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  1. Article: Deep time perspective on turtle neck evolution: chasing the Hox code by vertebral morphology

    Böhmer, Christine / Werneburg, Ingmar

    Scientific reports, 7:8939

    2017  

    Abstract: The unparalleled ability of turtle neck retraction is possible in three different modes, which characterize stem turtles, living side-necked (Pleurodira), and hidden-necked (Cryptodira) turtles, respectively. Despite the conservatism in vertebral count ... ...

    Institution Senckenberg Centre for Human Evolution and Palaeoenvironment
    Museum für Naturkunde Berlin
    Abstract The unparalleled ability of turtle neck retraction is possible in three different modes, which characterize stem turtles, living side-necked (Pleurodira), and hidden-necked (Cryptodira) turtles, respectively. Despite the conservatism in vertebral count among turtles, there is significant functional and morphological regionalization in the cervical vertebral column. Since Hox genes play a fundamental role in determining the differentiation in vertebra morphology and based on our reconstruction of evolutionary genetics in deep time, we hypothesize genetic differences among the turtle groups and between turtles and other land vertebrates. We correlated anterior Hox gene expression and the quantifiable shape of the vertebrae to investigate the morphological modularity in the neck across living and extinct turtles. This permitted the reconstruction of the hypothetical ancestral Hox code pattern of the whole turtle clade. The scenario of the evolution of axial patterning in turtles indicates shifts in the spatial expression of HoxA-5 in relation to the reduction of cervical ribs in modern turtles and of HoxB-5 linked with a lower morphological differentiation between the anterior cervical vertebrae observed in cryptodirans. By comparison with the mammalian pattern, we illustrate how the fixed count of eight cervical vertebrae in turtles resulted from the emergence of the unique turtle shell.
    Keywords Evolutionary developmental biology ; Paleontology ; carapacial ridge ; axial skeleton ; body plan ; genes result ; expression ; homeotic transformations ; soft-shelled turtle ; patterns ; rib cage ; trunk neural crest
    Language English
    Document type Article
    Database Repository for Life Sciences

    Full text online

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  2. Book ; Online ; Thesis: Die Expression und entzündungsabhängige Regulation von Fibroblast Growth Factor-Rezeptoren in bronchopulmonalen C-Faser-Neuronen und der Rezeptor-Liganden in der Mauslunge

    Böhmer, Rebecca [Verfasser]

    2017  

    Author's details Rebecca Böhmer
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek
    Publishing place Gießen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article ; Online: Skull Shape Diversity in Pet Rabbits and the Applicability of Anatomical Reference Lines for Objective Interpretation of Dental Disease.

    Böhmer, Christine / Böhmer, Estella

    Veterinary sciences

    2020  Volume 7, Issue 4

    Abstract: Acquired dental problems are among the most frequently encountered diseases in pet rabbits. However, early symptoms are often overlooked because the affected animals first appear completely asymptomatic. Alterations from anatomical reference lines ... ...

    Abstract Acquired dental problems are among the most frequently encountered diseases in pet rabbits. However, early symptoms are often overlooked because the affected animals first appear completely asymptomatic. Alterations from anatomical reference lines according to Böhmer and Crossley applied to standard skull X-ray images, have been shown to be indicative of tooth health problems in pet rabbits. Despite its proven usefulness, there are exceptions in which the anatomical reference lines appear not to be suitable for application. We addressed this issue by quantifying the cranial morphology of a large data set of pet rabbit patients (N = 80). The results of the morphometric analyses revealed considerable diversity in skull shape among the typical pet rabbits, but variance in only a few parameters influences the applicability of the anatomical reference lines. The most substantial parameter is the palatal angle. Specimens in which the anatomical reference lines could not be applied, have a rather large angle between the skull base and the palatal bone. We recommend to measure the palatal angle before applying the anatomical reference lines for objective interpretation of dental disease. Pet rabbits with a palatal angle larger than 18.8° are not strictly suitable for the successful application of the anatomical reference lines.
    Language English
    Publishing date 2020-11-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci7040182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: C-C-Verknüpfungen mit chelatisierten Eisencarbenkomplexen

    Böhmer, Jutta

    Reaktionen und Selektivitäten

    1998  

    Author's details von Jutta Böhmer
    Language German
    Size 143 S, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Erlangen-Nürnberg, 1998
    Database Former special subject collection: coastal and deep sea fishing

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  5. Book ; Thesis: C-C-Verknüpfungen mit chelatisierten Eisencarbenkomplexen

    Böhmer, Jutta

    Reaktionen und Selektivitäten

    1998  

    Author's details von Jutta Böhmer
    Language German
    Size 143 S, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Erlangen-Nürnberg, 1998
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Article: Elevated expression of PDGF-C in coxsackievirus B3-induced chronic myocarditis.

    Grün, Katja / Markova, Boyka / Böhmer, Frank-D / Berndt, Alexander / Kosmehl, Hartwig / Leipner, Carola

    European heart journal

    2005  Volume 26, Issue 7, Page(s) 728–739

    Abstract: ... are poorly understood. Enhanced levels of platelet-derived growth factors (PDGFs), especially PDGF-C ... PDGF-C, was detectable throughout the heart. The chronic inflammatory process was associated ...

    Abstract Aims: Coxsackievirus B3 (CVB3) is a frequent cause of human chronic myocarditis and subsequent fibrosis, leading to dilated cardiomyopathy. The molecular processes underlying the development of fibrosis are poorly understood. Enhanced levels of platelet-derived growth factors (PDGFs), especially PDGF-C, have recently been linked with the development of different forms of fibrosis. Therefore, the expression of PDGF was analysed in hearts of CVB3-infected major histocompatability complex class II knockout mice. The latter were recently established as mouse model mimicking the chronic inflammation and fibrosis characteristic for this disease.
    Methods and results: Expression of PDGF was analysed by reverse transcription-polymerase chain reaction, in situ hybridization, and immunohistochemistry. Hearts of C57BL/6 mice served as controls because infection of these animals leads to acute cardiac inflammation, but the hearts heal without signs of chronic inflammation. In uninfected hearts, basal expression of PDGF, notably PDGF-C, was detectable throughout the heart. The chronic inflammatory process was associated with elevated and sustained expression of all tested PDGF isoforms. Immunostaining and in situ hybridization analysis localized enhanced PDGF levels to areas with highest virus load and inflammatory infiltrations, adjacent to fibrotic areas.
    Conclusion: PDGF may participate in fibrosis development in CVB3-induced myocarditis. Therefore, PDGF signalling may be considered a target for therapeutic interference.
    MeSH term(s) Animals ; Chronic Disease ; Coxsackievirus Infections/metabolism ; Enterovirus B, Human ; Fibrosis ; Lymphokines/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myocarditis/metabolism ; Myocarditis/microbiology ; Myocardium/metabolism ; Myocardium/pathology ; Platelet-Derived Growth Factor/metabolism
    Chemical Substances Lymphokines ; Platelet-Derived Growth Factor ; platelet-derived growth factor C
    Language English
    Publishing date 2005-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehi168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

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  7. Article ; Online: Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells.

    Pollock, Stephanie / Nichita, Norica Branza / Böhmer, Annette / Radulescu, Cristina / Dwek, Raymond A / Zitzmann, Nicole

    Proceedings of the National Academy of Sciences of the United States of America

    2010  Volume 107, Issue 40, Page(s) 17176–17181

    Abstract: ... of viral systems, including hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV. Liposomes developed ...

    Abstract The pressing need for broad-spectrum antivirals could be met by targeting host rather than viral processes. Cholesterol biosynthesis within the infected cell is one promising target for a large number of viral systems, including hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV. Liposomes developed for intracellular, endoplasmic reticulum (ER)-targeted in vivo drug delivery have been modified to include polyunsaturated fatty acids that exert an independent antiviral activity through the reduction of cellular cholesterol. These polyunsaturated ER liposomes (PERLs) have greater activity than lovastatin (Mevacor, Altoprev), which is clinically approved for lowering cholesterol and preventing cardiovascular disease. Treatment of HCV, HBV, and HIV infections with PERLs significantly decreased viral secretion and infectivity, and pretreatment of naïve cells reduced the ability of both HCV and HIV to establish infections because of the decreased levels of plasma membrane cholesterol. Direct competition for cellular receptors was an added effect of PERLs against HCV infections. The greatest antiviral activity in all three systems was the inhibition of viral infectivity through the reduction of virus-associated cholesterol. Our study demonstrates that PERLs are a broadly effective antiviral therapy and should be developed further in combination with encapsulated drug mixtures for enhanced in vivo efficacy.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Cell Line ; Cholesterol/metabolism ; Fatty Acids, Unsaturated/pharmacology ; Fatty Acids, Unsaturated/therapeutic use ; HIV/drug effects ; HIV Infections/drug therapy ; Hepacivirus/drug effects ; Hepatitis B/drug therapy ; Hepatitis B virus/drug effects ; Hepatitis C, Chronic/drug therapy ; Humans ; Liposomes/chemistry ; Liposomes/pharmacology ; Liposomes/therapeutic use
    Chemical Substances Antiviral Agents ; Fatty Acids, Unsaturated ; Liposomes ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2010-09-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1009445107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Temperature oscillations provide access to high-order physical aging harmonics of a glass forming melt.

    Moch, Kevin / Böhmer, Roland / Gainaru, Catalin

    The Journal of chemical physics

    2023  Volume 159, Issue 22

    Abstract: A high-resolution, temperature oscillation-based probe of physical aging in complex systems is introduced. The Fourier analysis of the measured responses allows one to extract high-order, aging-related nonlinearities that are not accessible via ... ...

    Abstract A high-resolution, temperature oscillation-based probe of physical aging in complex systems is introduced. The Fourier analysis of the measured responses allows one to extract high-order, aging-related nonlinearities that are not accessible via traditional temperature-jump and temperature-ramp procedures. To demonstrate the potential of this oscillatory approach, we analyze the periodic time evolution of glycerol's structural relaxation using shear rheology as a vehicle. Thereby, we access up to the sixth harmonic and detect aging fingerprints within a resolution range of three orders of magnitude for temperature amplitudes of up to 4 K. The even harmonics are present since aging is not symmetrical with respect to the direction of temperature change. The high-order aging coefficients obtained for glycerol are described reasonably well within the Tool-Narayanaswamy-Moynihan formalism.
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0179801
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    In stock of ZB MED Bonn / Germany

    Z 4' 49/16: Show issues

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  9. Article: Correlation between

    Böhmer, Christine

    Zoological letters

    2017  Volume 3, Page(s) 8

    Abstract: Background: The importance of the cervical vertebrae as part of the skull-neck system in facilitating the success and diversity of tetrapods is clear. The reconstruction of its evolution, however, is problematic because of the variation in the number of ...

    Abstract Background: The importance of the cervical vertebrae as part of the skull-neck system in facilitating the success and diversity of tetrapods is clear. The reconstruction of its evolution, however, is problematic because of the variation in the number of vertebrae, making it difficult to identify homologous elements. Quantification of the morphological differentiation in the neck of diverse archosaurs established homologous units of vertebrae (i.e. modules) resulting from
    Results: In combination with up-to-date information on cervical
    Conclusion: Thus, the mouse
    Language English
    Publishing date 2017-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2809936-9
    ISSN 2056-306X
    ISSN 2056-306X
    DOI 10.1186/s40851-017-0069-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Skull Shape Diversity in Pet Rabbits and the Applicability of Anatomical Reference Lines for Objective Interpretation of Dental Disease

    Böhmer, Christine / Böhmer, Estella

    Veterinary sciences. 2020 Nov. 20, v. 7, no. 4

    2020  

    Abstract: Acquired dental problems are among the most frequently encountered diseases in pet rabbits. However, early symptoms are often overlooked because the affected animals first appear completely asymptomatic. Alterations from anatomical reference lines ... ...

    Abstract Acquired dental problems are among the most frequently encountered diseases in pet rabbits. However, early symptoms are often overlooked because the affected animals first appear completely asymptomatic. Alterations from anatomical reference lines according to Böhmer and Crossley applied to standard skull X-ray images, have been shown to be indicative of tooth health problems in pet rabbits. Despite its proven usefulness, there are exceptions in which the anatomical reference lines appear not to be suitable for application. We addressed this issue by quantifying the cranial morphology of a large data set of pet rabbit patients (N = 80). The results of the morphometric analyses revealed considerable diversity in skull shape among the typical pet rabbits, but variance in only a few parameters influences the applicability of the anatomical reference lines. The most substantial parameter is the palatal angle. Specimens in which the anatomical reference lines could not be applied, have a rather large angle between the skull base and the palatal bone. We recommend to measure the palatal angle before applying the anatomical reference lines for objective interpretation of dental disease. Pet rabbits with a palatal angle larger than 18.8° are not strictly suitable for the successful application of the anatomical reference lines.
    Keywords X-radiation ; data collection ; morphometry ; rabbits ; skull ; tooth diseases ; variance
    Language English
    Dates of publication 2020-1120
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2768971-2
    ISSN 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci7040182
    Database NAL-Catalogue (AGRICOLA)

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