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  1. Article ; Online: Re: Richard T. Bryan, Wenyu Liu, Sarah J. Pirrie, et al. Comparing an Imaging-guided Pathway with the Standard Pathway for Staging Muscle-invasive Bladder Cancer: Preliminary Data from the BladderPath Study. Eur Urol 2021;80:12-5.

    Hu, Henglong

    European urology

    2021  Volume 80, Issue 3, Page(s) e85

    MeSH term(s) Diagnostic Imaging ; Humans ; Muscles ; Preliminary Data ; Urinary Bladder Neoplasms
    Language English
    Publishing date 2021-06-30
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2021.06.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 294: Show issues

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  2. Article ; Online: Reinventing community in COVID-19: a case in Canberra, Australia.

    Hu, Richard

    Socio-ecological practice research

    2020  Volume 2, Issue 3, Page(s) 237–241

    Abstract: In this essay, I share my experiences and reflections of fighting COVID-19 from the perspective of a resident and a planner living and working in Canberra, Australia. I focus on three themes of building community compassion and collaboration and regard ... ...

    Abstract In this essay, I share my experiences and reflections of fighting COVID-19 from the perspective of a resident and a planner living and working in Canberra, Australia. I focus on three themes of building community compassion and collaboration and regard them as potential opportunities deriving from this crisis. First, COVID-19 presents a compulsory situation for establishing a virtual community and practising smart work. Second, COVID-19 helps rediscover a local community and nurture a special community spirit under the social distancing circumstance. Third, COVID-19 creates more opportunities of engaging and understanding nature, interestingly, in a context of staying home. These three themes are in large part rooted in the local communities of a city that is known for low density and being a 'bush capital' and possibly suggest some rethinking about the city's planning legacy.
    Language English
    Publishing date 2020-06-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2947249-0
    ISSN 2524-5287 ; 2524-5279
    ISSN (online) 2524-5287
    ISSN 2524-5279
    DOI 10.1007/s42532-020-00055-2
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  3. Article ; Online: COVID-19, smart work, and collaborative space

    Richard Hu

    Journal of Urban Management, Vol 9, Iss 3, Pp 276-

    A crisis-opportunity perspective

    2020  Volume 280

    Abstract: In this essay, I employ a crisis-opportunity perspective to approach the practice of smart work and the making of collaborative space in responding and adapting to COVID-19. These trends have been emerging at a faster pace in the recent decade, ... ...

    Abstract In this essay, I employ a crisis-opportunity perspective to approach the practice of smart work and the making of collaborative space in responding and adapting to COVID-19. These trends have been emerging at a faster pace in the recent decade, facilitated by a growing knowledge economy and information technological advancement. COVID-19 provides an extreme setting to test and trigger changes, and are likely to translate these emerging trends into a new normal in the way we work and the way we use space. This new normal, once established in the post-CVOID-19 world, will necessitate a new thinking about workplace management and space design to disrupt many norms rooted in an industrial age.
    Keywords COVID-19 ; Smart work ; Collaborative space ; Canberra ; Political institutions and public administration - Asia (Asian studies only) ; JQ1-6651 ; Urbanization. City and country ; HT361-384 ; covid19
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Reinventing community in COVID-19

    Hu, Richard

    Socio-Ecological Practice Research

    a case in Canberra, Australia

    2020  Volume 2, Issue 3, Page(s) 237–241

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2947249-0
    ISSN 2524-5287 ; 2524-5279
    ISSN (online) 2524-5287
    ISSN 2524-5279
    DOI 10.1007/s42532-020-00055-2
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: COVID-19, smart work, and collaborative space

    Hu, Richard

    Journal of Urban Management

    A crisis-opportunity perspective

    2020  Volume 9, Issue 3, Page(s) 276–280

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2837330-3
    ISSN 2226-5856
    ISSN 2226-5856
    DOI 10.1016/j.jum.2020.08.001
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  6. Article ; Online: Layered feedback control overcomes performance trade-off in synthetic biomolecular networks.

    Hu, Chelsea Y / Murray, Richard M

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 5393

    Abstract: Layered feedback is an optimization strategy in feedback control designs widely used in engineering. Control theory suggests that layering multiple feedbacks could overcome the robustness-speed performance trade-off limit. In natural biological networks, ...

    Abstract Layered feedback is an optimization strategy in feedback control designs widely used in engineering. Control theory suggests that layering multiple feedbacks could overcome the robustness-speed performance trade-off limit. In natural biological networks, genes are often regulated in layers to adapt to environmental perturbations. It is hypothesized layering architecture could also overcome the robustness-speed performance trade-off in genetic networks. In this work, we validate this hypothesis with a synthetic biomolecular network in living E. coli cells. We start with system dynamics analysis using models of various complexities to guide the design of a layered control architecture in living cells. Experimentally, we interrogate system dynamics under three groups of perturbations. We consistently observe that the layered control improves system performance in the robustness-speed domain. This work confirms that layered control could be adopted in synthetic biomolecular networks for performance optimization. It also provides insights into understanding genetic feedback control architectures in nature.
    MeSH term(s) Adaptation, Physiological ; Escherichia coli/genetics ; Feedback ; Feedback, Physiological ; Gene Regulatory Networks
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-33058-6
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  7. Article ; Online: Preclinical Evaluation of Novel Positron Emission Tomography (PET) Probes for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2).

    Chen, Zhen / Chen, Jiahui / Mori, Wakana / Yi, Yongjia / Rong, Jian / Li, Yinlong / Leon, Erick R Calderon / Shao, Tuo / Song, Zhendong / Yamasaki, Tomoteru / Ishii, Hideki / Zhang, Yiding / Kokufuta, Tomomi / Hu, Kuan / Xie, Lin / Josephson, Lee / Van, Richard / Shao, Yihan / Factor, Stewart /
    Zhang, Ming-Rong / Liang, Steven H

    Journal of medicinal chemistry

    2024  Volume 67, Issue 4, Page(s) 2559–2569

    Abstract: ... which affects millions of people worldwide, and leucine-rich repeat kinase 2 (LRRK2) mutations have been ...

    Abstract Parkinson's disease (PD) is one of the most highly debilitating neurodegenerative disorders, which affects millions of people worldwide, and leucine-rich repeat kinase 2 (LRRK2) mutations have been involved in the pathogenesis of PD. Developing a potent LRRK2 positron emission tomography (PET) tracer would allow for in vivo visualization of LRRK2 distribution and expression in PD patients. In this work, we present the facile synthesis of two potent and selective LRRK2 radioligands [
    MeSH term(s) Mice ; Animals ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Leucine ; Pyrimidines ; Positron-Emission Tomography/methods ; Parkinson Disease/metabolism ; Mutation ; Morpholines ; Nitriles
    Chemical Substances Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 (EC 2.7.11.1) ; (18F)PF-06455943 ; Leucine (GMW67QNF9C) ; Pyrimidines ; LRRK2 protein, human (EC 2.7.11.1) ; Morpholines ; Nitriles
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c01687
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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    Zs.MB 1: Show issues

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  8. Article ; Online: The pore-rhizosheath shapes maize root architecture by enhancing root distribution in macropores.

    Liu, Lingling / Qin, Shijie / Richard Whalley, W / Zhou, Hu / Ren, Tusheng / Gao, Weida

    Plant, cell & environment

    2024  

    Abstract: Pores and old root-channels are preferentially used by roots to allow them to penetrate hard soils. However, there are few studies that have accounted for the effects of pore-rhizosheath on root growth. In this study, we developed an approach by adding ... ...

    Abstract Pores and old root-channels are preferentially used by roots to allow them to penetrate hard soils. However, there are few studies that have accounted for the effects of pore-rhizosheath on root growth. In this study, we developed an approach by adding the synthetic root exudates using a porous stainless tube with 0.1-mm micropores through a peristaltic pump to reproduce the rhizosheath around the artificial pore, and investigated the effects of pores with and without rhizosheaths on maize root growth in a dense soil. The results indicated that the artificial rhizosheath was about 2.69 mm wide in the region surrounding the pores. The rhizosheath had a higher content of organic carbon, total nitrogen, and abundance of Actinobacteria than that of the bulk soil. Compared with the artificial macropores, the artificial root-pores with a rhizosheath increased the opportunities for root utilisation of the pores space, promoting steeper and deeper root growth. It is concluded that the pore-rhizosheath has a significant impact on root architecture by enhancing root distribution in macropores.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391893-2
    ISSN 1365-3040 ; 0140-7791
    ISSN (online) 1365-3040
    ISSN 0140-7791
    DOI 10.1111/pce.14915
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    In stock of ZB MED Bonn / Germany

    Z 80/729: Show issues

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  9. Article: COVID-19, smart work, and collaborative space_ A crisis-opportunity perspective

    Hu, Richard

    J. Urban Manag.

    Abstract: In this essay, I employ a crisis-opportunity perspective to approach the practice of smart work and the making of collaborative space in responding and adapting to COVID-19. These trends have been emerging at a faster pace in the recent decade, ... ...

    Abstract In this essay, I employ a crisis-opportunity perspective to approach the practice of smart work and the making of collaborative space in responding and adapting to COVID-19. These trends have been emerging at a faster pace in the recent decade, facilitated by a growing knowledge economy and information technological advancement. COVID-19 provides an extreme setting to test and trigger changes, and are likely to translate these emerging trends into a new normal in the way we work and the way we use space. This new normal, once established in the post-CVOID-19 world, will necessitate a new thinking about workplace management and space design to disrupt many norms rooted in an industrial age.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #712161
    Database COVID19

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  10. Article ; Online: COVID-19, smart work, and collaborative space

    Hu, Richard

    A crisis-opportunity perspective

    2020  

    Abstract: In this essay, I employ a crisis-opportunity perspective to approach the practice of smart work and the making of collaborative space in responding and adapting to COVID-19. These trends have been emerging at a faster pace in the recent decade, ... ...

    Abstract In this essay, I employ a crisis-opportunity perspective to approach the practice of smart work and the making of collaborative space in responding and adapting to COVID-19. These trends have been emerging at a faster pace in the recent decade, facilitated by a growing knowledge economy and information technological advancement. COVID-19 provides an extreme setting to test and trigger changes, and are likely to translate these emerging trends into a new normal in the way we work and the way we use space. This new normal, once established in the post-CVOID-19 world, will necessitate a new thinking about workplace management and space design to disrupt many norms rooted in an industrial age.
    Keywords ddc:710 ; Canberra ; Collaborative space ; COVID-19 ; Smart work
    Language English
    Publisher Amsterdam: Elsevier
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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