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Article ; Online: Dorothea Liebermann-Meffert (*1930: †2020)-A Life Dedicated to Surgery.

Stein, H J

2021 Volume 45, Issue 3, Page(s) 653–654

Language	English
Publishing date	2021-01-01
Publishing country	United States
Document type	Editorial
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-020-05891-7
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Book ; Online: Organic carbon and biomarker record from the Laptev Sea continental margin, supplementary data to: Stein, Ruediger; Fahl, Kirsten; Niessen, Frank; Siebold, Martina (1999): Late quaternary organic carbon and biomarker records from the Laptev Sea continental margin (Arctic Ocean): implications for organic carbon flux and composition. In: Kassens, H; Bauch, H A; Dmitrenko, I A; Eicken, H; Hubberten, H-W; Melles, M; Thiede, J & Timokhov, L A (eds.), Land-ocean systems in the Siberian Arctic: dynamics and history, Springer, Berlin, Heidelberg, 635-656

Stein, Ruediger / Fahl, Kirsten / Niessen, Frank / Siebold, Martina

1999

Abstract: In order to understand the processes controlling organic carbon deposition (i.e., primary productivity vs. terrigenous supply) and their paleoceanographic significance, three sediment cores (PS2471, PS2474. and PS2476) from the Laptev Sea continental ... ...

Abstract	In order to understand the processes controlling organic carbon deposition (i.e., primary productivity vs. terrigenous supply) and their paleoceanographic significance, three sediment cores (PS2471, PS2474. and PS2476) from the Laptev Sea continental margin were investigated for their content and composition of organic carbon. The characterization of organic matter indudes the determination of buk parameters (hydrogen index values and C/N ratios) and the analysis of specific biomarkers (n-alaknes, fatty acids, alkenones, and pigments). Total organic carbon (TOC) values vary between 0.3 and 2%. In general, the organic matter from the Laptev Sea continental margin is dominated by terrigenous matter throughout. However. significant amounts of marine organic carbon occur. The turbidites, according to a still preliminary stratigraphy probably deposited during glacial Oxygen Isotope Stages 2 and 4, are characterized by maximum amounts of organic carbon of terrigenous origin. Marine organic carbon appears to show enhanced relative abundances in the Termination I (?) and early Holocene time intervals, as indicated by maximum amounts of short chain n-alkanes, short-chain fatty acids, and alkenones. The increased amounts of faity acids, however, may also have a freshwater origin due to increased river discharge at that time. The occurrence of alkenones is suggested to indicate an intensification of Atlantic water inflow along the Eurasian continental margin starting at that time. Oxygen Isotope Stage l accumutation rates of total organic carhon are 0.3, 0.17, and 0.02 C/cm**2/ky in cores PS2476, PS2474, and PS2471, respectively.
Language	English
Dates of publication	1999-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
DOI	10.1594/PANGAEA.733566
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Current perspectives on perinatal mental health and neurobehavioral development: focus on regulation, coregulation and self-regulation.

Van den Bergh, Bea R H / Antonelli, Marta C / Stein, Dan J

Current opinion in psychiatry

2024 Volume 37, Issue 3, Page(s) 237–250

Abstract: Purpose of review: Perinatal mental health research provides an important perspective on neurobehavioral development. Here, we aim to review the association of maternal perinatal health with offspring neurodevelopment, providing an update on (self-) ... ...

Abstract	Purpose of review: Perinatal mental health research provides an important perspective on neurobehavioral development. Here, we aim to review the association of maternal perinatal health with offspring neurodevelopment, providing an update on (self-)regulation problems, hypothesized mechanistic pathways, progress and challenges, and implications for mental health. Recent findings: (1) Meta-analyses confirm that maternal perinatal mental distress is associated with (self-)regulation problems which constitute cognitive, behavioral, and affective social-emotional problems, while exposure to positive parental mental health has a positive impact. However, effect sizes are small. (2) Hypothesized mechanistic pathways underlying this association are complex. Interactive and compensatory mechanisms across developmental time are neglected topics. (3) Progress has been made in multiexposure studies. However, challenges remain and these are shared by clinical, translational and public health sciences. (4) From a mental healthcare perspective, a multidisciplinary and system level approach employing developmentally-sensitive measures and timely treatment of (self-)regulation and coregulation problems in a dyadic caregiver-child and family level approach seems needed. The existing evidence-base is sparse. Summary: During the perinatal period, addressing vulnerable contexts and building resilient systems may promote neurobehavioral development. A pluralistic approach to research, taking a multidisciplinary approach to theoretical models and empirical investigation needs to be fostered.
MeSH term(s)	Pregnancy ; Female ; Humans ; Mental Health ; Mental Disorders/etiology ; Emotions ; Delivery of Health Care ; Self-Control
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	645162-7
ISSN	1473-6578 ; 0951-7367
ISSN (online)	1473-6578
ISSN	0951-7367
DOI	10.1097/YCO.0000000000000932
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Article ; Online: Commentary: Measure twice, but cut early?

Won, Eugene J / Stein, Louis H

JTCVS open

2021 Volume 7, Page(s) 10–11

Language	English
Publishing date	2021-05-29
Publishing country	Netherlands
Document type	Editorial
ISSN	2666-2736
ISSN (online)	2666-2736
DOI	10.1016/j.xjon.2021.05.015
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Book ; Conference proceedings ; Online: Accumulation rates and composition of organic matter in sediments off Peru, supplementary data to: ten Haven, H Lo; Littke, Ralf; Rullk?tter, J?rgen; Stein, Ruediger; Welte, Dietrich Hugo (1990): Accumulation rates and composition of organic matter in late Cenozoic sediments underlying the active upwelling area off Peru. In: Suess, E; von Huene, R; et al. (eds.), Proceedings of the Ocean Drilling Program, Scientific Results, College Station, TX (Ocean Drilling Program), 112, 591-606

ten Haven, H Lo / Littke, Ralf / Rullk?tter, J?rgen / Stein, Ruediger / Welte, Dietrich Hugo

1990

Abstract: Deep-sea sediment samples from three Ocean Drilling Program (ODP) Leg 112 sites on the Peru continental margin were investigated, using a number of organic geochemical and organic petrographic techniques, for amounts and compositions of the organic ... ...

Abstract	Deep-sea sediment samples from three Ocean Drilling Program (ODP) Leg 112 sites on the Peru continental margin were investigated, using a number of organic geochemical and organic petrographic techniques, for amounts and compositions of the organic matter preserved. Preliminary results include mass accumulation rates of organic carbon at Site 679 and characteristics of the organic facies for sediments from Sites 679, 681, and 684. Organic-carbon contents are high, with few exceptions. Particularly high values were determined in the Pliocene interval at Site 684 (4%-7.5%) and in the early Pliocene to Quaternary section of Hole 679D (2%-9%). Older sediments at this site have distinctively lower organic-carbon contents (0.2%-2.5%). Mass accumulation rates of organic matter at Site 679 are 0.02 to 0.07 g carbon/cm**2/k.y. for late Miocene to early Pliocene sediments and higher by a factor of 5 to 10 in the Quaternary sediments. The organic matter in all samples has a predominantly marine planktonic and bacterial origin, with minor terrigenous contribution. Organic particle sizes are strikingly small, so that only a minor portion is covered by visual maceral analysis. Molecular organic-geochemical data were obtained for nonaromatic hydrocarbons, aromatic hydrocarbons (including sulfur compounds), alcohols, ketones, esters, and carboxylic acids. Among the total extractable lipids, long-chain unsaturated ketones from Prymnesiophyte algae strongly predominate among the gas chromatography (GC) amenable components. Steroids are major constituents of the ketone and free- and bound-alcohol fractions. Perylene is the most abundant aromatic hydrocarbon, whereas in the nonaromatic hydrocarbon fractions, long-chain n-alkanes from higher land plants predominate, although the total terrigenous organic matter proportion in the sediments is small.
Language	English
Dates of publication	1990-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Conference proceedings ; Online
Note	This dataset is supplement to doi:10.2973/odp.proc.sr.112.160.1990
DOI	10.1594/PANGAEA.753802
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Conference proceedings ; Online: Organic geochemistry of late Cenozoic sediments from the eastern subtropical Atlantic, supplementary data to: Stein, Ruediger; ten Haven, H Lo; Littke, Ralf; Rullk?tter, J?rgen; Welte, Dietrich Hugo (1989): Accumulation of marine and terrigenous organic carbon at upwelling Site 658 and nonupwelling Sites 657 and 659: implications for the reconstruction of paleoenvironments in the eastern subtropical Atlantic through Late Cenozoic times. In: Ruddiman, W; Sarnthein, M; et al. (eds.), Proceedings of the Ocean Drilling Program, Scientific Results, College Station, TX (Ocean Drilling Program), 108, 361-385

Stein, Ruediger / Littke, Ralf / Rullk?tter, J?rgen / Welte, Dietrich Hugo / ten Haven, H Lo

1989

Abstract: ... indicated by high hydrogen-index values of 200-400 mgHC/gC, low C/N ratios of 5-15, atomic H/C ratios of 1.0 ...

Abstract	Detailed organic geochemical investigations have been performed on sediment samples from upwelling Site 658 and nonupwelling Sites 657 and 659. The major objective of this study has been the relationship between organic carbon accumulation and paleoclimatic and paleoceanographic conditions in the upwelling area off northwest Africa during late Cenozoic times. The study is based on results from organic carbon, nitrogen, and hydrogen analyses, Rock-Eval pyrolysis, kerogen microscopy, gas chromatography, and gas chromatography/mass spectrometry. In general, nonupwelling Sites 657 and 659 are characterized by low organic carbon values of less than 0.5%. At Site 657, four events of high organic carbon deposition (total organic carbon of 1%-3%) occur and represent turbidites and a slump interval. The upper Pliocene to Pleistocene sediments of upwelling Site 658 display high organic carbon contents of 0.5%-4%, with higher contents concentrated in the upper Pliocene. Accumulation rates of organic carbon vary between 0.1 and 0.5 gC/cm-2/1000 yr, with maximum values between 3.5 and 3.1 Ma. Short-term cyclic ("Milankovitch-type") variations in organic carbon accumulation suggest climate-controlled mechanisms causing these fluctuations. The quality of organic matter at Site 658 is a mixture of kerogen type II and HI, with a dominance of the marine type. This is indicated by high hydrogen-index values of 200-400 mgHC/gC, low C/N ratios of 5-15, atomic H/C ratios of 1.0-1.5, and high amounts of marine macerals (alginite and liptodetrinite). We have estimated paleoproductivity for Sites 658 and 659 based on the amount of marine organic carbon. At open-marine Site 659, mean paleoproductivity varies between 20 and 50 gC/m2/yr. At Site 658, mean paleoproductivity reaches high values of 160 to 320 gC/m**2/yr, very similar to those recorded in modern upwelling areas. The changes in productivity off northwest Africa are linked to changes in nutrient supply caused by both upwelling and fluvial input. The change from a dominantly humid climate to one characterized by fluctuations between humid and fully arid climates in northwest Africa occurs between 3.1 and 2.45 Ma.
Language	English
Dates of publication	1989-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Conference proceedings ; Online
Note	This dataset is supplement to doi:10.2973/odp.proc.sr.108.143.1989
DOI	10.1594/PANGAEA.746635
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Occam's razor and Hickam's dictum: a dermatologic perspective.

Stein, Hadassah / Lowenstein, Eve J

Diagnosis (Berlin, Germany)

2022 Volume 10, Issue 2, Page(s) 96–99

Abstract: Diagnostic heuristics help ease the cognitive load in our day-to-day work. Occam's razor or the rule of diagnostic parsimony is a diagnostic heuristic often applied in dermatology. Occam's razor dictates that all things being equal, one diagnosis (as ... ...

Abstract	Diagnostic heuristics help ease the cognitive load in our day-to-day work. Occam's razor or the rule of diagnostic parsimony is a diagnostic heuristic often applied in dermatology. Occam's razor dictates that all things being equal, one diagnosis (as opposed to several diagnoses) should be sought to explain a patient's presentation. While this can often be helpful, it can also obscure the full picture. Hickam's dictum is an aphorism expressing the opposite opinion: "patients can have as many diseases as they damn (or darn) well please." This acknowledges that multiple simultaneous processes can be at play. This article delves into the implications of use of these approaches and offers tips through cases illustrating the limitations of Occam's razor and when Hickam's Dictum should be invoked.
MeSH term(s)	Humans ; Diagnosis, Differential ; Dermatology
Language	English
Publishing date	2022-11-18
Publishing country	Germany
Document type	Journal Article
ISSN	2194-802X
ISSN (online)	2194-802X
DOI	10.1515/dx-2022-0093
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Article ; Online: Letter: the sphingosine 1 phosphate/sphingosine 1 phosphate receptor axis-a unique therapeutic target in inflammatory bowel disease.

Radeke, Heinfried H / Stein, Jürgen

Alimentary pharmacology & therapeutics

2022 Volume 55, Issue 10, Page(s) 1359

MeSH term(s)	Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/metabolism ; Lysophospholipids/metabolism ; Molecular Targeted Therapy ; Signal Transduction/drug effects ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism ; Sphingosine-1-Phosphate Receptors/metabolism
Chemical Substances	Lysophospholipids ; Sphingosine-1-Phosphate Receptors ; sphingosine 1-phosphate (26993-30-6) ; Sphingosine (NGZ37HRE42)
Language	English
Publishing date	2022-04-26
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.16888
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Article ; Online: Synergistic effects of organic carbon and silica in preserving structural stability of drying soils.

Barbosa, Luis Alfredo Pires / Stein, Mathias / Gerke, Horst H / Schaller, Jörg

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8330

Abstract: Predicted climate warming and prolonged droughts pose a threat to the soil structure as organic carbon losses weaken the stability of soil aggregates. Well-structured soils are important for storage and movement of water, solutes, and air, the ... ...

Abstract	Predicted climate warming and prolonged droughts pose a threat to the soil structure as organic carbon losses weaken the stability of soil aggregates. Well-structured soils are important for storage and movement of water, solutes, and air, the development of plant roots, as habitat for soil organisms, and the microbial activity. Structural stability is measured in terms of hydro-mechanical properties. This study compares effects of amorphous silica with those of organic carbon on stability parameters during drying of aggregates from relatively finer- and coarser-textured soils. Silica amendment enhanced the positive effect of organic carbon on structural stability in terms of the tensile strength. Synergistic effects between silica and organic carbon in soil colloids appear to dynamically alter aggregate density and friability (i.e., ability to crumble) during drying. Silica together with organic carbon could help soil management to reduce negative effects of predicted prolonged droughts on soil structure and stability.
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58916-9
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Article ; Online: Torula yeast may improve intestinal health and immune function of weanling pigs.

Espinosa, Charmaine D / Torres-Mendoza, Leidy J / Stein, Hans H

Journal of animal science

2023 Volume 101

Abstract: An experiment was conducted to test the hypothesis that inclusion of a conventional torula yeast or a torula yeast produced from forestry byproducts (i.e., woody torula yeast) in diets for weanling pigs instead of fish meal and plasma protein improves ... ...

Abstract	An experiment was conducted to test the hypothesis that inclusion of a conventional torula yeast or a torula yeast produced from forestry byproducts (i.e., woody torula yeast) in diets for weanling pigs instead of fish meal and plasma protein improves growth performance and intestinal health of pigs. A total of 120 weanling pigs (6.53 ± 0.78 kg) were allotted to three treatments with ten replicate pens per diet. Pigs were fed one of three diets from days 1 to 14 post-weaning (phase 1), whereas all pigs were fed a common diet in phase 2 (days 15 to 28). The three treatments in phase 1 included a control diet with 5% fish meal, 3.5% plasma protein, and no torula yeast. The second diet contained 1.5% fish meal, 14% woody torula yeast, and no plasma protein, whereas the third diet contained 1.5% fish meal, 14% conventional torula yeast, and no plasma protein. Fecal scores were assessed every other day. On day 7, one pig per pen was euthanized to collect ileal tissue and mucosa for determination of morphology and for ribonucleic acid (RNA) sequencing analysis. At the end of phases 1 and 2, blood samples were collected and concentrations of cytokines, plasma urea nitrogen (PUN), peptide YY, immunoglobulin G, total protein, and albumin were analyzed. Results indicated that both torula yeast sources could replace fish meal and plasma protein without affecting growth performance, intestinal morphology, or blood characteristics of pigs. Pigs fed a diet containing torula yeast had improved (P < 0.05) fecal scores during phase 1. Pigs fed the conventional torula yeast diet had greater (P < 0.05) concentration of interleukin-2 compared with pigs fed the control diet. On day 14, greater (P < 0.05) concentrations of interleukin-4 and interleukin-10 were observed in pigs fed the diet containing the woody torula yeast or conventional torula yeast compared with pigs fed the control diet. Results from the RNA sequencing indicated that 19 of 24 analyzed genes involved in digestion and absorption of protein and vitamins were downregulated in pigs fed the diet containing woody torula yeast compared with pigs fed the control diet. However, only two genes (i.e., ANKS4B and FAM54A) were downregulated in pigs fed the woody torula yeast diet compared with the conventional torula yeast diet. In conclusion, using woody or conventional torula yeast instead of fish meal and plasma protein in the phase 1 diet for weanling pigs may improve intestinal health without influencing growth performance of pigs.
MeSH term(s)	Sus scrofa/growth & development ; Sus scrofa/physiology ; Male ; Female ; Weaning ; Candida ; Random Allocation ; Intestines/physiology ; Dietary Supplements ; Diet/veterinary ; Feces/microbiology ; Animals
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/skad087
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