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Article ; Online: Stimulation of a subset of natural killer T cells by CD103

Murray, Mallory Paynich / Crosby, Catherine M / Marcovecchio, Paola / Hartmann, Nadine / Chandra, Shilpi / Zhao, Meng / Khurana, Archana / Zahner, Sonja P / Clausen, Björn E / Coleman, Fadie T / Mizgerd, Joseph P / Mikulski, Zbigniew / Kronenberg, Mitchell

Cell reports

2022 Volume 38, Issue 2, Page(s) 110209

Abstract: Innate-like T cells, including invariant natural killer T cells, mucosal-associated invariant T ... cells, and γδ T cells, are present in various barrier tissues, including the lung, where they carry out ... pneumococcal infection. Following infection, innate-like T cells rapidly increase in lung tissue, in part ...

Abstract	Innate-like T cells, including invariant natural killer T cells, mucosal-associated invariant T cells, and γδ T cells, are present in various barrier tissues, including the lung, where they carry out protective responses during infections. Here, we investigate their roles during pulmonary pneumococcal infection. Following infection, innate-like T cells rapidly increase in lung tissue, in part through recruitment, but T cell antigen receptor activation and cytokine production occur mostly in interleukin-17-producing NKT17 and γδ T cells. NKT17 cells are preferentially located within lung tissue prior to infection, as are CD103
MeSH term(s)	Animals ; Cell Line ; Dendritic Cells/immunology ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Humans ; Interferon-gamma/immunology ; Interleukin-17/immunology ; Intraepithelial Lymphocytes/immunology ; Intraepithelial Lymphocytes/metabolism ; Lung/immunology ; Lung/microbiology ; Lymphocyte Activation ; Male ; Mice ; Mice, Inbred C57BL ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/metabolism ; Pneumococcal Infections/immunology ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Streptococcus pneumoniae/immunology
Chemical Substances	Interleukin-17 ; Receptors, Antigen, T-Cell, gamma-delta ; Interferon-gamma (82115-62-6) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2021.110209
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Article ; Online: A Faster Prostate MRI: Comparing a Novel Denoised, Single-Average T

Kelleher, Colm B / Macdonald, Jacob / Jaffe, Tracy A / Allen, Brian C / Kalisz, Kevin R / Kauffman, Travis H / Smith, Jordan D / Maurer, Kimberly R / Thomas, Sarah P / Coleman, Aaron D / Zaki, Islam H / Kannengiesser, Stephan / Lafata, Kyle / Gupta, Rajan T / Bashir, Mustafa R

Journal of magnetic resonance imaging : JMRI

2023 Volume 58, Issue 2, Page(s) 620–629

Abstract: Background: The T: Purpose/hypothesis: To determine whether a denoised, single-average T ... Field strength/sequence: A 3 T; T: Assessment: Nine readers randomly assessed complete exams ... including T: Statistical tests: Generalized linear mixed effects models for differences in lesion ...

Abstract	Background: The T Purpose/hypothesis: To determine whether a denoised, single-average T Study type: Retrospective. Population: A total of 45 males (age range 60-75 years) who underwent clinically indicated prostate MRI examinations, 21 of whom had pathologically proven prostate cancer. Field strength/sequence: A 3 T; T Assessment: Nine readers randomly assessed complete exams including T Statistical tests: Generalized linear mixed effects models for differences in lesion detection, image quality features, and overall preference between T Results: There was no significant difference between sequences regarding identification of lesions with PI-RADS ≥3 (P = 0.10) or PI-RADS score (P = 0.77). Reader agreement was excellent for lesion identification (ICC = 0.84). There was no significant overall preference between the two sequences regarding image quality (P = 0.07, 95% CI: [-0.23, 0.01]). Reader agreement was good regarding sequence preference (ICC = 0.62). Data conclusion: Use of single-average, denoised T Evidence level: 3. Technical efficacy: Stage 3.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Magnetic Resonance Imaging/methods ; Prostate/diagnostic imaging ; Prostate/pathology ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Retrospective Studies ; Pelvis/pathology
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28577
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.

Baxter, Ryan M / Wang, Christine S / Garcia-Perez, Josselyn E / Kong, Daniel S / Coleman, Brianne M / Larchenko, Valentyna / Schuyler, Ronald P / Jackson, Conner / Ghosh, Tusharkanti / Rudra, Pratyaydipta / Paul, Debdas / Claassen, Manfred / Rochford, Rosemary / Cambier, John C / Ghosh, Debashis / Cooper, Jennifer C / Smith, Mia J / Hsieh, Elena W Y

Frontiers in immunology

2023 Volume 14, Page(s) 1208282

Abstract: ... B cell subsets and their T cell collaborators play a role in specific organ involvement in cLN and ... expansion signature, with increased frequency of i) DN2, ii) Bnd2, iii) plasmablasts, and iv) peripheral T ... activity in cLN, supporting extrafollicular T/B interactions as a mechanism underlying pediatric renal ...

Abstract	Introduction: Most childhood-onset SLE patients (cSLE) develop lupus nephritis (cLN), but only a small proportion achieve complete response to current therapies. The prognosis of children with LN and end-stage renal disease is particularly dire. Mortality rates within the first five years of renal replacement therapy may reach 22%. Thus, there is urgent need to decipher and target immune mechanisms that drive cLN. Despite the clear role of autoantibody production in SLE, targeted B cell therapies such as rituximab (anti-CD20) and belimumab (anti-BAFF) have shown only modest efficacy in cLN. While many studies have linked dysregulation of germinal center formation to SLE pathogenesis, other work supports a role for extrafollicular B cell activation in generation of pathogenic antibody secreting cells. However, whether extrafollicular B cell subsets and their T cell collaborators play a role in specific organ involvement in cLN and/or track with disease activity remains unknown. Methods: We analyzed high-dimensional mass cytometry and gene expression data from 24 treatment naïve cSLE patients at the time of diagnosis and longitudinally, applying novel computational tools to identify abnormalities associated with clinical manifestations (cLN) and disease activity (SLEDAI). Results: cSLE patients have an extrafollicular B cell expansion signature, with increased frequency of i) DN2, ii) Bnd2, iii) plasmablasts, and iv) peripheral T helper cells. Most importantly, we discovered that this extrafollicular signature correlates with disease activity in cLN, supporting extrafollicular T/B interactions as a mechanism underlying pediatric renal pathogenesis. Discussion: This study integrates established and emerging themes of extrafollicular B cell involvement in SLE by providing evidence for extrafollicular B and peripheral T helper cell expansion, along with elevated type 1 IFN activation, in a homogeneous cohort of treatment-naïve cSLE patients, a point at which they should display the most extreme state of their immune dysregulation.
MeSH term(s)	Humans ; Child ; Lupus Erythematosus, Systemic ; Lupus Nephritis ; B-Lymphocytes ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes, Helper-Inducer
Language	English
Publishing date	2023-10-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1208282
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Article ; Online: Electrophysiological mechanisms underlying T wave pseudonormalisation on stress ECGs in hypertrophic cardiomyopathy.

Coleman, James A / Doste, Ruben / Beltrami, Matteo / Coppini, Raffaele / Olivotto, Iacopo / Raman, Betty / Bueno-Orovio, Alfonso

Computers in biology and medicine

2023 Volume 169, Page(s) 107829

Abstract: Background: Pseudonormal T waves may be detected on stress electrocardiograms (ECGs ... myocardial ischaemia on ECGs with T wave inversions at baseline. Virtual 12-lead ECGs were derived from a total of 520 ... Conclusions: Ischaemia-induced T wave pseudonormalisation can occur on stress ECG testing in HCM ...

Abstract	Background: Pseudonormal T waves may be detected on stress electrocardiograms (ECGs) in hypertrophic cardiomyopathy (HCM). Either myocardial ischaemia or purely exercise-induced changes have been hypothesised to contribute to this phenomenon, but the precise electrophysiological mechanisms remain unknown. Methods: Computational models of human HCM ventricles (n = 20) with apical and asymmetric septal hypertrophy phenotypes with variable severities of repolarisation impairment were used to investigate the effects of acute myocardial ischaemia on ECGs with T wave inversions at baseline. Virtual 12-lead ECGs were derived from a total of 520 biventricular simulations, for cases with regionally ischaemic K Results: Regional ischaemic K Conclusions: Ischaemia-induced T wave pseudonormalisation can occur on stress ECG testing in HCM before significant ST segment changes. Some anatomical and electrophysiological phenotypes may enable T wave pseudonormalisation due to exercise-induced increased serum K
MeSH term(s)	Humans ; Cardiomyopathy, Hypertrophic/diagnosis ; Electrocardiography ; Arrhythmias, Cardiac ; Myocardial Ischemia ; Phenotype
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2023.107829
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Zs.A 653: Show issues

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Article ; Online: Extracellular matrix modulates T cell clearance of malignant cells in vitro.

Robertson, Claire / Sebastian, Aimy / Hinckley, Aubree / Rios-Arce, Naiomy D / Hynes, William F / Edwards, Skye A / He, Wei / Hum, Nicholas R / Wheeler, Elizabeth K / Loots, Gabriela G / Coleman, Matthew A / Moya, Monica L

Biomaterials

2022 Volume 282, Page(s) 121378

Abstract: Despite the success of T cell checkpoint therapies, breast cancers rarely express ... whether extracellular matrix could alter T cell cytotoxicity against malignant mammary gland carcinoma cells (MCC) in a setup ... designed to promote maximal T cell efficacy (i.e., rich media with abundant IL2, high ratio of T ...

Abstract	Despite the success of T cell checkpoint therapies, breast cancers rarely express these immunotherapy markers and are believed to be largely "immune cold" with limited inflammation and immune activation. The reason for this limited immune activation remains poorly understood. We sought to determine whether extracellular matrix substrate could contribute to this limited immune activation. Specifically, we asked whether extracellular matrix could alter T cell cytotoxicity against malignant mammary gland carcinoma cells (MCC) in a setup designed to promote maximal T cell efficacy (i.e., rich media with abundant IL2, high ratio of T cells to MCC). We observed that T cell clearance of MCC varied from 0% in collagen 4 or 6 conditions to almost 100% in fibronectin or vitronectin. Transcriptomics revealed that T cell function was defective in MCC/T cell cocultures on collagen 4 (Col4), potentially corresponding to greater expression of cytokines MCC cultured in this environment. In contrast, transcriptomics revealed an effective, exhausted phenotype on vitronectin. The observation that Col4 induces T cell suppression suggests that targeting tumor-ECM interactions may permit new approaches for utilizing immunotherapy in tumors which do not provoke a strong immune response.
MeSH term(s)	Breast Neoplasms/metabolism ; Collagen/metabolism ; Extracellular Matrix/metabolism ; Female ; Humans ; T-Lymphocytes ; Vitronectin/metabolism
Chemical Substances	Vitronectin ; Collagen (9007-34-5)
Language	English
Publishing date	2022-01-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2022.121378
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Article ; Online: Vaccination with the Crimean-Congo hemorrhagic fever virus viral replicon vaccine induces NP-based T-cell activation and antibodies possessing Fc-mediated effector functions.

Scholte, F E M / Karaaslan, E / O'Neal, T J / Sorvillo, T E / Genzer, S C / Welch, S R / Coleman-McCray, J D / Spengler, J R / Kainulainen, M H / Montgomery, J M / Pegan, S D / Bergeron, E / Spiropoulou, C F

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1233148

Abstract: Crimean-Congo hemorrhagic fever virus (CCHFV; ... ...

Abstract	Crimean-Congo hemorrhagic fever virus (CCHFV; family
MeSH term(s)	Humans ; Animals ; Mice ; Hemorrhagic Fever Virus, Crimean-Congo ; Vaccination ; Vaccines ; Antibodies ; Nucleoproteins ; T-Lymphocytes
Chemical Substances	Vaccines ; Antibodies ; Nucleoproteins
Language	English
Publishing date	2023-08-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1233148
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Article ; Online: CD4 T Cells, CD8 T Cells, and Monocytes Coordinate To Prevent Rift Valley Fever Virus Encephalitis.

Harmon, Jessica R / Spengler, Jessica R / Coleman-McCray, Joann D / Nichol, Stuart T / Spiropoulou, Christina F / McElroy, Anita K

Journal of virology

2018 Volume 92, Issue 24

Abstract: Rift Valley fever virus (RVFV) is an arbovirus that causes disease in livestock and humans in Africa and the Middle East. While human disease is typically mild and self-limiting, some individuals develop severe manifestations, such as hepatitis, ... ...

Abstract	Rift Valley fever virus (RVFV) is an arbovirus that causes disease in livestock and humans in Africa and the Middle East. While human disease is typically mild and self-limiting, some individuals develop severe manifestations, such as hepatitis, hemorrhagic fever, or encephalitis. Encephalitis occurs 2 to 3 weeks after acute illness; therefore, we hypothesized that it was a result of an inadequate adaptive immunity. To test this hypothesis
MeSH term(s)	Animals ; Brain/immunology ; Brain/virology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Encephalitis, Viral/immunology ; Encephalitis, Viral/prevention & control ; Immunity, Humoral ; Immunity, Innate ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Monocytes/metabolism ; Receptors, CCR2/genetics ; Rift Valley Fever/immunology ; Rift Valley Fever/prevention & control ; Rift Valley fever virus/immunology ; Rift Valley fever virus/pathogenicity
Chemical Substances	Ccr2 protein, mouse ; Receptors, CCR2
Language	English
Publishing date	2018-11-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.01270-18
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Article ; Online: Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy.

Nature communications

2023 Volume 14, Issue 1, Page(s) 2041

Abstract: ... directed chimeric antigen receptor (CAR) T cell therapy. STEAP1 CAR T cells demonstrate reactivity in low ... with STEAP1 CAR T cell therapy enhances antitumor efficacy by remodeling the immunologically cold ...

Abstract	Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is a cell surface antigen for therapeutic targeting in prostate cancer. Here, we report broad expression of STEAP1 relative to prostate-specific membrane antigen (PSMA) in lethal metastatic prostate cancers and the development of a STEAP1-directed chimeric antigen receptor (CAR) T cell therapy. STEAP1 CAR T cells demonstrate reactivity in low antigen density, antitumor activity across metastatic prostate cancer models, and safety in a human STEAP1 knock-in mouse model. STEAP1 antigen escape is a recurrent mechanism of treatment resistance and is associated with diminished tumor antigen processing and presentation. The application of tumor-localized interleukin-12 (IL-12) therapy in the form of a collagen binding domain (CBD)-IL-12 fusion protein combined with STEAP1 CAR T cell therapy enhances antitumor efficacy by remodeling the immunologically cold tumor microenvironment of prostate cancer and combating STEAP1 antigen escape through the engagement of host immunity and epitope spreading.
MeSH term(s)	Male ; Mice ; Animals ; Humans ; Receptors, Chimeric Antigen ; T-Lymphocytes ; Interleukin-12 ; Cell Line, Tumor ; Prostatic Neoplasms/pathology ; Immunotherapy ; Tumor Microenvironment ; Antigens, Neoplasm ; Oxidoreductases
Chemical Substances	Receptors, Chimeric Antigen ; Interleukin-12 (187348-17-0) ; STEAP1 protein, human (EC 1.16.1.-) ; Antigens, Neoplasm ; Oxidoreductases (EC 1.-)
Language	English
Publishing date	2023-04-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-37874-2
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Article ; Online: Highly efficient C-to-T and A-to-G base editing in a Populus hybrid.

Li, Gen / Sretenovic, Simon / Eisenstein, Edward / Coleman, Gary / Qi, Yiping

Plant biotechnology journal

2021 Volume 19, Issue 6, Page(s) 1086–1088

MeSH term(s)	CRISPR-Associated Protein 9/genetics ; CRISPR-Cas Systems ; Gene Editing ; Populus/genetics ; Populus/metabolism
Chemical Substances	CRISPR-Associated Protein 9 (EC 3.1.-)
Language	English
Publishing date	2021-04-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2136367-5
ISSN	1467-7652 ; 1467-7644
ISSN (online)	1467-7652
ISSN	1467-7644
DOI	10.1111/pbi.13581
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Article ; Online: Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an altered HOX/MEIS axis.

Potluri, Sandeep / Kellaway, Sophie G / Coleman, Daniel J L / Keane, Peter / Imperato, Maria Rosaria / Assi, Salam A / Cockerill, Peter N / Bonifer, Constanze

Leukemia

2024 Volume 38, Issue 2, Page(s) 403–407

MeSH term(s)	Humans ; Leukemia, Myeloid, Acute/genetics ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; fms-Like Tyrosine Kinase 3/genetics ; Mutation ; Prognosis ; Nuclear Pore Complex Proteins/genetics
Chemical Substances	Nuclear Proteins ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1) ; FLT3 protein, human (EC 2.7.10.1) ; NUP214 protein, human ; Nuclear Pore Complex Proteins
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/s41375-023-02118-1
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