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  1. Book: Stroke recovery and rehabilitation

    Stein, Joel

    2015  

    Author's details ed. Joel Stein
    Keywords Stroke / rehabilitation ; Stroke / complications ; Stroke / therapy
    Language English
    Size XVII, 866 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher demosMedical
    Publishing place New York
    Publishing country United States
    Document type Book
    Note Includes bibliographical references
    Accompanying material Zugang zu Internetausgabe über Code
    HBZ-ID HT018321315
    ISBN 978-1-62070-006-8 ; 9781617051708 ; 1-62070-006-9 ; 1617051705
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Robotics in rehabilitation

    Stein, Joel

    (American journal of physical medicine & rehabilitation ; 91,11, Suppl.)

    2012  

    Author's details Joel Stein suppl. ed
    Series title American journal of physical medicine & rehabilitation ; 91,11, Suppl.
    Collection
    Language English
    Size S. S199 - S300 : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Hagerstown, MD
    Publishing country United States
    Document type Book
    HBZ-ID HT017458963
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Stepping Closer to Precision Rehabilitation.

    Lin, David J / Stein, Joel

    JAMA neurology

    2023  Volume 80, Issue 4, Page(s) 339–341

    MeSH term(s) Humans ; Gait ; Stroke Rehabilitation ; Walking
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2023.0044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Innovations in Stroke Recovery and Rehabilitation.

    Stilling, Joan / Stein, Joel

    Physical medicine and rehabilitation clinics of North America

    2023  Volume 35, Issue 2, Page(s) xvii–xviii

    MeSH term(s) Humans ; Stroke/therapy ; Stroke Rehabilitation ; Recovery of Function
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 1196791-2
    ISSN 1558-1381 ; 1047-9651
    ISSN (online) 1558-1381
    ISSN 1047-9651
    DOI 10.1016/j.pmr.2023.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Imaging of Head and Neck Infections.

    Stein, Joel M / Xian, Junfang

    Neuroimaging clinics of North America

    2022  Volume 33, Issue 1, Page(s) 185–206

    Abstract: The complex anatomy and deep spaces of the head and neck limit physical examination while also offering many points for entry and spread of infection. Radiologic imaging plays a crucial role in managing head and neck infections by defining the location ... ...

    Abstract The complex anatomy and deep spaces of the head and neck limit physical examination while also offering many points for entry and spread of infection. Radiologic imaging plays a crucial role in managing head and neck infections by defining the location and extent of disease, facilitating abscess drainage, and identifying complications. This review provides essential background and examples for imaging infection throughout the head and neck region.
    MeSH term(s) Humans ; Tomography, X-Ray Computed/methods ; Neck/diagnostic imaging ; Communicable Diseases ; Head/diagnostic imaging ; Drainage
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1314594-0
    ISSN 1557-9867 ; 1052-5149
    ISSN (online) 1557-9867
    ISSN 1052-5149
    DOI 10.1016/j.nic.2022.07.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Stage 3 perianal extra mammary Paget's disease: A case report of a non-operative approach.

    Apikotoa, Sharie / Stein, Joel

    International journal of surgery case reports

    2022  Volume 91, Page(s) 106796

    Abstract: Introduction and importance: Extra mammary Paget's disease (EMPD) is a rare disease characterised by intraepithelial involvement of the skin by non-squamous carcinoma cells in the vulva, perineum, and scrotum. Secondary EMPD is even rarer and accounts ... ...

    Abstract Introduction and importance: Extra mammary Paget's disease (EMPD) is a rare disease characterised by intraepithelial involvement of the skin by non-squamous carcinoma cells in the vulva, perineum, and scrotum. Secondary EMPD is even rarer and accounts for roughly 25% of cases (Delport, 2012) [1]. Surgery (Mohs/wide local excision) is the standard treatment for primary non-invasive disease, but management of secondary invasive EMPD is less defined as there are no current treatment guidelines.
    Case presentation: A 76-year-old lady had a 1-year history of a pruritic perianal rash that was refractory to multiple topical agents. A biopsy confirmed a diagnosis of EMPD in June 2020 and on staging imaging was found to have metastatic disease in her right inguinal lymph node. Upon discussion at a multi-disciplinary team (MDT) meeting, she proceeded chemo radiation therapy followed by systemic chemotherapy as she had such extensive perianal disease that would make surgery quite morbid. She had interval imaging 3 monthly to assess response to treatment. In June 2021, the patient had a complete clinical response and has ongoing 6 monthly surveillance.
    Clinical discussion: EMPD is extremely rare and currently treatment options for secondary EMPD are still being navigated. Specifically, there are no current randomised control trials (RCTs) that compare outcomes in secondary EMPD between radiation therapy and surgery and in the context of stage III disease. This case report documents the treatment approach governed by MDT consensus and has a 1 year follow up. The case report has been reported in line with the SCARE 2020 criteria (Agha et al., 2020) [2].
    Conclusion: The patient has had a good outcome with treatment, however ongoing surveillance is required.
    Language English
    Publishing date 2022-01-24
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2022.106796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits.

    Galimberti, Marco / Levey, Daniel F / Deak, Joseph D / Zhou, Hang / Stein, Murray B / Gelernter, Joel

    Molecular psychiatry

    2024  

    Abstract: Cannabis use disorder (CanUD) has increased with the legalization of the use of cannabis. Around 20% of individuals using cannabis develop CanUD, and the number of users has grown with increasing ease of access. CanUD and other substance use disorders ( ... ...

    Abstract Cannabis use disorder (CanUD) has increased with the legalization of the use of cannabis. Around 20% of individuals using cannabis develop CanUD, and the number of users has grown with increasing ease of access. CanUD and other substance use disorders (SUDs) are associated phenotypically and genetically. We leveraged new CanUD genomics data to undertake genetically-informed analyses with unprecedented power, to investigate the genetic architecture and causal relationships between CanUD and lifetime cannabis use with risk for developing SUDs and substance use traits. Analyses included calculating local and global genetic correlations, genomic structural equation modeling (genomicSEM), and Mendelian Randomization (MR). Results from the genetic correlation and genomicSEM analyses demonstrated that CanUD and cannabis use differ in their relationships with SUDs and substance use traits. We found significant causal effects of CanUD influencing all the analyzed traits: opioid use disorder (OUD) (Inverse variant weighted, IVW β = 0.925 ± 0.082), problematic alcohol use (PAU) (IVW β = 0.443 ± 0.030), drinks per week (DPW) (IVW β = 0.182 ± 0.025), Fagerström Test for Nicotine Dependence (FTND) (IVW β = 0.183 ± 0.052), cigarettes per day (IVW β = 0.150 ± 0.045), current versus former smokers (IVW β = 0.178 ± 0.052), and smoking initiation (IVW β = 0.405 ± 0.042). We also found evidence of bidirectionality showing that OUD, PAU, smoking initiation, smoking cessation, and DPW all increase risk of developing CanUD. For cannabis use, bidirectional relationships were inferred with PAU, smoking initiation, and DPW; cannabis use was also associated with a higher risk of developing OUD (IVW β = 0.785 ± 0.266). GenomicSEM confirmed that CanUD and cannabis use load onto different genetic factors. We conclude that CanUD and cannabis use can increase the risk of developing other SUDs. This has substantial public health implications; the move towards legalization of cannabis use may be expected to increase other kinds of problematic substance use. These harmful outcomes are in addition to the medical harms associated directly with CanUD.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-024-02548-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Neuronal activity in the human amygdala and hippocampus enhances emotional memory encoding.

    Qasim, Salman E / Mohan, Uma R / Stein, Joel M / Jacobs, Joshua

    Nature human behaviour

    2023  Volume 7, Issue 5, Page(s) 754–764

    Abstract: Emotional events comprise our strongest and most valuable memories. Here we examined how the brain prioritizes emotional information for storage using direct brain recording and deep brain stimulation. First, 148 participants undergoing intracranial ... ...

    Abstract Emotional events comprise our strongest and most valuable memories. Here we examined how the brain prioritizes emotional information for storage using direct brain recording and deep brain stimulation. First, 148 participants undergoing intracranial electroencephalographic (iEEG) recording performed an episodic memory task. Participants were most successful at remembering emotionally arousing stimuli. High-frequency activity (HFA), a correlate of neuronal spiking activity, increased in both the hippocampus and the amygdala when participants successfully encoded emotional stimuli. Next, in a subset of participants (N = 19), we show that applying high-frequency electrical stimulation to the hippocampus selectively diminished memory for emotional stimuli and specifically decreased HFA. Finally, we show that individuals with depression (N = 19) also exhibit diminished emotion-mediated memory and HFA. By demonstrating how direct stimulation and symptoms of depression unlink HFA, emotion and memory, we show the causal and translational potential of neural activity in the amygdalohippocampal circuit for prioritizing emotionally arousing memories.
    MeSH term(s) Humans ; Emotions/physiology ; Mental Recall/physiology ; Hippocampus/physiology ; Amygdala/diagnostic imaging ; Amygdala/physiology ; Brain
    Language English
    Publishing date 2023-01-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-022-01502-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Informed Hope in Rehabilitation Research.

    Benjaminy, Shelly / Stein, Joel / Jansen, Lynn / Mukherjee, Debjani

    PM & R : the journal of injury, function, and rehabilitation

    2021  Volume 13, Issue 8, Page(s) 915–921

    MeSH term(s) Humans ; Rehabilitation Research
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2608988-9
    ISSN 1934-1563 ; 1934-1482
    ISSN (online) 1934-1563
    ISSN 1934-1482
    DOI 10.1002/pmrj.12626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Overground Robotic Gait Trainer mTPAD Improves Gait Symmetry and Weight Bearing in Stroke Survivors.

    Stramel, Danielle Marie / Winterbottom, Lauren / Stein, Joel / Agrawal, Sunil K

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 6

    Abstract: Stroke is a leading cause of disability, impairing the ability to generate propulsive forces and causing significant lateral gait asymmetry. We aim to improve stroke survivors' gaits by promoting weight-bearing during affected limb stance. External ... ...

    Abstract Stroke is a leading cause of disability, impairing the ability to generate propulsive forces and causing significant lateral gait asymmetry. We aim to improve stroke survivors' gaits by promoting weight-bearing during affected limb stance. External forces can encourage this; e.g., vertical forces can augment the gravitational force requiring higher ground reaction forces, or lateral forces can shift the center of mass over the stance foot, altering the lateral placement of the center of pressure. With our novel design of a mobile Tethered Pelvic Assist Device (mTPAD) paired with the DeepSole system to predict the user's gait cycle percentage, we demonstrate how to apply three-dimensional forces on the pelvis without lower limb constraints. This work is the first result in the literature that shows that with an applied lateral force during affected limb stance, the center of pressure trajectory's lateral symmetry is significantly closer to a 0% symmetry (5.5%) than without external force applied (-9.8%,p<0.05). Furthermore, the affected limb's maximum relative pressure (p) significantly increases from 233.7p to 234.1p (p<0.05) with an applied downward force, increasing affected limb loading. This work highlights how the mTPAD increases weight-bearing and propulsive forces during gait, which is a crucial goal for stroke survivors.
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10060698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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