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  1. Book ; Online ; Thesis: Die Rolle von T-Zellen in der Pathogenese autoimmuner Arthritiden

    Leipe, Jan [Verfasser]

    2021  

    Author's details Jan Leipe
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Fortsetzen oder Pausieren? Die antirheumatische Therapie bei elektiven Operationen.

    Albrecht, Katinka / Leipe, Jan

    Zeitschrift fur Rheumatologie

    2022  Volume 81, Issue 6, Page(s) 492–500

    Abstract: In patients with inflammatory rheumatic diseases, a decision is needed prior to elective surgery on whether the medicinal treatment can be continued or whether the dose needs to be changed or interrupted. The German Society for Rheumatology (DGRh) has ... ...

    Title translation Continue or interrupt? Antirheumatic treatment in elective surgery.
    Abstract In patients with inflammatory rheumatic diseases, a decision is needed prior to elective surgery on whether the medicinal treatment can be continued or whether the dose needs to be changed or interrupted. The German Society for Rheumatology (DGRh) has developed updated recommendations that specify a course of action for disease-modifying antirheumatic drugs (DMARD) and glucocorticoids. The recommendations for action can be adapted to the individual situation and coordinated with the interdisciplinary treating physicians and the patient. Depending on the dose, glucocorticoids have a high risk of infection and should be set as low as possible in the preoperative period. Most of the conventional synthetic (cs)DMARDs can be continued. Under biologic (b)DMARDs treatment surgery can be scheduled for the end of each treatment interval. It is recommended that Janus kinase (JAK) inhibitors should be interrupted for 3-4 days before major interventions. Treatment should be restarted as soon as possible, depending on the wound healing.
    MeSH term(s) Antirheumatic Agents/adverse effects ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/surgery ; Glucocorticoids/therapeutic use ; Humans ; Janus Kinase Inhibitors/therapeutic use ; Rheumatology
    Chemical Substances Antirheumatic Agents ; Glucocorticoids ; Janus Kinase Inhibitors
    Language German
    Publishing date 2022-07-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-022-01236-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Die Rolle von GATA-3 in der humanen Th2-Zell-Differenzierung

    Leipe, Jan

    2004  

    Author's details vorgelegt von Jan Leipe
    Language German ; English
    Size 27 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss
    Note Beitr. teilw. dt., teilw. engl.
    HBZ-ID HT014718393
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  4. Article: Sicherheit von JAK-Inhibitoren

    Leipe, Jan

    Arthritis + Rheuma

    2019  Volume 39, Issue 4, Page(s) 249

    Language German
    Document type Article
    ZDB-ID 605764-0
    ISSN 0176-5167
    Database Current Contents Medicine

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  5. Article: Sicherheit von JAK-Inhibitoren

    Leipe, Jan

    Arthritis und Rheuma

    2019  Volume 39, Issue 04, Page(s) 249–252

    Abstract: Die zugelassenen Januskinase (JAK)-Inhibitoren Baricitinib und Tofacitinib haben bereits das Armamentarium hochwirksamer Therapien bei rheumatoider Arthritis, Psoriasis-Arthritis und Colitis ulcerosa erweitert. Als Alternative zu Biologika unterscheiden ... ...

    Abstract Die zugelassenen Januskinase (JAK)-Inhibitoren Baricitinib und Tofacitinib haben bereits das Armamentarium hochwirksamer Therapien bei rheumatoider Arthritis, Psoriasis-Arthritis und Colitis ulcerosa erweitert. Als Alternative zu Biologika unterscheiden sie sich jedoch durch den Wirkmechanismus (Hemmung intrazellulärer Signalübertragung) und die orale Verfügbarkeit. Die Sicherheit ist jedoch ähnlich gut wie bei Biologika, am häufigsten kommen leichtgradige Infekte der oberen Atemwege vor. Verhältnismäßig seltene, aber spezifische Nebenwirkungen stellen Herpes-Zoster-Infektionen dar. Schwere Infektionen werden nur selten beobachtet. Nicht-infektiöse Nebenwirkungen beinhalten Laborwertveränderungen in Form von Zytopenien, Anstieg von Cholesterin (scheinbar ohne Erhöhung des kardiovaskulären Risikos), selten Leber- und Nierenwert-Erhöhungen sowie vermutlich ein erhöhtes Thromboembolie-Risiko bei bestimmten Risikokonstellationen.

    The approved Janus kinase (JAK) inhibitors Baricitinib und Tofacitinib have already extended the armantarium of highly effective therapies in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ulcerative colitis. As alternatives to biologicals, JAK inhibitors however differ by their mode of action (inhibition of intracellular signaling) und oral availability. The safety is similarly favorable like already known for biologicals, with the most frequent adverse events being low-grade upper airway infections. Herpes zoster infections are rare, but specific for JAK inhibitors. Serious infections are very rare. Non-infectious adverse events include cytopenia, laboratory changes with increase of cholesterol (without changing the cardiovascular risk), very rare increases of transaminase and creatinine levels and as well as a potential risk of thromboembolic events in certain risk constellations.
    Keywords JAK-Inhibitoren ; Baricitinib ; Tofacitinib ; Sicherheit ; Infektionen ; JAK-inhibitors ; Baricitinib ; Tofacitinib ; safety ; infections
    Language German
    Publishing date 2019-08-01
    Publisher © Georg Thieme Verlag KG Stuttgart · New York
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2223481-0
    ISSN 2567-5753 ; 0176-5167
    ISSN (online) 2567-5753
    ISSN 0176-5167
    DOI 10.1055/a-0965-1781
    Database Thieme publisher's database

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  6. Article: Langfristige "Kortison"-Einnahme begünstigt Knochenbrüche

    Leipe, Jan / Holle, Julia U.

    Morbus-Bechterew-Journal

    2022  Volume 43, Issue 168, Page(s) 17

    Language German
    Document type Article
    ZDB-ID 2119820-2
    ISSN 1861-2105
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Mimickers of Immune Checkpoint Inhibitor-induced Inflammatory Arthritis.

    Gómez-Puerta, José A / Gente, Karolina / Katsumoto, Tamiko R / Leipe, Jan / Reid, Pankti / van Binsbergen, Wouter H / Suarez-Almazor, Maria E

    Rheumatic diseases clinics of North America

    2024  Volume 50, Issue 2, Page(s) 161–179

    Abstract: The differential diagnosis of inflammatory arthritis as an immune-related adverse event can be challenging as patients with cancer can present with musculoskeletal symptoms that can mimic arthritis because of localized or generalized joint pain. In ... ...

    Abstract The differential diagnosis of inflammatory arthritis as an immune-related adverse event can be challenging as patients with cancer can present with musculoskeletal symptoms that can mimic arthritis because of localized or generalized joint pain. In addition, immune checkpoint inhibitors can exacerbate joint conditions such as crystal-induced arthritis or osteoarthritis, or induce systemic disease that can affect the joints such as sarcoidosis. This distinction is important as the treatment of these conditions can be different from that of immune-related inflammatory arthritis.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Diagnosis, Differential ; Arthritis/diagnosis ; Arthritis/chemically induced ; Arthritis/drug therapy ; Sarcoidosis/chemically induced ; Sarcoidosis/diagnosis ; Sarcoidosis/immunology ; Neoplasms/drug therapy ; Neoplasms/immunology ; Osteoarthritis/drug therapy ; Osteoarthritis/immunology ; Crystal Arthropathies/diagnosis ; Crystal Arthropathies/immunology
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2024.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Management of rheumatic complications of ICI therapy: a rheumatology viewpoint.

    Leipe, Jan / Mariette, Xavier

    Rheumatology (Oxford, England)

    2019  Volume 58, Issue Suppl 7, Page(s) vii49–vii58

    Abstract: Since immune checkpoint inhibitors became the standard of care for an increasing number of indications, more patients have been exposed to these drugs and physicians are more challenged with the management of a unique spectrum of immune-related adverse ... ...

    Abstract Since immune checkpoint inhibitors became the standard of care for an increasing number of indications, more patients have been exposed to these drugs and physicians are more challenged with the management of a unique spectrum of immune-related adverse events (irAEs) associated with immune checkpoint inhibitors. Those irAEs of autoimmune or autoinflammatory origin, or both, can involve any organ or tissue, but most commonly affect the dermatological, gastrointestinal and endocrine systems. Rheumatic/systemic irAEs seem to be less frequent (although underreporting in clinical trials is probable), but information on their management is highly relevant given that they can persist longer than other irAEs. Their management consists of anti-inflammatory treatment including glucocorticoids, synthetic and biologic immunomodulatory/immunosuppressive drugs, symptomatic therapies as well as holding or, rarely, discontinuation of immune checkpoint inhibitors. Here, we summarize the management of rheumatic/systemic irAEs based on data from clinical trials but mainly from published case reports and series, contextualize them and propose perspectives for their treatment.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthritis/chemically induced ; Arthritis/drug therapy ; Connective Tissue Diseases/chemically induced ; Connective Tissue Diseases/drug therapy ; Glucocorticoids/therapeutic use ; Humans ; Immunologic Factors/adverse effects ; Immunologic Factors/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Immunotherapy/adverse effects ; Immunotherapy/methods ; Myositis/chemically induced ; Myositis/drug therapy ; Neoplasms/drug therapy ; Polymyalgia Rheumatica/chemically induced ; Polymyalgia Rheumatica/drug therapy ; Rheumatic Diseases/chemically induced ; Rheumatic Diseases/drug therapy
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Antineoplastic Agents, Immunological ; Antirheumatic Agents ; Glucocorticoids ; Immunologic Factors ; Immunosuppressive Agents
    Language English
    Publishing date 2019-12-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kez360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Rheuma-Therapie bei Operationen nur kurz unterbrechen

    Albrecht, Katinka / Poddubnyy, Denis / Leipe, Jan

    Morbus-Bechterew-Journal

    2022  Volume 43, Issue 169, Page(s) 14

    Language German
    Document type Article
    ZDB-ID 2119820-2
    ISSN 1861-2105
    Database Current Contents Medicine

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  10. Article: Entzündliche Wirbelsäulenerkrankungen im Verbund mit entzündlichen Darm-Erkrankungen

    Albrecht, Katinka / Poddubnyy, Denis / Leipe, Jan

    Morbus-Bechterew-Journal

    2022  Volume 43, Issue 170, Page(s) 13

    Language German
    Document type Article
    ZDB-ID 2119820-2
    ISSN 1861-2105
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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