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Article ; Online: In vitro Antioxidant and Antimicrobial Studies of Ethanolic Plant Extracts of P. granatum, O. stamineus, A. bilimbi, M. nigra, and E. longifolia.

Makky, Essam A / AlMatar, Manaf / Mahmood, Mahmood H / Wen, Khoo Xu / Qi, Tan Boon Gaik

2021 Volume 23, Issue 10, Page(s) 1284–1312

Abstract: ... of five plant extracts (A. bilimbi, M. nigra, O. stamineus, P. granatum, and E. longifolia). Furthermore ... antibacterial activities against acnecausing bacteria. Ethanolic extracts of A. bilimbi, O. stamineus, M. nigra ... P. granatum, and E. longifolia were prepared by the Ultrasound-Assisted Extraction (UAE) technique ...

Abstract	Background: Acne is a serious skin problem that affects mostly adolescents. The topical and systematic therapies are effective but could lead to several side effects and the emergence of antibacterial resistance of the acne-causing bacteria. Plant resources have been used as traditional medicine for centuries and can be the alternative therapies for acne treatment. Antioxidants are compounds that can prevent or delay the oxidation of substrates when present in low concentrations. Antioxidants are usually involved in several mechanisms of action, including the inhibition of free radical generation, enhancement of the scavenging capacity against free radicals, and reducing power. Methods: In this study, three antioxidant assays, DPPH, ABTS, and FRAP were used to evaluate the antioxidant properties of the ethanolic extracts of five plant extracts (A. bilimbi, M. nigra, O. stamineus, P. granatum, and E. longifolia). Furthermore, the study aimed to identify the most potent plant extracts and their combination which could provide better antibacterial activities against acnecausing bacteria. Ethanolic extracts of A. bilimbi, O. stamineus, M. nigra, P. granatum, and E. longifolia were prepared by the Ultrasound-Assisted Extraction (UAE) technique. Their phytochemical contents were screened using several biochemical tests and GC-MS analysis. Results: The study found that only the extracts of P. granatum and O. stamineus exhibited good antioxidant activity using DPPH assay (82.37% and 81.72% μg/mL respectively) and in ABTS assay (87.25% and 88.85% μg/mL respectively); their observed FRAP values were 115.1667 ± 5.6182 and 41.3860 ± 2.4583 μg/mL, respectively. The preliminary antibacterial screening using the disc diffusion method showed that P. granatum and O. stamineus were the most potent extracts; hence, both extracts were combined at the ratios of 1:1, 1:2, and 2:1 to a total concentration of 400 mg/mL. Discussion: The antibacterial efficacy of the mixture was studied using the disc diffusion method and the MIC value was determined. Both S. aureus and S. epidermidis were sensitive to all the individual and combined extracts but C. acnes was resistant to all of them. Conclusion: The antibacterial activity of the combined extracts against S. aureus showed a synergistic effect at the ratio of 2:1 with the inhibitory zone diameter of 18.00 ± 1.00 mm and MIC value of 12.5 mg/mL; however, antagonistic effects were observed against S. epidermidis while no effect was noted against C. acnes. Therefore, all the selected plant extracts exhibited antibacterial activities against certain bacteria and their effects may be enhanced by combining the plant extracts.
MeSH term(s)	Acne Vulgaris ; Adolescent ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Ethanol/chemistry ; Free Radicals ; Humans ; Microbial Sensitivity Tests ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Staphylococcus aureus ; Staphylococcus epidermidis
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Antioxidants ; Free Radicals ; Plant Extracts ; Ethanol (3K9958V90M)
Language	English
Publishing date	2021-06-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2132197-8
ISSN	1873-4316 ; 1389-2010
ISSN (online)	1873-4316
ISSN	1389-2010
DOI	10.2174/1389201022666210615113854
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Article ; Online: Prokaryotic soluble overexpression and purification of oncostatin M using a fusion approach and genetically engineered E. coli strains.

Nguyen, Minh Tan / Prima, Musharrat Jahan / Song, Jung-A / Kim, Julee / Do, Bich Hang / Yoo, Jiwon / Park, Sangsu / Jang, Jaepyeong / Lee, Sunju / Lee, Eunyoung / Novais, Michelle de Paula / Seo, Hyeon-Beom / Lee, Seon-Yeong / Cho, Mi-La / Kim, Chong Jai / Jang, Yeon Jin / Choe, Han

Scientific reports

2019 Volume 9, Issue 1, Page(s) 13706

Abstract: Human Oncostatin M (OSM), initially discovered as a tumour inhibitory factor secreted from U-937 ... the b'a' domain of PDI (PDIb'a'), were tested for soluble OSM expression in E. coli. The His6-OSM plasmid ...

Abstract	Human Oncostatin M (OSM), initially discovered as a tumour inhibitory factor secreted from U-937 cells, is a gp130 (IL-6/LIF) cytokine family member that exhibits pleiotropic effects in inflammation, haematopoiesis, skeletal tissue alteration, liver regeneration, cardiovascular and metabolic diseases. Cytoplasmic expression of OSM in Escherichia coli results in inclusion bodies, and complex solubilisation, refolding and purification is required to prepare bioactive protein. Herein, eight N-terminal fusion variants of OSM with hexahistidine (His6) tag and seven solubility-enhancing tags, including thioredoxin (Trx), small ubiquitin-related modifier (Sumo), glutathione S-transferase (GST), maltose-binding protein (MBP), N-utilisation substance protein A (Nusa), human protein disulphide isomerase (PDI) and the b'a' domain of PDI (PDIb'a'), were tested for soluble OSM expression in E. coli. The His6-OSM plasmid was also introduced into genetically engineered Origami 2 and SHuffle strains to test expression of the protein. At 18 °C, MBP-tagged OSM was highly expressed and solubility was dramatically enhanced. In addition, His6-OSM was more highly expressed and soluble in Origami 2 and SHuffle strains than in BL21(DE3). MBP-OSM and His6-OSM were purified more than 95% with yields of 11.02 mg and 3.27 mg from a 500 mL culture. Protein identity was confirmed by mass spectroscopy, and bioactivity was demonstrated by in vitro inhibition of Th17 cell differentiation.
MeSH term(s)	Escherichia coli ; Gene Expression ; Genetic Engineering ; Histidine ; Humans ; Maltose-Binding Proteins/metabolism ; Oligopeptides ; Oncostatin M/genetics ; Oncostatin M/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Solubility
Chemical Substances	His-His-His-His-His-His ; Maltose-Binding Proteins ; Oligopeptides ; Recombinant Fusion Proteins ; Oncostatin M (106956-32-5) ; Histidine (4QD397987E)
Language	English
Publishing date	2019-09-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-50110-6
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Article ; Online: Theoretical Investigation of Metallic Heterofullerenes of Silicon and Germanium Mixed with Phosphorus and Arsenic Atoms M-A8E6, A = Si, Ge; E = P, As; and M = Cr, Mo, W.

Pham, Hung Tan / Nguyen, Minh Tho

The journal of physical chemistry. A

2017 Volume 121, Issue 26, Page(s) 5056–5066

Abstract: Recently, metallic heterofullerenes were experimentally prepared from mixed Ge-As clusters and heavier elements of groups 14 and 15. We found that the shape of these heterofullerenes doped by transition metals appears to be a general structural motif for ...

Abstract	Recently, metallic heterofullerenes were experimentally prepared from mixed Ge-As clusters and heavier elements of groups 14 and 15. We found that the shape of these heterofullerenes doped by transition metals appears to be a general structural motif for both silicon and germanium clusters when mixing with phosphorus and arsenic atoms. Structural identifications for MSi
Language	English
Publishing date	2017-07-06
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.7b04631
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Article ; Online: Prokaryotic soluble overexpression and purification of oncostatin M using a fusion approach and genetically engineered E. coli strains

Minh Tan Nguyen / Musharrat Jahan Prima / Jung-A. Song / Julee Kim / Bich Hang Do / Jiwon Yoo / Sangsu Park / Jaepyeong Jang / Sunju Lee / Eunyoung Lee / Michelle de Paula Novais / Hyeon-Beom Seo / Seon-yeong Lee / Mi-La Cho / Chong Jai Kim / Yeon Jin Jang / Han Choe

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 13

Abstract: Abstract Human Oncostatin M (OSM), initially discovered as a tumour inhibitory factor secreted ... the b‘a’ domain of PDI (PDIb‘a’), were tested for soluble OSM expression in E. coli. The His6-OSM ...

Abstract	Abstract Human Oncostatin M (OSM), initially discovered as a tumour inhibitory factor secreted from U-937 cells, is a gp130 (IL-6/LIF) cytokine family member that exhibits pleiotropic effects in inflammation, haematopoiesis, skeletal tissue alteration, liver regeneration, cardiovascular and metabolic diseases. Cytoplasmic expression of OSM in Escherichia coli results in inclusion bodies, and complex solubilisation, refolding and purification is required to prepare bioactive protein. Herein, eight N-terminal fusion variants of OSM with hexahistidine (His6) tag and seven solubility-enhancing tags, including thioredoxin (Trx), small ubiquitin-related modifier (Sumo), glutathione S-transferase (GST), maltose-binding protein (MBP), N-utilisation substance protein A (Nusa), human protein disulphide isomerase (PDI) and the b‘a’ domain of PDI (PDIb‘a’), were tested for soluble OSM expression in E. coli. The His6-OSM plasmid was also introduced into genetically engineered Origami 2 and SHuffle strains to test expression of the protein. At 18 °C, MBP-tagged OSM was highly expressed and solubility was dramatically enhanced. In addition, His6-OSM was more highly expressed and soluble in Origami 2 and SHuffle strains than in BL21(DE3). MBP-OSM and His6-OSM were purified more than 95% with yields of 11.02 mg and 3.27 mg from a 500 mL culture. Protein identity was confirmed by mass spectroscopy, and bioactivity was demonstrated by in vitro inhibition of Th17 cell differentiation.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Molecular Characterization of QX-Like and Variant Infectious Bronchitis Virus Strains in Malaysia Based on Partial Genomic Sequences Comprising the S-3a/3b-E-M-Intergenic Region-5a/5b-N Gene Order.

Khanh, N P / Tan, S W / Yeap, S K / Satharasinghe, D A / Hair-Bejo, M / Bich, T N / Omar, A R

Avian diseases

2018 Volume 61, Issue 4, Page(s) 442–452

Abstract: ... comprising the S-3a/3b-E-M-intergenic region-5a/5b-N gene order of 11 Malaysian IBVs isolated in 2014 and ...

Abstract	Infectious bronchitis virus (IBV) is one of the major poultry pathogens of global importance. However, the prevalence of IBV strains in Malaysia is poorly characterized. The partial genomic sequences (6.8 kb) comprising the S-3a/3b-E-M-intergenic region-5a/5b-N gene order of 11 Malaysian IBVs isolated in 2014 and 2015 were sequenced using next-generation sequencing technology. Phylogenetic and pairwise sequence comparison analysis showed that the isolated IBVs are divided into two groups. Group 1 (IBS124/2015, IBS125/2015, IBS126/2015, IBS130/2015, IBS131/2015, IBS138/2015, and IBS142/2015) shared 90%-95% nucleotide and deduced amino acid similarities to the QX-like strain. Among these isolates, IBS142/2015 is the first IBV detected in Sarawak state located in East Malaysia (Borneo Island). Meanwhile, IBV isolates in Group 2 (IBS037A/2015, IBS037B/2015, IBS051/2015, and IBS180/2015) were 91.62% and 89.09% identical to Malaysian variant strain MH5365/95 (EU086600) at nucleotide and amino acid levels, respectively. In addition, all studied IBVs were distinctly separate from Massachusetts (70%-72% amino acid similarity) and European strains including 793/B, Italy-02, and D274 (68%-73% amino acid similarity). Viruses in Group 1 have the insertion of three amino acids at positions 23, 121, and 122 of the S1 protein and recombinant events detected at nucleotide position 4354-5864, with major parental sequence derived from QX-like (CK-CH-IBYZ-2011) and a minor parental sequence derived from Massachusetts vaccine strain (H120). This study demonstrated coexistence of the IBV Malaysian variant strain along with the QX-like strain in Malaysia.
MeSH term(s)	Animals ; Chickens ; Coronavirus Infections/epidemiology ; Coronavirus Infections/veterinary ; Coronavirus Infections/virology ; DNA, Intergenic ; Gene Order ; Genome, Viral ; Infectious bronchitis virus/genetics ; Malaysia/epidemiology ; Phylogeny ; Poultry Diseases/epidemiology ; Poultry Diseases/virology
Chemical Substances	DNA, Intergenic
Keywords	covid19
Language	English
Publishing date	2018-01-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	40871-2
ISSN	1938-4351 ; 0005-2086
ISSN (online)	1938-4351
ISSN	0005-2086
DOI	10.1637/11637-032817-Reg.1
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Article ; Online: A comparison of the dynamics of pantothenate synthetase from M. tuberculosis and E. coli: computational studies.

Tan, Yaw Sing / Fuentes, Gloria / Verma, Chandra

Proteins

2011 Volume 79, Issue 6, Page(s) 1715–1727

Abstract: ... the mobility of the gate loop in MTB PS and increased it in E. coli PS were designed and validated ...

Abstract	Pantothenate synthetase (PS) catalyzes the final step of the pantothenate pathway, in which pantothenate is formed from pantoate and β-alanine in an ATP-dependent reaction. Mycobacterium tuberculosis PS (MTB PS) is functionally a dimer and a potential target for novel antitubercular drugs. Molecular dynamics simulations show that the functional dynamics of the enzyme are dominated by motions of a flexible gate loop in the N-terminal domain and of the C-terminal domain. The gate loop motions dominate in MTB PS while the C-terminal domain motion dominates in Escherichia coli PS. Simulations also show that the correlated motions of the domains are severely compromised in the monomeric forms. Mutations that reduce the mobility of the gate loop in MTB PS and increased it in E. coli PS were designed and validated through simulations.
MeSH term(s)	Amino Acid Sequence ; Escherichia coli/chemistry ; Escherichia coli/enzymology ; Kinetics ; Molecular Dynamics Simulation ; Molecular Sequence Data ; Mycobacterium tuberculosis/chemistry ; Mycobacterium tuberculosis/enzymology ; Peptide Synthases/chemistry ; Protein Structure, Tertiary ; Sequence Alignment
Chemical Substances	Peptide Synthases (EC 6.3.2.-) ; pantothenate synthetase (EC 6.3.2.1)
Language	English
Publishing date	2011-06
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	806683-8
ISSN	1097-0134 ; 0887-3585
ISSN (online)	1097-0134
ISSN	0887-3585
DOI	10.1002/prot.22994
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Article: Molecular Characterization of QX-Like and Variant Infectious Bronchitis Virus Strains in Malaysia Based on Partial Genomic Sequences Comprising the S-3a/3b-E-M-Intergenic Region-5a/5b-N Gene Order

Khanh, N. P / A. R. Omar / D. A. Satharasinghe / M. Hair-Bejo / S. K. Yeap / S. W. Tan / T. N. Bich

Avian diseases. 2017 Dec., v. 61, no. 4

2017

Abstract: ... comprising the S-3a/3b-E-M-intergenic region-5a/5b-N gene order of 11 Malaysian IBVs isolated in 2014 and ...

Abstract	Infectious bronchitis virus (IBV) is one of the major poultry pathogens of global importance. However, the prevalence of IBV strains in Malaysia is poorly characterized. The partial genomic sequences (6.8 kb) comprising the S-3a/3b-E-M-intergenic region-5a/5b-N gene order of 11 Malaysian IBVs isolated in 2014 and 2015 were sequenced using next-generation sequencing technology. Phylogenetic and pairwise sequence comparison analysis showed that the isolated IBVs are divided into two groups. Group 1 (IBS124/2015, IBS125/2015, IBS126/2015, IBS130/2015, IBS131/2015, IBS138/2015, and IBS142/2015) shared 90%–95% nucleotide and deduced amino acid similarities to the QX-like strain. Among these isolates, IBS142/2015 is the first IBV detected in Sarawak state located in East Malaysia (Borneo Island). Meanwhile, IBV isolates in Group 2 (IBS037A/2015, IBS037B/2015, IBS051/2015, and IBS180/2015) were 91.62% and 89.09% identical to Malaysian variant strain MH5365/95 (EU086600) at nucleotide and amino acid levels, respectively. In addition, all studied IBVs were distinctly separate from Massachusetts (70%–72% amino acid similarity) and European strains including 793/B, Italy-02, and D274 (68%–73% amino acid similarity). Viruses in Group 1 have the insertion of three amino acids at positions 23, 121, and 122 of the S1 protein and recombinant events detected at nucleotide position 4354–5864, with major parental sequence derived from QX-like (CK-CH-IBYZ-2011) and a minor parental sequence derived from Massachusetts vaccine strain (H120). This study demonstrated coexistence of the IBV Malaysian variant strain along with the QX-like strain in Malaysia.
Keywords	amino acids ; genes ; high-throughput nucleotide sequencing ; Infectious bronchitis virus ; nucleotide sequences ; pathogens ; phylogeny ; poultry ; vaccines ; viruses ; Borneo ; Malaysia ; Massachusetts ; covid19
Language	English
Dates of publication	2017-12
Size	p. 442-452.
Publishing place	American Association of Avian Pathologists
Document type	Article
ZDB-ID	40871-2
ISSN	1938-4351 ; 0005-2086
ISSN (online)	1938-4351
ISSN	0005-2086
DOI	10.1637/11637-032817-Reg.1
Database	NAL-Catalogue (AGRICOLA)

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Article: Consecutive evaluation of immunoglobulin M and G antibodies against hepatitis E virus.

Ke, W M / Tan, D / Li, J G / Izumi, S / Shinji, Y / Hotta, H / Yao, J L

Journal of gastroenterology

1996 Volume 31, Issue 6, Page(s) 818–822

Abstract: Hepatitis E virus (HEV) infection is sporadic in the Guangzhou city southern China ... from patients with acute hepatitis E and compared that data with detection rates of IgM and IgG anti-HAV ...

Abstract	Hepatitis E virus (HEV) infection is sporadic in the Guangzhou city southern China. However, the evaluation of antibodies to HEV during consecutive time periods after infection has not been reported. We utilized enzyme immunosorbent assay (ELISA) to defect IgM and IgG anti-HEV in consecutive serum specimens from patients with acute hepatitis E and compared that data with detection rates of IgM and IgG anti-HAV in patients with acute hepatitis A. IgM anti-HEV can be detected as early as 4 days after onset of disease symptoms in some patients. The detection rate of IgM anti-HEV is significantly higher in specimens collected within 4 weeks (95%) of onset than in those specimens collected 4 to 18 weeks after onset (67.6%) (P < 0.005). IgM anti-HEV had a similar pattern to IgM anti-HAV and can be used as a marker of acute HEV infection. In contrast with IgG anti-HAV, 56.8% of the specimens did not contain detectable levels of IgG anti-HEV (P < 0.005). One should be cautioned against making a diagnosis of HEV infection solely by the currently available assays for IgG anti-HEV. In conclusion, IgM anti-HEV can be used as a reliable and sensitive marker for recent HEV infection, but serum specimens should be collected within 4 weeks after onset of symptoms to avoid false-negative results. In contrast, we should be aware of the failure to develop IgG anti-HEV in some patients. These patients carry the risk of reinfection.
MeSH term(s)	Acute Disease ; Adult ; Biomarkers ; Enzyme-Linked Immunosorbent Assay ; Female ; Hepatitis Antibodies/analysis ; Hepatitis E/immunology ; Hepatitis E virus/immunology ; Humans ; Immunoglobulin G/analysis ; Immunoglobulin M/analysis ; Male ; Recurrence ; Retrospective Studies ; Risk Factors
Chemical Substances	Biomarkers ; Hepatitis Antibodies ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	1996-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1186495-3
ISSN	0944-1174
ISSN	0944-1174
DOI	10.1007/bf02358608
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Book ; Online: Spatial Big Data, BIM and advanced GIS for Smart Transformation : City, Infrastructure and Construction

Shirowzhan, Sara / Tan, Willie / Sepasgozar, Samad M. E.

2020

Keywords	History of engineering & technology
Size	1 electronic resource (166 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021044750
ISBN	9783039360314 ; 3039360310
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Prevalence and prognostic significance of cardiac autonomic neuropathy in community-based people with type 2 diabetes: the Fremantle Diabetes Study Phase II.

Davis, Timothy M E / Tan, Eva / Davis, Wendy A

Cardiovascular diabetology

2024 Volume 23, Issue 1, Page(s) 102

Abstract: Background: There is a paucity of contemporary data on the prevalence and prognostic significance of cardiac autonomic neuropathy (CAN) from community-based cohorts with type 2 diabetes assessed using gold standard methods. The aim of this study was to ... ...

Abstract	Background: There is a paucity of contemporary data on the prevalence and prognostic significance of cardiac autonomic neuropathy (CAN) from community-based cohorts with type 2 diabetes assessed using gold standard methods. The aim of this study was to assess these aspects of CAN in the longitudinal observational Fremantle Diabetes Study Phase II (FDS2). Methods: FDS2 participants were screened at baseline using standardised cardiovascular reflex tests (CARTs) of heart rate variation during deep breathing, Valsalva manoeuvre and standing. CAN (no/possible/definite) was assessed from the number of abnormal CARTs. Multinomial regression identified independent associates of CAN status. Cox proportional hazards modelling determined independent baseline predictors of incident heart failure (HF) and ischaemic heart disease (IHD), and all-cause mortality. Results: Of 1254 participants assessed for CAN, 86 (6.9%) were outside CART age reference ranges and valid CART data were unavailable for 338 (27.0%). Of the remaining 830 (mean age 62.3 years, 55.3% males, median diabetes duration 7.3 years), 51.0%, 33.7% and 15.3% had no, possible or definite CAN, respectively. Independent associates of definite CAN (longer diabetes duration, higher body mass index and resting pulse rate, antidepressant and antihypertensive therapies, albuminuria, distal sensory polyneuropathy, prior HF) were consistent with those reported previously. In Kaplan-Meier analysis, definite CAN was associated with a lower likelihood of incident IHD and HF versus no/possible CAN (P < 0.001) and there was a graded increase in all-cause mortality risk from no CAN to possible and definite CAN (P < 0.001). When CAN category was added to the most parsimonious models, it was not a significant independent predictor of IHD (P ≥ 0.851) or HF (P ≥ 0.342). Possible CAN (hazard ratio (95% CI) 1.47 (1.01, 2.14), P = 0.046) and definite CAN (2.42 (1.60, 3.67), P < 0.001) increased the risk of all-cause mortality versus no CAN. Conclusions: Routine screening for CAN in type 2 diabetes has limited clinical but some prognostic value.
MeSH term(s)	Male ; Humans ; Middle Aged ; Female ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/complications ; Prognosis ; Prevalence ; Heart ; Cardiovascular System ; Coronary Artery Disease/complications ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/complications
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Observational Study ; Clinical Trial, Phase II ; Journal Article
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-024-02185-3
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