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  1. Article ; Online: My 100th JBC paper.

    Sancar, Aziz

    The Journal of biological chemistry

    2020  Volume 296, Page(s) 100061

    Abstract: Nobel laureate Aziz Sancar writes about his decades-long relationship with the Journal ...

    Abstract Nobel laureate Aziz Sancar writes about his decades-long relationship with the Journal of Biological Chemistry. Since 1984, he has published 100 papers in JBC, including this "Reflections."
    MeSH term(s) Biochemistry/history ; History, 20th Century ; History, 21st Century ; Humans ; Periodicals as Topic/history
    Language English
    Publishing date 2020-11-18
    Publishing country United States
    Document type Autobiography ; Historical Article ; Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2020.100061
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  2. Article ; Online: Biography.

    Sancar, Aziz

    Photochemistry and photobiology

    2017  Volume 93, Issue 1, Page(s) 7–14

    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/php.12731
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    Zs.B 1686: Show issues Location:
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  3. Article ; Online: Preface.

    Sancar, Aziz

    Photochemistry and photobiology

    2017  Volume 93, Issue 1, Page(s) 4

    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/php.12700
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  4. Article ; Online: Mutations of the circadian clock genes

    Yang, Yanyan / Wu, Gang / Sancar, Aziz / Hogenesch, John B

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 8, Page(s) e2316731121

    Abstract: One important goal of circadian medicine is to apply time-of-day dosing to improve the efficacy of chemotherapy. However, limited knowledge of how the circadian clock regulates DNA repair presents a challenge to mechanism-based clinical application. We ... ...

    Abstract One important goal of circadian medicine is to apply time-of-day dosing to improve the efficacy of chemotherapy. However, limited knowledge of how the circadian clock regulates DNA repair presents a challenge to mechanism-based clinical application. We studied time-series genome-wide nucleotide excision repair in liver and kidney of wild type and three different clock mutant genotypes (
    MeSH term(s) Animals ; Mice ; Circadian Clocks/genetics ; Circadian Rhythm/genetics ; CLOCK Proteins/genetics ; Mutation ; Nucleotides ; Cryptochromes/genetics ; ARNTL Transcription Factors/genetics ; Mammals
    Chemical Substances CLOCK Proteins (EC 2.3.1.48) ; Nucleotides ; Cryptochromes ; ARNTL Transcription Factors
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2316731121
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  5. Article: Genome-wide analysis of transcription-coupled repair reveals novel transcription events in

    Kose, Cansu / Lindsey-Boltz, Laura A / Sancar, Aziz / Jiang, Yuchao

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Bulky DNA adducts such as those induced by ultraviolet light are removed from the genomes of multicellular organisms by nucleotide excision repair, which occurs through two distinct mechanisms, global repair, requiring the DNA damage recognition-factor ... ...

    Abstract Bulky DNA adducts such as those induced by ultraviolet light are removed from the genomes of multicellular organisms by nucleotide excision repair, which occurs through two distinct mechanisms, global repair, requiring the DNA damage recognition-factor XPC (xeroderma pigmentosum complementation group C), and transcription-coupled repair (TCR), which does not. TCR is initiated when elongating RNA polymerase II encounters DNA damage, and thus analysis of genome-wide excision repair in XPC-mutants only repairing by TCR provides a unique opportunity to map transcription events missed by methods dependent on capturing RNA transcription products and thus limited by their stability and/or modifications (5'-capping or 3'-polyadenylation). Here, we have performed the eXcision Repair-sequencing (XR-seq) in the model organism
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.12.562083
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  6. Article ; Online: Claud S. Rupert (1919-2017): The Father of DNA Repair.

    Sancar, Aziz

    Photochemistry and photobiology

    2017  Volume 93, Issue 4, Page(s) 1133–1134

    MeSH term(s) DNA Repair ; History, 20th Century ; History, 21st Century ; Molecular Biology/history ; United States
    Language English
    Publishing date 2017-06-22
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/php.12792
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  7. Article ; Online: Oliver Smithies (1925-2017).

    Sancar, Aziz

    Science (New York, N.Y.)

    2017  Volume 355, Issue 6326, Page(s) 695

    MeSH term(s) Animals ; Biochemistry/history ; CLOCK Proteins/history ; Cryptochromes/history ; Gene Targeting/history ; Genome, Human ; History, 20th Century ; History, 21st Century ; Humans ; Mice ; Nobel Prize ; United Kingdom ; United States
    Chemical Substances Cry1 protein, mouse ; Cry2 protein, mouse ; Cryptochromes ; CLOCK Proteins (EC 2.3.1.48)
    Language English
    Publishing date 2017-02-17
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aam8635
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  8. Article ; Online: In vitro DNA repair genomics using XR-seq with

    Cao, Xuemei / Kose, Cansu / Selby, Christopher P / Sancar, Aziz

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 43, Page(s) e2314233120

    Abstract: The XR-seq (eXcision Repair-sequencing) method has been extensively used to map nucleotide excision repair genome-wide in organisms ranging ... ...

    Abstract The XR-seq (eXcision Repair-sequencing) method has been extensively used to map nucleotide excision repair genome-wide in organisms ranging from
    MeSH term(s) Humans ; Animals ; Mice ; Escherichia coli/genetics ; DNA Repair ; DNA Damage ; Genome ; Genomics ; Ultraviolet Rays ; Mammals/genetics
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2314233120
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  9. Article ; Online: Global repair is the primary nucleotide excision repair subpathway for the removal of pyrimidine-pyrimidone (6-4) damage from the Arabidopsis genome.

    Kaya, Sezgi / Erdogan, Dugcar Ebrar / Sancar, Aziz / Adebali, Ogun / Oztas, Onur

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3308

    Abstract: Ultraviolet (UV) component of solar radiation impairs genome stability by inducing the formation of pyrimidine-pyrimidone (6-4) photoproducts [(6-4)PPs] in plant genomes. (6-4)PPs disrupt growth and development by interfering with transcription and DNA ... ...

    Abstract Ultraviolet (UV) component of solar radiation impairs genome stability by inducing the formation of pyrimidine-pyrimidone (6-4) photoproducts [(6-4)PPs] in plant genomes. (6-4)PPs disrupt growth and development by interfering with transcription and DNA replication. To resist UV stress, plants employ both photoreactivation and nucleotide excision repair that excises oligonucleotide containing (6-4)PPs through two subpathways: global and transcription-coupled excision repair (TCR). Here, we analyzed the genome-wide excision repair-mediated repair of (6-4)PPs in Arabidopsis thaliana and found that (6-4)PPs can be repaired by TCR; however, the main subpathway to remove (6-4)PPs from the genome is global repair. Our analysis showed that open chromatin genome regions are more rapidly repaired than heterochromatin regions, and the repair level peaks at the promoter, transcription start site and transcription end site of genes. Our study revealed that the repair of (6-4)PP in plants showed a distinct genome-wide repair profile compared to the repair of other major UV-induced DNA lesion called cyclobutane pyrimidine dimers (CPDs).
    MeSH term(s) DNA Repair ; Arabidopsis/genetics ; Pyrimidinones ; Excision Repair ; Pyrimidine Dimers ; DNA Damage ; Receptors, Antigen, T-Cell/genetics ; Ultraviolet Rays
    Chemical Substances Pyrimidinones ; Pyrimidine Dimers ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53472-8
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  10. Article ; Online: Molecular Mechanisms of Transcription-Coupled Repair.

    Selby, Christopher P / Lindsey-Boltz, Laura A / Li, Wentao / Sancar, Aziz

    Annual review of biochemistry

    2023  Volume 92, Page(s) 115–144

    Abstract: Transcription-coupled repair (TCR), discovered as preferential nucleotide excision repair of UV-induced cyclobutane pyrimidine dimers located in transcribed mammalian genes compared to those in nontranscribed regions of the genome, is defined as faster ... ...

    Abstract Transcription-coupled repair (TCR), discovered as preferential nucleotide excision repair of UV-induced cyclobutane pyrimidine dimers located in transcribed mammalian genes compared to those in nontranscribed regions of the genome, is defined as faster repair of the transcribed strand versus the nontranscribed strand in transcribed genes. The phenomenon, universal in model organisms including
    MeSH term(s) Humans ; Animals ; Mice ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Transcription, Genetic ; Cryoelectron Microscopy ; DNA Repair ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Mammals/genetics
    Chemical Substances Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 207924-0
    ISSN 1545-4509 ; 0066-4154
    ISSN (online) 1545-4509
    ISSN 0066-4154
    DOI 10.1146/annurev-biochem-041522-034232
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