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Article ; Online: Recent updates in therapeutic approach using tolvaptan for autosomal dominant polycystic kidney disease.

Kim, Yaerim / Han, Seungyeup

2023 Volume 38, Issue 3, Page(s) 322–331

Abstract: As a genetic disease, there has been a long-standing effort to identify therapeutic options for autosomal dominant polycystic kidney disease (ADPKD). Following the development of tolvaptan, a vasopressin 2 receptor antagonist, the treatment strategy for ... ...

Abstract	As a genetic disease, there has been a long-standing effort to identify therapeutic options for autosomal dominant polycystic kidney disease (ADPKD). Following the development of tolvaptan, a vasopressin 2 receptor antagonist, the treatment strategy for ADPKD patients with rapid disease progression has been changed with a disease-targeted approach. Tolvaptan showed significant efficacy in preserving kidney function and reducing the total kidney volume (TKV) growth rate. These effects were especially pronounced in patients with more severe clinical phenotypes, such as higher TKV and rapidly declining kidney function. Despite the therapeutic effects of tolvaptan, aquaretic symptoms are unavoidable side effects related to the mechanism of the drug and are also directly related to the quality of life. A shared decision-making process could be a valuable strategy for reducing the incidence of side effects and improving medication adherence. Herein, we aimed to review overall clinical trials for applying tolvaptan and suggest important factors during the shared decision-making process.
MeSH term(s)	Humans ; Tolvaptan/adverse effects ; Polycystic Kidney, Autosomal Dominant/diagnosis ; Polycystic Kidney, Autosomal Dominant/drug therapy ; Quality of Life ; Antidiuretic Hormone Receptor Antagonists/adverse effects ; Kidney
Chemical Substances	Tolvaptan (21G72T1950) ; Antidiuretic Hormone Receptor Antagonists
Language	English
Publishing date	2023-04-25
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	639023-7
ISSN	2005-6648 ; 1226-3303
ISSN (online)	2005-6648
ISSN	1226-3303
DOI	10.3904/kjim.2022.376
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Acute interstitial nephritis with acute kidney injury after COVID-19 vaccination: a case report.

Lim, Jimin / Paek, Jin Hyuk / Shin, Hyeong Chan / Park, Woo Yeong / Jin, Kyubok / Choe, Misun / Han, Seungyeup / Kim, Yaerim

Clinical and experimental vaccine research

2024 Volume 13, Issue 1, Page(s) 68–71

Abstract: In the context of the massive spread of coronavirus disease 2019 (COVID-19), the development of a COVID-19 vaccine is urgently needed. The Pfizer-BioNTech COVID-19 vaccine has been widely applied across global populations. Herein, we report a case of ... ...

Abstract	In the context of the massive spread of coronavirus disease 2019 (COVID-19), the development of a COVID-19 vaccine is urgently needed. The Pfizer-BioNTech COVID-19 vaccine has been widely applied across global populations. Herein, we report a case of acute interstitial nephritis with acute kidney injury in a young healthy subject after administration of the COVID-19 vaccine. A 20-year-old man was admitted with abdominal discomfort and nausea. He had received the Pfizer-BioNTech COVID-19 vaccine 6 days before. At 9 days after vaccination, his kidney function was decreased, with serum creatinine levels of 1.8 mg/dL. Even with supportive care with hydration, his kidney function worsened, and he underwent a kidney biopsy. The pathology findings revealed diffuse interstitial infiltration of inflammatory cells, predominantly comprising lymphocytes, with preservation of the glomerulus. No abnormal findings were noted by immunofluorescence or electron microscopy. Based on a diagnosis of drug-related acute interstitial nephritis, we treated the patient with high-dose prednisolone. After administration of prednisolone, kidney function slowly improved. A close linkage between COVID-19 vaccination and acute interstitial nephritis should be considered in the clinic, despite the low incidence.
Language	English
Publishing date	2024-01-31
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	2684652-4
ISSN	2287-366X ; 2287-3651
ISSN (online)	2287-366X
ISSN	2287-3651
DOI	10.7774/cevr.2024.13.1.68
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Relapsing lupus enteritis in systemic lupus erythematosus.

Kim, Yaerim / Han, Seungyeup

Kidney research and clinical practice

2016 Volume 35, Issue 2, Page(s) 127

Language	English
Publishing date	2016-03-21
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2656420-8
ISSN	2211-9132
ISSN	2211-9132
DOI	10.1016/j.krcp.2016.03.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The estimated mediating roles of anemia-related variables in the association between kidney function and mortality: a National Health and Nutrition Examination Survey (NHANES) study.

Kim, Yae Hyun / Lee, Whanhee / Kim, Kyun Young / Kim, Yaerim / Ko, Ara / Weon, Boram / Lee, Jeonghwan / Jin, Wencheng / Kim, Dong Ki / Kim, Yon Su / Lim, Chun Soo / Lee, Jung Pyo

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6621

Abstract: Anemia is a common complication of chronic kidney disease (CKD), impacting long-term outcomes such as mortality and morbidity. Analyzing NHANES data from 1999 through 2016 for adults aged ≥ 20 years, we assessed the mediating effects of anemia biomarkers ...

Abstract	Anemia is a common complication of chronic kidney disease (CKD), impacting long-term outcomes such as mortality and morbidity. Analyzing NHANES data from 1999 through 2016 for adults aged ≥ 20 years, we assessed the mediating effects of anemia biomarkers (hemoglobin, hematocrit, red cell distribution width [RDW], and mean corpuscular hemoglobin concentration [MCHC]) on CKD-related outcomes by using hazard ratios from a biomarker-adjusted model. Of 44,099 participants, 7463 experienced all-cause death. Cox proportional hazard models revealed a higher all-cause mortality risk in the > 45 years and CKD groups than in the early CKD group. Hemoglobin, hematocrit and MCHC were inversely related to all-cause mortality; RDW was related to mortality. Single mediation analysis showed greater mediating effects of anemia indicators on CKD and mortality in the elderly (> 65 years) population than those in the general population. In the multimediation analysis, the combined mediating effect of anemia was higher in the CKD population than in the general population. This study showed a proportional increase in the mediating effect of anemia with CKD stage, suggesting potential therapeutic avenues. However, further exploration of other mediating factors on kidney outcomes is necessary.
MeSH term(s)	Adult ; Aged ; Humans ; Nutrition Surveys ; Anemia/epidemiology ; Anemia/etiology ; Kidney ; Biomarkers ; Renal Insufficiency, Chronic/diagnosis ; Hemoglobins ; Risk Factors
Chemical Substances	Biomarkers ; Hemoglobins
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56877-7
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Article ; Online: Non-indicated initiation of proton pump inhibitor and risk of adverse outcomes in patients with underlying chronic kidney disease: a nationwide, retrospective, cohort study.

Kim, Seong Geun / Cho, Jeong Min / Han, Kyungdo / Joo, Kwon-Wook / Lee, Soojin / Kim, Yaerim / Cho, Semin / Huh, Hyuk / Kim, Minsang / Kang, Eunjeong / Kim, Dong Ki / Park, Sehoon

BMJ open

2024 Volume 14, Issue 1, Page(s) e078032

Abstract: Objective: Evidence related to the risk of kidney damage by proton pump inhibitor (PPI) initiation in patients with 'underlying' chronic kidney disease (CKD) remains scarce, although PPI use is generally associated with acute interstitial nephritis or ... ...

Abstract	Objective: Evidence related to the risk of kidney damage by proton pump inhibitor (PPI) initiation in patients with 'underlying' chronic kidney disease (CKD) remains scarce, although PPI use is generally associated with acute interstitial nephritis or incident CKD. We aimed to investigate the association between PPI initiation and the risk of adverse outcomes in patients with CKD in the absence of any deterministic indications for PPI usage. Design: Retrospective observational study. Setting: Korea National Health Insurance Service database from 2009 to 2017. Participants: A retrospective cohort of new PPI and histamine H Primary and secondary outcome measures: The study subjects were followed to ascertain clinical outcomes including mortality, end-stage kidney disease (ESKD), myocardial infarction and stroke. The HRs of outcomes were measured using a Cox regression model after adjusting for multiple variables. We applied an inverse probability of treatment weighting (IPTW) model to control for residual confounders. Results: We included a total of 1038 PPI and 3090 H2RA users without deterministic indications for treatment. IPTW-weighted Cox regression analysis showed that PPI initiation was more significantly associated with a higher ESKD risk compared with that of H2RA initiation (adjusted HR 1.72 (95% CI 1.19 to 2.48)), whereas the risks of mortality or cardiovascular outcomes were similar between the two groups. In the subgroup analysis, multivariable Cox regression analysis showed that the association between PPI use and the progression to ESKD remained significant in non-diabetic and low estimated glomerular filtration rate (<60 mL/min/1.73 m Conclusions: Initiation of PPI administration may not be recommended in patients with CKD without deterministic indication, as their usage was associated with a higher risk of ESKD.
MeSH term(s)	Humans ; Cohort Studies ; Retrospective Studies ; Proton Pump Inhibitors/adverse effects ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/drug therapy ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/complications ; Risk Factors
Chemical Substances	Proton Pump Inhibitors
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-078032
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Article: Associations of metabolic variabilities and cardiovascular outcomes according to estimated glomerular filtration rate in chronic kidney disease: a nationwide observational cohort study.

Cho, Jeong Min / Han, Kyungdo / Joo, Kwon Wook / Lee, Soojin / Kim, Yaerim / Cho, Semin / Huh, Hyuk / Kim, Seong Geun / Kim, Minsang / Kang, Eunjeong / Kim, Dong Ki / Park, Sehoon

Kidney research and clinical practice

2024

Abstract: Background: The impact of baseline estimated glomerular filtration rate (eGFR) on the risk of adverse outcomes according to metabolic parameter variabilities in chronic kidney disease has rarely been investigated.: Methods: We conducted a ... ...

Abstract	Background: The impact of baseline estimated glomerular filtration rate (eGFR) on the risk of adverse outcomes according to metabolic parameter variabilities in chronic kidney disease has rarely been investigated. Methods: We conducted a retrospective nationwide cohort study using the National Health Insurance System data in Korea from 2007 to 2013 to identify individuals with three or more health screenings. The metabolic components variability was defined as intraindividual variability between measurements using the variability independent of the mean. The metabolic variability score was defined as the total number of high-variability metabolic components. Multivariable-adjusted Cox regression analysis was conducted to evaluate the risks of all-cause mortality, myocardial infarction, and ischemic stroke. Results: During a mean follow-up of 6.0 ± 0.7 years, 223,531 deaths, 107,140 myocardial infarctions, and 116,182 ischemic strokes were identified in 9,971,562 patients. Low eGFR categories and higher metabolic variability scores were associated with a higher risk of adverse outcomes. The degree of association between metabolic variability and adverse outcomes was significantly larger in those with low eGFR categories than in those with preserved eGFR (p for interaction < 0.001). Representatively, those with high metabolic variability in the eGFR of <15 mL/min/1.73 m2 group showed a prominently higher risk for all-cause mortality (adjusted hazard ratio [aHR], 5.28; 95% confidence interval [CI], 4.02-6.94) when the degree was compared to the findings in those with preserved (eGFR of ≥60 mL/min/1.73 m2) kidney function (aHR, 2.55; 95% CI, 2.41-2.69). Conclusion: The degree of adverse association between metabolic variability and poor prognosis is accentuated in patients with impaired kidney function.
Language	English
Publishing date	2024-01-12
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2656420-8
ISSN	2211-9132
ISSN	2211-9132
DOI	10.23876/j.krcp.23.135
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Article ; Online: Relapsing lupus enteritis in systemic lupus erythematosus

Yaerim Kim / Seungyeup Han

Kidney Research and Clinical Practice, Vol 35, Iss 2, p

2016 Volume 127

Keywords	Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951
Language	English
Publishing date	2016-06-01T00:00:00Z
Publisher	The Korean Society of Nephrology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Associations of MRI-derived kidney volume, kidney function, body composition and physical performance in ≈38 000 UK Biobank participants: a population-based observational study.

Cho, Jeong Min / Koh, Jung Hun / Kim, Seong Geun / Lee, Soojin / Kim, Yaerim / Cho, Semin / Kim, Kwangsoo / Kim, Yong Chul / Han, Seung Seok / Lee, Hajeong / Lee, Jung Pyo / Joo, Kwon Wook / Lim, Chun Soo / Kim, Yon Su / Kim, Dong Ki / Park, Sehoon

Clinical kidney journal

2024 Volume 17, Issue 4, Page(s) sfae068

Abstract: Background: Kidney volume is used as a predictive and therapeutic marker for several clinical conditions. However, there is a lack of large-scale studies examining the relationship between kidney volume and various clinicodemographic factors, including ... ...

Abstract	Background: Kidney volume is used as a predictive and therapeutic marker for several clinical conditions. However, there is a lack of large-scale studies examining the relationship between kidney volume and various clinicodemographic factors, including kidney function, body composition and physical performance. Methods: In this observational study, MRI-derived kidney volume measurements from 38 526 UK Biobank participants were analysed. Major kidney volume-related measures included body surface area (BSA)-adjusted total kidney volume (TKV) and the difference in bilateral kidneys. Multivariable-adjusted linear regression and cubic spline analyses were used to explore the association between kidney volume-related measures and clinicodemographic factors. Cox or logistic regression was used to identify the risks of death, non-kidney cancer, myocardial infarction, ischaemic stroke and chronic kidney disease (CKD). Results: The median of BSA-adjusted TKV and the difference in kidney volume were 141.9 ml/m Conclusion: Higher BSA-adjusted TKV and lower differences in bilateral kidney volumes are associated with higher kidney function, muscle volume and physical performance and a reduced risk of CKD.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfae068
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Article: Effectiveness of valacyclovir prophylaxis against the occurrence of cytomegalovirus infection in kidney transplant recipients.

Park, Woo Yeong / Kim, Yaerim / Paek, Jin Hyuk / Jin, Kyubok / Park, Sung Bae / Han, Seungyeup

Korean journal of transplantation

2022 Volume 34, Issue 1, Page(s) 15–23

Abstract: Background: Cytomegalovirus (CMV) infection is a crucial infection in kidney transplant recipients (KTRs) despite advancements in diagnostic and treatment methods. There are still many controversies about the ways to prevent CMV infection.: Methods: ... ...

Abstract	Background: Cytomegalovirus (CMV) infection is a crucial infection in kidney transplant recipients (KTRs) despite advancements in diagnostic and treatment methods. There are still many controversies about the ways to prevent CMV infection. Methods: We retrospectively analyzed 153 KTRs who underwent kidney transplantation (KT) between September 2013 and January 2016. We classified KTRs into two groups: valacyclovir prophylaxis group (intravenous ganciclovir for 2 weeks after KT, followed by oral valacyclovir for 3 months) and historical control group (only intravenous ganciclovir for 2 weeks after KT). We evaluated the incidence of CMV infection, clinical outcomes, CMV-free survival rate between the two groups and risk factors for the development of CMV infection. Results: Mean time between KT and diagnosis of CMV infection was 4.5±3.3 months. The valacyclovir prophylaxis group showed lower incidence of CMV infection than the historical control group (21.7% vs. 43.9%, P=0.011). The valacyclovir prophylaxis group showed higher CMV-free survival rate than the control group (P=0.011). In multivariable-adjusted analysis, independent risk factors for the development of CMV infection were no valacyclovir prophylaxis, older age at KT, thymoglobulin induction, and delayed graft function. Conclusions: Valacyclovir prophylaxis for 3 months showed significant reduction in the incidence of CMV infection in KTRs. Therefore, we suggest valacyclovir prophylaxis for 3 months in KTRs with risk factors such as old age, thymoglobulin induction, and delayed graft function.
Language	English
Publishing date	2022-06-25
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2671-8790
ISSN	2671-8790
DOI	10.4285/kjt.2020.34.1.15
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Article ; Online: Impact of decreased levels of total CO2 on in-hospital mortality in patients with COVID-19.

Kim, Yaerim / Kwon, Soie / Kim, Seong Geun / Lee, Jeonghwan / Han, Chung-Hee / Yu, Sungbong / Kim, Byunggun / Paek, Jin Hyuk / Park, Woo Yeong / Jin, Kyubok / Han, Seungyeup / Kim, Dong Ki / Lim, Chun Soo / Kim, Yon Su / Lee, Jung Pyo

Scientific reports

2023 Volume 13, Issue 1, Page(s) 16717

Abstract: Decreased total ... ...

Abstract	Decreased total CO
MeSH term(s)	Humans ; Carbon Dioxide ; Retrospective Studies ; Hospital Mortality ; COVID-19 ; Proportional Hazards Models
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2023-10-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41988-4
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