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  1. Article ; Online: High-flow 20% subcutaneous immunoglobulin G in patients with primary immunodeficiency disease.

    McCrary, Kaley / Leiding, Jennifer W / Duff, Carla

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2020  Volume 125, Issue 3, Page(s) 344–346

    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Humans ; Immunoglobulin G/administration & dosage ; Immunologic Deficiency Syndromes/drug therapy ; Injections, Subcutaneous/methods ; Male ; Middle Aged ; Primary Immunodeficiency Diseases/drug therapy ; Retrospective Studies ; Young Adult
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2020-05-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2020.05.022
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  2. Article ; Online: Meitner-Auger Electron Emitters for Targeted Radionuclide Therapy: Mercury-197m/g and Antimony-119

    Randhawa, Parmissa / Olson, Aeli P / Chen, Shaohuang / Gower-Fry, Kaley Lexi / Hoehr, Cornelia / Engle, Jonathan W / Ramogida, Caterina F / Radchenko, Valery

    Current radiopharmaceuticals

    2021  Volume 14, Issue 4, Page(s) 394–419

    Abstract: Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to fully exploit this potential, suitable radionuclides need to be applied ...

    Abstract Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate delivery systems. In this review, we summarize the state-of-the-art production, purification, chelation and applications of two promising candidates for Targeted Auger Therapy, namely antimony- 119 (
    MeSH term(s) Antimony/chemistry ; Antimony/pharmacology ; Electrons ; Mercury Radioisotopes/chemistry ; Mercury Radioisotopes/pharmacology ; Radiochemistry/methods ; Radioisotopes/chemistry ; Radioisotopes/pharmacology ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/pharmacology
    Chemical Substances Mercury Radioisotopes ; Mercury-197 ; Radioisotopes ; Radiopharmaceuticals ; Antimony (9IT35J3UV3)
    Language English
    Publishing date 2021-02-16
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1874-4729
    ISSN (online) 1874-4729
    DOI 10.2174/1874471014999210111201630
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  3. Article: Photocatalytic Activity of g-C3N4 Quantum Dots in Visible Light: Effect of Physicochemical Modifications

    Bandyopadhyay, Arkamita / Ghosh Dibyajyoti / Kaley Nisheal M / Pati Swapan K

    The Journal of Physical Chemistry C. 2017 Jan. 26, v. 121, no. 3

    2017  

    Abstract: Graphitic C₃N₄ (g-C₃N₄), a newly emerging layered semiconductor, has shown its promising ... substrate, functionalization, and doping of hydrogen-passivated g-C₃N₄ quantum dots (QDs). Performing ...

    Abstract Graphitic C₃N₄ (g-C₃N₄), a newly emerging layered semiconductor, has shown its promising performance for use as a photocatalyst in the hydrogen evolution reaction and as an active layer of solar cells. However, the unfavorable wide band gap seriously restricts its efficiency in this regard. To overcome the limitations, in the present study, we have explored several ways, such as modifying size, substrate, functionalization, and doping of hydrogen-passivated g-C₃N₄ quantum dots (QDs). Performing extensive density functional theory based calculations, we find that, unlike pristine QDs, proper modification of the electronic nature of the QDs can lead to efficient visible or near-infrared (NIR) light response, making them better functional materials toward solar cell or photocatalytic applications. Interestingly, our studies further suggest that the modified passivated QDs are better catalysts than pristine ones used so far in the H₂ evolution reaction. Also, the range of the optical gap these QDs display makes them appropriate for solar cell applications.
    Keywords carbon nitride ; hydrogen ; hydrogen production ; near infrared radiation ; photocatalysis ; photocatalysts ; photovoltaic cells ; physical chemistry ; quantum dots ; semiconductors
    Language English
    Dates of publication 2017-0126
    Size p. 1982-1989.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1932-7455
    DOI 10.1021%2Facs.jpcc.6b11520
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Wilderness as therapeutic landscape in later life: Towards an understanding of place-based mechanisms for wellbeing through nature-adventure activity.

    Milligan, Christine / Chalfont, Garuth / Kaley, Alex / Lobban, Fiona

    Social science & medicine (1982)

    2021  Volume 289, Page(s) 114411

    Abstract: While there is considerable evidence that therapeutic landscapes have a positive impact on wellbeing, we know little about the mechanisms through which this impact occurs. In this paper we go some way toward addressing this gap. Drawing on in-depth ... ...

    Abstract While there is considerable evidence that therapeutic landscapes have a positive impact on wellbeing, we know little about the mechanisms through which this impact occurs. In this paper we go some way toward addressing this gap. Drawing on in-depth interviews with 12 people aged between 52 and 75 years of age, who are engaged in nature-adventure activity in the UK, we focus on what they understand by 'wilderness'; their experiences of nature-adventure in wilderness settings; and the impact of these experiences on their wellbeing. Moving beyond the largely behavioural focus of laboratory-based studies prevalent within environmental psychology, we highlight the importance of understanding the role of the contextual in the therapeutic relationship. That is, how relational, embodied, social, lifecourse and/or cultural factors that are constitutive of wilderness environments impact wellbeing for those engaged in nature-adventure activity in later life. In doing so, we map out a working model of the mechanisms that impact wellbeing within this context. Our data suggest that there is no one single mechanism, rather we need to think about a range of mechanisms, often operating across a series of spectra (active/passive; safety/risk; alone/socially etc) and importantly, each are connected to place. Hence, we suggest, that where that activity takes place is instrumental for wellbeing.
    MeSH term(s) Aged ; Humans ; Middle Aged ; Recreation ; Wilderness
    Language English
    Publishing date 2021-10-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2021.114411
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    Zs.A 625: Show issues Location:
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  5. Article ; Online: Intraosseous resection of mandibular arteriovenous malformations: A mandible sparing multi-disciplinary case series.

    Ferguson, Kaley / Wong, Kevin / DeHart, Austin N / Richter, Gresham

    International journal of pediatric otorhinolaryngology

    2023  Volume 167, Page(s) 111458

    Abstract: Mandibular arteriovenous malformations (AVMs) are high flow vascular malformations that can cause pain, hypertrophy, deformity, malocclusion, jaw asymmetry, bone destruction, tooth loss, and severe bleeding [1]. Although general principles apply, the ... ...

    Abstract Mandibular arteriovenous malformations (AVMs) are high flow vascular malformations that can cause pain, hypertrophy, deformity, malocclusion, jaw asymmetry, bone destruction, tooth loss, and severe bleeding [1]. Although general principles apply, the rarity of mandibular AVMs limits definitive agreement on the best course of treatment. Current treatment options include embolization, sclerotherapy, surgical resection, or some combination of techniques [2]. [3]. An alternative multidisciplinary technique of embolization with mandibular-sparing resection is presented. This technique aims to mitigate bleeding with effective removal of the AVM, while preserving mandibular form, function, dentition, and occlusion.
    MeSH term(s) Humans ; Arteriovenous Malformations/diagnostic imaging ; Arteriovenous Malformations/surgery ; Sclerotherapy ; Embolization, Therapeutic/methods ; Mandible/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-01-20
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 754501-0
    ISSN 1872-8464 ; 0165-5876
    ISSN (online) 1872-8464
    ISSN 0165-5876
    DOI 10.1016/j.ijporl.2023.111458
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    Zs.A 1507: Show issues Location:
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    Zs.MO 134: Show issues

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  6. Article ; Online: Systematic review of cash plus or bundled interventions targeting adolescents in Africa to reduce HIV risk.

    Rogers, Kate / Le Kirkegaard, Rikke / Wamoyi, Joyce / Grooms, Kaley / Essajee, Shaffiq / Palermo, Tia

    BMC public health

    2024  Volume 24, Issue 1, Page(s) 239

    Abstract: ... HIV risk pathways (e.g., transactional sex, gender-based violence, and school attendance ...

    Abstract Background: HIV remains a leading cause of death for adolescents and young people aged 10-24 years. HIV prevention requires multisectoral approaches that target adolescents and young people, addressing HIV risk pathways (e.g., transactional sex, gender-based violence, and school attendance) through bundled interventions that combine economic strengthening, health capabilities, and gender equality education. However, best practices are unknown because evidence on multisectoral programming targeted to adolescents and combining these components has not been systematically reviewed.
    Methods: We conducted a systematic review to summarize the evidence on bundled interventions combining health and economic strengthening components for adolescents and young people and their effects on HIV/STI incidence and risk factors. We included studies from Africa published between 2005 and 2023, combining at least one economic strengthening and one health component, directed toward adolescents and young people aged 10-24 years. Included studies measured programmatic impacts on primary outcomes: HIV and STI incidence/prevalence; and mediators as secondary outcomes: sexual behaviours, sexual and reproductive health, school attendance, health-seeking behaviours, and violence. We conducted key word searches in PubMed, EMBASE, and Web of Science, imported titles/abstracts from the initial search, and reviewed them using the inclusion criteria. Full texts of selected articles were reviewed and information was extracted for analysis. Findings from the full texts identified were summarized.
    Results: We reviewed 58 studies, including 43 quantitative studies and 15 qualitative studies, evaluating 26 unique interventions. A majority of studies reviewed were conducted in Eastern and Southern Africa. Interventions reviewed showed a greater number of significant results in improving economic outcomes; mental health and psychosocial outcomes; sexual and reproductive health knowledge and services utilization; and HIV prevention knowledge and testing. They showed fewer significant results in improving outcomes related to HIV incidence/prevalence; sexual risk behaviours; gender-based violence; gender attitudes; education; STI incidence, prevalence and testing; and sexual debut.
    Conclusions: Our review demonstrated the potential for bundled, multisectoral interventions for preventing HIV and facilitating safe transitions to adulthood. Findings have implications for designing HIV sensitive programmes on a larger scale, including how interventions may need to address multiple strata of the social ecological model to achieve success in the prevention of HIV and related pathways.
    MeSH term(s) Humans ; Adolescent ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/prevention & control ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Sexual Behavior/psychology ; Acquired Immunodeficiency Syndrome ; Africa, Southern
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-17565-9
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  7. Article ; Online: Reducing gender differences in student motivational-affective factors: A meta-analysis of school-based interventions.

    Lesperance, Kaley / Hofer, Sarah / Retelsdorf, Jan / Holzberger, Doris

    The British journal of educational psychology

    2022  Volume 92, Issue 4, Page(s) 1502–1536

    Abstract: ... However, the descriptive effect size for female students (g = .49) was far greater than for male students (g = .28 ...

    Abstract Background: Research shows that gender differences tend to exist in student motivational-affective factors in core subjects such as math, science or reading, where one gender is stereotypically disadvantaged.
    Aims: This study aimed to investigate strategies that could reduce these gender differences by conducting a meta-analysis on school-based intervention studies that targeted student motivational-affective factors. We therefore evaluated whether interventions had differential effects for male and female students' motivational-affective factors in a given academic subject. We also evaluated potential moderator variables.
    Method: After conducting a systematic database search and screening abstracts for inclusion, we synthesized 71 effect sizes from 20 primary studies. All included studies were conducted in science or mathematics-related subjects, which are stereotypically female-disadvantaged.
    Results: While the interventions had significant positive effects for both genders, there was no statistically significant difference between the two genders with regard to the intervention effects on motivational-affective factors. However, the descriptive effect size for female students (g = .49) was far greater than for male students (g = .28). Moderator analyses showed no significant effects for grade level, intervention duration, or school subject, but there was a significant influence of intervention method used.
    Conclusions: This study demonstrated that school-based interventions have positive effects on motivational-affective factors for both genders. It also provides evidence that interventions in subjects where female students are stereotypically disadvantaged may have greater effects for females than for males. Implications and suggestions for future research are discussed.
    MeSH term(s) Female ; Humans ; Male ; Sex Factors ; Motivation ; Schools ; Students/psychology ; Mathematics
    Language English
    Publishing date 2022-05-17
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 1501130-6
    ISSN 2044-8279 ; 0007-0998
    ISSN (online) 2044-8279
    ISSN 0007-0998
    DOI 10.1111/bjep.12512
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  8. Article ; Online: Applying emerging core competencies to extension training courses for local food system practitioners

    Hannah Dankbar / Courtney Long / Dara Bloom / Kaley Hohenshell / Emma Brinkmeyer / Bre Miller

    Journal of Agriculture, Food Systems, and Community Development, Vol 12, Iss

    2023  Volume 2

    Abstract: In 2019, a national group of local food system educators and practitioners identified over 140 foundational core competencies critical to local food system development work and began to identify existing educational resources related to these ... ...

    Abstract In 2019, a national group of local food system educators and practitioners identified over 140 foundational core competencies critical to local food system development work and began to identify existing educational resources related to these competencies. This process resulted in a new aggregated resource: the Local Food System Practitioner and Educational Resource Database. Included in this database is a core competency matrix that distinguishes three levels of learning for each competency so that practitioners can identify learning opportunities most closely tailored to their educational needs. It also serves as a framework and competency matrix for educators to use to help assess and communicate the learn­ing out­comes of their curricula. This framework is the overall concept for understanding the compe­ten­cies, and the matrix is the tool developed to assess and evaluate the level at which an educa­tional resource teaches a competency. In this article we apply the newly create core competency matrix to two existing local food system develop­ment courses. We share lessons learned from applying the matrix and insights gained from com­paring two introductory level courses. We con­clude with recommendations for improving the resource database and matrix to a more user-friendly model for educators and local food system practitioners.
    Keywords Food Systems ; Competency Framework ; Professional Development ; Curricula Providers ; Professional Training ; Agriculture ; S ; Technology ; T ; Home economics ; TX1-1110 ; Nutrition. Foods and food supply ; TX341-641 ; Geography. Anthropology. Recreation ; G ; Recreation. Leisure ; GV1-1860 ; Human ecology. Anthropogeography ; GF1-900 ; Environmental sciences ; GE1-350 ; Social Sciences ; H ; Communities. Classes. Races ; HT51-1595 ; Urban groups. The city. Urban sociology ; HT101-395 ; Regional planning ; HT390-395
    Subject code 360
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Thomas A. Lyson Center for Civic Agriculture and Food Systems
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Flourishing (or lack thereof) during COVID-19: College students'social-psychological well-being during the Fall 2020 semester.

    Nyunt, Gudrun / McMillen, Jeanine / Oplt, Kaley / Beckham, Vanessa

    Journal of American college health : J of ACH

    2022  Volume 72, Issue 1, Page(s) 177–187

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Psychological Well-Being ; COVID-19/epidemiology ; Pandemics ; Universities ; Students
    Language English
    Publishing date 2022-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604907-2
    ISSN 1940-3208 ; 0744-8481
    ISSN (online) 1940-3208
    ISSN 0744-8481
    DOI 10.1080/07448481.2021.2024548
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    Zs.A 427: Show issues Location:
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  10. Article ; Online: A novel ERβ high throughput microscopy platform for testing endocrine disrupting chemicals

    Derek A. Abbott / Maureen G. Mancini / Michael J. Bolt / Adam T. Szafran / Kaley A. Neugebauer / Fabio Stossi / Daniel A. Gorelick / Michael A. Mancini

    Heliyon, Vol 10, Iss 1, Pp e23119- (2024)

    1481  

    Abstract: In this study we present an inducible biosensor model for the Estrogen Receptor Beta (ERβ), GFP-ERβ:PRL-HeLa, a single-cell-based high throughput (HT) in vitro assay that allows direct visualization and measurement of GFP-tagged ERβ binding to ER- ... ...

    Abstract In this study we present an inducible biosensor model for the Estrogen Receptor Beta (ERβ), GFP-ERβ:PRL-HeLa, a single-cell-based high throughput (HT) in vitro assay that allows direct visualization and measurement of GFP-tagged ERβ binding to ER-specific DNA response elements (EREs), ERβ-induced chromatin remodeling, and monitor transcriptional alterations via mRNA fluorescence in situ hybridization for a prolactin (PRL)-dsRED2 reporter gene. The model was used to accurately (Z’ = 0.58–0.8) differentiate ERβ-selective ligands from ERα ligands when treated with a panel of selective agonists and antagonists. Next, we tested an Environmental Protection Agency (EPA)-provided set of 45 estrogenic reference chemicals with known ERα in vivo activity and identified several that activated ERβ as well, with varying sensitivity, including a subset that is completely novel. We then used an orthogonal ERE-containing transgenic zebrafish (ZF) model to cross validate ERβ and ERα selective activities at the organism level. Using this environmentally relevant ZF assay, some compounds were confirmed to have ERβ activity, validating the GFP-ERβ:PRL-HeLa assay as a screening tool for potential ERβ active endocrine disruptors (EDCs). These data demonstrate the value of sensitive multiplex mechanistic data gathered by the GFP-ERβ:PRL-HeLa assay coupled with an orthogonal zebrafish model to rapidly identify environmentally relevant ERβ EDCs and improve upon currently available screening tools for this understudied nuclear receptor.
    Keywords Estrogen receptor beta ; High content analysis ; High throughput microscopy ; Endocrine disruptors ; Zebrafish ; Estrogen receptor alpha ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 570
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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