LIVIVO - Search results -

Search results

Result 1 - 10 of total 8095

Search options

Article: Pharmacological Mechanism of Shen Huang Chong Ji for Treating Alzheimer's Disease Based on Network Pharmacology and Experimental Validation.

Tang, Lei / Liu, Jing / Xu, Xiaozhuo / Zhao, Juan / Han, Xu

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9243348

Abstract: The traditional Chinese medicine (TCM) formula, Sheng Huang Chong Ji (SHCJ) is largely applied ...

Abstract	The traditional Chinese medicine (TCM) formula, Sheng Huang Chong Ji (SHCJ) is largely applied for treating Alzheimer's disease (AD), but not much is known regarding its active compounds, molecular targets, and mechanism of action. The current study aimed to predict the potential molecular mechanism of SHCJ against AD based on network pharmacology combined with in vitro validation. Using public databases, SHCJ's active compounds, their potential targets, and AD-related genes were screened, while Cytoscape Version 3.7.2 was used to build protein-protein interaction (PPI) and compound-disease-target (C-D-T) networks. Analysis of enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and Gene Ontology (GO) terms was then carried out in
Language	English
Publishing date	2022-05-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9243348
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5995: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Pharmacological Mechanism of Shen Huang Chong Ji for Treating Alzheimer’s Disease Based on Network Pharmacology and Experimental Validation

Lei Tang / Jing Liu / Xiaozhuo Xu / Juan Zhao / Xu Han

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: The traditional Chinese medicine (TCM) formula, Sheng Huang Chong Ji (SHCJ) is largely applied ...

Abstract	The traditional Chinese medicine (TCM) formula, Sheng Huang Chong Ji (SHCJ) is largely applied for treating Alzheimer’s disease (AD), but not much is known regarding its active compounds, molecular targets, and mechanism of action. The current study aimed to predict the potential molecular mechanism of SHCJ against AD based on network pharmacology combined with in vitro validation. Using public databases, SHCJ’s active compounds, their potential targets, and AD-related genes were screened, while Cytoscape Version 3.7.2 was used to build protein–protein interaction (PPI) and compound-disease-target (C-D-T) networks. Analysis of enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and Gene Ontology (GO) terms was then carried out in R 4.0.2, including associated packages. Subsequently, molecular docking analysis was performed with AutoDock Vina 1.1.2, with intro experiments involving SH-SY5Y cells used to further investigate the mechanism of SHCJ against AD. Finally, a total of 56 active compounds of SHCJ and 192 SHCJ-AD-related targets were identified. Quercetin was identified as the top potential candidate agent. HSP90AA1, AKT1, and MAPK1 represent potential therapeutic targets. The PI3K-Akt signaling pathway potentially represents a core one mediating the effects of SHCJ against AD. Additionally, molecular docking analysis indicated that quercetin could combine well with AKT1 and multiple apoptosis-related target genes. During cell experiments, a significant increase in cell viability along with a decrease in Aβ25-35-induced apoptosis was observed after treatment with SHCJ. Furthermore, SHCJ significantly increased the phosphorylation of PI3K and Akt while reversing Aβ25-35-induced apoptosis-related protein expression downregulation.
Keywords	Other systems of medicine ; RZ201-999
Subject code	500
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Three new 2-(2-phenylethyl)chromones from ‘Chong-lou’ agarwood of Aquilaria sinensis

Su, Xin / Cai, Cai-Hong / Dong, Wen-Hua / Gai, Cui-Juan / Wang, Ya-Li / Mei, Wen-Li / Xu, Xing-Lian / Dai, Hao-Fu / Chen, Hui-Qin

Phytochemical Society of Europe Phytochemistry letters. 2022 Oct., v. 51

2022

Abstract: ... isolated from ‘Chong-lou’ agarwood originating from Aquilaria sinensis for the first time. Their new ...

Abstract	Three new 2-(2-phenylethyl)chromones (1, 2 and 3), together with four known analogues 4~7 were isolated from ‘Chong-lou’ agarwood originating from Aquilaria sinensis for the first time. Their new structures were elucidated on the basis of spectroscopic techniques (UV, IR, MS, 1D and 2D NMR), as well as by comparison with the literature data. Compounds 6 and 7 exhibited significant cytotoxicity against human cancer cell line K562 with IC₅₀ values of 19.79 ± 0.03 and 21.39 ± 0.05 μM, respectively.
Keywords	Aquilaria sinensis ; cytotoxicity ; humans ; neoplasm cells ; plant biochemistry
Language	English
Dates of publication	2022-10
Size	p. 86-90.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	1874-3900
DOI	10.1016/j.phytol.2022.07.009
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Pregnancy outcome treated with stage-by-stage acupuncture and moxibustion therapy based on the chong channel being sea of blood theory in repeated IVF-ET failure patients: A randomized controlled trial.

Xing, Liwei / Xu, Jinlong / Zhang, Qiong / Li, Li / Li, Yunxiu / Zhuang, Haina / Yuan, Zhuojun / Zhao, Rong / Ma, Yanping

Medicine

2020 Volume 99, Issue 47, Page(s) e23234

Abstract: ... receptivity and Pregnancy Outcome based on the theory of "Chong channel being sea of blood," we will conduct ... acupuncture and moxibustion therapy based on the "Chong channel being sea of blood" theory) or ... on the "Chong Channel Being Sea of Blood" Theory in IVF.: Trial registration: http://www.chictr.org.cn/edit ...

Abstract	Introduction: Acupuncture and moxibustion has become a commonly used adjuvant treatment method to improve the success rate of in vitro fertilization-embryo transfer (IVF-ET). However, There is still insufficient evidence that acupuncture treatment can improve the local microenvironment of endometrium, the endometrial receptivity, and the pregnancy outcome of patients, which is worthy of further study. Method/design: To investigate the effect of Stage by Stage Acupuncture and Moxibustion Therapy on endometrial receptivity and Pregnancy Outcome based on the theory of "Chong channel being sea of blood," we will conduct a multicenter randomized controlled trial. Inclusion criteria are as follows: infertile women under 45 years of age who received IVF-ET or Intracytoplasmic sperm injection cycles. The study will only be applied to women who have failed repeated implantation, that is, women who have failed 3 or more embryo transplants in the past (existing frozen embryos do not require the retrieval of eggs). Those who are not prepared to receive IVF-ET or are at risk of pregnancy, have a serious medical condition, or are egg donors will be excluded. Subjects will be randomly assigned to either the acupuncture group (IVF-ET plus stage-by-stage acupuncture and moxibustion therapy based on the "Chong channel being sea of blood" theory) or the control group (IVF-ET only). The trial required a total sample size of 246 women to compare endometrial receptivity between the 2 groups. The acupuncture group will receive acupuncture and moxibustion treatment 3 times a week starting from the third day of menstruation in the ovary stimulation cycle. One menstrual cycle was one course of treatment, and a total of 3 menstrual cycles were treated. The main outcome indicator was clinical pregnancy rate. Secondary outcome indicators were the three-dimensional volume blood flow parameters (vascularization index, flow index, and vascularization flow index) of the endometrium, endometrial thickness, endometrial volume, uterine artery PI, RI, and S/D during the "implantation window period" (20-24 days after menstruation in the ovary stimulation cycle). Discussion: This study will provide important evidence for the use of Stage by Stage Acupuncture and Moxibustion Therapy Based on the "Chong Channel Being Sea of Blood" Theory in IVF. Trial registration: http://www.chictr.org.cn/edit.aspx?pid=28811&htm=4 ID: ChiCTR1800017191 (07/17/2018).
MeSH term(s)	Embryo Transfer ; Endometrium/blood supply ; Endometrium/diagnostic imaging ; Endometrium/physiology ; Female ; Humans ; Moxibustion ; Multicenter Studies as Topic ; Neovascularization, Physiologic ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Randomized Controlled Trials as Topic ; Regional Blood Flow ; Sperm Injections, Intracytoplasmic ; Uterine Artery
Language	English
Publishing date	2020-11-20
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000023234
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.171: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book: Duan lie, chong gou yu xin sheng

Xu, Xiaojun

E dong ai zi bing ren de cun zhuang she hui guan xi yan jiu

2010

Title variant	E dong ai zi bing ren de cun zhuang she hui guan xi yan jiu
Author's details	Xu Xiaojun zhu
MeSH term(s)	Acquired Immunodeficiency Syndrome/psychology ; Social Alienation ; Social Support
Keywords	China
Language	Chinese
Size	3, 3, 261 p. :, ill. ;, 24 cm.
Edition	Di 1 ban.
Publisher	Zhongguo she hui ke xue chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787500487067 ; 7500487061
Database	Catalogue of the US National Library of Medicine (NLM)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Ping-Chong-Jiang-Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway.

Liang, Rui-Ning / Li, Pei-Shuang / Zou, Yang / Liu, Yu-Ling / Jiang, Zhen / Liu, Zhen / Fan, Pei / Xu, Ling / Peng, Jia-Hua / Sun, Xue-Yan

Evidence-based complementary and alternative medicine : eCAM

2017 Volume 2017, Page(s) 6489427

Abstract: ... in modern medicine achieves usually temporary cure. Ping-Chong-Jiang-Ni formula (PCJNF), a Chinese herbal medicine ...

Abstract	Endometriosis is a common gynecological condition in childbearing age women and its therapy in modern medicine achieves usually temporary cure. Ping-Chong-Jiang-Ni formula (PCJNF), a Chinese herbal medicine (CHM), was shown to be clinically effective on endometriosis. Meanwhile, c-Jun N-terminal kinase (JNK) signaling pathway was involved in the therapeutic process of CHM on endometriosis. Here, we explored the effect of PCJNF on the ectopic endometrial stromal cells (EESCs) from endometriosis and test whether JNK signaling was involved. After being treated with PCJNF-containing serum obtained from Sprague Dawley rat, cell proliferation, migration, invasion, and apoptosis were evaluated in EESCs, and the total and phosphorylated JNK, ERK, and p38 proteins were detected. Our results showed that PCJNF could suppress cell proliferation, migration, and invasion and induce apoptosis in EESCs. The suppressed proliferation and increased apoptosis were dependent on JNK activation. Additionally, PCJNF caused cell cycle arrest at G2/M phase and this effect was mediated by JNK signaling, while the decreased cell migration and invasion treated by PCJNF were independent of JNK signaling. In summary, our results provided the first evidence that PCJNF could suppress cell proliferation, migration, and invasion, while increasing apoptosis in EESCs, and the suppressed proliferation and enhanced apoptosis were mediated by JNK signaling.
Language	English
Publishing date	2017-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2017/6489427
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5995: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: [Contributions of professor Xue Chong-cheng in acupuncture and neuropsychiatry].

Yang, Qiu-li / Liu, Wan-ting / Xu, Rui

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2008 Volume 28, Issue 7, Page(s) 535–539

Abstract: Professor Xue Chong-cheng devotes himself in clinical and research of integrative works of TCM ...

Abstract	Professor Xue Chong-cheng devotes himself in clinical and research of integrative works of TCM, acupuncture, neuropsychiatry, neurosurgery and medicopsychology for more than 70 years. He firstly confirmed acupoints are identical with nerve and motor points, found propagating meridian sensation on phantom limbs of acquired and congenital amputates. The sensation can pass over fresh incision wound and it exits and disappears with the cortical sensation. He proposed a central theory that a meridians model is present in the brain. He suggested examination of general afferent system, cortical sensation and deep pain of syringomyelia with acupuncture as they are absent in routine methods but still present during needling. He firstly reported meridian type of sensory epilepsy and it was recognized by the Epilepsy Center of the USA. He treated psychosis with electroacupuncture convulsive therapy, the dosage of current used was less than 4% of the conventional method. The Journal of Psychiatry of USA recognized it is a dramatic progress for more than 40 years. He compiled first integrative medical questionnaire for assessment of pain. According to TCM theories and modern method of standardization he established inventories and national norms of personality and constitution for the corresponding examinations. They fulfill the gap of China. He firstly proposed the model of TCM is temporo-spatio-socio-psycho-biological. Now he is nearly ninety years old but is still struggling on the first line.
MeSH term(s)	Acupuncture ; China ; History, 20th Century ; History, 21st Century ; Medicine, Chinese Traditional ; Psychiatry
Language	Chinese
Publishing date	2008-07
Publishing country	China
Document type	Biography ; English Abstract ; Historical Article ; Journal Article
ISSN	0255-2930
ISSN	0255-2930
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Ping-Chong-Jiang-Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway

Rui-Ning Liang / Pei-Shuang Li / Yang Zou / Yu-Ling Liu / Zhen Jiang / Zhen Liu / Pei Fan / Ling Xu / Jia-Hua Peng / Xue-Yan Sun

Evidence-Based Complementary and Alternative Medicine, Vol

2017 Volume 2017

Abstract: ... in modern medicine achieves usually temporary cure. Ping-Chong-Jiang-Ni formula (PCJNF), a Chinese herbal medicine ...

Abstract	Endometriosis is a common gynecological condition in childbearing age women and its therapy in modern medicine achieves usually temporary cure. Ping-Chong-Jiang-Ni formula (PCJNF), a Chinese herbal medicine (CHM), was shown to be clinically effective on endometriosis. Meanwhile, c-Jun N-terminal kinase (JNK) signaling pathway was involved in the therapeutic process of CHM on endometriosis. Here, we explored the effect of PCJNF on the ectopic endometrial stromal cells (EESCs) from endometriosis and test whether JNK signaling was involved. After being treated with PCJNF-containing serum obtained from Sprague Dawley rat, cell proliferation, migration, invasion, and apoptosis were evaluated in EESCs, and the total and phosphorylated JNK, ERK, and p38 proteins were detected. Our results showed that PCJNF could suppress cell proliferation, migration, and invasion and induce apoptosis in EESCs. The suppressed proliferation and increased apoptosis were dependent on JNK activation. Additionally, PCJNF caused cell cycle arrest at G2/M phase and this effect was mediated by JNK signaling, while the decreased cell migration and invasion treated by PCJNF were independent of JNK signaling. In summary, our results provided the first evidence that PCJNF could suppress cell proliferation, migration, and invasion, while increasing apoptosis in EESCs, and the suppressed proliferation and enhanced apoptosis were mediated by JNK signaling.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Evaluation of coastal zone sustainability: an integrated approach applied in Shanghai Municipality and Chong Ming Island.

Shi, C / Hutchinson, S M / Xu, S

Journal of environmental management

2004 Volume 71, Issue 4, Page(s) 335–344

Abstract: ... of the Municipality of Shanghai and Chong Ming Island (in the Yangtze Estuary) have been selected as two coastal zones ... at the cost of environment and resource degradation. In contrast, social and economic development in Chong ...

Abstract	A systems approach has been applied to the examination of sustainable development in the coastal zone. This complex system is envisaged as comprising three sub-systems: environment and resources, economic development and society. A sustainability indicator system based on these three sub-systems has been set up to evaluate the nature of development in the coastal zone. The administrative regions of the Municipality of Shanghai and Chong Ming Island (in the Yangtze Estuary) have been selected as two coastal zones in which to demonstrate the feasibility and effectiveness of the approach. The approach indicated that the development process in Shanghai is one of weak sustainability with relatively rapid social and economic development at the cost of environment and resource degradation. In contrast, social and economic development in Chong Ming County has been limited to protect the regional environment and resources indicating a more sustainable approach to development.
MeSH term(s)	Algorithms ; China ; Conservation of Natural Resources/trends ; Economics/trends ; Models, Theoretical ; Social Conditions/trends
Language	English
Publishing date	2004-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2004.03.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 7556: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Book: Zhong yao ji sheng chong bing zhen zhi zhi nan

Xu, Longqi

2002

Title translation	Handbook on diagnosis and treatment of major parasitic diseases.
Author's details	zhu bian Xu Longqi, Xue Chunliang
MeSH term(s)	Intestinal Diseases, Parasitic/diagnosis ; Intestinal Diseases, Parasitic/therapy
Language	Chinese
Size	2, 3, 243 p. :, ill.
Edition	Di 1 ban.
Publisher	Beijing ke xue ji shu chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787530426517 ; 7530426516
Database	Catalogue of the US National Library of Medicine (NLM)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED