Article ; Online: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Fresh Look at an Old Foe.
2023 Volume 68, Issue 1, Page(s) 34–40
Abstract: Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are some of the less common cutaneous adverse drug reactions with significant mortality.: Objectives: This study was undertaken with the objective of studying the ... ...
| Abstract | Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are some of the less common cutaneous adverse drug reactions with significant mortality. Objectives: This study was undertaken with the objective of studying the demographics and clinical profile of SJS/TEN and identifying parameters associated with mortality. Materials and methods: All patients with SJS/TEN over 10 years (2010-2020) were included in the study. Data obtained from in-patient and out-patient records were analysed. Results: A total of 82 patients with SJS/TEN were admitted to our centre over a period of 10 years. Patients with SJS were significantly younger than those with TEN, with a male: female ratio >1 in SJS and <1 in TEN. The most commonly implicated drugs were antiepileptics ( Conclusion: Factors significantly associated with increased mortality in TEN were cutaneous onset of lesions, mean BSA of involvement and transfer to the intensive care unit (ICU) beyond day 7 of admission. |
|---|---|
| Language | English |
| Publishing date | 2023-05-06 |
| Publishing country | India |
| Document type | Journal Article |
| ZDB-ID | 416069-1 |
| ISSN | 1998-3611 ; 0019-5154 |
| ISSN (online) | 1998-3611 |
| ISSN | 0019-5154 |
| DOI | 10.4103/ijd.ijd_726_22 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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