LIVIVO - Search results -

Search results

Result 1 - 10 of total 58

Search options

Article ; Online: IL-2 targeted to CD8+ T cells promotes robust effector T cell responses and potent antitumor immunity.

Moynihan, Kelly D / Kumar, Manu P / Sultan, Hussein / Pappas, Danielle C / Park, Terrence / Chin, S Michael / Bessette, Paul / Lan, Ruth Y / Nguyen, Henry C / Mathewson, Nathan D / Ni, Irene / Chen, Wei / Lee, Yonghee / Liao-Chan, Sindy / Chen, Jessie / Schumacher, Ton N M / Schreiber, Robert D / Yeung, Yik A / Djuretic, Ivana M

Cancer discovery

2024

Abstract: IL-2 signals pleiotropically on diverse cell types, some of which contribute to therapeutic activity against tumors, while others drive undesired activity, such as immunosuppression or toxicity. We explored the theory that targeting of IL-2 to CD8+ T ... ...

Abstract	IL-2 signals pleiotropically on diverse cell types, some of which contribute to therapeutic activity against tumors, while others drive undesired activity, such as immunosuppression or toxicity. We explored the theory that targeting of IL-2 to CD8+ T cells, which are key anti-tumor effectors, could enhance its therapeutic index. To this aim, we developed AB248, CD8 cis-targeted IL-2 that demonstrates over 500-fold preference for CD8+ T cells over NK and Treg cells, which may contribute to toxicity and immunosuppression, respectively. AB248 recapitulated IL-2's effects on CD8+ T cells in vitro and induced selective expansion of CD8+ T cells in primates. In mice, an AB248 surrogate demonstrated superior anti-tumor activity and enhanced tolerability as compared to an untargeted IL-2RBy agonist. Efficacy was associated with expansion and phenotypic enhancement of tumor-infiltrating CD8+ T cells, including the emergence of a "better effector" population. These data support the potential utility of AB248 in clinical settings.
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625242-9
ISSN	2159-8290 ; 2159-8274
ISSN (online)	2159-8290
ISSN	2159-8274
DOI	10.1158/2159-8290.CD-23-1266
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6916: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Enhanced Biofilm Eradication and Reduced Cytotoxicity of a Novel Polygalacturonic and Caprylic Acid Wound Ointment Compared with Common Antiseptic Ointments.

Gerges, Bahgat Z / Rosenblatt, Joel / Truong, Y-Lan / Reitzel, Ruth A / Hachem, Ray / Raad, Issam I

BioMed research international

2021 Volume 2021, Page(s) 2710484

Abstract: Antiseptic wound ointments are widely used to treat dermal wounds that are microbially contaminated. Polygalacturonic acid (PG)+caprylic acid (CAP) is a novel combination that has been shown to eradicate biofilms. We developed a novel PG+CAP ointment and ...

Abstract	Antiseptic wound ointments are widely used to treat dermal wounds that are microbially contaminated. Polygalacturonic acid (PG)+caprylic acid (CAP) is a novel combination that has been shown to eradicate biofilms. We developed a novel PG+CAP ointment and compared the biofilm eradication capability and cytotoxicity of PG+CAP with that of commercially available antiseptic wound ointments. We used a well-established biofilm model to quantitatively assess the eradication of organisms following exposure to the wound ointments for 2 hours. PG+CAP ointment completely eradicated
MeSH term(s)	Animals ; Anti-Infective Agents, Local/chemistry ; Anti-Infective Agents, Local/pharmacology ; Biofilms/drug effects ; Biofilms/growth & development ; Candida albicans/physiology ; Caprylates/chemistry ; Caprylates/pharmacology ; Cell Line ; Methicillin-Resistant Staphylococcus aureus/physiology ; Mice ; Ointments ; Pectins/chemistry ; Pectins/pharmacology ; Pseudomonas aeruginosa/physiology
Chemical Substances	Anti-Infective Agents, Local ; Caprylates ; Ointments ; Pectins (89NA02M4RX) ; octanoic acid (OBL58JN025) ; polygalacturonic acid (VV3XD4CL04)
Language	English
Publishing date	2021-02-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2021/2710484
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Review of allergic reactions from use of chlorhexidine on medical products in clinical settings over 40 years: Risks and mitigations.

Gerges, Bahgat Z / Rosenblatt, Joel / Truong, Y-Lan / Reitzel, Ruth A / Raad, Isaam

Infection control and hospital epidemiology

2021 Volume 43, Issue 6, Page(s) 775–789

Abstract: Chlorhexidine is an antimicrobial agent widely used for infection prevention in medical settings. Nevertheless, allergic reactions ranging from mild to severe have been reported following its use. In this review, we analyzed all case reports published ... ...

Abstract	Chlorhexidine is an antimicrobial agent widely used for infection prevention in medical settings. Nevertheless, allergic reactions ranging from mild to severe have been reported following its use. In this review, we analyzed all case reports published between the introduction of chlorhexidine and the end of 2019 for allergic responses associated with the use of medical devices and or other medical products containing chlorhexidine (CHX) to ascertain the prevalence of severe CHX allergic reactions and what practices might best mitigate those risks.In total, 77 publications containing 124 reported cases of allergic reactions were grouped into 3 product categories, catheters, semisolids, and fluid products. The country, type of reaction, route of sensitization, allergy confirmation, and intervention or mitigation was extracted for each case. Overall, 30 cases were associated with catheters, 46 cases were associated with semisolid products, and 48 cases were associated with the use of other medical products. Severe cases were managed with intravenous fluids, steroids, and epinephrine (adrenaline). None of the reported cases were fatal. The allergy risks can be mitigated by better warning and training clinicians and by recording and screening patient histories for CHX presensitization from prior exposure. For patients undergoing pre-use blood tests, IgE antibody screens can also be performed. Finally, as a precaution in the event a rare severe allergic reaction occurs, procedure carts and rooms can be prestocked with injectable epinephrine and other rapidly acting anti-inflammatory medications.
MeSH term(s)	Anti-Infective Agents, Local/adverse effects ; Chlorhexidine/adverse effects ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/epidemiology ; Epinephrine ; Humans ; Prevalence
Chemical Substances	Anti-Infective Agents, Local ; Chlorhexidine (R4KO0DY52L) ; Epinephrine (YKH834O4BH)
Language	English
Publishing date	2021-06-03
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2021.150
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1714: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Enhanced Biofilm Eradication and Reduced Cytotoxicity of a Novel Polygalacturonic and Caprylic Acid Wound Ointment Compared with Common Antiseptic Ointments

Bahgat Z. Gerges / Joel Rosenblatt / Y-Lan Truong / Ruth A. Reitzel / Ray Hachem / Issam I. Raad

BioMed Research International, Vol

2021 Volume 2021

Abstract	Antiseptic wound ointments are widely used to treat dermal wounds that are microbially contaminated. Polygalacturonic acid (PG)+caprylic acid (CAP) is a novel combination that has been shown to eradicate biofilms. We developed a novel PG+CAP ointment and compared the biofilm eradication capability and cytotoxicity of PG+CAP with that of commercially available antiseptic wound ointments. We used a well-established biofilm model to quantitatively assess the eradication of organisms following exposure to the wound ointments for 2 hours. PG+CAP ointment completely eradicated Candida albicans, multidrug-resistant Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus biofilms, whereas MediHoney, polyhexamethylene biguanide (PHMB), and benzalkonium chloride (BZK) ointments failed to eradicate all biofilms within 2 hours. We assessed cytotoxicity by exposing L-929 fibroblasts to extracts of each ointment; Trypan blue exclusion was used to assess cell viability, and Alamar blue conversion was used to assess metabolic function. After exposure to PG+CAP and MediHoney, fibroblast viability was 96.23% and 95.23%, respectively (Trypan blue), and was comparable to untreated cells (98.77%). PHMB and BZK showed reduced viability (83.25% and 77.83%, respectively, p<0.05). Metabolic activity results followed a similar pattern. Cytotoxicity of PG+CAP ointment towards erythrocytes was comparable to saline. PG+CAP ointment seems to be safe and can rapidly eradicate microbial biofilm; thus, PG+CAP ointment merits further in vivo testing as a potential antimicrobial wound ointment.
Keywords	Medicine ; R
Subject code	580
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models.

Campbell, Joseph R / McDonald, Bryan R / Mesko, Paul B / Siemers, Nathan O / Singh, Priti B / Selby, Mark / Sproul, Tim W / Korman, Alan J / Vlach, Logan M / Houser, Jeff / Sambanthamoorthy, Sharmila / Lu, Kai / Hatcher, Sandra V / Lohre, Jack / Jain, Renu / Lan, Ruth Y

Cancer research

2021 Volume 81, Issue 11, Page(s) 2983–2994

Abstract: ... ...

Abstract	FOXP3
MeSH term(s)	Animals ; Antibodies, Monoclonal/pharmacology ; Apoptosis ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immune Tolerance/immunology ; Immunoglobulin Fc Fragments/immunology ; Immunotherapy/methods ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Receptors, CCR8/antagonists & inhibitors ; Receptors, CCR8/immunology ; Skin/drug effects ; Skin/immunology ; Skin/metabolism ; Skin/pathology ; T-Lymphocytes, Regulatory/immunology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Chemical Substances	Antibodies, Monoclonal ; CCR8 protein, human ; Immunoglobulin Fc Fragments ; Programmed Cell Death 1 Receptor ; Receptors, CCR8
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-20-3585
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.135/5: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates axon guidance genes in Drosophila.

Singh, Badri Nath / Tran, Hiep / Kramer, Joseph / Kirichenko, Elmira / Changela, Neha / Wang, Fei / Feng, Yaping / Kumar, Dibyendu / Tu, Min / Lan, Jie / Bizet, Martin / Fuks, François / Steward, Ruth

PloS one

2024 Volume 19, Issue 2, Page(s) e0293894

Abstract: Modifications of mRNA, especially methylation of adenosine, have recently drawn much attention. The much rarer modification, 5-hydroxymethylation of cytosine (5hmC), is not well understood and is the subject of this study. Vertebrate Tet proteins are 5- ... ...

Abstract	Modifications of mRNA, especially methylation of adenosine, have recently drawn much attention. The much rarer modification, 5-hydroxymethylation of cytosine (5hmC), is not well understood and is the subject of this study. Vertebrate Tet proteins are 5-methylcytosine (5mC) hydroxylases and catalyze the transition of 5mC to 5hmC in DNA. These enzymes have recently been shown to have the same function in messenger RNAs in both vertebrates and in Drosophila. The Tet gene is essential in Drosophila as Tet knock-out animals do not reach adulthood. We describe the identification of Tet-target genes in the embryo and larval brain by mapping one, Tet DNA-binding sites throughout the genome and two, the Tet-dependent 5hmrC modifications transcriptome-wide. 5hmrC modifications are distributed along the entire transcript, while Tet DNA-binding sites are preferentially located at the promoter where they overlap with histone H3K4me3 peaks. The identified mRNAs are preferentially involved in neuron and axon development and Tet knock-out led to a reduction of 5hmrC marks on specific mRNAs. Among the Tet-target genes were the robo2 receptor and its slit ligand that function in axon guidance in Drosophila and in vertebrates. Tet knock-out embryos show overlapping phenotypes with robo2 and both Robo2 and Slit protein levels were markedly reduced in Tet KO larval brains. Our results establish a role for Tet-dependent 5hmrC in facilitating the translation of modified mRNAs primarily in cells of the nervous system.
MeSH term(s)	Animals ; Cytosine/metabolism ; Drosophila/genetics ; Drosophila/metabolism ; DNA Methylation ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Axon Guidance ; DNA-Binding Proteins/metabolism ; 5-Methylcytosine/metabolism ; DNA/metabolism ; Dioxygenases/genetics
Chemical Substances	Cytosine (8J337D1HZY) ; RNA, Messenger ; DNA-Binding Proteins ; 5-Methylcytosine (6R795CQT4H) ; DNA (9007-49-2) ; Dioxygenases (EC 1.13.11.-)
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0293894
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Relationship between Emphysema Progression at CT and Mortality in Ever-Smokers: Results from the COPDGene and ECLIPSE Cohorts.

Ash, Samuel Y / San José Estépar, Raúl / Fain, Sean B / Tal-Singer, Ruth / Stockley, Robert A / Nordenmark, Lars H / Rennard, Stephen / Han, MeiLan K / Merrill, Debora / Humphries, Stephen M / Diaz, Alejandro A / Mason, Stefanie E / Rahaghi, Farbod N / Pistenmaa, Carrie L / Sciurba, Frank C / Vegas-Sánchez-Ferrero, Gonzalo / Lynch, David A / Washko, George R

Radiology

2021 Volume 299, Issue 1, Page(s) 222–231

Abstract: Background The relationship between emphysema progression and long-term outcomes is unclear. Purpose To determine the relationship between emphysema progression at CT and mortality among participants with emphysema. Materials and Methods In a secondary ... ...

Abstract	Background The relationship between emphysema progression and long-term outcomes is unclear. Purpose To determine the relationship between emphysema progression at CT and mortality among participants with emphysema. Materials and Methods In a secondary analysis of two prospective observational studies, COPDGene (
MeSH term(s)	Aged ; Clinical Trials as Topic ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Pulmonary Emphysema/diagnostic imaging ; Pulmonary Emphysema/mortality ; Smokers ; Tomography, X-Ray Computed/methods ; United States/epidemiology
Language	English
Publishing date	2021-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.2021203531
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ue I Zs.106: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates the axon guidance genes

Singh, Badri Nath / Tran, Hiep / Kramer, Joseph / Kirishenko, Elmira / Changela, Neha / Wang, Fei / Feng, Yaping / Kumar, Dibyendu / Tu, Min / Lan, Jie / Bizet, Martin / Fuks, François / Steward, Ruth

Research square

2023

Abstract	Modifications of mRNA, especially methylation of adenosine, have recently drawn much attention. The much rarer modification, 5-hydroxymethylation of cytosine (5hmC), is not well understood and is the subject of this study. Vertebrate Tet proteins are 5-methylcytosine (5mC) hydroxylases enzymes catalyzing the transition of 5mC to 5hmC in DNA and have recently been shown to have the same function in messenger RNAs in both vertebrates and in Drosophila. The
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-2511705/v1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates axon guidance genes in Drosophila.

bioRxiv : the preprint server for biology

2023

Abstract	Modifications of mRNA, especially methylation of adenosine, have recently drawn much attention. The much rarer modification, 5-hydroxymethylation of cytosine (5hmC), is not well understood and is the subject of this study. Vertebrate Tet proteins are 5-methylcytosine (5mC) hydroxylases and catalyze the transition of 5mC to 5hmC in DNA. These enzymes have recently been shown to have the same function in messenger RNAs in both vertebrates and in Drosophila. The Tet gene is essential in Drosophila as Tet knock-out animals do not reach adulthood. We describe the identification of Tet-target genes in the embryo and larval brain by mapping one, Tet DNA-binding sites throughout the genome and two, the Tet-dependent 5hmrC modifications transcriptome-wide. 5hmrC modifications are distributed along the entire transcript, while Tet DNA-binding sites are preferentially located at the promoter where they overlap with histone H3K4me3 peaks. The identified mRNAs are preferentially involved in neuron and axon development and Tet knock-out led to a reduction of 5hmrC marks on specific mRNAs. Among the Tet-target genes were the robo2 receptor and its slit ligand that function in axon guidance in Drosophila and in vertebrates. Tet knock-out embryos show overlapping phenotypes with robo2 and both Robo2 and Slit protein levels were markedly reduced in Tet KO larval brains. Our results establish a role for Tet-dependent 5hmrC in facilitating the translation of modified mRNAs primarily in cells of the nervous system.
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.03.522592
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: The immunopathology of human biliary cell epithelium.

Chuang, Ya-Hui / Lan, Ruth Y / Gershwin, M Eric

Seminars in immunopathology

2009 Volume 31, Issue 3, Page(s) 323–331

Abstract: Bile ducts lined with biliary epithelial cells, or cholangiocytes, are the main components of the biliary system in liver. Cholangiocytes participate in the production and transport of bile substances, as well as participate in immune responses. ... ...

Abstract	Bile ducts lined with biliary epithelial cells, or cholangiocytes, are the main components of the biliary system in liver. Cholangiocytes participate in the production and transport of bile substances, as well as participate in immune responses. Cholangiocytes protect against pathogens by expressing toll-like receptors and anti-microbial peptides; act as antigen-presenting cells by expressing human leukocyte antigen molecules and costimulatory molecules; recruit leukocytes to the target site by expressing adhesion molecules, cytokines, and chemokines; and induce apoptosis of leukocytes to limit the immune responses. Several cholangiopathies result from dysfunctions of the biliary system. They can broadly be divided into autoimmune, genetic, infectious, drug, and ischemic-injury-induced categories. The pathogenesis of many of these cholangiopathies is unclear and treatment is limited. Further understanding of the complexity of the biliary system is critical for medical advancements in this field.
MeSH term(s)	Antigen Presentation/immunology ; Antimicrobial Cationic Peptides/immunology ; Antimicrobial Cationic Peptides/metabolism ; Apoptosis/immunology ; Biliary Tract/immunology ; Biliary Tract/metabolism ; Biliary Tract Diseases/immunology ; Biliary Tract Diseases/metabolism ; Biliary Tract Diseases/physiopathology ; Cell Adhesion Molecules/immunology ; Cell Adhesion Molecules/metabolism ; Cytokines/immunology ; Cytokines/metabolism ; Epithelium/immunology ; Epithelium/metabolism ; Humans ; Immunoglobulin A, Secretory/immunology ; Immunoglobulin A, Secretory/metabolism ; Liver/immunology ; Liver/pathology ; Toll-Like Receptors/immunology ; Toll-Like Receptors/metabolism
Chemical Substances	Antimicrobial Cationic Peptides ; Cell Adhesion Molecules ; Cytokines ; Immunoglobulin A, Secretory ; Toll-Like Receptors
Language	English
Publishing date	2009-06-17
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2316828-6
ISSN	1863-2300 ; 1863-2297
ISSN (online)	1863-2300
ISSN	1863-2297
DOI	10.1007/s00281-009-0172-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1425: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito