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  1. Article ; Online: The perfluorinated alcohols c-C

    Schaab, Jonas / Schwab, Miriam / Kratzert, Daniel / Schwabedissen, Jan / Stammler, Hans-Georg / Mitzel, Norbert W / Krossing, Ingo

    Chemical communications (Cambridge, England)

    2018  Volume 54, Issue 67, Page(s) 9294–9297

    Abstract: The thermally unstable α-fluoroalcohol undecafluorocyclohexanol (c-C6F11OH) was prepared ... by addition of hydrogen fluoride to the corresponding ketone. c-C6F10(CF3)OH was obtained by protonation ... of its alkoxide [NMe4]+[C7F13O]-. Decafluorocyclohexane-1,1-diol (c-C6F10(OH)2) was prepared by acidic workup ...

    Abstract The thermally unstable α-fluoroalcohol undecafluorocyclohexanol (c-C6F11OH) was prepared by addition of hydrogen fluoride to the corresponding ketone. c-C6F10(CF3)OH was obtained by protonation of its alkoxide [NMe4]+[C7F13O]-. Decafluorocyclohexane-1,1-diol (c-C6F10(OH)2) was prepared by acidic workup of the corresponding alkoxide [NMe4]+[C6F11O]- with sulfuric acid, which yielded (c-C6F10(OH)2) and fluorosulfonic acid. The structures of c-C6F10(CF3)OH·2H2O and of (c-C6F10(OH)2) were elucidated by single-crystal X-ray and gas-phase electron-diffraction studies.
    Language English
    Publishing date 2018-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c8cc05148h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Vitamin C deficiency in patients with acute myeloid leukemia: a case series and review of the literature.

    Milbar, Heather C / Caplan, Avrom / Schwab, Robert D / Coromilas, Alexandra J / Baumrin, Emily / Forrestel, Amy / Steele, Katharine T / Micheletti, Robert G / Perl, Alexander / Rosenbach, Misha

    Blood advances

    2023  Volume 7, Issue 19, Page(s) 5780–5783

    MeSH term(s) Humans ; Leukemia, Myeloid, Acute/complications ; Ascorbic Acid Deficiency/complications
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023009923
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7153: Show issues Location:
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  3. Article ; Online: Letter to the Editors: "Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination" by C. Schwab et al.

    Schirmacher, Peter / Longerich, Thomas / Schwab, Constantin

    Clinical research in cardiology : official journal of the German Cardiac Society

    2023  Volume 113, Issue 2, Page(s) 356–357

    MeSH term(s) Humans ; Myocarditis/diagnosis ; Myocarditis/etiology ; COVID-19/prevention & control
    Language English
    Publishing date 2023-04-25
    Publishing country Germany
    Document type Letter
    ZDB-ID 2213295-8
    ISSN 1861-0692 ; 1861-0684
    ISSN (online) 1861-0692
    ISSN 1861-0684
    DOI 10.1007/s00392-023-02198-0
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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs 10: Show issues Location:
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  4. Article ; Online: Comparison of cisplatin and mitomycin C/5-FU as radiosensitisers in the treatment of locally advanced vulvar cancer: results of a retrospective, observational, single-institutional cohort study.

    Linz, Valerie Catherine / Schwanbeck, Carina / Krajnak, Slavomir / Anic, Katharina / Jäkel, Jörg / Schwab, Roxana / Schmidt, Marcus / Schmidberger, Heinz / Hasenburg, Annette / Battista, Marco Johannes

    Journal of cancer research and clinical oncology

    2022  Volume 149, Issue 4, Page(s) 1391–1399

    Abstract: ... C/5-fluorouracil (5-FU) in patients with locally advanced vulvar cancer for outcome and toxicity ... patients with vulvar cancer were screened. Twenty-nine patients received chemoradiation (mitomycin C/5-FU n ... However, the mitomycin C/5-FU group had more advanced tumour stages. The 2-year recurrence-free survival (RFS) was ...

    Abstract Purpose: We retrospectively investigated the widely used radiosensitisers cisplatin and mitomycin C/5-fluorouracil (5-FU) in patients with locally advanced vulvar cancer for outcome and toxicity.
    Methods: We screened the archive for patients treated with chemoradiation for vulvar cancer diagnosed between 01/2010 and 08/2021 at our institution. The impact of both radiosensitisers on prognosis was compared using Kaplan-Meier method and Cox-regression analysis.
    Results: One hundred and forty-three patients with vulvar cancer were screened. Twenty-nine patients received chemoradiation (mitomycin C/5-FU n = 14; cisplatin n = 12; others n = 3) as a primary, neoadjuvant or adjuvant treatment. Median follow-up was 15.5 months. Patients in the cisplatin group were older (mean age 54.4 vs. 70.7; p = 0.004). However, the mitomycin C/5-FU group had more advanced tumour stages. The 2-year recurrence-free survival (RFS) was comparable (44.5% vs. 33.3%; p = 0.932). The 2-year overall survival (OS) showed a numerical but not statistically significant difference in favour of the mitomycin C/5-FU group (59.7% vs. 31.7%; p = 0.37). 64.3% (9 out of 14) patients, who received mitomycin C/5-FU achieved clinical complete response (cCR) compared to 41.7% (5 out of 12) who received cisplatin (p = 0.505). Radiodermatitis was the most common adverse event in both groups (81%) and more severe in the mitomycin C/5-FU cohort. Myelotoxicity was frequently observed in both groups. Eighteen patients received an additional radiation boost with 10.0 (9-16) Gy and showed a significantly prolonged RFS (p = 0.027) and OS (p = 0.003).
    Conclusion: Mitomycin C/5-FU may be considered in the treatment of young and healthy patients with locally advanced vulvar cancer.
    MeSH term(s) Female ; Humans ; Middle Aged ; Cisplatin/adverse effects ; Mitomycin/adverse effects ; Retrospective Studies ; Fluorouracil/adverse effects ; Vulvar Neoplasms/drug therapy ; Vulvar Neoplasms/radiotherapy ; Vulvar Neoplasms/etiology ; Cohort Studies ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
    Chemical Substances Cisplatin (Q20Q21Q62J) ; Mitomycin (50SG953SK6) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2022-04-22
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-022-04006-0
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.10: Show issues Location:
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  5. Article ; Online: The role of miR-200b/c in balancing EMT and proliferation revealed by an activity reporter.

    Gollavilli, Paradesi Naidu / Parma, Beatrice / Siddiqui, Aarif / Yang, Hai / Ramesh, Vignesh / Napoli, Francesca / Schwab, Annemarie / Natesan, Ramakrishnan / Mielenz, Dirk / Asangani, Irfan Ahmed / Brabletz, Thomas / Pilarsky, Christian / Ceppi, Paolo

    Oncogene

    2021  Volume 40, Issue 12, Page(s) 2309–2322

    Abstract: ... signatures, based on miR-200b/c activity. The system was further combined with a CRISPR-Cas9 screening ... platform to unbiasedly identify miR-200b/c upstream regulating genes. The sensor allows to infer miRNAs ... fundamental biological properties, as profiling of sorted cells indicated miR-200b/c as a molecular switch ...

    Abstract Since their discovery, microRNAs (miRNAs) have been widely studied in almost every aspect of biology and medicine, leading to the identification of important gene regulation circuits and cellular mechanisms. However, investigations are generally focused on the analysis of their downstream targets and biological functions in overexpression and knockdown approaches, while miRNAs endogenous levels and activity remain poorly understood. Here, we used the cellular plasticity-regulating process of epithelial-to-mesenchymal transition (EMT) as a model to show the efficacy of a fluorescent sensor to separate cells with distinct EMT signatures, based on miR-200b/c activity. The system was further combined with a CRISPR-Cas9 screening platform to unbiasedly identify miR-200b/c upstream regulating genes. The sensor allows to infer miRNAs fundamental biological properties, as profiling of sorted cells indicated miR-200b/c as a molecular switch between EMT differentiation and proliferation, and suggested a role for metabolic enzymes in miR-200/EMT regulation. Analysis of miRNAs endogenous levels and activity for in vitro and in vivo applications could lead to a better understanding of their biological role in physiology and disease.
    MeSH term(s) Cell Differentiation/genetics ; Cell Plasticity/genetics ; Cell Proliferation/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Epithelial-Mesenchymal Transition/genetics ; HCT116 Cells ; Humans ; MicroRNAs/genetics
    Chemical Substances MIRN200 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2021-03-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-021-01708-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2218: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Not all very-low-carbohydrate diets are created equal. Reply to Conte C, Camajani E, Lai A, Caprio M [letter].

    Reynolds, Andrew N / Kahleova, Hana / Uusitupa, Matti / Hermansen, Kjeld / Aas, Anne-Marie / Schwab, Ursula / Lean, Michael E J / Pfeiffer, Andreas / Salas-Salvadó, Jordi / Mann, Jim I

    Diabetologia

    2023  Volume 66, Issue 9, Page(s) 1754–1755

    MeSH term(s) Diet, Carbohydrate-Restricted ; Dietary Carbohydrates
    Chemical Substances Dietary Carbohydrates
    Language English
    Publishing date 2023-07-06
    Publishing country Germany
    Document type Letter
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-023-05963-y
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 279: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Triplet Emitting C^N^C Cyclometalated Dibenzo[c,h]Acridine Pt(II) Complexes.

    Friedel, Joshua / Krause, Maren / Jordan, Rose / Maisuls, Iván / Brünink, Dana / Schwab, Dominik / Doltsinis, Nikos L / Strassert, Cristian A / Klein, Axel

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 22

    Abstract: ... cyclometalating, tridentate C^N^C2− heterocyclic ligand dba2− (H2dba = dibenzo[c,h]acridine), the coligand ...

    Abstract In a series of Pt(II) complexes [Pt(dba)(L)] containing the very rigid, dianionic, bis-cyclometalating, tridentate C^N^C2− heterocyclic ligand dba2− (H2dba = dibenzo[c,h]acridine), the coligand (ancillary ligand) L = dmso, PPh3, CNtBu and Me2Imd (N,N’-dimethylimidazolydene) was varied in order to improve its luminescence properties. Beginning with the previously reported dmso complex, we synthesized the PPh3, CNtBu and Me2Imd derivatives and characterized them by elemental analysis, 1H (and 31P) NMR spectroscopy and MS. Cyclic voltammetry showed partially reversible reduction waves ranging between −1.89 and −2.10 V and increasing along the series Me2Imd < dmso ≈ PPh3 < CNtBu. With irreversible oxidation waves ranging between 0.55 (L = Me2Imd) and 1.00 V (dmso), the electrochemical gaps range between 2.65 and 2.91 eV while increasing along the series Me2Imd < CNtBu < PPh3 < dmso. All four complexes show in part vibrationally structured long-wavelength absorption bands peaking at around 530 nm. TD-DFT calculated spectra agree quite well with the experimental spectra, with only a slight redshift. The photoluminescence spectra of all four compounds are very similar. In fluid solution at 298 K, they show broad, only partially structured bands, with maxima at around 590 nm, while in frozen glassy matrices at 77 K, slightly blue-shifted (~580 nm) bands with clear vibronic progressions were found. The photoluminescence quantum yields ΦL ranged between 0.04 and 0.24, at 298 K, and between 0.80 and 0.90 at 77 K. The lifetimes τ at 298 K ranged between 60 and 14040 ns in Ar-purged solutions and increased from 17 to 43 µs at 77 K. The TD-DFT calculated emission spectra are in excellent agreement with the experimental findings. In terms of high ΦL and long τ, the dmso and PPh3 complexes outperform the CNtBu and Me2Imd derivatives. This is remarkable in view of the higher ligand strength of Me2Imd, compared with all other coligands, as concluded from the electrochemical data.
    Language English
    Publishing date 2022-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27228054
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  8. Article ; Online: Hydrogen-Driven Cofactor Regeneration for Stereoselective Whole-Cell C=C Bond Reduction in Cupriavidus necator.

    Assil-Companioni, Leen / Schmidt, Sandy / Heidinger, Petra / Schwab, Helmut / Kourist, Robert

    ChemSusChem

    2019  Volume 12, Issue 11, Page(s) 2361–2365

    Abstract: ... biotransformations, whole cells catalyzed asymmetric C=C bond reduction of unsaturated cyclic ketones ...

    Abstract The coupling of recombinantly expressed oxidoreductases to endogenous hydrogenases for cofactor recycling permits the omission of organic cosubstrates as sacrificial electron donors in whole-cell biotransformations. This increases atom efficiency and simplifies the reaction. A recombinant ene-reductase was expressed in the hydrogen-oxidizing proteobacterium Cupriavidus necator H16. In hydrogen-driven biotransformations, whole cells catalyzed asymmetric C=C bond reduction of unsaturated cyclic ketones with stereoselectivities up to >99 % enantiomeric excess. The use of hydrogen as a substrate for growth and cofactor regeneration is particularly attractive because it represents a strategy for improving atom efficiency and reducing side product formation associated with the recycling of organic cofactors.
    MeSH term(s) Bacterial Proteins/metabolism ; Biotransformation ; Carbon/metabolism ; Cupriavidus necator/metabolism ; Electrons ; Hydrogen/metabolism
    Chemical Substances Bacterial Proteins ; Carbon (7440-44-0) ; Hydrogen (7YNJ3PO35Z)
    Language English
    Publishing date 2019-04-29
    Publishing country Germany
    Document type Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.201900327
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  9. Article ; Online: Six Uridine-Diphosphate Glycosyltransferases Catalyze the Glycosylation of Bioactive C

    Sun, Guangxin / Putkaradze, Natalia / Bohnacker, Sina / Jonczyk, Rafal / Fida, Tarik / Hoffmann, Thomas / Bernhardt, Rita / Härtl, Katja / Schwab, Wilfried

    Plant physiology

    2020  Volume 184, Issue 4, Page(s) 1744–1761

    Abstract: C ...

    Abstract C
    MeSH term(s) Biosynthetic Pathways/genetics ; Carotenoids/metabolism ; Gene Expression Regulation, Plant ; Genes, Plant ; Genetic Variation ; Genotype ; Glycosylation ; Glycosyltransferases/genetics ; Glycosyltransferases/metabolism ; Mentha piperita/genetics ; Mentha piperita/metabolism ; Nicotiana/genetics ; Nicotiana/metabolism ; Uridine Diphosphate/metabolism
    Chemical Substances Carotenoids (36-88-4) ; Uridine Diphosphate (58-98-0) ; Glycosyltransferases (EC 2.4.-)
    Language English
    Publishing date 2020-10-05
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1104/pp.20.00953
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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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  10. Book ; Thesis: Geschlechtsspezifische Unterschiede in Zwerchfell- und Brustkorbbewegung während des Singens bei professionellen Sängern

    Schwab, Carmen

    eine dynamische MRT-Studie

    2021  

    Author's details vorgelegt 2020 von Carmen Schwab
    Language German
    Size 87 Blätter, Illustrationen, Diagramme
    Publishing place Freiburg im Breisgau
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Albert-Ludwigs-Universität Freiburg im Breisgau, 2021
    HBZ-ID HT021129930
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 E 1352 order for loan Magazin

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