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  1. Article: Kul'tura kletok pochechnogo épiteliia: fiziologicheskie i farmakologicheskie aspekty.

    Berkhin, E B

    Eksperimental'naia i klinicheskaia farmakologiia

    1995  Volume 58, Issue 4, Page(s) 69–75

    Abstract: Cultured renal epithelial cells are widely used to examine renal functions and drug control, as well as renal transport of drugs and other xenobiotics. This review is aimed at attracting attention to the techniques of cell strains that show the ... ...

    Title translation The culture of renal epithelial cells: the physiological and pharmacological aspects.
    Abstract Cultured renal epithelial cells are widely used to examine renal functions and drug control, as well as renal transport of drugs and other xenobiotics. This review is aimed at attracting attention to the techniques of cell strains that show the properties typical of a proximal or distal parts of a nephron. It considers the existing primary and identified cultures and the most important recent experimental findings.
    MeSH term(s) Animals ; Cell Culture Techniques/methods ; Cell Line ; Cells, Cultured ; Epithelial Cells ; Epithelium/drug effects ; Epithelium/physiology ; Humans ; Kidney/cytology ; Kidney/drug effects ; Kidney/physiology
    Language Russian
    Publishing date 1995-07
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1112638-3
    ISSN 0869-2092
    ISSN 0869-2092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Regulation of renal tubular secretion of organic compounds.

    Berkhin, E B / Humphreys, M H

    Kidney international

    2001  Volume 59, Issue 1, Page(s) 17–30

    Abstract: Background: Information on the molecular basis underlying organic anion and cation transport in renal tubules has expanded in recent years with the identification and characterization of numerous transporters. However, little is known about the ... ...

    Abstract Background: Information on the molecular basis underlying organic anion and cation transport in renal tubules has expanded in recent years with the identification and characterization of numerous transporters. However, little is known about the regulation of this transport.
    Methods: Both English and Russian language studies dealing with the regulation of organic ion transport by the kidney have been reviewed.
    Results: This review summarizes the literature on the physiological and pharmacological aspects of the regulation of organic ion transport, linking this information where possible to underlying transport mechanisms. Current models of the tubular secretion of organic anions and cations are reviewed. Factors that inhibit or enhance tubular secretion of xenobiotics are described, and their influence on proximal tubule cell transport and function is discussed. Important roles for substrate stimulation, the adrenergic nervous system, numerous hormones, P-glycoprotein, and protein kinase C activity have been identified.
    Conclusions: Despite considerable advances in the understanding of basic transport pathways and mechanisms involved in the tubular secretion of organic compounds, there is still relatively little information on the regulation of this transport. Studies combining the techniques of integrative and cell physiology and molecular biology will provide significant new insights into the pathways regulating the tubular transport of these compounds.
    MeSH term(s) Animals ; Anion Transport Proteins ; Carrier Proteins/metabolism ; Hormones/physiology ; Humans ; Kidney/innervation ; Kidney Tubules/metabolism ; Membrane Proteins/metabolism ; Membrane Transport Proteins ; Nervous System Physiological Phenomena ; Organic Cation Transport Proteins ; Organic Cation Transporter 2 ; Solute Carrier Family 22 Member 5 ; Solute Carrier Proteins ; Stimulation, Chemical
    Chemical Substances Anion Transport Proteins ; Carrier Proteins ; Hormones ; Membrane Proteins ; Membrane Transport Proteins ; Organic Cation Transport Proteins ; Organic Cation Transporter 2 ; SLC22A2 protein, human ; SLC22A4 protein, human ; SLC22A5 protein, human ; Slc22a4 protein, rat ; Solute Carrier Family 22 Member 5 ; Solute Carrier Proteins
    Language English
    Publishing date 2001-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1046/j.1523-1755.2001.00461.x
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  3. Article: Antiateroskleroticheskie sredstva.

    Berkhin, E B

    Klinicheskaia meditsina

    1987  Volume 65, Issue 2, Page(s) 14–20

    Title translation Anti-atherosclerotic drugs.
    MeSH term(s) Anticoagulants/therapeutic use ; Antioxidants/therapeutic use ; Arteriosclerosis/drug therapy ; Humans ; Hypolipidemic Agents/therapeutic use
    Chemical Substances Anticoagulants ; Antioxidants ; Hypolipidemic Agents
    Language Russian
    Publishing date 1987-02
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 391034-9
    ISSN 0023-2149
    ISSN 0023-2149
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  4. Article: Rol' pochek v zashchite organizma ot ksenobiotikov.

    Berkhin, E B

    Farmakologiia i toksikologiia

    1986  Volume 49, Issue 2, Page(s) 104–106

    Title translation Role of the kidneys in protecting the body from xenobiotics.
    MeSH term(s) Animals ; Antigen-Antibody Reactions/drug effects ; Biological Transport/drug effects ; Dogs ; Humans ; Immunity/drug effects ; Kidney/drug effects ; Kidney/immunology ; Kidney/physiology ; Kidney Tubules/drug effects ; Kidney Tubules/secretion ; Rabbits
    Language Russian
    Publishing date 1986-03
    Publishing country Russia (Federation)
    Document type Journal Article ; Review
    ZDB-ID 280713-0
    ISSN 0014-8318
    ISSN 0014-8318
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  5. Article: Prakticheskie voprosy farmakodinamiki.

    Berkhin, E B

    Klinicheskaia meditsina

    1986  Volume 64, Issue 2, Page(s) 146–152

    Title translation Practical problems of pharmacodynamics.
    MeSH term(s) Chemical Phenomena ; Chemistry, Physical ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions ; Higher Nervous Activity/drug effects ; Humans ; Pharmacogenetics ; Pharmacology, Clinical ; Receptors, Drug/drug effects ; Structure-Activity Relationship
    Chemical Substances Receptors, Drug
    Language Russian
    Publishing date 1986-02
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 391034-9
    ISSN 0023-2149
    ISSN 0023-2149
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  6. Article: Vliianie dofamina i ego sochetaniia s furosemidom na mocheotdelenie u krys.

    Berkhin, E B

    Farmakologiia i toksikologiia

    1985  Volume 48, Issue 2, Page(s) 89–92

    Abstract: Subcutaneous injection of dopamine (0.2-0.5 mg/kg) increased the daily diuresis and excretion of sodium, potassium and creatinine. The raising of the dose to 1 mg/kg did not alter renal function, but the initial effect recurred when the alpha-adrenolytic ...

    Title translation Effect of dopamine and its combination with furosemide on urination in the rat.
    Abstract Subcutaneous injection of dopamine (0.2-0.5 mg/kg) increased the daily diuresis and excretion of sodium, potassium and creatinine. The raising of the dose to 1 mg/kg did not alter renal function, but the initial effect recurred when the alpha-adrenolytic phentolamine was administered simultaneously. Dopamine (0.4-0.5 mg/kg) potentiated the natriuretic action of furosemide apparently at the expense of more pronounced inhibition of tubular reabsorption of sodium.
    MeSH term(s) Animals ; Diuresis/drug effects ; Dopamine/pharmacology ; Dose-Response Relationship, Drug ; Furosemide/pharmacology ; Natriuresis/drug effects ; Rats ; Urination/drug effects
    Chemical Substances Furosemide (7LXU5N7ZO5) ; Dopamine (VTD58H1Z2X)
    Language Russian
    Publishing date 1985-03
    Publishing country Russia (Federation)
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 280713-0
    ISSN 0014-8318
    ISSN 0014-8318
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  7. Article: Vliianie immunostimuliatorov na kanal'tsevuiu sekretsiiu ksenobiotikov v pochke.

    Berkhin, E B

    Biulleten' eksperimental'noi biologii i meditsiny

    1985  Volume 100, Issue 11, Page(s) 584–586

    Abstract: Excretion of cardiotrast (diotrast) was used to study tubular secretion of organic compounds in rats. Immunostimulants prodigiosin (0.05 mg/kg) and levamisole (10 mg/kg) injected subcutaneously three times every other day increased cardiotrast excretion. ...

    Title translation Effect of immunostimulants on kidney tubule secretion of xenobiotics.
    Abstract Excretion of cardiotrast (diotrast) was used to study tubular secretion of organic compounds in rats. Immunostimulants prodigiosin (0.05 mg/kg) and levamisole (10 mg/kg) injected subcutaneously three times every other day increased cardiotrast excretion. High levamisole dose (50 mg/kg), having no stimulating effect on the immunity, failed also to influence tubular cardiotrast transport. Possible mechanisms of immunostimulants' action on the tubular secretion of xenobiotics is discussed.
    MeSH term(s) Adjuvants, Immunologic/pharmacology ; Animals ; Iodopyracet/urine ; Kidney Tubules/drug effects ; Kidney Tubules/secretion ; Levamisole/pharmacology ; Polysaccharides, Bacterial/pharmacology ; Prodigiozan/pharmacology ; Rats
    Chemical Substances Adjuvants, Immunologic ; Polysaccharides, Bacterial ; Levamisole (2880D3468G) ; Prodigiozan (9057-00-5) ; Iodopyracet (ZTK4026YJ5)
    Language Russian
    Publishing date 1985-11
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 127365-6
    ISSN 0365-9615 ; 0006-4041
    ISSN 0365-9615 ; 0006-4041
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  8. Article: Prakticheskie voprosy farmakokinetiki.

    Berkhin, E B

    Klinicheskaia meditsina

    1984  Volume 62, Issue 11, Page(s) 11–17

    Title translation Practical problems of pharmacokinetics.
    MeSH term(s) Biological Availability ; Biological Transport ; Biotransformation ; Diffusion ; Half-Life ; Humans ; Kinetics ; Pharmaceutical Preparations/metabolism ; Protein Binding/drug effects ; Tissue Distribution
    Chemical Substances Pharmaceutical Preparations
    Language Russian
    Publishing date 1984-11
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 391034-9
    ISSN 0023-2149
    ISSN 0023-2149
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  9. Article: O mekhanizme transporta sekretiruemykh organicheskikh veshchestv cherez kletku pochechnogo kanal'tswa.

    Berkhin, E B

    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova

    1982  Volume 68, Issue 2, Page(s) 244–247

    Abstract: Vinblastin or copper chloride inhibiting the microtubules, decrease tubular excretion of cardiotrast in rats. After incubation of the kidney tissue homogenat at pH 9.0 the augmentation of inorganic phosphate was more obvious in rats preliminarily ... ...

    Title translation Mechanism of transport of secreted organic substances through kidney tubule cells.
    Abstract Vinblastin or copper chloride inhibiting the microtubules, decrease tubular excretion of cardiotrast in rats. After incubation of the kidney tissue homogenat at pH 9.0 the augmentation of inorganic phosphate was more obvious in rats preliminarily injected with cardiotrast. The data obtained indicate the possible role of microtubules in the tubular secretion of organic substances and the participation of phosphorylation in this process.
    MeSH term(s) Animals ; Biological Transport, Active ; Copper/pharmacology ; Iodopyracet/metabolism ; Kidney Tubules/drug effects ; Kidney Tubules/metabolism ; Microtubules/drug effects ; Phosphates/metabolism ; Rats ; Vinblastine/pharmacology
    Chemical Substances Phosphates ; Vinblastine (5V9KLZ54CY) ; Copper (789U1901C5) ; cuprous chloride (C955P95064) ; Iodopyracet (ZTK4026YJ5)
    Language Russian
    Publishing date 1982-02
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 219224-x
    ISSN 0015-329X
    ISSN 0015-329X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Klinicheskaia farmakologiia i podgotovka vracha.

    Berkhin, E B

    Sovetskaia meditsina

    1981  , Issue 6, Page(s) 77–78

    Title translation Clinical pharmacology and medical training.
    MeSH term(s) Curriculum ; Drug Therapy ; Education, Medical ; Pharmacology, Clinical/education ; USSR
    Language Russian
    Publishing date 1981
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 128565-8
    ISSN 0038-5077
    ISSN 0038-5077
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