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  1. Article: Introduction of Posterior Axilla Sling Traction in Simulated Shoulder Dystocia.

    Whittington, Julie R / Poole, Aaron T

    AJP reports

    2018  Volume 8, Issue 4, Page(s) e247–e250

    Abstract: ... ...

    Abstract Objective
    Language English
    Publishing date 2018-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2628074-7
    ISSN 2157-7005 ; 2157-6998
    ISSN (online) 2157-7005
    ISSN 2157-6998
    DOI 10.1055/s-0038-1675350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Targeting transitioning lung monocytes/macrophages as treatment strategies in lung disease related to environmental exposures.

    Schwab, Aaron D / Wyatt, Todd A / Moravec, Grace / Thiele, Geoffrey M / Nelson, Amy J / Gleason, Angela / Schanze, Oliver / Duryee, Michael J / Romberger, Debra J / Mikuls, Ted R / Poole, Jill A

    Respiratory research

    2024  Volume 25, Issue 1, Page(s) 157

    Abstract: Background: Environmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component lipopolysaccharide (LPS) induce recruited, transitioning murine lung monocytes/macrophages, yet their ... ...

    Abstract Background: Environmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component lipopolysaccharide (LPS) induce recruited, transitioning murine lung monocytes/macrophages, yet their cellular role remains unclear.
    Methods: CCR2 RFP
    Results: Intratracheal instillation of ODE, LPS, or PGN robustly induced the recruitment of inflammatory CCR2
    Conclusion: Highly concentrated environmental/occupational exposures induced the recruitment of CCR2
    MeSH term(s) Mice ; Animals ; Monocytes/metabolism ; Liposomes/metabolism ; Vimentin/metabolism ; Lipopolysaccharides/pharmacology ; Clodronic Acid/pharmacology ; Clodronic Acid/metabolism ; CD8-Positive T-Lymphocytes ; Lung ; Macrophages/metabolism ; Lung Diseases/metabolism ; Environmental Exposure ; Collagen/metabolism ; Mice, Inbred C57BL
    Chemical Substances Liposomes ; Vimentin ; Lipopolysaccharides ; Clodronic Acid (0813BZ6866) ; Collagen (9007-34-5)
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-024-02804-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Towards an understanding of regulating Cajal body activity by protein modification.

    Hebert, Michael D / Poole, Aaron R

    RNA biology

    2017  Volume 14, Issue 6, Page(s) 761–778

    Abstract: The biogenesis of small nuclear ribonucleoproteins (snRNPs), small Cajal body-specific RNPs (scaRNPs), small nucleolar RNPs (snoRNPs) and the telomerase RNP involves Cajal bodies (CBs). Although many components enriched in the CB contain post- ... ...

    Abstract The biogenesis of small nuclear ribonucleoproteins (snRNPs), small Cajal body-specific RNPs (scaRNPs), small nucleolar RNPs (snoRNPs) and the telomerase RNP involves Cajal bodies (CBs). Although many components enriched in the CB contain post-translational modifications (PTMs), little is known about how these modifications impact individual protein function within the CB and, in concert with other modified factors, collectively regulate CB activity. Since all components of the CB also reside in other cellular locations, it is also important that we understand how PTMs affect the subcellular localization of CB components. In this review, we explore the current knowledge of PTMs on the activity of proteins known to enrich in CBs in an effort to highlight current progress as well as illuminate paths for future investigation.
    Language English
    Publishing date 2017-06-03
    Publishing country United States
    Document type Journal Article
    ISSN 1555-8584
    ISSN (online) 1555-8584
    DOI 10.1080/15476286.2016.1243649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: SMN and coilin negatively regulate dyskerin association with telomerase RNA.

    Poole, Aaron R / Hebert, Michael D

    Biology open

    2016  Volume 5, Issue 6, Page(s) 726–735

    Abstract: Telomerase is a ribonucleoprotein comprising telomerase RNA and associated proteins. The formation of the telomerase holoenzyme takes place in the Cajal body (CB), a subnuclear domain that participates in the formation of ribonucleoproteins. CBs also ... ...

    Abstract Telomerase is a ribonucleoprotein comprising telomerase RNA and associated proteins. The formation of the telomerase holoenzyme takes place in the Cajal body (CB), a subnuclear domain that participates in the formation of ribonucleoproteins. CBs also contribute to the delivery of telomerase to telomeres. The protein WRAP53 is enriched within the CB and is instrumental for the targeting of telomerase RNA to CBs. Two other CB proteins, SMN and coilin, are also suspected of taking part in some aspect of telomerase biogenesis. Here we demonstrate newly discovered associations between SMN and coilin with telomerase components, and further show that reduction of SMN or coilin is correlated with increased association of telomerase RNA with one these components, dyskerin. These findings argue that SMN and coilin may negatively regulate the formation of telomerase. Furthermore, clinically defined SMN mutants found in individuals with spinal muscular atrophy are altered in their association with telomerase complex proteins. Additionally, we observe that a coilin derivative also associates with dyskerin, and the amount of this protein in the complex is regulated by SMN, WRAP53 and coilin levels. Collectively, our findings bolster the link between SMN, coilin and the coilin derivative in the biogenesis of telomerase.
    Language English
    Publishing date 2016-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2632264-X
    ISSN 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.018804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pyelonephritis in Pregnancy: Relationship of Fever and Maternal Morbidity.

    DeYoung, Tracey H / Whittington, Julie R / Ennen, Christopher S / Poole, Aaron T

    AJP reports

    2019  Volume 9, Issue 4, Page(s) e366–e371

    Abstract: ... ...

    Abstract Objective
    Language English
    Publishing date 2019-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2628074-7
    ISSN 2157-7005 ; 2157-6998
    ISSN (online) 2157-7005
    ISSN 2157-6998
    DOI 10.1055/s-0039-1695746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Combined repetitive inhalant endotoxin and collagen-induced arthritis drive inflammatory lung disease and arthritis severity in a testosterone-dependent manner.

    Poole, Jill A / Thiele, Geoffrey M / Ramler, Elizabeth / Nelson, Amy J / Duryee, Michael J / Schwab, Aaron D / Gleason, Angela / Hunter, Carlos D / Gaurav, Rohit / Wyatt, Todd A / England, Bryant R / Mikuls, Ted R

    American journal of physiology. Lung cellular and molecular physiology

    2023  Volume 326, Issue 3, Page(s) L239–L251

    Abstract: Respiratory-related diseases are a leading cause of death in rheumatoid arthritis (RA) and are disproportionately higher in men, which may be attributable to environmental risk factors. Animal studies have demonstrated potentiated autoimmunity, arthritis, ...

    Abstract Respiratory-related diseases are a leading cause of death in rheumatoid arthritis (RA) and are disproportionately higher in men, which may be attributable to environmental risk factors. Animal studies have demonstrated potentiated autoimmunity, arthritis, and profibrotic/inflammatory lung disease with a combination of airborne exposures and collagen-induced arthritis (CIA). This study aimed to determine whether hormone-dependent differences explained these observations. Arthritis-prone male intact and castrated DBA/1J mice received intranasal inhalation of lipopolysaccharide (LPS) daily for 5 wk and CIA induction. Arthritis scores and serum pentraxin-2 levels were increased in castrated versus intact mice. In contrast, airway cell influx, lung tissue infiltrates, and lung levels of proinflammatory and profibrotic markers (C5a, IL-33, and matrix metalloproteinases) were reduced in castrated versus intact mice. CIA + LPS-induced lung histopathology changes and the expression of lung autoantigens including malondialdehyde acetaldehyde (MAA)- and citrulline (CIT)-modified proteins and vimentin were reduced in castrated animals. There were no differences in serum anti-MAA or anti-CIT protein antibody (ACPA) levels or serum pentraxin levels between groups. Testosterone replacement led to a reversal of several lung inflammatory/profibrotic endpoints noted earlier in castrated male CIA + LPS-treated mice with testosterone supplementation promoting neutrophil influx, MAA expression, and TNF-α, IL-6, and MMP-9. These findings imply that testosterone contributes to lung and arthritis inflammatory responses following CIA + LPS coexposure, but not to systemic autoantibody responses. The CIA + LPS model provides a paradigm for investigations focused on the mechanistic underpinnings for epidemiologic and phenotypic sex differences in RA-related lung disease.
    MeSH term(s) Humans ; Male ; Female ; Animals ; Mice ; Arthritis, Experimental ; Lipopolysaccharides/pharmacology ; Endotoxins ; Testosterone/pharmacology ; Mice, Inbred DBA ; Arthritis, Rheumatoid ; Lung Diseases ; Autoantigens
    Chemical Substances Lipopolysaccharides ; Endotoxins ; Testosterone (3XMK78S47O) ; Autoantigens
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00221.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2749: Show issues Location:
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  7. Article: Introduction of Posterior Axilla Sling Traction in Simulated Shoulder Dystocia

    Whittington, Julie R. / Poole, Aaron T.

    American Journal of Perinatology Reports

    2018  Volume 08, Issue 04, Page(s) e247–e250

    Abstract: Objective: Aim of this study was to introduce posterior axilla sling traction (PAST) in delivering providers and nursing staff as an adjunct to the management of shoulder dystocia and evaluate comfort in performing the maneuver.: Methods: A ... ...

    Abstract Objective: Aim of this study was to introduce posterior axilla sling traction (PAST) in delivering providers and nursing staff as an adjunct to the management of shoulder dystocia and evaluate comfort in performing the maneuver.
    Methods: A presimulation questionnaire had given to all participants. A brief training on how to perform PAST was also given. A simulated shoulder dystocia was run where usual maneuvers failed. Participants used PAST for delivery of posterior shoulder, delivery of posterior arm, and to assist with rotation. Participants were then given a post-simulation questionnaire. A Chi-squared test was used to evaluate comfort with performing the procedure pre and post-simulation.
    Results: Data were collected from 43 participants at pre and post-simulation. Designations (attending, resident, midwife, registered nurse) and responses were recorded to the questionnaires. There was a statistically significant increase in the number of providers and nurses who would feel comfortable using PAST for shoulder dystocia management and for rotational maneuvers. Ninety-three percent of participants would consider using PAST in future shoulder dystocia when usual maneuvers failed.
    Conclusion: PAST is an adjunct to management of shoulder dystocia that has not previously been taught in our facility. The majority of participants in our simulation felt comfortable with using PAST.
    Keywords simulation ; shoulder dystocia ; posterior axilla sling traction ; obstetric emergency
    Language English
    Publishing date 2018-10-01
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2628074-7
    ISSN 2157-7005 ; 2157-6998
    ISSN (online) 2157-7005
    ISSN 2157-6998
    DOI 10.1055/s-0038-1675350
    Database Thieme publisher's database

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  8. Article ; Online: Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition.

    Huynh, Minh V / Parsonage, Derek / Forshaw, Tom E / Chirasani, Venkat R / Hobbs, G Aaron / Wu, Hanzhi / Lee, Jingyun / Furdui, Cristina M / Poole, Leslie B / Campbell, Sharon L

    The Journal of biological chemistry

    2022  Volume 298, Issue 8, Page(s) 102186

    Abstract: The recent development of mutant-selective inhibitors for the oncogenic ... ...

    Abstract The recent development of mutant-selective inhibitors for the oncogenic KRAS
    MeSH term(s) Kinetics ; Mutation ; Oxidation-Reduction ; Proto-Oncogene Proteins p21(ras)/genetics ; Sulfhydryl Compounds
    Chemical Substances Sulfhydryl Compounds ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.102186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Lung-delivered IL-10 therapy elicits beneficial effects via immune modulation in organic dust exposure-induced lung inflammation.

    Schwab, Aaron D / Wyatt, Todd A / Nelson, Amy J / Gleason, Angela / Gaurav, Rohit / Romberger, Debra J / Poole, Jill A

    Journal of immunotoxicology

    2024  Volume 21, Issue 1, Page(s) 2332172

    Abstract: Efficacious therapeutic options capable of resolving inflammatory lung disease associated with environmental and occupational exposures are lacking. This study sought to determine the preclinical therapeutic potential of lung-delivered recombinant ... ...

    Abstract Efficacious therapeutic options capable of resolving inflammatory lung disease associated with environmental and occupational exposures are lacking. This study sought to determine the preclinical therapeutic potential of lung-delivered recombinant interleukin (IL)-10 therapy following acute organic dust exposure in mice. Here, C57BL/6J mice were intratracheally instilled with swine confinement organic dust extract (ODE) (12.5%, 25%, 50% concentrations) with IL-10 (1 μg) treatment or vehicle control intratracheally-administered three times: 5 hr post-exposure and then daily for 2 days. The results showed that IL-10 treatment reduced ODE (25%)-induced weight loss by 66% and 46% at Day 1 and Day 2 post-exposure, respectively. IL-10 treatment reduced ODE (25%, 50%)-induced lung levels of TNFα (-76%, -83% [reduction], respectively), neutrophil chemoattractant CXCL1 (-51%, -60%), and lavage fluid IL-6 (-84%, -89%). IL-10 treatment reduced ODE (25%, 50%)-induced lung neutrophils (-49%, -70%) and recruited CD11c
    MeSH term(s) Animals ; Mice ; Swine ; Interleukin-10/metabolism ; Mice, Inbred C57BL ; Pneumonia/drug therapy ; Lung/pathology ; Lung Diseases/chemically induced ; Lung Diseases/drug therapy ; Dust
    Chemical Substances Interleukin-10 (130068-27-8) ; Dust
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2205064-4
    ISSN 1547-6901 ; 1547-691X
    ISSN (online) 1547-6901
    ISSN 1547-691X
    DOI 10.1080/1547691X.2024.2332172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A Novel Mutation in ACTG2 Gene in Mother with Chronic Intestinal Pseudoobstruction and Fetus with Megacystis Microcolon Intestinal Hypoperistalsis Syndrome.

    Whittington, Julie R / Poole, Aaron T / Dutta, Eryn H / Munn, Mary B

    Case reports in genetics

    2017  Volume 2017, Page(s) 9146507

    Abstract: Background. ...

    Abstract Background.
    Language English
    Publishing date 2017-12-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2664417-4
    ISSN 2090-6552 ; 2090-6544
    ISSN (online) 2090-6552
    ISSN 2090-6544
    DOI 10.1155/2017/9146507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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