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Article: Chronic Hepatitis C Virus Infection Modulates the Transcriptional Profiles of CD4

Holub, Michal / Stráníková, Alžběta / Beran, Ondřej / Arientová, Simona / Bartoš, Oldřich / Kondelková, Kateřina / Plíšek, Stanislav / Chalupa, Pavel

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

2021 Volume 2021, Page(s) 6689834

Abstract: Background: Chronic hepatitis C (CHC) is associated with altered cell-mediated immune response.: Objective: The aim of the study was to characterize functional alterations in CD4: Result: The patients with CHC had significantly lower percentages ... ...

Abstract	Background: Chronic hepatitis C (CHC) is associated with altered cell-mediated immune response. Objective: The aim of the study was to characterize functional alterations in CD4 Result: The patients with CHC had significantly lower percentages of CD4 Conclusion: Chronic HCV infection is associated with downregulation of TFs Gata3 and Ror
Language	English
Publishing date	2021-03-12
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1057056-1
ISSN	1712-9532 ; 1180-2332
ISSN	1712-9532 ; 1180-2332
DOI	10.1155/2021/6689834
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Article ; Online: The role of autoimmunity in gastroenterology.

Krejsek, Jan / Hrncirova, Lucia / Kondelkova, Katerina / Andrys, Ctirad

Digestive diseases (Basel, Switzerland)

2012 Volume 30, Issue 2, Page(s) 208–211

Abstract: Crohn's disease (CD) is an immune-mediated chronic intestinal disorder thought to be the result of an aggressive immune response to a subset of enteric bacteria in a genetically predisposed host. Numerous environmental factors are apparently involved in ... ...

Abstract	Crohn's disease (CD) is an immune-mediated chronic intestinal disorder thought to be the result of an aggressive immune response to a subset of enteric bacteria in a genetically predisposed host. Numerous environmental factors are apparently involved in disease pathogenesis. Impaired ability of CD patients to control the gut microflora is associated with defects in the production of some antibacterial compounds (cryptdins) by epithelial cells. In addition, there are the defects in cytoplasmic NOD-like receptors which are sensing intracellularly localized bacteria in CD patients. These defects together with the failure to induce autophagy lead to lack of bacterial clearance and subsequently to mucosal immunopathology.
MeSH term(s)	Autoimmunity/immunology ; Autophagy/immunology ; Crohn Disease/genetics ; Crohn Disease/immunology ; Gastroenterology ; Humans ; Receptors, Pattern Recognition/immunology ; Signal Transduction/immunology
Chemical Substances	Receptors, Pattern Recognition
Language	English
Publishing date	2012
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632798-9
ISSN	1421-9875 ; 0257-2753
ISSN (online)	1421-9875
ISSN	0257-2753
DOI	10.1159/000336685
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Article: CD200/CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; Part II: CD200/CD200R potential clinical applications.

Holmannová, Drahomíra / Kolácková, Martina / Kondelková, Katerina / Kunes, Pavel / Krejsek, Jan / Ctirad, Andrjos

Acta medica (Hradec Kralove)

2012 Volume 55, Issue 2, Page(s) 59–65

Abstract: Summary: CD200 and its receptor were recognized as having the multiple immunoregulatory functions. Their immunoregulatory, suppressive, and tolerogenic potentials could be very effectively exploited in the treatment of many diseases, e.g. Alzheimer ... ...

Abstract	Summary: CD200 and its receptor were recognized as having the multiple immunoregulatory functions. Their immunoregulatory, suppressive, and tolerogenic potentials could be very effectively exploited in the treatment of many diseases, e.g. Alzheimer disease, rheumatoid arthritis, and allergy to name only some. Many research projects are aimed to develop clinically valuable methods being based on the structure and function of these paired molecules. In this review, we would like to introduce CD200/CD200R functions in a clinical context.
MeSH term(s)	Animals ; Antigens, CD/immunology ; Antigens, CD/therapeutic use ; Autoimmune Diseases/immunology ; Central Nervous System Diseases/immunology ; Humans ; Immunity ; Neoplasms/immunology ; Neoplasms/therapy ; Transplantation Immunology ; Virus Diseases/immunology
Chemical Substances	Antigens, CD ; antigens, CD200
Language	English
Publishing date	2012
Publishing country	Czech Republic
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1360995-6
ISSN	1211-4286
ISSN	1211-4286
DOI	10.14712/18059694.2015.56
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Article: CD200/CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; Part I: CD200/CD200R structure, activation, and function.

Holmannová, Drahomíra / Kolácková, Martina / Kondélková, Katerina / Kunes, Pavel / Krejsek, Jan / Andrýs, Ctirad

Acta medica (Hradec Kralove)

2012 Volume 55, Issue 1, Page(s) 12–17

Abstract: CD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to the Ig superfamily containing a two immunoglobulin-like domain (V, C). CD200 is broadly distributed in a variety of cell types, whereas CD200R is primarily expressed in ...

Abstract	CD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to the Ig superfamily containing a two immunoglobulin-like domain (V, C). CD200 is broadly distributed in a variety of cell types, whereas CD200R is primarily expressed in myeloid and lymphoid cells. They fulfill multiple functions in regulating inflammation. The interaction between CD200/CD200R results in activation of the intracellular inhibitory pathway with RasGAP recruitment and thus contributes to effector cell inhibition. It was confirmed that the CD200R activation stimulates the differentiation ofT cells to the Treg subset, upregulates indoleamine 2,3-dioxygenase activity, modulates cytokine environment from a Thl to a Th2 pattern, and facilitates an antiinflammatory IL-10 and TGF-beta synthesis. CD200/CD200R are required for maintaining self-tolerance. Many studies have demonstrated the importance of CD200 in controlling autoimmunity, inflammation, the development and spread of cancer, hypersensitivity, and spontaneous fetal loss.
MeSH term(s)	Animals ; Antigens, CD/physiology ; Antigens, Surface/physiology ; Humans ; Immunity/physiology ; Inflammation/physiopathology ; Receptors, Cell Surface/physiology ; Signal Transduction
Chemical Substances	Antigens, CD ; Antigens, Surface ; CD200R1 protein, human ; Receptors, Cell Surface ; antigens, CD200
Language	English
Publishing date	2012
Publishing country	Czech Republic
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1360995-6
ISSN	1211-4286
ISSN	1211-4286
DOI	10.14712/18059694.2015.68
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Article: The number of immunoregulatory T cells is increased in patients with psoriasis after Goeckerman therapy.

Kondelková, Katerina / Vokurková, Doris / Krejsek, Jan / Borská, Lenka / Fiala, Zdenek / Hamáková, Kveta / Andrýs, Ctirad

Acta medica (Hradec Kralove)

2012 Volume 55, Issue 2, Page(s) 91–95

Abstract: Regulatory T cells (Treg) are a specialized subpopulation of T cells that act to suppress inadequate immune response. Psoriasis is recognized as a T-cell driven immune-mediated systemic inflammatory disease with skin manifestation. Effective ... ...

Abstract	Regulatory T cells (Treg) are a specialized subpopulation of T cells that act to suppress inadequate immune response. Psoriasis is recognized as a T-cell driven immune-mediated systemic inflammatory disease with skin manifestation. Effective therapeutical approach to treat psoriasis is Goeckerman therapy (GT). The aim of this study was to compare the number of Treg in the peripheral blood of 27 psoriatic patients and 19 controls and to evaluate the influence of GT on Treg population in peripheral blood of patients with psoriasis. There was no significant difference in the relative number of Treg cells in the peripheral blood of healthy blood donors and patients with psoriasis before initiation of GT (P = 0.2668). In contrary, the relative number of Treg cells in peripheral blood of patients with psoriasis after GT was significantly higher than those found in healthy blood donors (P = 0.0019). Moreover, the relative number of Treg is significantly increased in psoriatic patients after Goeckerman therapy compared to the pre-treatment level (P = 0.0042). In conclusion, this significant increase in Treg count after GT is probably associated with amelioration of inflammation by GT, as disease activity expressed as PASI decreased in our patients by GT (P = 0.0001).
MeSH term(s)	Adult ; Coal Tar/therapeutic use ; Dermatologic Agents/therapeutic use ; Female ; Humans ; Lymphocyte Count ; Male ; Middle Aged ; Psoriasis/immunology ; Psoriasis/therapy ; T-Lymphocytes, Regulatory/immunology ; Ultraviolet Therapy
Chemical Substances	Dermatologic Agents ; Coal Tar (8007-45-2)
Language	English
Publishing date	2012
Publishing country	Czech Republic
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1360995-6
ISSN	1211-4286
ISSN	1211-4286
DOI	10.14712/18059694.2015.62
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Zs.B 908: Show issues

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Article ; Online: Effect of antiviral treatment of chronic hepatitis C on the frequency of regulatory T cells, T-cell activation, and serum levels of TGF-beta.

Chalupa, Pavel / Davidová, Alžběta / Beran, Ondřej / Arientová, Simona / Boštík, Pavel / Kapla, Jaroslav / Kondělková, Kateřina / Plíšek, Stanislav / Holub, Michal

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

2016 Volume 124, Issue 8, Page(s) 711–718

Abstract: The aim was to analyze T-regulatory cells (Tregs), activated CD8(+) T cells, and transforming growth factor-beta (TGF)-β in hepatitis C patients. We enrolled 31 patients with chronic genotype 1 hepatitis C virus (HCV) infection, 30 seropositive persons ... ...

Abstract	The aim was to analyze T-regulatory cells (Tregs), activated CD8(+) T cells, and transforming growth factor-beta (TGF)-β in hepatitis C patients. We enrolled 31 patients with chronic genotype 1 hepatitis C virus (HCV) infection, 30 seropositive persons with spontaneous HCV elimination, and 23 healthy volunteers. The patients were examined at the beginning of the interferon-alpha (IFN-α)-based therapy (baseline) and at weeks 4 (W4) and 12 (W12) of the therapy. The percentage of Tregs and the expression of activation markers CD38 and HLA-DR on CD8(+) T cells were analyzed in the peripheral blood by flow cytometry. Serum levels of TGF-β were measured in a multiplex assay using flow cytometry. The percentage of Tregs in patients was higher than in controls and seropositive persons. Similarly, the percentage of CD8(+) T cells expressing CD38 and HLA-DR was higher in patients compared with controls and seropositive persons. Chronic HCV infection is associated with elevated circulating Tregs and activated CD8(+) T cells. During IFN-α-based therapy these cells gradually increase, whereas TGF-β serum levels decrease.
MeSH term(s)	ADP-ribosyl Cyclase 1/analysis ; Adult ; Aged ; Antiviral Agents/therapeutic use ; CD8-Positive T-Lymphocytes/chemistry ; CD8-Positive T-Lymphocytes/immunology ; Female ; Flow Cytometry ; Genotype ; HLA-DR Antigens/analysis ; Hepacivirus/classification ; Hepacivirus/genetics ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/pathology ; Hepatitis C, Chronic/virology ; Humans ; Immunophenotyping ; Interferon-alpha/therapeutic use ; Lymphocyte Activation ; Male ; Membrane Glycoproteins/analysis ; Middle Aged ; Protease Inhibitors/therapeutic use ; Ribavirin/therapeutic use ; Serum/chemistry ; T-Lymphocytes, Regulatory/immunology ; Transforming Growth Factor beta/blood ; Young Adult
Chemical Substances	Antiviral Agents ; HLA-DR Antigens ; Interferon-alpha ; Membrane Glycoproteins ; Protease Inhibitors ; Transforming Growth Factor beta ; Ribavirin (49717AWG6K) ; CD38 protein, human (EC 3.2.2.5) ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6)
Language	English
Publishing date	2016-08
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	93340-5
ISSN	1600-0463 ; 0903-4641
ISSN (online)	1600-0463
ISSN	0903-4641
DOI	10.1111/apm.12561
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Article: Regulatory T cells (TREG) and their roles in immune system with respect to immunopathological disorders.

Kondĕlková, Katerina / Vokurková, Doris / Krejsek, Jan / Borská, Lenka / Fiala, Zdenĕk / Ctirad, Andrýs

Acta medica (Hradec Kralove)

2010 Volume 53, Issue 2, Page(s) 73–77

Abstract: Regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress immune response, thereby maintaining homeostasis and self-tolerance. It has been shown that Tregs are able to inhibit T cell proliferation and cytokine production ... ...

Abstract	Regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress immune response, thereby maintaining homeostasis and self-tolerance. It has been shown that Tregs are able to inhibit T cell proliferation and cytokine production and play a critical role in preventing autoimmunity. Different subsets with various functions of Treg cells exist. Tregs can be usually identified by flow cytometry. The most specific marker for these cells is FoxP3, which is localized intracellulary. Selected surface markers such as CD25high (high molecular density) and CD127low (low molecular density) could serve as surrogate markers to detect Tregs in a routine clinical practice. Dysregulation in Treg cell frequency or functions may lead to the development of autoimmune disease. Therapeutical Treg modulation is considered to be a promising therapeutical approach to treat some selected disorders, such as allergies, and to prevent allograft rejection.
MeSH term(s)	Autoimmune Diseases/immunology ; CD4-Positive T-Lymphocytes/immunology ; Flow Cytometry ; Immune System Diseases/immunology ; Lymphocyte Subsets ; Self Tolerance/immunology ; T-Lymphocytes, Regulatory/immunology
Language	English
Publishing date	2010-07-28
Publishing country	Czech Republic
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1360995-6
ISSN	1211-4286
ISSN	1211-4286
DOI	10.14712/18059694.2016.63
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Article ; Online: Membrane and soluble Toll-like receptor 2 in patients with psoriasis treated by Goeckerman therapy.

Kondelkova, Katerina / Krejsek, Jan / Borska, Lenka / Fiala, Zdenek / Hamakova, Kveta / Ettler, Karel / Andrys, Ctirad

International journal of dermatology

2014 Volume 53, Issue 11, Page(s) e512–7

Abstract: Background: Toll-like receptor (TLR) 2 belongs to the large TLR receptor family comprised of at least 10 members with different roles in innate immunity. Psoriasis is recognized as a T-cell driven immune-mediated systemic inflammatory disease with a ... ...

Abstract	Background: Toll-like receptor (TLR) 2 belongs to the large TLR receptor family comprised of at least 10 members with different roles in innate immunity. Psoriasis is recognized as a T-cell driven immune-mediated systemic inflammatory disease with a skin manifestation. An effective therapeutic approach to treat psoriasis is Goeckerman therapy (GT). The aim of this study was to assess both the kinetics of the expression of TLR2 on blood cells and the concentration of soluble (s)TLR2 in serum of patients with psoriasis and to examine the effect of GT on both TLR2 expression and sTLR2 level. Methods: Both membrane and sTLR2 were determined in 20 patients and 20 healthy controls. sTLR2 was evaluated by enzyme-linked immunosorbent assay. Flow cytometry method was used to determine the expression of membrane TLR2 of monocytes and granulocytes. Results: The serum level of sTLR2 was significantly lower (P < 0.0001) in patients both before and after GT compared to the control group. Compared to the membrane expression of TLR2 on monocytes of healthy blood donors, TLR2 expression was significantly higher in patients both before and after GT (P = 0.0001). Similarly, TLR2 expression on granulocytes was significantly higher in patients both before (P = 0.0061) and after (P < 0.0001) therapy than in control. Conclusions: Membrane and soluble TLR2 may be involved in the pathogenesis of psoriasis. Both remained unchanged by GT.
MeSH term(s)	Adult ; Case-Control Studies ; Cell Membrane/chemistry ; Coal Tar/therapeutic use ; Female ; Granulocytes/chemistry ; Healthy Volunteers ; Humans ; Keratolytic Agents/therapeutic use ; Male ; Middle Aged ; Monocytes/chemistry ; Photochemotherapy ; Psoriasis/blood ; Psoriasis/drug therapy ; Toll-Like Receptor 2/analysis ; Toll-Like Receptor 2/blood ; Ultraviolet Therapy ; Young Adult
Chemical Substances	Keratolytic Agents ; TLR2 protein, human ; Toll-Like Receptor 2 ; Coal Tar (8007-45-2)
Language	English
Publishing date	2014-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.12381
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Article: The Role of Autoimmunity in Gastroenterology

Krejsek, Jan / Hrncirova, Lucia / Kondelkova, Katerina / Andrys, Ctirad

Digestive Diseases

2012 Volume 30, Issue 2, Page(s) 208–211

Abstract: Crohn’s disease (CD) is an immune-mediated chronic intestinal disorder thought to be the result of an aggressive immune response to a subset of enteric bacteria in a genetically predisposed host. Numerous environmental factors are apparently involved in ... ...

Institution	Department of Clinical Immunology, Faculty of Medicine, University Hospital, Charles University in Prague, Hradec Kralove, Czech Republic
Abstract	Crohn’s disease (CD) is an immune-mediated chronic intestinal disorder thought to be the result of an aggressive immune response to a subset of enteric bacteria in a genetically predisposed host. Numerous environmental factors are apparently involved in disease pathogenesis. Impaired ability of CD patients to control the gut microflora is associated with defects in the production of some antibacterial compounds (cryptdins) by epithelial cells. In addition, there are the defects in cytoplasmic NOD-like receptors which are sensing intracellularly localized bacteria in CD patients. These defects together with the failure to induce autophagy lead to lack of bacterial clearance and subsequently to mucosal immunopathology.
Keywords	Crohn’s disease ; Genetics ; Innate immunity ; Pattern recognition receptors ; NOD-like receptors ; Autophagy ; Inflammation
Language	English
Publishing date	2012-06-20
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Paper
ZDB-ID	632798-9
ISBN	978-3-8055-9998-6 ; 978-3-8055-9999-3 ; 3-8055-9998-6 ; 3-8055-9999-4
ISSN	1421-9875 ; 0257-2753
ISSN (online)	1421-9875
ISSN	0257-2753
DOI	10.1159/000336685
Database	Karger publisher's database

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Article: The dynamics of selected local inflammatory markers to talc in the treatment of malignant pleural effusions.

Habal, Petr / Jankovicova, Karolina / Omran, Nedal / Kondelkova, Katerina / Krejsek, Jan / Mandak, Jiri

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

2013 Volume 157, Issue 4, Page(s) 311–315

Abstract: Background: Malignant pleural effusions accumulate in the space between the visceral (inner) layer covering the lungs and the parietal (outer) layer covering the chest wall. Larger effusions compress the pulmonary parenchyma resulting in increasing ... ...

Abstract	Background: Malignant pleural effusions accumulate in the space between the visceral (inner) layer covering the lungs and the parietal (outer) layer covering the chest wall. Larger effusions compress the pulmonary parenchyma resulting in increasing dyspnoea. Treatment is always local and palliative. Among others, chemical pleurodesis using talc can be performed in selected patients. Talc is hydrated magnesium silicate (chemically H₂Mg₃(SiO₃)₄) and has been used for pleurodesis since 1935. Videothoracoscopic talc powder insufflation (talc poudrage) is the most effective.However, markers of inflammatory reactions to extraneous substances like talc are not fully understood. The aim of this study was to assess the course of local inflammatory changes in the pleural cavity after talc insufflation. Methods: The Department of Cardiac Surgery of the Faculty of Medicine and University Hospital in Hradec Kralove, treated 47 patients aged 65 on average; 29 males and 18 females with proven recurrent malignant pleural effusion of various aetiologies from January 2009 to December 2010. They were retrospectively divided into group A (40 patients) without recurring effusion, and group B (7 patients) with recurring effusion and the need for thoracentesis or chest drainage during the 9-month monitoring. Results: Major findings were made in soluble forms of cell receptors. Group B showed statistically higher levels of the anti-inflammatory form of sCD-163 receptor in pleural fluid before the talc poudrage. This showed limited ability to create an adequate inflammatory response to external stimuli. This group also showed lower levels of the inflammatory form of sTLR-2 receptor immediately after the talc insufflation. This revealed low local reactivity to external stimuli. The effect of the treatment was not influenced by morphologic tumour type. No statistically significant differences in postoperative complications were found. This confirmed the safety of both videothoracoscopy and treatment. Conclusions: There was no correlation between the type of malignant affection and the outcome of the chemical pleurodesis. Patients with relapsing effusion have higher values of concentration of anti-inflammatory sCD-163 in pleural fluid even before the application of talc, and lower levels of concentration of inflammatory sTLR-2 immediately after application of talc.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antigens, CD/analysis ; Antigens, Differentiation, Myelomonocytic/analysis ; Biomarkers/analysis ; Female ; Humans ; Male ; Middle Aged ; Pleural Effusion, Malignant/immunology ; Pleural Effusion, Malignant/therapy ; Pleurodesis ; Receptors, Cell Surface/analysis ; Retrospective Studies ; Talc/immunology ; Talc/therapeutic use ; Toll-Like Receptor 2/analysis
Chemical Substances	Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; Biomarkers ; CD163 antigen ; Receptors, Cell Surface ; TLR2 protein, human ; Toll-Like Receptor 2 ; Talc (14807-96-6)
Language	English
Publishing date	2013-12
Publishing country	Czech Republic
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	17196-7
ISSN	1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
ISSN (online)	1804-7521
ISSN	1213-8118 ; 0231-5599 ; 0862-481X
DOI	10.5507/bp.2012.095
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