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  1. Article ; Online: Regulatory T-cells in asthma.

    Harb, Hani / Chatila, Talal A

    Current opinion in allergy and clinical immunology

    2023  Volume 23, Issue 2, Page(s) 151–157

    Abstract: Purpose of review: This review addresses recent progress in our understanding of the role of regulatory T (Treg) cells in enforcing immune tolerance and tissue homeostasis in the lung at steady state and in directing the immune response in asthmatic ... ...

    Abstract Purpose of review: This review addresses recent progress in our understanding of the role of regulatory T (Treg) cells in enforcing immune tolerance and tissue homeostasis in the lung at steady state and in directing the immune response in asthmatic lung inflammation.
    Recent findings: Regulatory T cells regulate the innate and adaptive immune responses at steady state to enforce immune tolerance in lung tissues at steady state and their control of the allergic inflammatory responses induced by allergens. This regulatory function can break down in the context of chronic asthmatic airway inflammation such that the lung tissue Treg cells become skewed towards a pathogenic phenotype that aggravates and perpetuates disease. Subversion of lung tissue Treg cell function involves their upregulation of Notch4 expression, which in turn acts to amplify T helper type 2 and type 17 and innate lymphoid cell type 2 responses in the airways.
    Summary: A dual role for Treg cells has emerged both as immune regulators but also a potential disease effectors in asthma, with implications for disease therapy.
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; Immunity, Innate ; Lymphocytes ; Asthma ; Lung/pathology ; Inflammation/metabolism ; Allergens
    Chemical Substances Allergens
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000887
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  2. Article ; Online: Recent patents in allergy and immunology: Method for treating asthma or allergic disease via anti-Notch4 mAb.

    Harb, Hani / Chatila, Talal A

    Allergy

    2022  Volume 77, Issue 7, Page(s) 2260–2261

    MeSH term(s) Allergy and Immunology ; Asthma/therapy ; Humans ; Hypersensitivity/therapy
    Language English
    Publishing date 2022-04-28
    Publishing country Denmark
    Document type News ; Research Support, N.I.H., Extramural
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15317
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  3. Article ; Online: An embarrassment of riches: RORγt

    Stephen-Victor, Emmanuel / Chatila, Talal A

    Immunity

    2022  Volume 55, Issue 11, Page(s) 1978–1980

    Abstract: ... ...

    Abstract RORγt
    MeSH term(s) Nuclear Receptor Subfamily 1, Group F, Member 3 ; Peripheral Tolerance ; Embarrassment ; T-Lymphocytes, Regulatory ; Antigen-Presenting Cells ; Th17 Cells ; Forkhead Transcription Factors ; Immune Tolerance
    Chemical Substances Nuclear Receptor Subfamily 1, Group F, Member 3 ; Forkhead Transcription Factors
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.10.009
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  4. Article ; Online: Regulatory T cells in allergic inflammation.

    Benamar, Mehdi / Chen, Qian / Martinez-Blanco, Monica / Chatila, Talal A

    Seminars in immunology

    2023  Volume 70, Page(s) 101847

    Abstract: Regulatory T (Treg) cells maintain immune tolerance to allergens at the environmental interfaces in the airways, skin and gut, marshalling in the process distinct immune regulatory circuits operative in the respective tissues. Treg cells are coordinately ...

    Abstract Regulatory T (Treg) cells maintain immune tolerance to allergens at the environmental interfaces in the airways, skin and gut, marshalling in the process distinct immune regulatory circuits operative in the respective tissues. Treg cells are coordinately mobilized with allergic effector mechanisms in the context of a tissue-protective allergic inflammatory response against parasites, toxins and potentially harmful allergens, serving to both limit the inflammation and promote local tissue repair. Allergic diseases are associated with subverted Treg cell responses whereby a chronic allergic inflammatory environment can skew Treg cells toward pathogenic phenotypes that both perpetuate and aggravate disease. Interruption of Treg cell subversion in chronic allergic inflammatory conditions may thus provide novel therapeutic strategies by re-establishing effective immune regulation.
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; Hypersensitivity/therapy ; Allergens ; Inflammation/pathology ; Immune Tolerance
    Chemical Substances Allergens
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2023.101847
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  5. Article ; Online: Innate Immunity in Asthma.

    Chatila, Talal A

    The New England journal of medicine

    2016  Volume 375, Issue 5, Page(s) 477–479

    MeSH term(s) Agriculture ; Animals ; Asthma/immunology ; Environmental Exposure ; Female ; Humans ; Immunity, Innate ; Male
    Language English
    Publishing date 2016-08-04
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1607438
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  6. Article ; Online: Regulatory T cells in dominant immunologic tolerance.

    Georgiev, Peter / Benamar, Mehdi / Han, SeongJun / Haigis, Marcia C / Sharpe, Arlene H / Chatila, Talal A

    The Journal of allergy and clinical immunology

    2023  Volume 153, Issue 1, Page(s) 28–41

    Abstract: Regulatory T cells expressing the transcription factor forkhead box protein 3 mediate peripheral immune tolerance both to self-antigens and to the commensal flora. Their defective function due to inborn errors of immunity or acquired insults is ... ...

    Abstract Regulatory T cells expressing the transcription factor forkhead box protein 3 mediate peripheral immune tolerance both to self-antigens and to the commensal flora. Their defective function due to inborn errors of immunity or acquired insults is associated with a broad range of autoimmune and immune dysregulatory diseases. Although their function in suppressing autoimmunity and enforcing commensalism is established, a broader role for regulatory T cells in tissue repair and metabolic regulation has emerged, enabled by unique programs of tissue adaptability and specialization. In this review, we focus on the myriad roles played by regulatory T cells in immunologic tolerance and host homeostasis and the potential to harness these cells in novel therapeutic approaches to human diseases.
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; Immune Tolerance ; Immune System Diseases/metabolism ; Autoimmunity ; Forkhead Transcription Factors ; Autoimmune Diseases
    Chemical Substances Forkhead Transcription Factors
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.09.025
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  7. Article ; Online: Mechanisms of Dupilumab.

    Harb, Hani / Chatila, Talal A

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2019  Volume 50, Issue 1, Page(s) 5–14

    Abstract: The Th2 cytokines interleukin 4 (IL-4) and IL-13 and the heterodimeric IL-4 receptor (IL-4R) complexes that they interact with play a key role in the pathogenesis of allergic disorders. Dupilumab is a humanized IgG4 monoclonal antibody that targets the ... ...

    Abstract The Th2 cytokines interleukin 4 (IL-4) and IL-13 and the heterodimeric IL-4 receptor (IL-4R) complexes that they interact with play a key role in the pathogenesis of allergic disorders. Dupilumab is a humanized IgG4 monoclonal antibody that targets the IL-4 receptor alpha chain (IL-4Rα), common to both IL-4R complexes: type 1 (IL-4Rα/γc; IL-4 specific) and type 2 (IL-4Rα/IL-13Rα1; IL-4 and IL-13 specific). In this review, we detail the current state of knowledge of the different signalling pathways coupled to the IL-4R complexes and examine the possible mechanisms of Dupilumab action and survey its clinical efficacy in different allergic disorders. The development of Dupilumab and the widening spectrum of its clinical applications is relevant to the current emphasis on precision medicine approaches to the blockade of pathways involved in allergic diseases.
    MeSH term(s) Anaphylaxis/immunology ; Anti-Allergic Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Asthma/immunology ; Chronic Disease ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/immunology ; Eosinophilic Esophagitis/drug therapy ; Eosinophilic Esophagitis/immunology ; Food Hypersensitivity/drug therapy ; Food Hypersensitivity/immunology ; Humans ; Inflammation/immunology ; Interleukin-13/immunology ; Interleukin-4/immunology ; Interleukin-4 Receptor alpha Subunit/antagonists & inhibitors ; Interleukin-4 Receptor alpha Subunit/immunology ; Nasal Polyps/drug therapy ; Nasal Polyps/immunology ; Rhinitis, Allergic/drug therapy ; Rhinitis, Allergic/immunology ; STAT6 Transcription Factor/immunology ; Sinusitis/drug therapy ; Sinusitis/immunology ; T-Lymphocytes, Regulatory/immunology ; Th2 Cells/immunology
    Chemical Substances Anti-Allergic Agents ; Antibodies, Monoclonal, Humanized ; Interleukin-13 ; Interleukin-4 Receptor alpha Subunit ; STAT6 Transcription Factor ; Interleukin-4 (207137-56-2) ; dupilumab (420K487FSG)
    Language English
    Publishing date 2019-09-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.13491
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  8. Article ; Online: CPHEN-014: Comprehensive phenotyping of mouse regulatory T cells relevant to viral infections.

    Chen, Qian / Benamar, Mehdi / Chan, Tsz Man Fion / Wang, Muyun / Chatila, Talal A

    Cytometry. Part A : the journal of the International Society for Analytical Cytology

    2022  Volume 101, Issue 12, Page(s) 1000–1005

    Abstract: Regulatory T (Treg) cells are a specialized subpopulation of ... ...

    Abstract Regulatory T (Treg) cells are a specialized subpopulation of CD4
    MeSH term(s) Mice ; Animals ; T-Lymphocytes, Regulatory/metabolism ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Immune Tolerance ; Cell Differentiation ; Virus Diseases/metabolism
    Chemical Substances Forkhead Transcription Factors
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2099868-5
    ISSN 1552-4930 ; 0196-4763 ; 1552-4922
    ISSN (online) 1552-4930
    ISSN 0196-4763 ; 1552-4922
    DOI 10.1002/cyto.a.24655
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  9. Article ; Online: The Impact of Russia-Ukraine geopolitical conflict on the air quality and toxicological properties of ambient PM

    Aghaei, Yashar / Badami, Mohammad Mahdi / Tohidi, Ramin / Subramanian, P S Ganesh / Boffi, Roberto / Borgini, Alessandro / De Marco, Cinzia / Contiero, Paolo / Ruprecht, Ario Alberto / Verma, Vishal / Chatila, Talal / Sioutas, Constantinos

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5996

    Abstract: The geopolitical conflict between Russia and Ukraine has disrupted Europe's natural gas supplies, driving up gas prices and leading to a shift towards biomass for residential heating during colder months. This study assessed the consequent air quality ... ...

    Abstract The geopolitical conflict between Russia and Ukraine has disrupted Europe's natural gas supplies, driving up gas prices and leading to a shift towards biomass for residential heating during colder months. This study assessed the consequent air quality and toxicological impacts in Milan, Italy, focusing on fine particulate matter (PM
    MeSH term(s) Air Pollutants/analysis ; Ukraine ; Environmental Monitoring ; Air Pollution/analysis ; Particulate Matter/analysis ; Italy ; Polycyclic Aromatic Hydrocarbons/analysis ; Seasons
    Chemical Substances Air Pollutants ; Particulate Matter ; Polycyclic Aromatic Hydrocarbons
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55292-2
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  10. Article ; Online: Dietary and Microbial Determinants in Food Allergy.

    Stephen-Victor, Emmanuel / Crestani, Elena / Chatila, Talal A

    Immunity

    2020  Volume 53, Issue 2, Page(s) 277–289

    Abstract: The steep rise in food allergy (FA) has evoked environmental factors involved in disease pathogenesis, including the gut microbiota, diet, and their metabolites. Early introduction of solid foods synchronizes with the "weaning reaction," a time during ... ...

    Abstract The steep rise in food allergy (FA) has evoked environmental factors involved in disease pathogenesis, including the gut microbiota, diet, and their metabolites. Early introduction of solid foods synchronizes with the "weaning reaction," a time during which the microbiota imprints durable oral tolerance. Recent work has shown that children with FA manifest an early onset dysbiosis with the loss of Clostridiales species, which promotes the differentiation of ROR-γt
    MeSH term(s) Animals ; Clostridiales/isolation & purification ; Desensitization, Immunologic/methods ; Diet ; Dysbiosis/microbiology ; Food Hypersensitivity/immunology ; Gastrointestinal Microbiome/physiology ; Humans ; Immune Tolerance/immunology ; Immunoglobulin E/immunology ; Mice ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Nuclear Receptor Subfamily 1, Group F, Member 3 ; RORC protein, human ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2020.07.025
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