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  1. Article ; Online: Moringin, an isothiocyanate modulates multiple cellular signalling molecules in breast cancer cells.

    Srivastava, Ankit / Mishra, Shruti / Avadhesh / Shekher, Anusmita / Rai, Vipin / Dhasmana, Anupam / Das, Jayanta / Perenzoni, Daniele / Iori, Renato / Gupta, Subash C

    Cellular signalling

    2024  Volume 119, Page(s) 111181

    Abstract: Prohibitin (PHB) is a pleiotropic molecule with a variety of known functions and subcellular locations. PHB's function in breast cancer is poorly understood. Herein, we report that PHB is expressed in cancer types of diverse origin including breast ... ...

    Abstract Prohibitin (PHB) is a pleiotropic molecule with a variety of known functions and subcellular locations. PHB's function in breast cancer is poorly understood. Herein, we report that PHB is expressed in cancer types of diverse origin including breast cancer. The cancer patients with changes in PHB were reported to have significantly reduced 'overall survival' in comparison to the cases without alterations in PHB. The expression of PHB was increased by H
    Language English
    Publishing date 2024-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2024.111181
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2579: Show issues Location:
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  2. Article: Immunotherapy: A New Hope for Cancer Patients.

    Gupta, Shalini / Gupta, Subash C / Hunter, Keith D / Pant, Aditya B

    Journal of oncology

    2020  Volume 2020, Page(s) 3548603

    Language English
    Publishing date 2020-07-09
    Publishing country Egypt
    Document type Editorial
    ZDB-ID 2461349-6
    ISSN 1687-8469 ; 1687-8450
    ISSN (online) 1687-8469
    ISSN 1687-8450
    DOI 10.1155/2020/3548603
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  3. Article ; Online: Inflammation and ROS in arthritis: management by Ayurvedic medicinal plants.

    Prasad, Sahdeo / Kulshreshtha, Alok / Lall, Rajiv / Gupta, Subash C

    Food & function

    2021  Volume 12, Issue 18, Page(s) 8227–8247

    Abstract: Chronic joint inflammatory disorders like osteoarthritis and rheumatoid arthritis, which are manifested by joint dysfunction, show an upsurge in inflammation and oxidative stress. Although conventional anti-arthritic drugs are being used to relieve pain ... ...

    Abstract Chronic joint inflammatory disorders like osteoarthritis and rheumatoid arthritis, which are manifested by joint dysfunction, show an upsurge in inflammation and oxidative stress. Although conventional anti-arthritic drugs are being used to relieve pain from arthritic symptoms, they usually cause severe side effects. Traditionally used Ayurvedic medicinal plants are a promising alternative for the management of arthritic symptoms, as they are safe and effective. Ayurvedic medicinal plants improve arthritic symptoms by reducing joint tenderness, joint pain, swelling, bone and cartilage damage, and increasing knee flexion, walking distance and sports activities. These beneficial effects of Ayurvedic medicinal plants on arthritis are mediated through various cellular mechanisms including inhibition of the inflammatory markers NF-κB, cytokines, adipokines, PGE2, NO, iNOS, COX-2, and MMPs and induction of antioxidant status by decreasing free radicals, lipid peroxidation, and myeloperoxidase, and increasing antioxidant enzymes, Nrf2, and HO-1. Thus, a strategy requires using these Ayurvedic medicinal plants to treat arthritis. This article describes the status of inflammation and oxidative stress in arthritic conditions. We also provide evidence that Ayurvedic medicinal plants and their bioactive components are highly effective in improving arthritic symptoms.
    MeSH term(s) Animals ; Arthritis/drug therapy ; Humans ; Inflammation/drug therapy ; Medicine, Ayurvedic ; Phytotherapy ; Plants, Medicinal ; Reactive Oxygen Species/metabolism
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2021-09-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo01078f
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  4. Article: Natural Products for the Prevention and Treatment of Chronic Inflammatory Diseases: Integrating Traditional Medicine into Modern Chronic Diseases Care.

    Kim, Ji Hye / Kismali, Gorkem / Gupta, Subash C

    Evidence-based complementary and alternative medicine : eCAM

    2018  Volume 2018, Page(s) 9837863

    Language English
    Publishing date 2018-04-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2018/9837863
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  5. Article ; Online: Next generation sequencing uncovers multiple miRNAs associated molecular targets in gallbladder cancer patients.

    Saxena, Rahul / Chakrapani, Baskar / Sarath Krishnan, M P / Gupta, Amit / Gupta, Sweety / Das, Jayanta / Gupta, Subash C / Mirza, Anissa A / Rao, Shalinee / Goyal, Bela

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 19101

    Abstract: Gallbladder cancer (GBC) is a lethal disease with surgical resection as the only curative treatment. However, many patients are ineligible for surgery, and current adjuvant treatments exhibit limited effectiveness. Next-generation sequencing has improved ...

    Abstract Gallbladder cancer (GBC) is a lethal disease with surgical resection as the only curative treatment. However, many patients are ineligible for surgery, and current adjuvant treatments exhibit limited effectiveness. Next-generation sequencing has improved our understanding of molecular pathways in cancer, sparking interest in microRNA-based gene regulation. The aim of the study is to identify dysregulated miRNAs in GBC and investigate their potential as therapeutic tools for effective and targeted treatment strategies. GBC and control tissue samples were sequenced for miRNA expression using the Illumina HiSeq platform. Biological processes and related pathways were determined using the Panther and Gene Ontology databases. 439 significantly differentially expressed miRNAs were identified; 19 of them were upregulated and 29 were downregulated. Key enriched biological processes included immune cell apoptosis, endoplasmic reticulum (ER) overload response, and negative regulation of the androgen receptor (AR) signaling pathway. Panther analysis revealed the insulin-like growth factor (IGF)-mitogen activated protein kinases (MAPK) cascade, p38 MAPK pathway, p53 pathway, and FAS (a subgroup of the tumor necrosis factor receptor) signaling pathway as highly enriched among dysregulated miRNAs. Kirsten rat sarcoma virus (KRAS), AR, and interferon gamma (IFN-γ) pathways were identified among the key pathways potentially amenable to targeted therapy. We concluded that a combination approach involving miRNA-based interventions could enhance therapeutic outcomes. Our research emphasizes the importance of precision medicine, targeting pathways using sense and anti-sense miRNAs as potential therapies in GBC.
    MeSH term(s) Humans ; MicroRNAs/metabolism ; Gallbladder Neoplasms/pathology ; High-Throughput Nucleotide Sequencing ; Signal Transduction/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Carcinoma in Situ
    Chemical Substances MicroRNAs ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2023-11-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44767-3
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  6. Article ; Online: Next generation sequencing uncovers multiple miRNAs associated molecular targets in gallbladder cancer patients

    Rahul Saxena / Baskar Chakrapani / M. P. Sarath Krishnan / Amit Gupta / Sweety Gupta / Jayanta Das / Subash C. Gupta / Anissa A. Mirza / Shalinee Rao / Bela Goyal

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 12

    Abstract: Abstract Gallbladder cancer (GBC) is a lethal disease with surgical resection as the only curative treatment. However, many patients are ineligible for surgery, and current adjuvant treatments exhibit limited effectiveness. Next-generation sequencing has ...

    Abstract Abstract Gallbladder cancer (GBC) is a lethal disease with surgical resection as the only curative treatment. However, many patients are ineligible for surgery, and current adjuvant treatments exhibit limited effectiveness. Next-generation sequencing has improved our understanding of molecular pathways in cancer, sparking interest in microRNA-based gene regulation. The aim of the study is to identify dysregulated miRNAs in GBC and investigate their potential as therapeutic tools for effective and targeted treatment strategies. GBC and control tissue samples were sequenced for miRNA expression using the Illumina HiSeq platform. Biological processes and related pathways were determined using the Panther and Gene Ontology databases. 439 significantly differentially expressed miRNAs were identified; 19 of them were upregulated and 29 were downregulated. Key enriched biological processes included immune cell apoptosis, endoplasmic reticulum (ER) overload response, and negative regulation of the androgen receptor (AR) signaling pathway. Panther analysis revealed the insulin-like growth factor (IGF)-mitogen activated protein kinases (MAPK) cascade, p38 MAPK pathway, p53 pathway, and FAS (a subgroup of the tumor necrosis factor receptor) signaling pathway as highly enriched among dysregulated miRNAs. Kirsten rat sarcoma virus (KRAS), AR, and interferon gamma (IFN-γ) pathways were identified among the key pathways potentially amenable to targeted therapy. We concluded that a combination approach involving miRNA-based interventions could enhance therapeutic outcomes. Our research emphasizes the importance of precision medicine, targeting pathways using sense and anti-sense miRNAs as potential therapies in GBC.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Combination Therapy Comprising Paclitaxel and 5-Fluorouracil by Using Folic Acid Functionalized Bovine Milk Exosomes Improves the Therapeutic Efficacy against Breast Cancer.

    Kumar, Dulla Naveen / Chaudhuri, Aiswarya / Dehari, Deepa / Shekher, Anusmita / Gupta, Subash C / Majumdar, Shreyasi / Krishnamurthy, Sairam / Singh, Sanjay / Kumar, Dinesh / Agrawal, Ashish Kumar

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 8

    Abstract: Paclitaxel (PAC) has been approved by FDA for clinical use ( ... ...

    Abstract Paclitaxel (PAC) has been approved by FDA for clinical use (Taxol
    Language English
    Publishing date 2022-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12081143
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  8. Article: Green Carbon Dots: Synthesis, Characterization, Properties and Biomedical Applications.

    Jing, Hong Hui / Bardakci, Fevzi / Akgöl, Sinan / Kusat, Kevser / Adnan, Mohd / Alam, Mohammad Jahoor / Gupta, Reena / Sahreen, Sumaira / Chen, Yeng / Gopinath, Subash C B / Sasidharan, Sreenivasan

    Journal of functional biomaterials

    2023  Volume 14, Issue 1

    Abstract: Carbon dots (CDs) are a new category of crystalline, quasi-spherical fluorescence, "zero-dimensional" carbon nanomaterials with a spatial size between 1 nm to 10 nm and have gained widespread attention in recent years. Green CDs are carbon dots ... ...

    Abstract Carbon dots (CDs) are a new category of crystalline, quasi-spherical fluorescence, "zero-dimensional" carbon nanomaterials with a spatial size between 1 nm to 10 nm and have gained widespread attention in recent years. Green CDs are carbon dots synthesised from renewable biomass such as agro-waste, plants or medicinal plants and other organic biomaterials. Plant-mediated synthesis of CDs is a green chemistry approach that connects nanotechnology with the green synthesis of CDs. Notably, CDs made with green technology are economical and far superior to those manufactured with physicochemical methods due to their exclusive benefits, such as being affordable, having high stability, having a simple protocol, and being safer and eco-benign. Green CDs can be synthesized by using ultrasonic strategy, chemical oxidation, carbonization, solvothermal and hydrothermal processes, and microwave irradiation using various plant-based organic resources. CDs made by green technology have diverse applications in biomedical fields such as bioimaging, biosensing and nanomedicine, which are ascribed to their unique properties, including excellent luminescence effect, strong stability and good biocompatibility. This review mainly focuses on green CDs synthesis, characterization techniques, beneficial properties of plant resource-based green CDs and their biomedical applications. This review article also looks at the research gaps and future research directions for the continuous deepening of the exploration of green CDs.
    Language English
    Publishing date 2023-01-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb14010027
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  9. Article ; Online: Neuroblastoma: Emerging trends in pathogenesis, diagnosis, and therapeutic targets.

    Katta, Santharam S / Nagati, Veerababu / Paturi, Atreya S V / Murakonda, Swati P / Murakonda, Ajay B / Pandey, Manoj K / Gupta, Subash C / Pasupulati, Anil K / Challagundla, Kishore B

    Journal of controlled release : official journal of the Controlled Release Society

    2023  Volume 357, Page(s) 444–459

    Abstract: Neuroblastoma (NB) accounts for about 13% of all pediatric cancer mortality and is the leading cause of pediatric cancer death for children aged 1 to 5 years. NB, a developmental malignancy of neural ganglia, originates from neural crest-derived cells, ... ...

    Abstract Neuroblastoma (NB) accounts for about 13% of all pediatric cancer mortality and is the leading cause of pediatric cancer death for children aged 1 to 5 years. NB, a developmental malignancy of neural ganglia, originates from neural crest-derived cells, which undergo a defective sympathetic neuronal differentiation due to genomic and epigenetic aberrations. NB is a complex disease with remarkable biological and genetic variation and clinical heterogeneity, such as spontaneous regression, treatment resistance, and poor survival rates. Depending on its severity, NB is categorized as high-risk, intermediate-risk, and low-risk., whereas high-risk NB accounts for a high infant mortality rate. Several studies revealed that NB cells suppress immune cell activity through diverse signaling pathways, including exosome-based signaling pathways. Exosome signaling has been shown to modulate gene expression in the target immune cells and attenuate the signaling events through non-coding RNAs. Since high-risk NB is characterized by a low survival rate and high clinical heterogeneity with current intensive therapies, it is crucial to unravel the molecular events of pathogenesis and develop novel therapeutic targets in high-risk, relapsed, or recurrent tumors in NB to improve patient survival. This article discusses etiology, pathophysiology, risk assessment, molecular cytogenetics, and the contribution of extracellular vesicles, non-coding RNAs, and cancer stem cells in the tumorigenesis of NB. We also detail the latest developments in NB immunotherapy and nanoparticle-mediated drug delivery treatment options.
    MeSH term(s) Humans ; Child ; Neuroblastoma/diagnosis ; Neuroblastoma/drug therapy ; Neuroblastoma/genetics ; Signal Transduction ; Immunotherapy
    Language English
    Publishing date 2023-04-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2023.04.001
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    Zs.A 2055: Show issues Location:
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  10. Article ; Online: Cannabis and its constituents for cancer: History, biogenesis, chemistry and pharmacological activities.

    Lal, Samridhi / Shekher, Anusmita / Puneet / Narula, Acharan S / Abrahamse, Heidi / Gupta, Subash C

    Pharmacological research

    2020  Volume 163, Page(s) 105302

    Abstract: Cannabis has long been used for healing and recreation in several regions of the world. Over 400 bioactive constituents, including more than 100 phytocannabinoids, have been isolated from this plant. The non-psychoactive cannabidiol (CBD) and the ... ...

    Abstract Cannabis has long been used for healing and recreation in several regions of the world. Over 400 bioactive constituents, including more than 100 phytocannabinoids, have been isolated from this plant. The non-psychoactive cannabidiol (CBD) and the psychoactive Δ
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cannabinoids/pharmacology ; Cannabinoids/therapeutic use ; Cannabis/chemistry ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Medical Marijuana/chemistry ; Medical Marijuana/history ; Medical Marijuana/pharmacology ; Medical Marijuana/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Receptors, Cannabinoid/metabolism
    Chemical Substances Antineoplastic Agents ; Cannabinoids ; Medical Marijuana ; Receptors, Cannabinoid
    Language English
    Publishing date 2020-11-24
    Publishing country Netherlands
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2020.105302
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