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  1. Article ; Online: The absolute percent deviation of IGHV mutation rather than a 98% cut-off predicts survival of chronic lymphocytic leukaemia patients treated with fludarabine, cyclophosphamide and rituximab.

    Gocke, Christopher D / Gladstone, Douglas E

    British journal of haematology

    2018  Volume 180, Issue 1, Page(s) 7–8

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols ; Cyclophosphamide ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell ; Mutation ; Rituximab/genetics ; Vidarabine/analogs & derivatives
    Chemical Substances Rituximab (4F4X42SYQ6) ; Cyclophosphamide (8N3DW7272P) ; Vidarabine (FA2DM6879K) ; fludarabine (P2K93U8740)
    Language English
    Publishing date 2018
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.15015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ECMO Therapy for Cardiac Lymphoma.

    Leef, George / Gladstone, Douglas E / Cingolani, Oscar

    Circulation

    2020  Volume 142, Issue 12, Page(s) 1219–1223

    MeSH term(s) Extracorporeal Membrane Oxygenation ; Heart Neoplasms/diagnosis ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/physiopathology ; Heart Neoplasms/therapy ; Humans ; Hypertension/diagnosis ; Hypertension/diagnostic imaging ; Hypertension/physiopathology ; Hypertension/therapy ; Lymphoma/diagnosis ; Lymphoma/diagnostic imaging ; Lymphoma/physiopathology ; Lymphoma/therapy ; Male ; Middle Aged
    Language English
    Publishing date 2020-09-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.047518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: HLA donor-specific antibodies in allogeneic hematopoietic stem cell transplantation: challenges and opportunities.

    Gladstone, Douglas E / Bettinotti, Maria P

    Hematology. American Society of Hematology. Education Program

    2017  Volume 2017, Issue 1, Page(s) 645–650

    Abstract: Allogenic hematopoietic stem cell recipients may have preformed antibodies directed against foreign HLA antigens. The use of partially HLA-mismatched allogeneic hematopoietic stem cell donors allows for the possibility of the presence of circulating HLA ... ...

    Abstract Allogenic hematopoietic stem cell recipients may have preformed antibodies directed against foreign HLA antigens. The use of partially HLA-mismatched allogeneic hematopoietic stem cell donors allows for the possibility of the presence of circulating HLA donor-specific antibodies (DSAs) in the recipient. The presence of DSAs at the time of stem cell infusion increases the risk of primary graft failure. More recently developed technology using solid phase immunoassays (SPIs) with fluorochrome-conjugated beads has greatly improved the ability to detect and classify DSAs. When used in combination with the classic lymphocytotoxic complement-dependent and flow cytometric crossmatch tests, SPIs help provide DSA strength assessment. Parous females frequently harbor DSAs. DSAs tend to be of higher intensity when directed against haploidentical first-degree relatives. DSA assessment requires frequent monitoring as their relative strength can change over time. Although the criteria that constitutes a prohibitive DSA is unknown, desensitization techniques can result in engraftment rates as experienced in fully HLA-matched allogeneic blood or marrow transplantation recipients.
    MeSH term(s) Allografts ; Desensitization, Immunologic ; Female ; Flow Cytometry ; Graft Rejection/blood ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Graft Survival/immunology ; HLA Antigens/immunology ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunoassay ; Isoantibodies/blood ; Isoantibodies/immunology ; Male ; Unrelated Donors
    Chemical Substances HLA Antigens ; Isoantibodies
    Language English
    Publishing date 2017-12-06
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1520-4383
    ISSN (online) 1520-4383
    DOI 10.1182/asheducation-2017.1.645
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  4. Article ; Online: Checkpoint inhibitor-induced autoimmune encephalitis reversed by rituximab after allogeneic bone marrow transplant in a patient with Hodgkin lymphoma.

    Thummalapalli, Rohit / Sena, Laura A / Probasco, John C / Gladstone, Douglas E

    Leukemia & lymphoma

    2019  Volume 61, Issue 1, Page(s) 228–230

    MeSH term(s) Adolescent ; Bone Marrow Transplantation ; Encephalitis ; Hashimoto Disease/chemically induced ; Hashimoto Disease/drug therapy ; Hodgkin Disease/complications ; Hodgkin Disease/therapy ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Male ; Rituximab/therapeutic use
    Chemical Substances Immune Checkpoint Inhibitors ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2019-09-10
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2019.1658104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2997: Show issues Location:
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  5. Article ; Online: Regulatory T Cells for Treating Patients With COVID-19 and Acute Respiratory Distress Syndrome: Two Case Reports.

    Gladstone, Douglas E / Kim, Bo Soo / Mooney, Kathy / Karaba, Andrew H / D'Alessio, Franco R

    Annals of internal medicine

    2020  Volume 173, Issue 10, Page(s) 852–853

    MeSH term(s) Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/therapy ; Humans ; Immunotherapy/methods ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/therapy ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/virology ; SARS-CoV-2 ; T-Lymphocytes, Regulatory/physiology
    Keywords covid19
    Language English
    Publishing date 2020-07-06
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L20-0681
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  6. Article ; Online: Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones.

    Osman, Afaf / Gocke, Christopher D / Gladstone, Douglas E

    Clinical lymphoma, myeloma & leukemia

    2017  Volume 17, Issue 2, Page(s) 97–99

    Abstract: Background: Fluorescence in situ hybridization and immunoglobulin (Ig) heavy-chain variable-region (IgHV) mutational status are used to predict outcome in chronic lymphocytic leukemia (CLL). Although DNA aberrations change over time, IgHV sequences and ... ...

    Abstract Background: Fluorescence in situ hybridization and immunoglobulin (Ig) heavy-chain variable-region (IgHV) mutational status are used to predict outcome in chronic lymphocytic leukemia (CLL). Although DNA aberrations change over time, IgHV sequences and mutational status are considered stable.
    Patients and methods: In a retrospective review, 409 CLL patients, between 2008 and 2015, had IgHV analysis: 56 patients had multiple analyses performed. Seven patients' IgHV results changed: 2 from unmutated to mutated and 5 from mutated to unmutated IgHV sequence.
    Results: Three concurrently changed their variable heavy-chain sequence. Secondary to allelic exclusion, 2 of the new variable heavy chains produced were biologically nonplausible.
    Conclusion: The existence of these new nonplausible heavy-chain variable regions suggests either the CLL cancer stem-cell maintains the ability to rearrange a previously silenced IgH allele or more likely that the cancer stem-cell produced at least 2 subclones, suggesting that the CLL cancer stem cell exists before the process of allelic exclusion occurs.
    MeSH term(s) Alleles ; Clone Cells/metabolism ; Genes, Immunoglobulin Heavy Chain/genetics ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Variable Region/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Mutation/genetics ; Retrospective Studies
    Chemical Substances Immunoglobulin Heavy Chains ; Immunoglobulin Variable Region
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2016.11.008
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    Zs.A 5903: Show issues Location:
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  7. Article ; Online: CD34+ cell of origin for immunoglobulin heavy chain variable region unmutated, but not mutated, chronic lymphocytic leukemia.

    Perkins, Brandy / Showel, Margaret / Schoch, Laura / Imus, Philip H / Karantanos, Theodoros / Yonescu, Raluca / Morsberger, Laura / Ghiaur, Gabriel / Gladstone, Douglas E / Jones, Richard J

    Leukemia & lymphoma

    2022  Volume 63, Issue 7, Page(s) 1617–1623

    Abstract: The clinical course of chronic lymphocytic leukemia (CLL) is highly variable. Immunoglobulin heavy chain variable region (IgHV) mutation status is among the most important prognostic factors, with unmutated IgHV associated with inferior outcomes. CLL ... ...

    Abstract The clinical course of chronic lymphocytic leukemia (CLL) is highly variable. Immunoglobulin heavy chain variable region (IgHV) mutation status is among the most important prognostic factors, with unmutated IgHV associated with inferior outcomes. CLL presumably arises from mature B cells. However, we hypothesized that IgHV unmutated CLL could arise early in B cell differentiation. We prospectively studied 29 patients with mutated and 88 with unmutated IgHV CLL for the presence of CD34
    MeSH term(s) Animals ; Antigens, CD19 ; Antigens, CD34 ; Chromosome Aberrations ; Flow Cytometry ; Heterografts ; Humans ; Immunoglobulin Heavy Chains/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Mice ; Mutation ; Precursor Cells, B-Lymphoid/immunology ; Prognosis
    Chemical Substances Antigens, CD19 ; Antigens, CD34 ; Immunoglobulin Heavy Chains
    Language English
    Publishing date 2022-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2022.2038375
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  8. Article ; Online: Hematopoietic stem cell transplantation for chronic lymphocytic leukemia.

    Gladstone, Douglas E / Fuchs, Ephraim

    Current opinion in oncology

    2012  Volume 24, Issue 2, Page(s) 176–181

    Abstract: Purpose of review: Although hematopoietic stem cell transplantation (HSCT) is the treatment of choice for many aggressive hematologic malignancies, the role of HSCT in chronic lymphocytic leukemia (CLL) has remained controversial. Now in the era of ... ...

    Abstract Purpose of review: Although hematopoietic stem cell transplantation (HSCT) is the treatment of choice for many aggressive hematologic malignancies, the role of HSCT in chronic lymphocytic leukemia (CLL) has remained controversial. Now in the era of improved conventional treatment and better prognostication of long-term outcome, a review of autologous and allogeneic HSCT in CLL treatment is warranted.
    Recent findings: Despite an improved disease-free survival in some patients, multiple, prospective, randomized autologous HSCT CLL trials fail to demonstrate an overall survival benefit as compared to conventional therapy. Allogeneic bone marrow transplantation, although limited by donor availability, can successfully eradicate CLL with adverse prognostic features. In the older CLL patients, nonmyeloablative allogeneic transplants are better tolerated than myeloablative transplants. Nonmyeloablative allogeneic transplants are less effective in heavily diseased burdened patients.
    Summary: Outside of a clinical protocol, autologous HSCT for CLL cannot be justified. Nonmyeloablative allogeneic transplantation should be considered in high-risk populations early in the disease process, when disease burden is most easily controlled. Alternative donor selection using haploidentical donors and posttransplantation cyclophosphamide has the potential to vastly increase the availability of curative therapy in CLL while retaining a low treatment-related toxicity.
    MeSH term(s) Clinical Trials as Topic ; Disease-Free Survival ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cell Transplantation/mortality ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/mortality ; Leukemia, Lymphocytic, Chronic, B-Cell/surgery ; Transplantation, Autologous ; Transplantation, Homologous
    Language English
    Publishing date 2012-01-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0b013e32834f8011
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  9. Article: Regulatory T Cells for Treating Patients With COVID-19 and Acute Respiratory Distress Syndrome: Two Case Reports

    Gladstone, Douglas E / Kim, Bo Soo / Mooney, Kathy / Karaba, Andrew H / D039, / Alessio, Franco R

    Ann Intern Med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #633091
    Database COVID19

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  10. Article ; Online: Maintaining hemostasis in acquired von Willebrand syndrome: a review of intravenous immunoglobulin and the importance of rituximab dose scheduling.

    Kanakry, Jennifer A / Gladstone, Douglas E

    Transfusion

    2012  Volume 53, Issue 8, Page(s) 1730–1735

    Abstract: Background: The acute management of acquired von Willebrand syndrome (AVWS) is aimed at achieving hemostasis with von Willebrand factor replacement, counteracting the pathologic antibodies with intravenous immunoglobulin (IVIG), and supportive care with ...

    Abstract Background: The acute management of acquired von Willebrand syndrome (AVWS) is aimed at achieving hemostasis with von Willebrand factor replacement, counteracting the pathologic antibodies with intravenous immunoglobulin (IVIG), and supportive care with blood transfusions. However, strategies for the long-term management of AVWS are not described, resulting in persistent use of these acute strategies to achieve hemostasis via high utilization of blood products. Herein, we provide an updated review of the use of IVIG and rituximab for AVWS and present rituximab maintenance as an effective and durable strategy for the management of these patients.
    Case report: We report the successful treatment of AVWS with anti-CD20 monoclonal antibody therapy (375 mg/m2 rituximab as four weekly doses followed by 375 mg/m2 every 90 days) in a patient with concurrent monoclonal B-cell lymphocytosis allowing for the early discontinuation of blood product support after only 2 g/kg IVIG achieved acute hemostasis control.
    Results: This is the first documentation of the successful long-term management of AVWS without prolonged blood product or IVIG support. This result contrasts sharply to previously reported rituximab strategies that were deemed ineffective in AVWS.
    Conclusion: A maintenance regimen of rituximab may be an effective long-term management strategy for AVWS associated with lymphoproliferative disorders, which may minimize the use of blood products and IVIG.
    MeSH term(s) Aged, 80 and over ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Blood Transfusion ; Combined Modality Therapy ; Drug Administration Schedule ; Hemostasis ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunologic Factors/therapeutic use ; Induction Chemotherapy ; Maintenance Chemotherapy ; Male ; Rituximab ; von Willebrand Diseases/blood ; von Willebrand Diseases/drug therapy ; von Willebrand Diseases/therapy
    Chemical Substances Antibodies, Monoclonal, Murine-Derived ; Immunoglobulins, Intravenous ; Immunologic Factors ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2012-12-17
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.12017
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