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  1. Article ; Online: Manejo en atención primaria de las infecciones de transmisión sexual (I). Epidemiología. Síndrome secretor.

    Besa Castellà, Marta / Agustí Benito, Cristina / Roca Saumell, Carme / Mascort Roca, Juan José

    Atencion primaria

    2023  Volume 55, Issue 5, Page(s) 102597

    Abstract: These days sexually transmitted infections (STIs) are important public health problems not only due to their high prevalence, but also because they require early diagnosis and treatment to avoid complications. In recent years, there has been an ... ...

    Title translation Primary care management of sexually transmitted infections (I). Epidemiology. Secreting syndrome.
    Abstract These days sexually transmitted infections (STIs) are important public health problems not only due to their high prevalence, but also because they require early diagnosis and treatment to avoid complications. In recent years, there has been an exponential increase in cases of infections caused by Chlamydia trachomatis and gonococcus in the population under 25years of age. In addition, an increase in the incidence of syphilis and hepatitisC (HCV) has also been detected, especially in men who have sex with other men (MSM). Genital herpes continues to be the second most frequent STI in the world, behind condyloma acuminata, and the first cause of genital ulcer among Spain in the sexually active population. A decrease in reported HIV cases was observed during 2020, but almost half of these new cases had a late diagnosis (<350CD4cell/μL). Current guidelines recommend offering STI annual screening to populations at risk or more often depending on the risk. STIs can appear in the form of syndromes, such as secretory syndrome (urethritis, proctitis, and cervicitis) or ulcerated syndrome (ulcers). The STIs that can cause secretory syndrome are mainly caused by Neisseria gonorrhoeae and C.trachomatis, which co-infect up to 40% of cases, and also cause urethritis, cervicitis or proctitis depending on where they are located. Gonococcus has an incubation period of 2-7days and Chlamydia 2-6weeks, and they are diagnosed using PCR and/or culture (the last one only valid for gonococcus) of samples collected according to sexual activities. Empirical treatment to cover both germs will be accomplished with ceftriaxone, 1g single intramuscular dose plus doxycycline 100mg every 12h orally for 7days, or azithromycin 1g single dose orally (we will use azithromycin only if we suspect a poor compliance with treatment, difficulty in going to the control or in pregnancy). Likewise, whenever we diagnose an STI firstly, we must offer advice and health education in order to promote the adoption of safe sexual behaviours and the correct use of barrier methods. Secondly, we must also screen for other STIs (HIV, syphilis, hepatitisB, and hepatitisA andC depending on the risk), offer HBV and HAV vaccination if it is appropriate, and finally study and treat all sexual partners from the previous 3months.
    MeSH term(s) Male ; Pregnancy ; Female ; Humans ; Syphilis ; Azithromycin ; Urethritis ; Homosexuality, Male ; Uterine Cervicitis ; Sexual and Gender Minorities ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/therapy ; Neisseria gonorrhoeae ; HIV Infections/prevention & control ; Primary Health Care
    Chemical Substances Azithromycin (83905-01-5)
    Language Spanish
    Publishing date 2023-03-17
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 1200787-0
    ISSN 1578-1275 ; 0212-6567
    ISSN (online) 1578-1275
    ISSN 0212-6567
    DOI 10.1016/j.aprim.2023.102597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reproductive physiology of the boar: What defines the potential fertility of an ejaculate?

    Rodriguez-Martinez, Heriberto / Martinez-Serrano, Cristina A / Alvarez-Rodriguez, Manuel / Martinez, Emilio A / Roca, Jordi

    Animal reproduction science

    2024  , Page(s) 107476

    Abstract: Despite decades of research and handling of semen for use in artificial insemination (AI) and other assisted reproductive technologies, 5-10% of selected boar sires are still considered sub-fertile, escaping current assessment methods for sperm quality ... ...

    Abstract Despite decades of research and handling of semen for use in artificial insemination (AI) and other assisted reproductive technologies, 5-10% of selected boar sires are still considered sub-fertile, escaping current assessment methods for sperm quality and resilience to preservation. As end-product, the ejaculate (emitted spermatozoa sequentially exposed to the composite seminal plasma, the SP) ought to define the homeostasis of the testes, the epididymis, and the accessory sexual glands. Yet, linking findings in the ejaculate to sperm production biology and fertility is suboptimal. The present essay critically reviews how the ejaculate of a fertile boar can help us to diagnose both reproductive health and resilience to semen handling, focusing on methods -available and under development- to identify suitable biomarkers for cryotolerance and fertility. Bulk SP, semen proteins and microRNAs (miRNAs) have, albeit linked to sperm function and fertility after AI, failed to enhance reproductive outcomes at commercial level, perhaps for just being components of a complex functional pathway. Hence, focus is now on the interaction sperm-SP, comparing in vivo with ex vivo, and regarding nano-sized lipid bilayer seminal extracellular vesicles (sEVs) as priority. sEVs transport fragile molecules (lipids, proteins, nucleic acids) which, shielded from degradation, mediate cell-to-cell communication with spermatozoa and the female internal genital tract. Such interaction modulates essential reproductive processes, from sperm homeostasis to immunological female tolerance. sEVs can be harvested, characterized, stored, and manipulated, e.g. can be used for andrological diagnosis, selection of breeders, and alternatively be used as additives to improve cryosurvival and fertility.
    Language English
    Publishing date 2024-04-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 429674-6
    ISSN 1873-2232 ; 0378-4320
    ISSN (online) 1873-2232
    ISSN 0378-4320
    DOI 10.1016/j.anireprosci.2024.107476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Implications of the COVID-19 Pandemic on Children and Adolescents: Cognitive and Emotional Representations.

    Maftei, Alexandra / Merlici, Ioan-Alex / Roca, Iulia-Cristina

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 3

    Abstract: The present research investigated children and adolescents' explicit and spontaneous representation of the COVID-19 pandemic and their related emotions, cognitions, and coping strategies. We explored the self-reported protective factors and coping ... ...

    Abstract The present research investigated children and adolescents' explicit and spontaneous representation of the COVID-19 pandemic and their related emotions, cognitions, and coping strategies. We explored the self-reported protective factors and coping mechanisms, in addition to similar attributional emotional experiences, i.e., the ways participants evaluated others' pandemic experiences. Our sample consisted of 155 children and adolescents aged 10 to 13 (
    Language English
    Publishing date 2022-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9030359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Manejo en atención primaria de las infecciones de transmisión sexual (I). Epidemiología. Síndrome secretor

    Marta Besa Castellà / Cristina Agustí Benito / Carme Roca Saumell / Juan José Mascort Roca

    Atención Primaria, Vol 55, Iss 5, Pp 102597- (2023)

    2023  

    Abstract: Resumen: Actualmente las infecciones de transmisión sexual (ITS) son un problema de salud pública importante debido a su elevada prevalencia y a que precisan de un diagnóstico y un tratamiento precoces para evitar complicaciones.En los últimos años se ... ...

    Abstract Resumen: Actualmente las infecciones de transmisión sexual (ITS) son un problema de salud pública importante debido a su elevada prevalencia y a que precisan de un diagnóstico y un tratamiento precoces para evitar complicaciones.En los últimos años se está observando un aumento exponencial de los casos de infecciones causadas por Chlamydia trachomatis y gonococo en población menor de 25 años. También se ha detectado un aumento de la incidencia de sífilis y de hepatitis C (VHC), sobre todo en hombres que tienen sexo con hombres (HSH).El herpes genital sigue siendo la segunda ITS más frecuente en el mundo, por detrás del condiloma acuminado, y la primera causa de úlcera genital en España en la población sexualmente activa.Durante el año 2020 se observó un descenso de los casos notificados de VIH, pero casi la mitad de estos nuevos casos presentaban un diagnóstico tardío (< 350 CD4 cel/μl).Las guías actuales recomiendan ofrecer anualmente el cribado de ITS a las poblaciones de riesgo y más frecuentemente en función de dicho riesgo.Las ITS pueden presentarse, entre otras, en forma de síndromes, como son el síndrome secretor (uretritis, proctitis, cervicitis) o el síndrome ulcerado (úlceras). Las ITS que pueden cursar con síndrome secretor están causadas principalmente por Neisseria gonorrhoeae y C. trachomatis, que infectan conjuntamente hasta en el 40% de los casos, y que producen uretritis, cervicitis o proctitis según el lugar en que se localizan.El gonococo tiene un periodo de incubación de 2 a 7 días y la clamidia de 2 a 6 semanas, y se diagnostican a través de PCR y/o cultivo (este último solo válido para gonococo) de las muestras recogidas según prácticas sexuales.El tratamiento empírico para cubrir ambos gérmenes se realizará con ceftriaxona 1 g en dosis única intramuscular más doxiciclina 100 mg cada 12 horas por vía oral durante 7 días o azitromicina 1 g en dosis única por vía oral (utilizaremos azitromicina solo si sospechamos que el paciente va a ser mal cumplidor del tratamiento, si hay dificultad ...
    Keywords Sexually transmitted diseases ; Primary health care ; Epidemiology ; Urethritis ; Uterine cervicitis ; Proctitis ; Medicine (General) ; R5-920
    Language Spanish
    Publishing date 2023-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Editorial: Molecular Biomarkers in Animal Reproduction.

    Martínez, Cristina Alicia / Roca, Jordi / Barranco, Isabel

    Frontiers in veterinary science

    2021  Volume 8, Page(s) 802187

    Language English
    Publishing date 2021-12-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2021.802187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Seminal extracellular vesicles alter porcine in vitro fertilization outcome by modulating sperm metabolism.

    Barranco, Isabel / Spinaci, Marcella / Nesci, Salvatore / Mateo-Otero, Yentel / Baldassarro, Vito Antonio / Algieri, Cristina / Bucci, Diego / Roca, Jordi

    Theriogenology

    2024  Volume 219, Page(s) 167–179

    Abstract: Porcine seminal plasma (SP) is loaded with a heterogeneous population of extracellular vesicles (sEVs) that modulate several reproductive-related processes. This study investigated the effect of two sEV subsets, small (S-sEVs) and large (L-sEVs), on ... ...

    Abstract Porcine seminal plasma (SP) is loaded with a heterogeneous population of extracellular vesicles (sEVs) that modulate several reproductive-related processes. This study investigated the effect of two sEV subsets, small (S-sEVs) and large (L-sEVs), on porcine in vitro fertilization (IVF). The sEVs were isolated from nine SP pools (five ejaculates/pool) using a size-exclusion chromatography-based procedure and characterized for quantity (total protein), morphology (cryogenic electron microscopy), size distribution (dynamic light scattering), purity and EV-protein markers (flow cytometry; albumin, CD81, HSP90β). The characterization confirmed the existence of two subsets of high purity (low albumin content) sEVs that differed in size (S- and L-sEVs). In vitro fertilization was performed with in vitro matured oocytes and frozen-thawed spermatozoa and the IVF medium was supplemented during gamete coincubation (1 h at 38.5 °C, 5 % CO
    MeSH term(s) Male ; Swine ; Animals ; Sperm-Ovum Interactions ; Semen ; Fertilization in Vitro/veterinary ; Fertilization in Vitro/methods ; Spermatozoa/metabolism ; Oocytes ; Zona Pellucida/metabolism ; Albumins/metabolism ; Tyrosine/metabolism
    Chemical Substances Albumins ; Tyrosine (42HK56048U)
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189232-0
    ISSN 1879-3231 ; 0093-691X
    ISSN (online) 1879-3231
    ISSN 0093-691X
    DOI 10.1016/j.theriogenology.2024.02.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Significance of Umbilical Cord Leptin Profile during Pregnancy in Gestational Diabetes Mellitus-A Systematic Review and Meta-Analysis.

    Roca-Rodríguez, María Del Mar / Ramos-García, Pablo / López-Tinoco, Cristina / Aguilar-Diosdado, Manuel

    Journal of clinical medicine

    2023  Volume 12, Issue 14

    Abstract: Background: The literature provides limited evidence of cord blood leptin levels in gestational diabetes mellitus (GDM), with contradictory and inconsistent results with respect to their possible implications for maternal, perinatal, and future ... ...

    Abstract Background: The literature provides limited evidence of cord blood leptin levels in gestational diabetes mellitus (GDM), with contradictory and inconsistent results with respect to their possible implications for maternal, perinatal, and future complications.
    Methods: MEDLINE/PubMed, Embase, Scopus, and Web of Science databases were searched in order to investigate the state of evidence on the association of leptin profile in cord blood during perinatal complications in GDM. We critically assessed the risk of bias using the Newcastle-Ottawa scale. Meta-analyses were performed, and heterogeneity and publication bias were analyzed.
    Results: sixteen primary-level studies were included, recruiting 573 GDM and 1118 control pregnant women. Cord blood leptin levels were significantly higher in GDM participants compared to controls (standardized mean difference [SMD] = 0.59, 95% confidence intervals (CI) = 0.37 to 0.80,
    Conclusion: Cord blood leptin levels were significantly higher in GDM compared to controls. Further research is needed to clarify its role as a predictive biomarker of subsequent metabolic diseases in mothers with GDM and offspring.
    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12144756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Significance of cell adhesion molecules profile during pregnancy in gestational diabetes mellitus. A systematic review and meta-analysis.

    Roca-Rodríguez, María Del Mar / Ramos-García, Pablo / López-Tinoco, Cristina / Aguilar-Diosdado, Manuel

    Diabetes research and clinical practice

    2023  Volume 202, Page(s) 110740

    Abstract: Endothelial dysfunction has been considered as a key etiological factor contributed to the development of vascular disease in diabetes mellitus. Serum level of endothelial cell adhesion molecules (AMs) were reported to be increased in GDM and pregnant ... ...

    Abstract Endothelial dysfunction has been considered as a key etiological factor contributed to the development of vascular disease in diabetes mellitus. Serum level of endothelial cell adhesion molecules (AMs) were reported to be increased in GDM and pregnant women with normal glucose tolerance when compared with nonpregnant women. The literature provides limited evidence of endothelial dysfunction in GDM with heterogeneous and contradictory results respect to their possible involvement in maternal, perinatal and future complications. Our objective is to evaluate current evidence on the role of AMs in maternal and perinatal complications in women with GDM. PubMed, Embase, Web of Science, and Scopus databases were searched. We evaluated the studies' quality using the Newcastle-Ottawa scale. Meta-analyses were conducted, and heterogeneity and publication bias were examined. Nineteen relevant studies were finally included, recruiting 765 GDM and 2368 control pregnant women. AMs levels were generally higher in GDM participants showing statistical significance maternal ICAM-1 levels (SMD = 0.58, 95% CI = 0.25 to 0.91; p = 0.001). Our meta-analysis did not detect significant differences in subgroups or in meta-regression analyses. Future studies are needed to establish the potential role of these biomarkers in GDM and its complications.
    MeSH term(s) Pregnancy ; Female ; Humans ; Diabetes, Gestational/diagnosis ; Vascular Diseases ; Glucose
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-06-03
    Publishing country Ireland
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2023.110740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Blood and Salivary Cortisol Variations in Athletes in Relation to Cardiopulmonary Exercise Testing.

    Honceriu, Cezar / Roca, Mihai / Costache, Alexandru Dan / Abălașei, Beatrice / Popescu, Lucian / Puni, Alexandru Rareș / Maștaleru, Alexandra / Oancea, Andra / Drugescu, Andrei / Adam, Cristina / Mitu, Ovidiu / Costache, Irina-Iuliana / Leon, Maria Magdalena / Roca, Iulia Cristina / Mocanu, Veronica / Mitu, Florin

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 10

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Male ; Exercise Test/methods ; Hydrocortisone ; Oxygen Consumption ; Oxygen ; Athletes
    Chemical Substances Hydrocortisone (WI4X0X7BPJ) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59101726
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  10. Article ; Online: Editorial

    Cristina Alicia Martínez / Jordi Roca / Isabel Barranco

    Frontiers in Veterinary Science, Vol

    Molecular Biomarkers in Animal Reproduction

    2021  Volume 8

    Keywords omics ; biomarker ; reproduction ; fertility ; livestock species ; Veterinary medicine ; SF600-1100
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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