Chemical Substances	Receptors, Notch
Language	English
Publishing date	2019-02-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.172148
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ub I Zs.183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 91: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Tissue-wide coordination of epithelium-to-neural stem cell transition in the Drosophila optic lobe requires Neuralized.

Shard, Chloé / Luna-Escalante, Juan / Schweisguth, François

The Journal of cell biology

2021 Volume 219, Issue 11

Abstract: Many tissues are produced by specialized progenitor cells emanating from epithelia via epithelial-to-mesenchymal transition (EMT). Most studies have so far focused on EMT involving single or isolated groups of cells. Here we describe an EMT-like process ... ...

Abstract	Many tissues are produced by specialized progenitor cells emanating from epithelia via epithelial-to-mesenchymal transition (EMT). Most studies have so far focused on EMT involving single or isolated groups of cells. Here we describe an EMT-like process that requires tissue-level coordination. This EMT-like process occurs along a continuous front in the Drosophila optic lobe neuroepithelium to produce neural stem cells (NSCs). We find that emerging NSCs remain epithelial and apically constrict before dividing asymmetrically to produce neurons. Apical constriction is associated with contractile myosin pulses and involves RhoGEF3 and down-regulation of the Crumbs complex by the E3 ubiquitin ligase Neuralized. Anisotropy in Crumbs complex levels also results in accumulation of junctional myosin. Disrupting the regulation of Crumbs by Neuralized lowered junctional myosin and led to imprecision in the integration of emerging NSCs into the front. Thus, Neuralized promotes smooth progression of the differentiation front by coupling epithelium remodeling at the tissue level with NSC fate acquisition.
MeSH term(s)	Animals ; Cell Polarity ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/metabolism ; Epithelium/physiology ; Morphogenesis ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Neurons/cytology ; Neurons/metabolism ; Optic Lobe, Nonmammalian/cytology ; Optic Lobe, Nonmammalian/metabolism ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Drosophila Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2021-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.202005035
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ub I Zs.190: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Activation of Arp2/3 by WASp Is Essential for the Endocytosis of Delta Only during Cytokinesis in Drosophila.

Trylinski, Mateusz / Schweisguth, François

Cell reports

2019 Volume 28, Issue 1, Page(s) 1–10.e3

Abstract: The actin nucleator Arp2/3 generates pushing forces in response to signals integrated by SCAR and WASp. In Drosophila, the activation of Arp2/3 by WASp is specifically required for Notch signaling following asymmetric cell division. How WASp and Arp2/3 ... ...

Abstract	The actin nucleator Arp2/3 generates pushing forces in response to signals integrated by SCAR and WASp. In Drosophila, the activation of Arp2/3 by WASp is specifically required for Notch signaling following asymmetric cell division. How WASp and Arp2/3 regulate Notch activity and why receptor activation requires WASp and Arp2/3 only in the context of intra-lineage fate decisions are unclear. Here, we find that WASp, but not SCAR, is required for Notch activation soon after division of the sensory organ precursor cell. Conversely, SCAR, but not WASp, is required to expand the cell-cell contact between the two SOP daughters. Thus, these two activities of Arp2/3 can be uncoupled. Using a time-resolved endocytosis assay, we show that WASp and Arp2/3 are required for the endocytosis of Dl only during cytokinesis. We propose that WASp-Arp2/3 provides an extra pushing force that is specifically required for the efficient endocytosis of Dl during cytokinesis.
MeSH term(s)	Actin-Related Protein 2/genetics ; Actin-Related Protein 2/metabolism ; Actins/genetics ; Actins/metabolism ; Animals ; Cytokinesis/genetics ; Drosophila/genetics ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Endocytosis/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Membrane Proteins/metabolism ; Microfilament Proteins/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Notch/metabolism ; Wiskott-Aldrich Syndrome Protein/genetics ; Wiskott-Aldrich Syndrome Protein/metabolism
Chemical Substances	Actin-Related Protein 2 ; Actins ; Arp3 protein, Drosophila ; Drosophila Proteins ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; Microfilament Proteins ; N protein, Drosophila ; Receptors, Notch ; SCAR protein, Drosophila ; WASp protein, Drosophila ; Wiskott-Aldrich Syndrome Protein ; delta protein ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2019-07-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2019.06.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Activation of Arp2/3 by WASp Is Essential for the Endocytosis of Delta Only during Cytokinesis in Drosophila

Mateusz Trylinski / François Schweisguth

Cell Reports, Vol 28, Iss 1, Pp 1-10.e

2019 Volume 3

Abstract: ... decisions. Trylinski and Schweisguth report that WASp-Arp2/3 is key for the efficient endocytosis of Delta ...

Abstract	Summary: The actin nucleator Arp2/3 generates pushing forces in response to signals integrated by SCAR and WASp. In Drosophila, the activation of Arp2/3 by WASp is specifically required for Notch signaling following asymmetric cell division. How WASp and Arp2/3 regulate Notch activity and why receptor activation requires WASp and Arp2/3 only in the context of intra-lineage fate decisions are unclear. Here, we find that WASp, but not SCAR, is required for Notch activation soon after division of the sensory organ precursor cell. Conversely, SCAR, but not WASp, is required to expand the cell-cell contact between the two SOP daughters. Thus, these two activities of Arp2/3 can be uncoupled. Using a time-resolved endocytosis assay, we show that WASp and Arp2/3 are required for the endocytosis of Dl only during cytokinesis. We propose that WASp-Arp2/3 provides an extra pushing force that is specifically required for the efficient endocytosis of Dl during cytokinesis. : WASp-Arp2/3 is required for Notch-mediated intra-lineage fate decisions. Trylinski and Schweisguth report that WASp-Arp2/3 is key for the efficient endocytosis of Delta only during cytokinesis. This helps explain how and why how actin polymerization is key for Notch activation only in the context of asymmetric cell divisions. Keywords: Notch, actin, Arp2/3, WASp, endocytosis, Drosophila, asymmetric cell division, cell fate, cytokinesis, neurogenesis
Keywords	Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Response to "Does pupal communication influence Wolbachia-mediated cytoplasmic incompatibility?"

Pontier, Stephanie M / Schweisguth, François

Current biology : CB

2017 Volume 27, Issue 2, Page(s) R55–R56

Abstract: In a recent Current Biology paper [1], we reported that pheromone communication occurred during metamorphosis in Drosophila melanogaster. Female pheromones appeared to influence various aspects of the physiology and development of adult males. In ... ...

Abstract	In a recent Current Biology paper [1], we reported that pheromone communication occurred during metamorphosis in Drosophila melanogaster. Female pheromones appeared to influence various aspects of the physiology and development of adult males. In particular, we observed that this communication regulated testis development and had a positive impact on reproduction, as measured by a difference in the % of eggs developing into larvae in crosses involving adult male flies that had developed at metamorphosis with or without female pupae [1].
MeSH term(s)	Animals ; Drosophila ; Drosophila melanogaster ; Female ; Germ Cells ; Male ; Pupa ; Wolbachia
Language	English
Publishing date	2017-01-23
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2016.12.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3208: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: HaloTag-based reporters for sparse labeling and cell tracking.

Couturier, Lydie / Luna, Juan / Mazouni, Khalil / Mestdagh, Claire / Phan, Minh-Son / Corson, Francis / Schweisguth, Francois

Fly

2022 Volume 16, Issue 1, Page(s) 360–366

Abstract: Multiscale analysis of morphogenesis requires to follow and measure in real-time ... ...

Abstract	Multiscale analysis of morphogenesis requires to follow and measure in real-time the
MeSH term(s)	Animals ; Cell Tracking ; Single-Cell Analysis ; Drosophila
Chemical Substances	haloalkane dehalogenase (EC 3.8.1.5)
Language	English
Publishing date	2022-11-02
Publishing country	United States
Document type	Journal Article
ISSN	1933-6942
ISSN (online)	1933-6942
DOI	10.1080/19336934.2022.2142460
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila.

Couturier, Lydie / Mazouni, Khalil / Corson, Francis / Schweisguth, François

Nature communications

2019 Volume 10, Issue 1, Page(s) 3486

Abstract: The stereotyped arrangement of sensory bristles on the adult fly thorax arises from a self-organized process, in which inhibitory Notch signaling both delimits proneural stripes and singles out sensory organ precursor cells (SOPs). A dynamic balance ... ...

Abstract	The stereotyped arrangement of sensory bristles on the adult fly thorax arises from a self-organized process, in which inhibitory Notch signaling both delimits proneural stripes and singles out sensory organ precursor cells (SOPs). A dynamic balance between proneural factors and Enhancer of split-HLH (E(spl)-HLH) Notch targets underlies patterning, but how this is regulated is unclear. Here, were identify two classes of E(spl)-HLH factors, whose expression both precedes and delimits proneural activity, and is dependent on proneural activity and required for proper SOP spacing within the stripes, respectively. These two classes are partially redundant, since a member of the second class, that is normally cross-repressed by members of the first class, can functionally compensate for their absence. The regulation of specific E(spl)-HLH genes by proneural factors amplifies the response to Notch as SOPs are being selected, contributing to patterning dynamics in the notum, and likely operates in other developmental contexts.
Language	English
Publishing date	2019-08-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-019-11477-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: When you are Dishevelled, fat is good and acid is bad!

Schweisguth, François

Nature cell biology

2009 Volume 11, Issue 3, Page(s) 237–239

Abstract: Frizzled receptors regulate cell fate decisions and planar cell polarity by means of distinct intracellular effectors. The choice between these two signalling outputs may involve a pH-dependent interaction between Dishevelled and negatively charged ... ...

Abstract	Frizzled receptors regulate cell fate decisions and planar cell polarity by means of distinct intracellular effectors. The choice between these two signalling outputs may involve a pH-dependent interaction between Dishevelled and negatively charged lipids at the plasma membrane.
MeSH term(s)	Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cell Membrane/metabolism ; Cell Polarity ; Dishevelled Proteins ; Drosophila Proteins ; Drosophila melanogaster/cytology ; Drosophila melanogaster/metabolism ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Frizzled Receptors/chemistry ; Frizzled Receptors/metabolism ; Hydrogen-Ion Concentration ; Phospholipids/metabolism ; Phosphoproteins/chemistry ; Phosphoproteins/metabolism ; Protein Binding ; Signal Transduction
Chemical Substances	Adaptor Proteins, Signal Transducing ; Dishevelled Proteins ; Drosophila Proteins ; Frizzled Receptors ; Phospholipids ; Phosphoproteins ; dsh protein, Drosophila
Language	English
Publishing date	2009-03-02
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/ncb0309-237
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5169: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 12: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito