LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 92

Search options

  1. Article ; Online: The Effect of COVID-19 Pandemic on Patients with Primary Immunodeficiency: A Cohort Study.

    Babaei, Maryam / Kanannejad, Zahra / Sepahi, Najmeh / Alyasin, Soheila

    Iranian journal of medical sciences

    2022  Volume 47, Issue 2, Page(s) 162–166

    Abstract: Both adaptive and innate immune responses are essential for an effective defense against the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate the effect of the coronavirus disease 2019 (COVID-19) pandemic on ...

    Abstract Both adaptive and innate immune responses are essential for an effective defense against the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate the effect of the coronavirus disease 2019 (COVID-19) pandemic on patients with primary immunodeficiency (PID). This study was performed on patients who were diagnosed with PID by immunologist specialists and referred to Imam Reza Clinic of Asthma and Allergy, affiliated with Shiraz University of Medical Sciences, (Shiraz, Iran) for regular check-ups. The patients were enrolled in this cohort study and followed for any sign of COVID-19 from March 2020 to May 2021. COVID-19 infection was confirmed using a real-time polymerase chain reaction (RT-PCR) assay of nasal and pharyngeal swabs. Among the 90 PID patients under study, nine patients (10%) were diagnosed positive for COVID-19 infection. Five out of these nine patients belonged to the combined immunodeficiency (CID) category, while four patients were categorized as having primary antibody deficiencies (PADs). Eight patients with COVID-19 were required to be admitted to the hospital, and three patients died after hospitalization due to COVID-19 infection. It seems that patients with CID are at a higher risk of mortality, due to COVID-19 infection, that other types of PID.
    MeSH term(s) COVID-19/epidemiology ; Cohort Studies ; Humans ; Immunity, Innate ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-01-31
    Publishing country Iran
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603872-4
    ISSN 1735-3688 ; 0253-0716
    ISSN (online) 1735-3688
    ISSN 0253-0716
    DOI 10.30476/IJMS.2022.92862.2415
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1634: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: The Effect of COVID-19 Pandemic on Patients with Primary Immunodeficiency

    Maryam Babaei / Zahra Kanannejad / Najmeh Sepahi / Soheila Alyasin

    Iranian Journal of Medical Sciences, Vol 47, Iss 2, Pp 162-

    A Cohort Study

    2022  Volume 166

    Abstract: Both adaptive and innate immune responses are essential for an effective defense against the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate the effect of the coronavirus disease 2019 (COVID-19) pandemic on ...

    Abstract Both adaptive and innate immune responses are essential for an effective defense against the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate the effect of the coronavirus disease 2019 (COVID-19) pandemic on patients with primary immunodeficiency (PID). This study was performed on patients who were diagnosed with PID by immunologist specialists and referred to Imam Reza Clinic of Asthma and Allergy, affiliated with Shiraz University of Medical Sciences, (Shiraz, Iran) for regular check-ups. The patients were enrolled in this cohort study and followed for any sign of COVID-19 from March 2020 to May 2021. COVID-19 infection was confirmed using a real-time polymerase chain reaction (RT-PCR) assay of nasal and pharyngeal swabs. Among the 90 PID patients under study, nine patients (10%) were diagnosed positive for COVID-19 infection. Five out of these nine patients belonged to the combined immunodeficiency (CID) category, while four patients were categorized as having primary antibody deficiencies (PADs). Eight patients with COVID-19 were required to be admitted to the hospital, and three patients died after hospitalization due to COVID-19 infection. It seems that patients with CID are at a higher risk of mortality, due to COVID-19 infection, that other types of PID.
    Keywords covid-19 ; mortality ; primary immunodeficiency diseases ; Medicine (General) ; R5-920
    Subject code 610 ; 616
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Shiraz University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Immune checkpoint molecules in prevention and development of asthma.

    Kanannejad, Zahra / Soleimanian, Saeede / Ghahramani, Zahra / Sepahi, Najmeh / Mohkam, Milad / Alyasin, Soheila / Kheshtchin, Nasim

    Frontiers in immunology

    2023  Volume 14, Page(s) 1070779

    Abstract: Allergic asthma is a respiratory disease initiated by type-2 immune responses characterized by secretion of alarmins, interleukin-4 (IL-4), IL-5, and IL-13, eosinophilic inflammation, and airway hyperresponsiveness (AHR). Immune checkpoints (ICPs) are ... ...

    Abstract Allergic asthma is a respiratory disease initiated by type-2 immune responses characterized by secretion of alarmins, interleukin-4 (IL-4), IL-5, and IL-13, eosinophilic inflammation, and airway hyperresponsiveness (AHR). Immune checkpoints (ICPs) are inhibitory or stimulatory molecules expressed on different immune cells, tumor cells, or other cell types that regulate immune system activation and maintain immune homeostasis. Compelling evidence indicates a key role for ICPs in both the progression and prevention of asthma. There is also evidence of asthma development or exacerbation in some cancer patients receiving ICP therapy. The aim of this review is to provide an updated overview of ICPs and their roles in asthma pathogenesis, and to assess their implications as therapeutic targets in asthma.
    MeSH term(s) Humans ; Immune Checkpoint Proteins ; Asthma/prevention & control ; Respiratory Hypersensitivity ; Alarmins ; Homeostasis
    Chemical Substances Immune Checkpoint Proteins ; Alarmins
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1070779
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Systemic aspergillosis in a patient with interferon gamma receptor 1 deficiency; a case report.

    Esmaeilzadeh, Hossein / Chavoshzadeh, Zahra / Nabavizadeh, Seyed Hesamedin / Alyasin, Soheila / Amanati, Ali / Askarisarvestani, Aida

    BMC pediatrics

    2023  Volume 23, Issue 1, Page(s) 278

    Abstract: Background: Interferon-gamma receptor deficiency is a heterogeneous spectrum of disease which involves mutations in IFNGR1, IFNGR2 genes, and the downstream signaling proteins such as STAT1. These mutations are associated with immunodeficiency 27 A and ... ...

    Abstract Background: Interferon-gamma receptor deficiency is a heterogeneous spectrum of disease which involves mutations in IFNGR1, IFNGR2 genes, and the downstream signaling proteins such as STAT1. These mutations are associated with immunodeficiency 27 A and 27B, making the patient prone to mycobacterial infections. Patients with this condition are also at increased risk for affliction with viral and bacterial infections, such as with the Herpesviridae family, Listeria, and Salmonella. Moreover, SH2B3 mutation is associated with autoimmune and lymphoproliferative conditions.
    Case presentation: the patient was a 19-month-old infant girl who presented with a two-week history of fever. She had near-normal flowcytometry with high IgM and IgE. She had pneumonic infiltration in her chest and right hilar and para-aortic lymphadenopathy. PCR of whole blood for Aspergillus fumigatus came back positive. In her Whole Exome Sequencing she had IFNGR1 and SH2B3 mutations.
    Conclusion: systemic fungal infections such as Aspergillosis can occur in patients with interferon-gamma receptor one deficiency. This type of immunodeficiency should be considered in treating patients with systemic Aspergillosis.
    MeSH term(s) Infant ; Female ; Humans ; Interferon-gamma/genetics ; Aspergillosis/diagnosis ; Aspergillosis/genetics ; Receptors, Interferon/genetics ; Immunologic Deficiency Syndromes/complications ; Immunologic Deficiency Syndromes/genetics ; Interferon gamma Receptor
    Chemical Substances Interferon-gamma (82115-62-6) ; Receptors, Interferon
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-023-04093-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Homozygous Autosomal Recessive

    Esmaeilzadeh, Hossein / Noeiaghdam, Rafat / Johari, Leila / Hosseini, Seyed Ali / Nabavizadeh, Sayyed Hesamedin / Alyasin, Soheila Sadat

    Case reports in genetics

    2022  Volume 2022, Page(s) 4142214

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2664417-4
    ISSN 2090-6552 ; 2090-6544
    ISSN (online) 2090-6552
    ISSN 2090-6544
    DOI 10.1155/2022/4142214
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Geo-climatic variability and adult asthma hospitalization in Fars, Southwest Iran

    Zahra Kanannejad / Yousef Shokri / Soheila Alyasin / Mohammad Amin Ghatee / Saeede Soleimanian

    Frontiers in Environmental Science, Vol

    2023  Volume 11

    Abstract: Asthma is a chronic respiratory disease resulting from a complex interaction between genetic and environmental factors. Many environmental factors have been associated with incidence or prevalence of asthma although there is still limited knowledge of ... ...

    Abstract Asthma is a chronic respiratory disease resulting from a complex interaction between genetic and environmental factors. Many environmental factors have been associated with incidence or prevalence of asthma although there is still limited knowledge of major environmental causes of asthma in the general population. This study, for the first time, investigated the effects of climatic and geographical variability on asthma hospitalization among an adult population living in Fars province, southwest Iran. During the study period, the home addresses of patients hospitalized with acute asthma from 2016 to 2019 were mapped. The effects of geo-climatic factors including temperature, rainfall, humidity, evaporation, number of rainy and frosty days, slope, and land covers were assessed on adult asthma hospitalization by Geographical Information System (GIS). Data were analyzed using univariate and multivariate binary logistic regression. A total of 349 patients were recruited, including 157 (44.98%) males and 192 (55%) females. The mean age was 57.77 ± 18.84 years, ranging from 19 to 98 years. Asthmatic patients came from a total of 82 points including villages, towns, and cities. In the univariate analysis, urban setting (OR = 13) and Mean Annual Rainy Days (OR = 1.03) were identified as the factors associated with increased asthma hospitalization, while Mean Annual Temperature (MAT) (OR = 0.927), MinMAT (OR = 0.933), MaxMAT (OR = 0.925), Mean Annual Evaporation (MAE) (OR = 0.999), and slope (OR = 0.925) negatively affected asthma hospitalization. Urban setting was considered the only significant factor in multivariate analysis (OR = 11.026). The major risk zones for adulthood acute asthma in southwest Iran were urban settings and areas with higher numbers of rainy days, lower temperatures, and evaporation at lower slopes.
    Keywords asthma hospitalization ; climatic changes ; geographical factors ; land cover ; GIS ; Environmental sciences ; GE1-350
    Subject code 333
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: An unusual case of cystic fibrosis with pancytopenia due to copper deficiency and blindness caused by vitamin A deficiency: A case-report.

    Nabavizadeh, Hesamedin / Johari, Leila / Noeiaghdam, Rafat / Alyasin, Soheila / Esmaeilzadeh, Hossein / Kanannejad, Zahra / Emaminia, Maryam

    Respiratory medicine case reports

    2022  Volume 40, Page(s) 101774

    Abstract: Cystic fibrosis (CF) is a multi-systemic autosomal recessive disease which mostly involves the respiratory, digestive, and reproductive systems, but it can present with various clinical presentations, especially in adulthood. We describe a 19-year-old ... ...

    Abstract Cystic fibrosis (CF) is a multi-systemic autosomal recessive disease which mostly involves the respiratory, digestive, and reproductive systems, but it can present with various clinical presentations, especially in adulthood. We describe a 19-year-old boy, a known case of CF who presented with less known clinical presentations of CF, blindness, liver cirrhosis, vitamin A deficiency, and pancytopenia.
    Language English
    Publishing date 2022-11-07
    Publishing country England
    Document type Case Reports
    ZDB-ID 2666110-X
    ISSN 2213-0071
    ISSN 2213-0071
    DOI 10.1016/j.rmcr.2022.101774
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: A rare case of SRD5A3-CDG in a patient with ataxia and telangiectasia: A case report.

    Nabavizadeh, Sayyed Hesamedin / Noeiaghdam, Rafat / Johari, Leila / Hosseini, Seyed Ali / Esmaeilzadeh, Hossein / Alyasin, Soheila Sadat

    Clinical case reports

    2022  Volume 10, Issue 11, Page(s) e6564

    Abstract: Steroid 5α-reductase type 3 congenital disorder of glycosylation (SRD5A3-CDG) is an extremely rare congenital disease. Common manifestations are developmental delay, intellectual disability, ophthalmological abnormalities, cerebellar abnormalities, ... ...

    Abstract Steroid 5α-reductase type 3 congenital disorder of glycosylation (SRD5A3-CDG) is an extremely rare congenital disease. Common manifestations are developmental delay, intellectual disability, ophthalmological abnormalities, cerebellar abnormalities, ataxia, and hypotonia. Here, we discuss a seven-year-old boy with SRD5A3-CDG (homozygous variant c.57G>A [p.Trp19Ter]), featuring the unprecedented finding of telangiectasia.
    Language English
    Publishing date 2022-11-23
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6564
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Evaluation of Alpha-1 Antitrypsin Level in the Serum of Children With Idiopathic Bronchiectasis

    Maryam Babaei / Zahra Kanannejad / Soheila Alyasin

    Acta Medica Iranica, Vol 59, Iss

    2021  Volume 11

    Abstract: Bronchiectasis is a clinical syndrome characterized by chronic cough, sputum production, recurrent respiratory infections, and permanent bronchial dilation. The association between the level of alpha-1 antitrypsin (AAT) and bronchiectasis is ... ...

    Abstract Bronchiectasis is a clinical syndrome characterized by chronic cough, sputum production, recurrent respiratory infections, and permanent bronchial dilation. The association between the level of alpha-1 antitrypsin (AAT) and bronchiectasis is controversial. In this study, we aimed to investigate this association in children with idiopathic bronchiectasis. The study was conducted on 20 patients with idiopathic bronchiectasis as the case group (mean age 15.9±2.1) and 20 healthy individuals as the control group (mean age 14.9±2.6). Serum AAT level was measured using nephelometric analysis (g/L). Other criteria including sex, parent consanguinity, number of hospitalizations, age of the first symptom were evaluated in both groups related to AAT level. The mean serum level of AAT in the case and control groups were 1.3±0.29; 1.5±0.59, respectively, with statistical significance (P=0.001). There was a significant difference between the two groups in the AAT level distribution, according to AAT normal range (P=0.01). The case group had a more positive attitude toward consanguinity than the control group (66.7% versus 33.3%; P<0.001). The results showed that 80% of patients had the first symptom of disease under one year of age, 6.6% 1-5 years, 6.6% 5-10 years, and 6.6% in more than ten years old. In the case group, 53.3% had a history of medical hospitalization for one time, 26.7% two times, while 20% of the patients had no medical hospitalization. Decreased AAT serum level and high consanguinity rates may be considered as two risk factors for idiopathic bronchiectasis occurrence in children.
    Keywords Alpha-1 antitrypsin ; Idiopathic bronchiectasis ; Nephelometry ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: COVID-19 in Chronic Granulomatosis Disease: A Case Report.

    Esmaeilzadeh, Hossein / Dehghani, Seyed Sina / Shahhoseini, Babak / Alyasin, Soheila / Nabavizadeh, Sayyed Hesamedin / Askari, Aida

    Iranian journal of allergy, asthma, and immunology

    2022  Volume 21, Issue 4, Page(s) 478–483

    Abstract: A novel coronavirus disease known as Coronavirus Disease 2019 (COVID-19) has spread quickly throughout the world, and it was declared a pandemic in March 2022. Chronic granulomatous disease (CGD) is a diverse group of genetic disorders characterized by ... ...

    Abstract A novel coronavirus disease known as Coronavirus Disease 2019 (COVID-19) has spread quickly throughout the world, and it was declared a pandemic in March 2022. Chronic granulomatous disease (CGD) is a diverse group of genetic disorders characterized by recurrent bacterial and fungal infections, resulting in granulomas due to the inability of phagocytes to destroy microbes. Even though it is thought that impaired neutrophil activity is a protective mechanism against severe COVID-19-induced cytokine storms and hyper-inflammatory responses, patients with CGD have normal immunity to most viruses. Here, we present two CGD patients who were hospitalized due to severe COVID-19 infections, which suggests that COVID-19 might have a different pathogenesis than other viruses.
    MeSH term(s) COVID-19 ; Granulomatous Disease, Chronic/complications ; Granulomatous Disease, Chronic/diagnosis ; Granulomatous Disease, Chronic/genetics ; Humans ; Phagocytes
    Language English
    Publishing date 2022-08-12
    Publishing country Iran
    Document type Case Reports ; Journal Article
    ZDB-ID 2488724-9
    ISSN 1735-5249 ; 1735-1502
    ISSN (online) 1735-5249
    ISSN 1735-1502
    DOI 10.18502/ijaai.v21i4.10295
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6806: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top