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  1. Article ; Online: Neuroendocrine interactions in the immune system.

    Taub, Dennis D

    Cellular immunology

    2008  Volume 252, Issue 1-2, Page(s) 1–6

    MeSH term(s) Humans ; Immune System/metabolism ; Immunity ; Neurosecretory Systems/metabolism
    Language English
    Publishing date 2008-07-10
    Publishing country Netherlands
    Document type Introductory Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2008.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Novel connections between the neuroendocrine and immune systems: the ghrelin immunoregulatory network.

    Taub, Dennis D

    Vitamins and hormones

    2008  Volume 77, Page(s) 325–346

    Abstract: There appears to be bidirectional communication between the neuroendocrine and immune systems. This communication is mediated by way of an array of cytokines, hormones, and neuropeptides. Inflammatory cytokines released by immune cells have been shown to ...

    Abstract There appears to be bidirectional communication between the neuroendocrine and immune systems. This communication is mediated by way of an array of cytokines, hormones, and neuropeptides. Inflammatory cytokines released by immune cells have been shown to act on the central nervous system to control food intake and energy homeostasis. Decrease in food intake or anorexia is one of the most common symptoms of illness, injury, or inflammation. The adipocyte-derived hormone, leptin, is considered a critical sensory anorexigenic mediator that signals to the brain changes in stored energy, determined by an altered balance between food intake and energy expenditure and has been shown to exert certain proinflammatory effects on immune cells. In contrast, ghrelin, the endogenous ligand for growth hormone secretagogue receptors (GHSRs), is produced primarily from stomach serving as a potent circulating orexigen controlling energy expenditure, adiposity, and GH secretion. However, the functional role of ghrelin and GHS in immune cell function remains unclear. Here, we review the current literature supporting a role for ghrelin in controlling inflammation and immunity and the potential therapeutic use of ghrelin and GHSR agonists in the management of inflammation and in restoration of thymic function in immunocompromised individuals.
    MeSH term(s) Animals ; Ghrelin/physiology ; Humans ; Immune System/immunology ; Mice ; Neurosecretory Systems/immunology ; Rats ; Receptors, Ghrelin/immunology
    Chemical Substances Ghrelin ; Receptors, Ghrelin
    Language English
    Publishing date 2008
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 201161-x
    ISSN 2162-2620 ; 0083-6729
    ISSN (online) 2162-2620
    ISSN 0083-6729
    DOI 10.1016/S0083-6729(06)77014-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Live or Die: Choice Mechanisms in Stressed Cells.

    Cecconi, Francesco / Soucek, Laura / Taub, Dennis D / Ziparo, Elio

    Mediators of inflammation

    2015  Volume 2015, Page(s) 454863

    MeSH term(s) Animals ; Cell Cycle ; Cell Hypoxia ; Endoplasmic Reticulum Stress ; Homeostasis ; Humans ; Inflammation/pathology ; Liver/injuries ; Liver Diseases/pathology ; Neoplasms/immunology ; Neoplasms/pathology ; Oxidative Stress ; Signal Transduction ; Stress, Physiological
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2015/454863
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  4. Article ; Online: Cytokine, growth factor, and chemokine ligand database.

    Taub, Dennis D

    Current protocols in immunology

    2004  Volume Chapter 6, Page(s) Unit 6.29

    Abstract: Cytokines, chemokines, and growth factors are soluble proteins produced by leukocytes and other cell types, which act as chemical communicators between cells and tissues within the body. These proteins mediate a number of functions, ranging from effects ... ...

    Abstract Cytokines, chemokines, and growth factors are soluble proteins produced by leukocytes and other cell types, which act as chemical communicators between cells and tissues within the body. These proteins mediate a number of functions, ranging from effects on cell growth, differentiation, survival, and a number of effector activities. The main purpose of this unit is to provide an easy-to-use reference summarizing some of the current information on well-established cytokine, growth factore, and chemokine ligands. The information provided is confined largely to alternative names, protein properties, genetic chracteristics, chromosomal localization, cellular expression patters, cellular-tissue targets, stimuli regulating expression, functional properties, expression analysis, and clinical utility.
    MeSH term(s) Animals ; Cell Communication/physiology ; Cell Differentiation/physiology ; Cell Survival/physiology ; Chemokines/classification ; Chemokines/genetics ; Chemokines/metabolism ; Chromosomes/genetics ; Databases, Factual ; Gene Expression Regulation/physiology ; Humans ; Ligands
    Chemical Substances Chemokines ; Ligands
    Language English
    Publishing date 2004-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1934-368X
    ISSN (online) 1934-368X
    DOI 10.1002/0471142735.im0629s61
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  5. Article ; Online: Role of neuropeptides, hormones, and growth factors in regulating thymopoiesis in middle to old age.

    Patel, Kalpesh / Taub, Dennis D

    F1000 biology reports

    2009  Volume 1, Page(s) 42

    Abstract: The deterioration in adaptive immunity and T-lymphocyte output and the narrowing of the T cell receptor repertoire with age are largely attributable to thymic involution. The loss of thymic function with age may be due to diminished numbers of early ... ...

    Abstract The deterioration in adaptive immunity and T-lymphocyte output and the narrowing of the T cell receptor repertoire with age are largely attributable to thymic involution. The loss of thymic function with age may be due to diminished numbers of early thymic progenitors and epithelial cells, and the loss of critical tropic factors within the thymic microenvironment. Here we review some of the recent literature demonstrating a role for neuropeptides, hormones, and growth factors that can influence thymopoiesis associated with stress and aging.
    Language English
    Publishing date 2009-05-28
    Publishing country England
    Document type Journal Article
    ISSN 1757-594X
    ISSN (online) 1757-594X
    DOI 10.3410/B1-42
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  6. Article ; Online: Cytokines and chemokines: disease models, mechanisms, and therapies.

    Ahmed, Salahuddin / Malemud, Charles J / Koch, Alisa E / Athar, Mohammad / Taub, Dennis D

    Mediators of inflammation

    2014  Volume 2014, Page(s) 296356

    MeSH term(s) Chemokines/genetics ; Chemokines/metabolism ; Cytokines/genetics ; Cytokines/metabolism ; Humans
    Chemical Substances Chemokines ; Cytokines
    Language English
    Publishing date 2014-07-24
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2014/296356
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  7. Article ; Online: Biological responses to chemokine superfamily members.

    Taub, Dennis D / Schaffer, Eric

    Current protocols in immunology

    2008  Volume Chapter 6, Page(s) 6.12.1–6.12.32

    Abstract: A detailed summary of all the chemokine subfamily members including alternative names, receptor-ligand pairs, receptor cellular distribution, and leukocyte responsiveness is presented here along with assays to measure the biological activities of ... ...

    Abstract A detailed summary of all the chemokine subfamily members including alternative names, receptor-ligand pairs, receptor cellular distribution, and leukocyte responsiveness is presented here along with assays to measure the biological activities of chemokines on each of the major leukocyte subsets (i.e., microchemotaxis chambers, fluorescence-based assays, use of nitrocellulose filters and membranes coated with extracellular matrix proteins, cellular adhesion assays, mobilization of intracellular free calcium, actin polymerization, degranulation assays, and the use of chemokine receptor-specific antibodies in flow cytometric analysis and radiolabeled chemokine binding assays).
    MeSH term(s) Actins/metabolism ; Animals ; Biological Assay/methods ; Calcium/blood ; Cell Polarity ; Chemokines/analysis ; Chemokines/metabolism ; Chemotaxis, Leukocyte ; Humans ; Leukocytes/cytology ; Leukocytes/physiology ; Lymphocyte Subsets/cytology ; Lymphocyte Subsets/physiology ; Receptors, Chemokine/immunology ; Receptors, Chemokine/metabolism
    Chemical Substances Actins ; Chemokines ; Receptors, Chemokine ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2008-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2179059-0
    ISSN 1934-368X ; 1934-3671
    ISSN (online) 1934-368X
    ISSN 1934-3671
    DOI 10.1002/0471142735.im0612s38
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  8. Article: Microarray data analysis: an overview of design, methodology, and analysis.

    Weeraratna, Ashani T / Taub, Dennis D

    Methods in molecular biology (Clifton, N.J.)

    2007  Volume 377, Page(s) 1–16

    Abstract: Microarray analysis results in the gathering of massive amounts of information concerning gene expression profiles of different cells and experimental conditions. Analyzing these data can often be a quagmire, with endless discussion as to what the ... ...

    Abstract Microarray analysis results in the gathering of massive amounts of information concerning gene expression profiles of different cells and experimental conditions. Analyzing these data can often be a quagmire, with endless discussion as to what the appropriate statistical analyses for any given experiment might be. As a result many different methods of data analysis have evolved, the basics of which are outlined in this chapter.
    MeSH term(s) Cluster Analysis ; Data Interpretation, Statistical ; Databases, Genetic ; Forecasting ; Gene Expression Profiling/statistics & numerical data ; Humans ; Microarray Analysis/methods ; Microarray Analysis/statistics & numerical data ; Molecular Biology/methods
    Language English
    Publishing date 2007
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1064-3745
    ISSN 1064-3745
    DOI 10.1007/978-1-59745-390-5_1
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  9. Article ; Online: The effects of ghrelin on inflammation and the immune system.

    Baatar, Dolgor / Patel, Kalpesh / Taub, Dennis D

    Molecular and cellular endocrinology

    2011  Volume 340, Issue 1, Page(s) 44–58

    Abstract: A number of hormones and metabolic mediators signal the brain of changes in the body's energy status and when an imbalance occurs; the brain coordinates the appropriate changes in energy intake and utilization via the control of appetite and food ... ...

    Abstract A number of hormones and metabolic mediators signal the brain of changes in the body's energy status and when an imbalance occurs; the brain coordinates the appropriate changes in energy intake and utilization via the control of appetite and food consumption. Under conditions of chronic inflammation and immune activation, there is often a significant loss of body mass and appetite suggesting the presence of shared ligands and signaling pathways mediating "crosstalk" between the immune and neuroendocrine systems. Ghrelin, the endogenous ligand for growth hormone secretagogue receptor (GHS-R), is produced primarily by cells in the stomach and serves as a potent circulating orexigenic hormone controlling food intake, energy expenditure, adiposity and GH secretion. The functional roles of ghrelin and other growth hormone secretagogues (GHS) within the immune system and under states of inflammatory stress and injury are only now coming to light. A number of reports over the past decade have described ghrelin to be a potent anti-inflammatory mediator both in vitro and in vivo and a promising therapeutic agent in the treatment of inflammatory diseases and injury. Moreover, ghrelin has also been shown to promote lymphocyte development in the primary lymphoid organs (bone marrow and thymus) and to ablate age-associated thymic involution. In the current report, we review the literature supporting a role for ghrelin as an anti-inflammatory agent and immunoregulatory hormone/cytokine and its potential use in the treatment of inflammatory diseases and injury.
    MeSH term(s) Animals ; Ghrelin/blood ; Ghrelin/metabolism ; Humans ; Immune System/metabolism ; Inflammation/metabolism ; Inflammation/pathology ; Lymphocytes/metabolism ; Receptors, Ghrelin/metabolism ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism
    Chemical Substances Ghrelin ; Receptors, Ghrelin
    Language English
    Publishing date 2011-06-20
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 187438-x
    ISSN 1872-8057 ; 0303-7207
    ISSN (online) 1872-8057
    ISSN 0303-7207
    DOI 10.1016/j.mce.2011.04.019
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  10. Article ; Online: The role of inflammatory mediators in immune-to-brain communication during health and disease.

    Gomez-Nicola, Diego / Teeling, Jessica / Guaza, Carmen / Godbout, Jonathan P / Taub, Dennis D

    Mediators of inflammation

    2013  Volume 2013, Page(s) 429231

    MeSH term(s) Animals ; Brain/pathology ; Brain Diseases/immunology ; Brain Diseases/pathology ; Disease Progression ; Gene Expression Regulation ; Humans ; Immune System ; Inflammation/pathology ; Nervous System
    Language English
    Publishing date 2013-09-10
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2013/429231
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