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  1. Article ; Online: "Founding Its Empire on Spells of Pleasure": Brunonian Excitability, the Invigorated English Opium-Eater, and De Quincey's "China Question".

    Gao, Menglu

    Literature and medicine

    2021  Volume 38, Issue 1, Page(s) 1–25

    Abstract: What light can De Quincey's Confessions of an English Opium-Eater (1821) shed on its author's later advocacy of the First Opium War? To what degree did De Quincey's and other contemporaneous accounts of opium use in Britain influence metaphorical ... ...

    Abstract What light can De Quincey's Confessions of an English Opium-Eater (1821) shed on its author's later advocacy of the First Opium War? To what degree did De Quincey's and other contemporaneous accounts of opium use in Britain influence metaphorical connections between bodily energy and national power in the 1830s and 1840s? Placing Confessions alongside John Brown's 1780 treatise, Elements of Medicine, this essay argues that De Quincey "nationalized" opium-eating by transforming mental exceptionality in British Romanticism into a medical body's connection with internal energies and external stimuli from China and "the Orient." The essay concludes that opium serves in De Quincey's Confessions as a crucial bridge between Romantic sublimity, in which it purportedly acted as a mysterious technology for self-strengthening, and Victorian consumerism, when the drug became both a popular commodity among national and global users.
    MeSH term(s) China ; Internationality ; Medicine in Literature ; Opium ; United Kingdom
    Chemical Substances Opium (8008-60-4)
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 1080-6571 ; 0278-9671
    ISSN (online) 1080-6571
    ISSN 0278-9671
    DOI 10.1353/lm.2020.0001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: (NH

    Gao, Shenyuan / Cai, Menglu / Xu, Gang / Jin, Qiaolin / Wang, Xiaozhong / Xu, Linze / Wang, Lixiang / Dai, Liyan

    Organic & biomolecular chemistry

    2024  Volume 22, Issue 11, Page(s) 2241–2251

    Abstract: A novel cascade radical addition/cyclization reaction of non-activated olefins and oxamic acids has been proposed. Under transition metal-free conditions, 36 quinazolinone derivatives containing an amide moiety were successfully synthesized, with the ... ...

    Abstract A novel cascade radical addition/cyclization reaction of non-activated olefins and oxamic acids has been proposed. Under transition metal-free conditions, 36 quinazolinone derivatives containing an amide moiety were successfully synthesized, with the highest yield being 81%. This method involves the preparation of aminoacyl fused quinazolinone derivatives under mild conditions, offering advantages such as a high yield, a broad substrate compatibility, and a high atom economy.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob02081a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: External Electric Field Effects on AFM-like Magnetism in Nitroxide-Functionalized C

    Zhao, Yu / Cui, Menglu / Lyu, Yongkang / Gao, Wen / Cui, Xixi / Zhang, Changzhe / Meng, Qingtian

    Journal of chemical information and modeling

    2023  Volume 63, Issue 7, Page(s) 2037–2046

    Abstract: In this work, we computationally designed a set of nitroxide diradical base pairs ( ... ...

    Abstract In this work, we computationally designed a set of nitroxide diradical base pairs (rC
    MeSH term(s) Base Pairing ; Nitrogen Oxides ; Magnetics ; Electricity
    Chemical Substances nitroxyl (GFQ4MMS07W) ; Nitrogen Oxides
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.2c01489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Association of

    Gao, Menglu / Sang, Ruirui / Wang, Gang / Xu, Yuanhong

    Infection and drug resistance

    2019  Volume 12, Page(s) 1649–1656

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2019-06-14
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S197167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Theoretical Simulation on Regulating the Magnetic Coupling Properties of Diradical Artificial Bases.

    Cui, Menglu / Zhao, Yu / Gao, Wen / Cui, Xixi / Zhang, Chenyang / Zhang, Changzhe / Meng, Qingtian

    The journal of physical chemistry. A

    2022  Volume 126, Issue 43, Page(s) 7820–7828

    Abstract: In this work, we computationally designed a series of diradical molecules with obvious magnetic coupling properties based on newly synthesized artificial bases, 6-amino-3-(1'-β-d-2'-deoxyribofuranosyl)-5-nitro- ... ...

    Abstract In this work, we computationally designed a series of diradical molecules with obvious magnetic coupling properties based on newly synthesized artificial bases, 6-amino-3-(1'-β-d-2'-deoxyribofuranosyl)-5-nitro-1
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.2c04354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comparison of two contrasting Leymus chinensis accessions reveals the roles of the cell wall and auxin in rhizome development.

    Gao, Jie / Duan, Menglu / Hasi, Gaowa / Yang, Jia / Yan, Chunxia / Kang, Yan / Qi, Zhi

    Journal of plant physiology

    2023  Volume 287, Page(s) 154003

    Abstract: Leymus chinensis, a perennial native forage grass, is widely distributed in the steppes of Inner Mongolia as the dominant species. The main reproductive strategy of this grass is clonal propagation, which occurs via the proliferation of subterranean ... ...

    Abstract Leymus chinensis, a perennial native forage grass, is widely distributed in the steppes of Inner Mongolia as the dominant species. The main reproductive strategy of this grass is clonal propagation, which occurs via the proliferation of subterranean horizontal stems known as rhizomes. To elucidate the mechanism underlying rhizome development in this grass, we collected 60 accessions of L. chinensis and evaluated their rhizome development. One accession, which we named SR-74 (Strong Rhizomes), had significantly better rhizome development capacity than the accession WR-16 (Weak Rhizomes) in terms of rhizome number, total and primary rhizome length, and number of rhizome seedlings. Rhizome elongation was positively correlated with the number of internodes in the rhizome, which affected plant biomass. Compared to WR-16, SR-74 had higher rhizome tip hardness, higher abundance of transcripts participating in the biosynthesis of cell wall components, and higher levels of the metabolites L-phenylalanine, trans-cinnamic acid, 3-coumaric acid, ferulic acid, and coniferin. These metabolites in the phenylpropanoid biosynthesis pathway are precursors of lignin. In addition, SR-74 rhizomes contained higher amounts of auxin and auxin metabolites, including L-Trp, IPA, IBA, IAA and IAA-Asp, as well as upregulated expression of the auxin biosynthesis and signaling genes YUCCA6, YUCCA8, YUCCA10, YUCCA11, PIN1, PIN2, UGT1, UGT2, UGT4, UGT10, GH3, IAA7, IAA23, and IAA30. We propose a network between auxin signaling and the cell wall underlying rhizome development in L. chinensis.
    MeSH term(s) Rhizome/genetics ; Poaceae/genetics ; Biomass ; Seedlings ; Cell Wall
    Language English
    Publishing date 2023-05-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 283647-6
    ISSN 1618-1328 ; 0176-1617
    ISSN (online) 1618-1328
    ISSN 0176-1617
    DOI 10.1016/j.jplph.2023.154003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 46/302: Show issues

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  7. Article ; Online: Pathogenic mechanisms and therapeutic implications of extracellular matrix remodelling in cerebral vasospasm.

    Hu, Ziliang / Deng, Xinpeng / Zhou, Shengjun / Zhou, Chenhui / Shen, Menglu / Gao, Xiang / Huang, Yi

    Fluids and barriers of the CNS

    2023  Volume 20, Issue 1, Page(s) 81

    Abstract: Cerebral vasospasm significantly contributes to poor prognosis and mortality in patients with aneurysmal subarachnoid hemorrhage. Current research indicates that the pathological and physiological mechanisms of cerebral vasospasm may be attributed to the ...

    Abstract Cerebral vasospasm significantly contributes to poor prognosis and mortality in patients with aneurysmal subarachnoid hemorrhage. Current research indicates that the pathological and physiological mechanisms of cerebral vasospasm may be attributed to the exposure of blood vessels to toxic substances, such as oxyhaemoglobin and inflammation factors. These factors disrupt cerebral vascular homeostasis. Vascular homeostasis is maintained by the extracellular matrix (ECM) and related cell surface receptors, such as integrins, characterised by collagen deposition, collagen crosslinking, and elastin degradation within the vascular ECM. It involves interactions between the ECM and smooth muscle cells as well as endothelial cells. Its biological activities are particularly crucial in the context of cerebral vasospasm. Therefore, regulating ECM homeostasis may represent a novel therapeutic target for cerebral vasospasm. This review explores the potential pathogenic mechanisms of cerebral vasospasm and the impacts of ECM protein metabolism on the vascular wall during ECM remodelling. Additionally, we underscore the significance of an ECM protein imbalance, which can lead to increased ECM stiffness and activation of the YAP pathway, resulting in vascular remodelling. Lastly, we discuss future research directions.
    MeSH term(s) Humans ; Vasospasm, Intracranial/drug therapy ; Vasospasm, Intracranial/metabolism ; Vasospasm, Intracranial/pathology ; Endothelial Cells/metabolism ; Extracellular Matrix/metabolism ; Subarachnoid Hemorrhage ; Extracellular Matrix Proteins/metabolism ; Collagen
    Chemical Substances Extracellular Matrix Proteins ; Collagen (9007-34-5)
    Language English
    Publishing date 2023-11-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2595406-4
    ISSN 2045-8118 ; 2045-8118
    ISSN (online) 2045-8118
    ISSN 2045-8118
    DOI 10.1186/s12987-023-00483-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Nonlinear iterative perturbation scheme with simplified spherical harmonics (SP

    Wang, Yihan / Xu, Menglu / Gao, Feng / Kang, Fei / Zhu, Shouping

    Journal of biophotonics

    2021  Volume 14, Issue 6, Page(s) e202000446

    Abstract: When using quantitative photoacoustic tomography (q-PAT) reconstruction to recover the optical absorption coefficients of tissue, the commonly used diffusion equation has several limitations in the case of the objects that have small geometries and high- ... ...

    Abstract When using quantitative photoacoustic tomography (q-PAT) reconstruction to recover the optical absorption coefficients of tissue, the commonly used diffusion equation has several limitations in the case of the objects that have small geometries and high-absorption or low-scattering areas. Furthermore, the conventional perturbation reconstruction strategy is unsatisfactory when the target tissue containing large heterogeneous features. We herein present a modified q-PAT implementation that employs the higher-order photon migration model achieving the tradeoff between mathematical rigidity and computational efficiency. Besides, a nonlinear iterative method is proposed to obtain the perturbations of optical absorption considering the updating of the sensitivity matrix in calculating the fluence perturbations. Consequently, the distribution of tissue optical properties can be recovered in a robust way even if the targets with high absorption are included. The proposed approach has been validated by simulation, phantom and in vivo experiments, exhibiting promising performances in image fidelity and quantitative feasibility for practical applications.
    MeSH term(s) Algorithms ; Computer Simulation ; Diffusion ; Phantoms, Imaging ; Photoacoustic Techniques ; Tomography, Optical ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-02-26
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202000446
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6723: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: One-Step Preparative Separation of Phytosterols from Edible Brown Seaweed

    Xia, Menglu / Liu, Chunping / Gao, Lei / Lu, Yanbin

    Marine drugs

    2019  Volume 17, Issue 12

    Abstract: Sargassum ... ...

    Abstract Sargassum horneri
    MeSH term(s) Countercurrent Distribution/methods ; Magnetic Resonance Spectroscopy ; Phytol/chemistry ; Phytol/isolation & purification ; Phytosterols/chemistry ; Phytosterols/isolation & purification ; Sargassum/chemistry ; Solvents/chemistry ; Stigmasterol/analogs & derivatives ; Stigmasterol/chemistry ; Stigmasterol/isolation & purification
    Chemical Substances Phytosterols ; Solvents ; saringosterol ; Phytol (150-86-7) ; fucosterol (504ZAM710C) ; Stigmasterol (99WUK5D0Y8)
    Language English
    Publishing date 2019-12-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md17120691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Efficient Recovery of Complete Gut Viral Genomes by Combined Short- and Long-Read Sequencing.

    Chen, Jingchao / Sun, Chuqing / Dong, Yanqi / Jin, Menglu / Lai, Senying / Jia, Longhao / Zhao, Xueyang / Wang, Huarui / Gao, Na L / Bork, Peer / Liu, Zhi / Chen, Wei-Hua / Zhao, Xing-Ming

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  Volume 11, Issue 13, Page(s) e2305818

    Abstract: Current metagenome assembled human gut phage catalogs contained mostly fragmented genomes. Here, comprehensive gut virome detection procedure is developed involving virus-like particle (VLP) enrichment from ≈500 g feces and combined sequencing of short- ... ...

    Abstract Current metagenome assembled human gut phage catalogs contained mostly fragmented genomes. Here, comprehensive gut virome detection procedure is developed involving virus-like particle (VLP) enrichment from ≈500 g feces and combined sequencing of short- and long-read. Applied to 135 samples, a Chinese Gut Virome Catalog (CHGV) is assembled consisting of 21,499 non-redundant viral operational taxonomic units (vOTUs) that are significantly longer than those obtained by short-read sequencing and contained ≈35% (7675) complete genomes, which is ≈nine times more than those in the Gut Virome Database (GVD, ≈4%, 1,443). Interestingly, the majority (≈60%, 13,356) of the CHGV vOTUs are obtained by either long-read or hybrid assemblies, with little overlap with those assembled from only the short-read data. With this dataset, vast diversity of the gut virome is elucidated, including the identification of 32% (6,962) novel vOTUs compare to public gut virome databases, dozens of phages that are more prevalent than the crAssphages and/or Gubaphages, and several viral clades that are more diverse than the two. Finally, the functional capacities are also characterized of the CHGV encoded proteins and constructed a viral-host interaction network to facilitate future research and applications.
    MeSH term(s) Humans ; Bacteriophages/genetics ; Sequence Analysis ; Genome, Viral/genetics ; Metagenome/genetics ; Feces
    Language English
    Publishing date 2024-01-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202305818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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