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Article ; Online: Efficacy of Fufang E’jiao Jiang in the Treatment of Patients with Qi and Blood Deficiency Syndrome

Mengjie Zhao / Mengli Xiao / Jiake Ying / Panbo Qiu / Hongxian Wu / Qin Tan / Shiliang Chen / Lulu Zhang / Sanfei Shi / Guida Li / Yang Zhao / Fang Lu

Evidence-Based Complementary and Alternative Medicine, Vol

A Real-World Prospective Multicenter Study with a Patient Registry

2023 Volume 2023

Abstract: ... designed to evaluate the efficacy of Fufang E’jiao Jiang (FEJ) in Chinese patients with Qi and blood ...

Abstract	Objective. This nationwide, multicenter prospective observational study with a patient registry was designed to evaluate the efficacy of Fufang E’jiao Jiang (FEJ) in Chinese patients with Qi and blood deficiency syndrome (QBDS). Methods. QBDS patients were consecutively recruited from 81 investigational sites in China from July, 2019, to December, 2020. Patients who met the eligibility criteria were enrolled in a prospective registry database. Baseline characteristics and changes in scores on the traditional Chinese medicine (TCM) symptom evaluation scale for Qi and blood deficiency, the clinical global impression (CGI) scale, the fatigue scale-14 (FS-14), and the Pittsburgh sleep quality index (PSQI) were analyzed to determine the clinical efficacy of FEJ. Results. A total of 3,203 patients were recruited. The average remission rate (i.e., the sum of the cure rate and improvement rate) of the 20 symptoms of QBDS was 92.49% after 4 weeks of FEJ treatment, which was higher than at baseline; the rate increased to 94.69% at 8 weeks. The CGI scale revealed that the number of total remissions at 4 and 8 weeks was 3,120 (97.41%) and 415 (100%), respectively. The total FS-14 scores decreased by 1.67 ± 4.11 (p<0.001) at 4 weeks and 1.72 ± 3.09 (p<0.001) at 8 weeks of treatment. The PSQI scores were 6.6 ± 4.7 and 6.52 ± 3.07 at 4 and 8 weeks, respectively, which were significantly lower than the baseline scores (p<0.001; p=0.0033). Both the subhealth fatigue (SF) and iron deficiency anemia (IDA) groups showed significantly improved clinical symptoms of QBDS (p<0.01). Between-group comparisons revealed significantly greater improvements in FS-14 and PSQI scores in the SF group than in the IDA group (p<0.05). A multivariate logistic regression analysis showed that disease course, FS-14 score at baseline, and four-week FEJ doses were independent risk factors for the degree of symptom relief in QBDS patients (p<0.05). Conclusion. In real-world settings, FEJ has a promising effect in treating QBDS and can ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Application of Jiao Xue on men's diseases].

Zhao, Jiayou / Song, Chunsheng

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2015 Volume 35, Issue 6, Page(s) 623–624

MeSH term(s)	Acupuncture Points ; Acupuncture Therapy ; Adult ; Genital Diseases, Male/therapy ; Humans ; Male ; Middle Aged
Language	Chinese
Publishing date	2015-06
Publishing country	China
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0255-2930
ISSN	0255-2930
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Discussion on application of Jiao Xue].

Zhao, Jia-You / Zhang, Ying / Zhang, Xue-Song

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2013 Volume 33, Issue 6, Page(s) 560

MeSH term(s)	Acupuncture Points ; Acupuncture Therapy ; Adult ; Aged ; Coronary Disease/therapy ; Humans ; Male ; Middle Aged
Language	Chinese
Publishing date	2013-06
Publishing country	China
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0255-2930
ISSN	0255-2930
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The southwestern extension of the Jiao-Liao-Ji belt in the North China Craton

Liu, Chaohui / Zhao, Guochun / Liu, Fulai / Cai, Jia

Geochronological and geochemical evidence from the Wuhe Group in the Bengbu area

2018

Abstract: ... granulite-facies metamorphism suggest that the Wuhe complex and the Jiao-Liao-Ji Belt share the same late ...

Abstract	The Wuhe complex is located at the southeastern margin of the North China Craton. The complex consists of metamorphosed Paleoproterozoic potassic granitoids and supracrustal rocks, of which the latter include the Fengyang and Wuhe groups. Meta-mafic rocks from the lower Wuhe Group have igneous zircon U-Pb ages of 2126 ± 37 Ma with εHf(t) values of −6.22 to +8.38, and xenocrystic zircons of 2.39–2.36 Ga, 2.55–2.54 Ga and 2.77–2.69 Ga. Geochemically, the meta-mafic rocks can be classified into two groups. Group 1 island arc tholeiites display flat to slightly right declined REE patterns and moderately negative Nb, Ta, Zr, and Ti anomalies. Group 2 mature arc calcalkaline basalts display strongly fractionated chondrite-normalized REE patterns and evidently negative Nb, Ta and Ti anomalies. These meta-mafic rocks formed by partial melting of sub-arc depleted mantle wedge which had been modified by slab-derived melts at an active continental margin. Depositional age of the group can be constrained in the period of 2.16–2.10 Ga based on ages of the youngest detrital zircons and latter intrusions. U-Pb ages of detrital zircons yield major age peaks of 2.69 Ga and 2.52 Ga, with minor peaks at 2.88 Ga, 2.78 Ga, 2.35 Ga and 2.17 Ga, most of which are derived from the late Mesoarchean to early Paleoproterozoic granitoids in the Wuhe complex and the Jiaodong Terrane. Metamorphic zircons in the marbles coexisting with garnet amphibolites or granulites occur as either single grains or overgrowth (or recrystallization) rims surrounding magmatic zircon cores and yield ages of 1882 ± 19 Ma to 1844 ± 15 Ma. The comparable ca. 2.1 Ga potassic granites with A-type granite affinity, the ca. 2.1 Ga meta-mafic rocks with arc-like geochemical features, the 2.1–1.9 Ga meta-sedimentary units and the 1.9–1.8 Ga subduction- and collision-related granulite-facies metamorphism suggest that the Wuhe complex and the Jiao-Liao-Ji Belt share the same late Paleoproterozoic tectonic evolution process and the former is the southwestern extension of ...
Subject code	550
Language	English
Publisher	Elsevier
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Bei xin jiao ji

Li, Shutong / Zhao, Haiyan

(Mei xue san bu cong shu ; 美学散步丛书)

2010

Author's details	Li Shutong zhu; Zhao Haiyan bian
Series title	Mei xue san bu cong shu 美学散步丛书
Language	Chinese
Size	8, 234 p, Ill
Edition	Di 1 ban
Publisher	Beijing da xue chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787301164327 ; 7301164327
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: The effects of Jiao-Tai-Wan on sleep, inflammation and insulin resistance in obesity-resistant rats with chronic partial sleep deprivation.

Zou, Xin / Huang, Wenya / Lu, Fuer / Fang, Ke / Wang, Dingkun / Zhao, Shuyong / Jia, Jiming / Xu, Lijun / Wang, Kaifu / Wang, Nan / Dong, Hui

BMC complementary and alternative medicine

2017 Volume 17, Issue 1, Page(s) 165

Abstract: Background: Jiao-Tai-Wan (JTW), composed of Rhizome Coptidis and Cortex Cinnamomi, is a classical ...

Abstract	Background: Jiao-Tai-Wan (JTW), composed of Rhizome Coptidis and Cortex Cinnamomi, is a classical traditional Chinese prescription for treating insomnia. Several in vivo studies have concluded that JTW could exert its therapeutical effect in insomnia rats. However, the specific mechanism is still unclear. The present study aimed to explore the effect of JTW on sleep in obesity-resistant (OR) rats with chronic partial sleep deprivation (PSD) and to clarify its possible mechanism. Methods: JTW was prepared and the main components contained in the granules were identified by 3D-High Performance Liquid Chromatography (3D-HPLC) assay. The Male Sprague-Dawley (SD) rats underwent 4 h PSD by environmental noise and the treatment with low and high doses of JTW orally for 4 weeks, respectively. Then sleep structure was analyzed by electroencephalographic (EEG). Inflammation markers including high-sensitivity C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were examined in the rat plasma. Meanwhile, metabolic parameters as body weight increase rate, fasting plasma glucose (FPG), fasting insulin (FINS) levels and insulin resistance index (HOMA-IR) were measured. The expressions of clock gene cryptochromes (Cry1 and Cry2) and inflammation gene nuclear factor-κB (NF-κB) in peripheral blood monocyte cells (PBMC) were also determined. Results: The result showed that the administration of JTW significantly increased total sleep time and total slow wave sleep (SWS) time in OR rats with PSD. Furthermore, the treatment with JTW reversed the increase in the markers of systemic inflammation and insulin resistance caused by sleep loss. These changes were also associated with the up-regulation of Cry1 mRNA and Cry 2 mRNA and the down-regulation of NF-κB mRNA expression in PBMC. Conclusions: This study suggests that JTW has the beneficial effects of improving sleep, inflammation and insulin sensitivity. The mechanism appears to be related to the modulation of circadian clock and inflammation genes expressions in PBMC.
MeSH term(s)	Animals ; C-Reactive Protein/metabolism ; Drugs, Chinese Herbal/administration & dosage ; Humans ; Insulin Resistance ; Interleukin-6/metabolism ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Male ; NF-kappa B/metabolism ; Obesity/drug therapy ; Obesity/metabolism ; Obesity/physiopathology ; Rats ; Rats, Sprague-Dawley ; Sleep/drug effects ; Sleep Deprivation/drug therapy ; Sleep Deprivation/metabolism ; Sleep Deprivation/physiopathology
Chemical Substances	Drugs, Chinese Herbal ; Interleukin-6 ; NF-kappa B ; jiao tai wan ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2017-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2050429-9
ISSN	1472-6882 ; 1472-6882
ISSN (online)	1472-6882
ISSN	1472-6882
DOI	10.1186/s12906-017-1648-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metabolomics-based evidence of the hypoglycemic effect of Ge-Gen-Jiao-Tai-Wan in type 2 diabetic rats via UHPLC-QTOF/MS analysis.

Wang, Wenbo / Zhao, Linlin / He, Zhenyu / Wu, Ning / Li, Qiuxia / Qiu, Xinjian / Zhou, Lu / Wang, Dongsheng

Journal of ethnopharmacology

2018 Volume 219, Page(s) 299–318

Abstract: Ethnopharmacological relevance: Ge-Gen-Jiao-Tai-Wan (GGJTW) formula, derived from traditional ...

Abstract	Ethnopharmacological relevance: Ge-Gen-Jiao-Tai-Wan (GGJTW) formula, derived from traditional Chinese herbal medicine, is composed of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep (Ge-Gen in Chinese), Coptis chinensis Franch (Huang-Lian), and Cinnamomum cassia (L.) J. Presl (Rou-Gui). GGJTW is used for treatment of diabetes in China, reflecting the potent hypoglycemic effect of its ingredients. However, little is known of the hypoglycemic effect of GGJTW and the underlying metabolic mechanism. Aim of the study: This study aimed to investigate the hypoglycemic effect of GGJTW in type 2 diabetic rats and the metabolic mechanism of action. Materials and methods: Ultra high-performance liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry (UHPLC-QTOF/MS)-based metabolomics approach was used for monitoring hyperglycaemia induced by high-sugar high-fat fodder and streptozotocin (STZ), and the protective effect of GGJTW. Dynamic fasting blood glucose (FBG) levels, body weight, and biochemical parameters, including lipid levels, hepatic-renal function, and hepatic histopathology were used to confirm the hyperglycaemic toxicity and attenuation effects. An orthogonal partial least squared-discriminant analysis (OPLS-DA) approach highlighted significant differences in the metabolome of the healthy control, diabetic, and drug-treated rats. The metabolomics pathway analysis (MetPA) and Kyoto encyclopedia of genes and genomes (KEGG) database were used to investigate the underlying metabolic pathways. Results: Metabolic profiling revealed 37 metabolites as the most potential biomarker metabolites distinguishing GGJTW-treated rats from model rats. Most of the metabolites were primarily associated with bile acid metabolism and lipid metabolism. The most critical pathway was primary bile acid biosynthesis pathway involving the up-regulation of the levels of cholic acid (CA), chenodeoxycholic acid (CDCA), taurocholic acid (TCA), glycocholic acid (GCA), taurochenodesoxycholic acid (TCDCA), and taurine. Conclusions: The significantly-altered metabolite levels indicated the hypoglycemic effect of GGJTW on diabetic rats and the underlying metabolic mechanism. This study will be meaningful for the clinical application of GGJTW and valuable for further exploration of the mechanism.
MeSH term(s)	Animals ; Chromatography, High Pressure Liquid/methods ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/therapeutic use ; Hypoglycemic Agents/analysis ; Hypoglycemic Agents/therapeutic use ; Male ; Metabolomics/methods ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal ; Hypoglycemic Agents ; jiao tai wan
Language	English
Publishing date	2018-03-23
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2018.03.026
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Timing of metamorphism in the Paleoproterozoic Jiao-Liao-Ji Belt

Tam, Pui Yuk / Zhao, Guochun / Liu, Fulai / Zhou, Xiwen / Sun, Min / Li, Sanzhong

New SHRIMP U–Pb zircon dating of granulites, gneisses and marbles of the Jiaobei massif in the North China Craton

2011

Abstract: The Paleoproterozoic Jiao-Liao-Ji Belt lies in the Eastern Block of the North China Craton ... South Liaohe Groups and the Laoling Group in the northern segment of the Jiao-Liao-Ji Belt. Metamorphic ... in the northern segment of the Jiao-Liao-Ji Belt and c. 1.86–1.80 Ga obtained for the high-pressure pelitic ...

Abstract	The Paleoproterozoic Jiao-Liao-Ji Belt lies in the Eastern Block of the North China Craton, with its southern segment extending across the Bohai Sea into the Jiaobei massif. High-pressure pelitic and mafic granulites have been recently recognized in the Paleoproterozoic Jingshan Group (Jiaobei massif). New SHRIMP U–Th–Pb geochronology combined with cathodoluminescence (CL) imaging of zircon has been applied to the determination of the timing of the metamorphism of the high-temperature and high-pressure granulites and associated gneisses and marbles. Metamorphic zircons in these high-pressure granulites, gneisses and marbles occur as either single grains or overgrowth (or recrystallization) rims surrounding and truncating oscillatory-zoned magmatic zircon cores. Metamorphic zircons are all characterized by nebulous zoning or being structureless, with high luminescence and relatively low Th/U values. Metamorphic zircons from two high-pressure mafic granulites yielded 207Pb/206Pb ages of 1956 ± 41 Ma and 1884 ± 24 Ma. One metamorphic zircon from a garnet–sillimanite gneiss also gave an apparent 207Pb/206Pb age of 1939 ± 15 Ma. These results are consistent with interval of ages of c. 1.93–1.90 Ga already obtained by previous studies for the North and South Liaohe Groups and the Laoling Group in the northern segment of the Jiao-Liao-Ji Belt. Metamorphic zircons from a high-pressure pelitic granulite and two pelitic gneisses yielded weighted mean 207Pb/206Pb ages of 1837 ± 8 Ma, 1821 ± 8 Ma and 1836 ± 8 Ma respectively. Two diopside–olivine–phlogopite marbles yielded weighted mean 207Pb/206Pb ages of 1817 ± 9 Ma and 1790 ± 6 Ma. These Paleoproterozoic metamorphic ages are largely in accordance with metamorphic ages of c. 1.85 Ga produced from the Ji'an Group in the northern segment of the Jiao-Liao-Ji Belt and c. 1.86–1.80 Ga obtained for the high-pressure pelitic granulites from the Jingshan Group in the southern segment. As this metamorphic event was coeval with the emplacement of A-type granites in the Jiao-Liao-Ji ...
Subject code	550
Language	English
Publisher	Elsevier
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effects of Jiao-Tai-Wan on sleep, inflammation and insulin resistance in obesity-resistant rats with chronic partial sleep deprivation

Zou, Xin / Huang, Wenya / Lu, Fuer / Fang, Ke / Wang, Dingkun / Zhao, Shuyong / Jia, Jiming / Xu, Lijun / Wang, Kaifu / Wang, Nan / Dong, Hui

BMC Complement Altern Med. 2017 Dec., v. 17, no. 1 p.165-165

2017

Abstract: BACKGROUND: Jiao-Tai-Wan (JTW), composed of Rhizome Coptidis and Cortex Cinnamomi, is a classical ...

Abstract	BACKGROUND: Jiao-Tai-Wan (JTW), composed of Rhizome Coptidis and Cortex Cinnamomi, is a classical traditional Chinese prescription for treating insomnia. Several in vivo studies have concluded that JTW could exert its therapeutical effect in insomnia rats. However, the specific mechanism is still unclear. The present study aimed to explore the effect of JTW on sleep in obesity-resistant (OR) rats with chronic partial sleep deprivation (PSD) and to clarify its possible mechanism. METHODS: JTW was prepared and the main components contained in the granules were identified by 3D-High Performance Liquid Chromatography (3D-HPLC) assay. The Male Sprague-Dawley (SD) rats underwent 4 h PSD by environmental noise and the treatment with low and high doses of JTW orally for 4 weeks, respectively. Then sleep structure was analyzed by electroencephalographic (EEG). Inflammation markers including high-sensitivity C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were examined in the rat plasma. Meanwhile, metabolic parameters as body weight increase rate, fasting plasma glucose (FPG), fasting insulin (FINS) levels and insulin resistance index (HOMA-IR) were measured. The expressions of clock gene cryptochromes (Cry1 and Cry2) and inflammation gene nuclear factor-κB (NF-κB) in peripheral blood monocyte cells (PBMC) were also determined. RESULTS: The result showed that the administration of JTW significantly increased total sleep time and total slow wave sleep (SWS) time in OR rats with PSD. Furthermore, the treatment with JTW reversed the increase in the markers of systemic inflammation and insulin resistance caused by sleep loss. These changes were also associated with the up-regulation of Cry1 mRNA and Cry 2 mRNA and the down-regulation of NF-κB mRNA expression in PBMC. CONCLUSIONS: This study suggests that JTW has the beneficial effects of improving sleep, inflammation and insulin sensitivity. The mechanism appears to be related to the modulation of circadian clock and inflammation genes expressions in PBMC.
Keywords	blood glucose ; body weight ; circadian clocks ; complement ; cortex ; cryptochromes ; electroencephalography ; gene expression ; genes ; inflammation ; insulin ; insulin resistance ; interleukin-6 ; liquid chromatography ; males ; mononuclear leukocytes ; necrosis ; neoplasms ; rats ; rhizomes ; sleep deprivation
Language	English
Dates of publication	2017-12
Size	p. 165.
Publishing place	BioMed Central
Document type	Article ; Online
Note	Resource is Open Access
ZDB-ID	2050429-9
ISSN	1472-6882
ISSN	1472-6882
DOI	10.1186/s12906-017-1648-9
Database	NAL-Catalogue (AGRICOLA)

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Book: Zhong ji han yu jing du jiao cheng

Zhao, Xin

2010

Author's details	Zhao Xin
Language	Chinese
Size	2, 1, 280 S.
Publisher	Beijing da xue chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787301179789 ; 7301179782
Database	Former special subject collection: coastal and deep sea fishing

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