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Article ; Online: Navigating the Omics Frontier: Challenges, Opportunities, and the Future of Precision Nephrology.

Rinschen, Markus M / Knepper, Mark A

Journal of the American Society of Nephrology : JASN

2023 Volume 34, Issue 12, Page(s) 1943–1944

MeSH term(s)	Nephrology ; Genomics ; Proteomics ; Forecasting
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.0000000000000255
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Book ; Thesis: Lebensqualität und Langzeitergebnisse nach benigner Ösophagusperforation

Knepper, Laura Katharina / Leers, Jessica Marzelline / Nierhoff, Dirk

2020

Institution	Universitätsklinikum Köln / Klinik und Poliklinik für Allgemein-, Viszeral- und Tumorchirurgie
Author's details	vorgelegt von Laura Katharina Knepper ; 1. Gutachterin: Professorin Dr. med. J.M. Leers, 2. Gutachter: Privatodzent Dr. med. D. Nierhoff ; aus dem Zentrum für Operative Medizin der Universität zu Köln, Klinik und Poliklinik für Allgemein-, Viszeral-, und Tumorchirurgie
Subject code	610
Language	German
Size	54 Blätter, Illustrationen, Diagramme
Publishing place	Köln
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Universität zu Köln, 2020
HBZ-ID	HT020661236
Database	Catalogue ZB MED Medicine, Health

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2020 D 873	order for loan	Magazin

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Article ; Online: Pharmacist-Driven Precision Medicine: A Ferry to Cross the Chasm of Interpreting Biomarker Testing Reports.

Knepper, Todd C / Boyle, Theresa A / Hicks, J Kevin / Walko, Christine M

JCO oncology practice

2023 Volume 19, Issue 8, Page(s) 679–680

MeSH term(s)	Humans ; Precision Medicine ; Pharmacists ; Biomarkers, Tumor
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3028198-2
ISSN	2688-1535 ; 2688-1527
ISSN (online)	2688-1535
ISSN	2688-1527
DOI	10.1200/OP.23.00216
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Zs.A 7198: Show issues

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Article ; Online: Insurance expansions and hospital utilization: Relabeling and reabling?

Dunn, Abe / Knepper, Matthew / Dauda, Seidu

Journal of health economics

2021 Volume 78, Page(s) 102482

Abstract: The 2010 Patient Protection & Affordable Care Act (ACA) significantly expanded access to private and public health insurance for low-income individuals through income-based subsidies and income-based eligibility expansions, respectively. In this paper, ... ...

Abstract	The 2010 Patient Protection & Affordable Care Act (ACA) significantly expanded access to private and public health insurance for low-income individuals through income-based subsidies and income-based eligibility expansions, respectively. In this paper, we use the universe of hospitals from 2009 to 2015 to characterize how these expansions affected the financing of hospital visits, along with price, utilization, and potential spillovers in the quality of care. The insurance coverage expansions generated a shift in the composition of payers and a modest increase in the utilization of hospital outpatient services. While concerns have been raised that these shifts in utilization could cause negative spillovers to the already insured population (e.g., Medicare enrollees), we find no significant change in the quality of care experienced by those already insured. The primary result of both federally funded insurance expansions was to increase the profits generated and prices charged by the hospitals providing such services.
MeSH term(s)	Aged ; Health Services Accessibility ; Hospitals ; Humans ; Insurance Coverage ; Insurance, Health ; Medicaid ; Medicare ; Patient Protection and Affordable Care Act ; United States
Language	English
Publishing date	2021-06-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	625797-5
ISSN	1879-1646 ; 0167-6296
ISSN (online)	1879-1646
ISSN	0167-6296
DOI	10.1016/j.jhealeco.2021.102482
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Zs.A 1779: Show issues

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Book: The Rhine

Bik, M. H. / Knepper, Thomas P.

(The handbook of environmental chemistry : Vol. 5, Water pollution ; Pt. L)

2006

Author's details	with contributions by M. H. Bik ... Vol. ed.: Thomas P. Knepper
Series title	The handbook of environmental chemistry : Vol. 5, Water pollution Pt. L The handbook of environmental chemistry The handbook of environmental chemistry ; Vol. 5, Water pollution
Collection	The handbook of environmental chemistry The handbook of environmental chemistry ; Vol. 5, Water pollution
Keywords	Rhein ; Wasserverschmutzung
Subject	Wasser ; Gewässerbelastung ; Wasserverunreinigung ; Gewässerverschmutzung ; Gewässerverunreinigung ; Gewässer ; Wasserbelastung
Language	English
Size	XVI, 373 S. : graph. Darst., Kt.
Publisher	Springer
Publishing place	Berlin u.a.
Publishing country	Germany
Document type	Book
HBZ-ID	HT014674061
ISBN	3-540-29393-0 ; 978-3-540-29393-4
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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068/457	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Impact of an automated hand hygiene monitoring system combined with a performance improvement intervention on hospital-acquired infections.

Knepper, Bryan C / Miller, Amber M / Young, Heather L

Infection control and hospital epidemiology

2020 Volume 41, Issue 8, Page(s) 931–937

Abstract: Objective: Hand hygiene adherence has been associated with reductions in nosocomial infection. We assessed the effect of improvements in electronically measured hand hygiene adherence on the incidence of hospital-acquired infections.: Methods: This ... ...

Abstract	Objective: Hand hygiene adherence has been associated with reductions in nosocomial infection. We assessed the effect of improvements in electronically measured hand hygiene adherence on the incidence of hospital-acquired infections. Methods: This quasi-experimental study was conducted in a 555-bed urban safety-net level I trauma center. The preintervention period was January 2015 through June 2016. Baseline electronic hand hygiene data collection took place from April through June 2016. The intervention period was July 2016 through December 2017. An electronic hand hygiene system was installed in 4 locations in our hospital. Performance improvement strategies were implemented that included education, troubleshooting, data dissemination, and feedback. Adherence rates were tracked over time. Rates of hospital-acquired infections were evaluated in the intervention units and in control units selected for comparison. The intervention period was subdivided into the initial and subsequent 9-month periods and were compared to the baseline period. Results: Electronically measured hand hygiene rates improved significantly from baseline to intervention, from 47% 77% adherence. Rates >70% continued to be measured 18 months after the intervention. Interrupted time series analysis indicated a significant effect of hand hygiene on healthcare facility-onset Clostridioides difficile infection rates during the first 9 months of the intervention. This trend continued during the final 9 months of the intervention but was nonsignificant. No effects were observed for other hospital-acquired infection rates. Conclusions: Implementation of electronic hand hygiene monitoring and performance improvement interventions resulted in reductions in hospital-onset Clostridioides difficile infection rates.
MeSH term(s)	Cross Infection/epidemiology ; Cross Infection/prevention & control ; Guideline Adherence ; Hand Disinfection ; Hand Hygiene ; Hospitals ; Humans ; Infection Control
Language	English
Publishing date	2020-05-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2020.182
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Zs.A 1714: Show issues

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Article ; Online: Primary care-based screening and recruitment for an adolescent depression prevention trial: Contextual considerations during a youth mental health crisis.

Knepper, Amanda K / Feinstein, Rebecca T / Sanchez-Flack, Jennifer / Fitzgibbon, Marian / Lefaiver, Cheryl / McHugh, Ashley / Gladstone, Tracy R G / Van Voorhees, Benjamin W

Implementation research and practice

2024 Volume 5, Page(s) 26334895241246203

Abstract: Background: Rising rates of adolescent depression in the wake of COVID-19 and a youth mental health crisis highlight the urgent need for accessible mental healthcare and prevention within primary care. Digital mental health interventions (DMHIs) may ... ...

Abstract	Background: Rising rates of adolescent depression in the wake of COVID-19 and a youth mental health crisis highlight the urgent need for accessible mental healthcare and prevention within primary care. Digital mental health interventions (DMHIs) may increase access for underserved populations. However, these interventions are not well studied in adolescents, nor healthcare settings. The purpose of this study was to identify barriers and facilitators to screening and recruitment activities for Method: This qualitative study is a component of a larger Hybrid Type I trial. We conducted semi-structured key informant interviews with clinical and non-clinical implementers involved with screening and recruitment for the P2P trial. Informed by the Consolidated Framework for Implementation Research (CFIR), interviews were conducted at the midpoint of the trial to identify barriers, facilitators, and needed adaptations, and to gather information on determinants that may affect future implementation. Findings: Respondents perceived the P2P trial as valuable, well aligned with the mission of their health systems. However, several barriers were identified, many of which stemmed from influences outside of the healthcare settings. Universal and site-specific outer setting influences (COVID-19 pandemic, youth mental health crisis, local community conditions) interacted with Inner Setting and Innovation domains to create numerous challenges to the implementation of screening and recruitment. Conclusion: Our findings emphasize the need for ongoing, comprehensive assessment of dynamic inner and outer setting contexts prior to and during implementation of clinical trials, as well as flexibility for adaptation to unique clinical contexts. The CFIR is useful for assessing determinants during times of rapid inner and outer setting change, such as those brought on by the COVID-19 pandemic, youth mental health crisis, and the corresponding exacerbation of resource strain within healthcare settings. Clinical trial registration: PATH 2 Purpose: Primary Care and Community-Based Prevention of Mental Disorders in Adolescents https://www.clinicaltrials.gov/study/NCT04290754.
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ISSN	2633-4895
ISSN (online)	2633-4895
DOI	10.1177/26334895241246203
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Article ; Online: Previously unidentified sources of perfluoroalkyl and polyfluoroalkyl substances from building materials and industrial fabrics.

Janousek, Raphael M / Lebertz, Stephan / Knepper, Thomas P

Environmental science. Processes & impacts

2019 Volume 21, Issue 11, Page(s) 1936–1945

Abstract: Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are applied during the production of various consumer and industrial goods. As a consequence of their use in building materials and fabrics, unreacted nonpolymeric PFASs might enter the environment by ...

Abstract	Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are applied during the production of various consumer and industrial goods. As a consequence of their use in building materials and fabrics, unreacted nonpolymeric PFASs might enter the environment by evaporation or urban run-off. Since the PFAS content of building materials and industrial fabrics is hardly investigated, studies have to be performed in order to assess their total PFAS load. Building material samples (n = 23) and fabric samples (n = 28) were collected and their PFAS content was investigated. A total of 29 PFASs were analyzed (chain length in the range of C
MeSH term(s)	Construction Materials/analysis ; Environmental Monitoring/methods ; Environmental Pollutants/analysis ; Fluorocarbons/analysis ; Fluorocarbons/chemistry ; Textiles/analysis
Chemical Substances	Environmental Pollutants ; Fluorocarbons
Language	English
Publishing date	2019-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2703814-2
ISSN	2050-7895 ; 2050-7887
ISSN (online)	2050-7895
ISSN	2050-7887
DOI	10.1039/c9em00091g
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Article ; Online: Combined study of source, environmental monitoring and fate of branched alkylphenols: The chain length matters.

Janousek, Raphael M / Müller, Jutta / Knepper, Thomas P

Chemosphere

2019 Volume 241, Page(s) 124950

Abstract: Alkylphenols (APs) are chemicals of largely anthropogenic origin. Longer chain derivatives like 4-nonylphenol (4NP) or 4-tert.-octylphenol (4tOP) are mainly used for the production of alkylphenol ethoxylates, while short chain alkylphenols (SCAPs) can be ...

Abstract	Alkylphenols (APs) are chemicals of largely anthropogenic origin. Longer chain derivatives like 4-nonylphenol (4NP) or 4-tert.-octylphenol (4tOP) are mainly used for the production of alkylphenol ethoxylates, while short chain alkylphenols (SCAPs) can be applied during the production of phenolic or epoxide resins that are used in paint, glue or adhesive formulations. The source, environmental distribution and fate of 4NP and 4tOP were thoroughly demonstrated leading to growing concerns regarding their endocrine properties. Although, SCAPs are also expected to entail risks to the aquatic environment, only few studies dealt with the identification of possible sources or environmental concentrations thereof. In order to evaluate the role of resin-based building materials as a possible source of 4-tert.-butylphenol (4tBP), 4-tert.-pentylphenol (4tPP), 4tOP and 4NP, 18 formulations were tested. Furthermore, AP concentrations of four wastewater treatment plants (WWTPs) and 50 surface waters were analyzed to assess and compare environmental concentrations and the discharge of APs depending on their chain length. 4tBP was the dominant AP in analyzed building materials with concentrations up to 320 g kg
MeSH term(s)	Biotransformation ; Construction Materials/toxicity ; Environmental Monitoring/methods ; Phenols/analysis ; Waste Water/chemistry ; Water Pollutants, Chemical/analysis ; Water Purification/methods
Chemical Substances	Phenols ; Waste Water ; Water Pollutants, Chemical ; 4-pentylphenol (40069Q368Q) ; 4-nonylphenol (I03GBV4WEL) ; 4-tert-octylphenol (IOY9FVU3J3)
Language	English
Publishing date	2019-09-24
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2019.124950
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Article ; Online: Developing Drugs for Tissue-Agnostic Indications: A Paradigm Shift in Leveraging Cancer Biology for Precision Medicine.

Seligson, Nathan D / Knepper, Todd C / Ragg, Susanne / Walko, Christine M

Clinical pharmacology and therapeutics

2020 Volume 109, Issue 2, Page(s) 334–342

Abstract: Targeted therapies have reshaped the landscape of the development of cancer therapeutics. Recent biomarker-driven, tissue-agnostic clinical trials represent a significant paradigm shift in precision cancer medicine. Despite their growth in preclinical ... ...

Abstract	Targeted therapies have reshaped the landscape of the development of cancer therapeutics. Recent biomarker-driven, tissue-agnostic clinical trials represent a significant paradigm shift in precision cancer medicine. Despite their growth in preclinical and clinical studies, to date only a few biomarker-driven, tissue-agnostic indications have seen approval by the US Food and Drug Administration (FDA). These approvals include pembrolizumab in microsatellite instability-high or mismatch repair deficient solid tumors, as well as both larotrectinib and entrectinib in NTRK fusion-positive tumors. Complex cancer biology, clinical trial design, and identification of resistance mechanisms represent some of the challenges that future tissue-agnostic therapies have to overcome. In this Review, we present a brief history of the development of tissue-agnostic therapies, comparing the similarities in the approval of pembrolizumab, larotrectinib, and entrectinib for tissue-agnostic indications. We also explore the future of tissue-agnostic cancer therapeutics while identifying important challenges for the future that drugs targeting tissue-agnostic indications will face.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/metabolism ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Precision Medicine/methods ; United States ; United States Food and Drug Administration
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor
Language	English
Publishing date	2020-07-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.1946
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