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  1. AU=Howatt Deborah A.
  2. AU="Basir, Seemi Farhat"
  3. AU="Luc Girard"
  4. AU="Sujay Ray"
  5. AU="Raziel J Davison"
  6. AU="O'Connor, Andrew"
  7. AU="Mendoza, Luis Alfonso"
  8. AU="Shadyro, Oleg I"
  9. AU="Duce, James A"
  10. AU="Jiménez‐Yuste, Victor"
  11. AU=Jang Jinah
  12. AU="Ullman, Natalie L"
  13. AU="Ding, Xiao-Qiang"
  14. AU="Goyal, Madhav"
  15. AU="Schwarz, E Bimla"
  16. AU="Yamamoto, Naoyuki"
  17. AU="Mansi, Ruaa Abdullah"
  18. AU="Feng, Ruifang"
  19. AU="Rzaigui, Mohamed"
  20. AU="Kuznetsova, Iren"
  21. AU="Töreki, Josefin"
  22. AU="Simon Hatcher" AU="Simon Hatcher"
  23. AU="Gui, Wenwu"
  24. AU="Komdeur, Annemarijn"
  25. AU="Stange, E. F."
  26. AU="McKenzie, Jodi A"
  27. AU="Chung, Mei"
  28. AU="Cezmi A Akdis"
  29. AU="Schlechter, Chelsey R"
  30. AU=Hedayati Manouchehr Ahmadi AU=Hedayati Manouchehr Ahmadi
  31. AU="Gould, Sven B"
  32. AU="Ko, Kyung Dae"
  33. AU="Elaheh Mahmoodi-Khaledi"
  34. AU=Jenkins Kathy J
  35. AU="Joseph Burgess"
  36. AU="Barbosa da Costa, Alana Vitor"
  37. AU="François Lebargy"
  38. AU=Serag Eman AU=Serag Eman
  39. AU="Yang, Guichun"
  40. AU="Amory, Jonathan R"
  41. AU="Reformat, Marek"

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  1. Artikel: Antisense oligonucleotides targeting hepatic angiotensinogen reduce atherosclerosis and liver steatosis in hypercholesterolemic mice.

    Ye, Dien / Wu, Congqing / Cai, Lei / Howatt, Deborah A / Liang, Ching-Ling / Katsumata, Yuriko / Mullick, Adam E / Temel, Ryan E / Danser, A H Jan / Daugherty, Alan / Lu, Hong S

    Global translational medicine

    2023  Band 2, Heft 1

    Abstract: Hepatocyte-derived angiotensinogen (AGT) is the precursor of angiotensin II (AngII). We determined the effects of hepatocyte-specific ( ...

    Abstract Hepatocyte-derived angiotensinogen (AGT) is the precursor of angiotensin II (AngII). We determined the effects of hepatocyte-specific (
    Sprache Englisch
    Erscheinungsdatum 2023-02-24
    Erscheinungsland Singapore
    Dokumenttyp Journal Article
    DOI 10.36922/gtm.288
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Functional Exploration of Conserved Sequences in the Distal Face of Angiotensinogen-Brief Report.

    Amioka, Naofumi / Wu, Chia-Hua / Sawada, Hisashi / Ito, Sohei / Pettey, Alex C / Wu, Congqing / Moorleghen, Jessica J / Howatt, Deborah A / Graf, Gregory A / Vander Kooi, Craig W / Daugherty, Alan / Lu, Hong S

    Arteriosclerosis, thrombosis, and vascular biology

    2023  Band 43, Heft 8, Seite(n) 1524–1532

    Abstract: Background: Angiotensinogen (AGT) is an essential component in the renin-angiotensin system. AGT has highly conserved sequences in the loop and β-sheet regions among species; however, their functions have not been studied.: Methods: Adeno-associated ... ...

    Abstract Background: Angiotensinogen (AGT) is an essential component in the renin-angiotensin system. AGT has highly conserved sequences in the loop and β-sheet regions among species; however, their functions have not been studied.
    Methods: Adeno-associated viral vector (AAV) serotype 2/8 encoding mouse AGT with mutations of conserved sequences in the loop (AAV.loop-Mut), β-sheet (AAV.βsheet-Mut), or both regions (AAV.loop/βsheet-Mut) was injected into male hepatocyte-specific AGT-deficient (hepAGT
    Results: In hepAGT
    Conclusions: The conserved sequences in either the loop or β-sheet region individually have no effect on AGT regulation, but the conserved sequences in both regions synergistically contribute to the secretion of AGT from hepatocytes.
    Mesh-Begriff(e) Animals ; Mice ; Angiotensinogen/blood ; Angiotensinogen/chemistry ; Angiotensinogen/genetics ; Angiotensinogen/metabolism ; Conserved Sequence ; Amino Acid Sequence ; Male ; Female ; Hepatocytes/metabolism ; Protein Conformation, beta-Strand ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Endoplasmic Reticulum/metabolism ; Glycosylation ; Liver/cytology ; Liver/metabolism ; Renin-Angiotensin System
    Chemische Substanzen Angiotensinogen (11002-13-4) ; Agt protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.122.318930
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Chronic environmental circadian disruption increases atherosclerosis and dyslipidemia in female, but not male,

    Chalfant, Jeffrey M / Howatt, Deborah A / Johnson, Victoria B / Tannock, Lisa R / Daugherty, Alan / Pendergast, Julie S

    Frontiers in physiology

    2023  Band 14, Seite(n) 1167858

    Abstract: Shift work chronically disrupts circadian rhythms and increases the risk of developing cardiovascular disease. However, the mechanisms linking shift work and cardiovascular disease are largely unknown. The goal of this study was to investigate the ... ...

    Abstract Shift work chronically disrupts circadian rhythms and increases the risk of developing cardiovascular disease. However, the mechanisms linking shift work and cardiovascular disease are largely unknown. The goal of this study was to investigate the effects of chronically shifting the light-dark (LD) cycle, which models the disordered exposure to light that may occur during shift work, on atherosclerosis. Atherosclerosis is the progressive accumulation of lipid-filled lesions within the artery wall and is the leading cause of cardiovascular disease. We studied
    Sprache Englisch
    Erscheinungsdatum 2023-03-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1167858
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Fludrocortisone Induces Aortic Pathologies in Mice.

    Ye, Dien / Wu, Congqing / Chen, Hui / Liang, Ching-Ling / Howatt, Deborah A / Franklin, Michael K / Moorleghen, Jessica J / Tyagi, Samuel C / Uijl, Estrellita / Danser, A H Jan / Sawada, Hisashi / Daugherty, Alan / Lu, Hong S

    Biomolecules

    2022  Band 12, Heft 6

    Abstract: Background and objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate ...

    Abstract Background and objective: In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice infused with fludrocortisone. The purpose of this study was to investigate whether fludrocortisone induces aortic pathologies in both normocholesterolemic and hypercholesterolemic mice.
    Methods and results: Male adult C57BL/6J mice were infused with either vehicle (85% polyethylene glycol 400 (PEG-400) and 15% dimethyl sulfoxide (DMSO);
    Conclusion: Fludrocortisone induces aortic pathologies independent of hypercholesterolemia. As indicated by the findings in mouse studies, people who are taking or have taken fludrocortisone might have an increased risk of aortic pathologies.
    Mesh-Begriff(e) Angiotensin II/pharmacology ; Animals ; Aorta, Abdominal/pathology ; Dimethyl Sulfoxide ; Disease Models, Animal ; Fludrocortisone/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; Receptors, LDL
    Chemische Substanzen Receptors, LDL ; Angiotensin II (11128-99-7) ; Fludrocortisone (U0476M545B) ; Dimethyl Sulfoxide (YOW8V9698H)
    Sprache Englisch
    Erscheinungsdatum 2022-06-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12060825
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: β-aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice.

    Franklin, Michael K / Sawada, Hisashi / Ito, Sohei / Howatt, Deborah A / Amioka, Naofumi / Liang, Ching-Ling / Zhang, Nancy / Graf, David B / Moorleghen, Jessica J / Katsumata, Yuriko / Lu, Hong S / Daugherty, Alan

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Background: β-aminopropionitrile (BAPN) is a pharmacological inhibitor of lysyl oxidase and lysyl oxidase-like proteins. Administration of BAPN promotes aortopathies, although there is a paucity of data on experimental conditions to generate pathology. ... ...

    Abstract Background: β-aminopropionitrile (BAPN) is a pharmacological inhibitor of lysyl oxidase and lysyl oxidase-like proteins. Administration of BAPN promotes aortopathies, although there is a paucity of data on experimental conditions to generate pathology. The objective of this study was to define experimental parameters and determine whether equivalent or variable aortopathies were generated throughout the aortic tree during BAPN administration in mice.
    Methods: BAPN was administered in drinking water for a period ranging from 1 to 12 weeks. The impacts of BAPN were first assessed with regard to dose, strain, age, and sex. BAPN-induced aortic pathological characterization was conducted using histology and immunostaining. To investigate the mechanistic basis of regional heterogeneity, ascending and descending thoracic aortas were harvested after one week of BAPN administration before the appearance of overt pathology.
    Results: BAPN-induced aortic rupture predominantly occurred or originated in the descending thoracic aorta in young C57BL/6J or N mice. No apparent differences were found between male and female mice. For mice surviving 12 weeks of BAPN administration, profound dilatation was consistently observed in the ascending region, while there were more heterogeneous changes in the descending thoracic region. Pathological features were distinct between the ascending and descending thoracic regions. Aortic pathology in the ascending region was characterized by luminal dilatation and elastic fiber disruption throughout the media. The descending thoracic region frequently had dissections with false lumen formation, collagen deposition, and remodeling of the wall surrounding the false lumen. Cells surrounding the false lumen were predominantly positive for α-smooth muscle actin. One week of BAPN administration compromised contractile properties in both regions equivalently, and RNA sequencing did not show obvious differences between the two aortic regions in smooth muscle cell markers, cell proliferation markers, and extracellular components.
    Conclusions: BAPN-induced pathologies show distinct, heterogeneous features within and between ascending and descending aortic regions in mice.
    Sprache Englisch
    Erscheinungsdatum 2024-05-02
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.10.22.563474
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: β-Aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice.

    Franklin, Michael K / Sawada, Hisashi / Ito, Sohei / Howatt, Deborah A / Amioka, Naofumi / Liang, Ching-Ling / Zhang, Nancy / Graf, David B / Moorleghen, Jessica J / Katsumata, Yuriko / Lu, Hong S / Daugherty, Alan

    Arteriosclerosis, thrombosis, and vascular biology

    2024  

    Abstract: Background: β-aminopropionitrile (BAPN) is a pharmacological inhibitor of LOX (lysyl oxidase) and LOXLs (LOX-like proteins). Administration of BAPN promotes aortopathies, although there is a paucity of data on experimental conditions to generate ... ...

    Abstract Background: β-aminopropionitrile (BAPN) is a pharmacological inhibitor of LOX (lysyl oxidase) and LOXLs (LOX-like proteins). Administration of BAPN promotes aortopathies, although there is a paucity of data on experimental conditions to generate pathology. The objective of this study was to define experimental parameters and determine whether equivalent or variable aortopathies were generated throughout the aortic tree during BAPN administration in mice.
    Methods: BAPN was administered in drinking water for a period ranging from 1 to 12 weeks. The impacts of BAPN were first assessed with regard to dose, strain, age, and sex. BAPN-induced aortic pathological characterization was conducted using histology and immunostaining. To investigate the mechanistic basis of regional heterogeneity, the ascending and descending thoracic aortas were harvested after 1 week of BAPN administration before the appearance of overt pathology.
    Results: BAPN-induced aortic rupture predominantly occurred or originated in the descending thoracic aorta in young C57BL/6J or N mice. No apparent differences were found between male and female mice. For mice surviving 12 weeks of BAPN administration, profound dilatation was consistently observed in the ascending region, while there were more heterogeneous changes in the descending thoracic region. Pathological features were distinct between the ascending and descending thoracic regions. Aortic pathology in the ascending region was characterized by luminal dilatation and elastic fiber disruption throughout the media. The descending thoracic region frequently had dissections with false lumen formation, collagen deposition, and remodeling of the wall surrounding the false lumen. Cells surrounding the false lumen were predominantly positive for α-SMA (α-smooth muscle actin). One week of BAPN administration compromised contractile properties in both regions equivalently, and RNA sequencing did not show obvious differences between the 2 aortic regions in smooth muscle cell markers, cell proliferation markers, and extracellular components.
    Conclusions: BAPN-induced pathologies show distinct, heterogeneous features within and between ascending and descending aortic regions in mice.
    Sprache Englisch
    Erscheinungsdatum 2024-05-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.123.320402
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Two Amino Acids Proximate to the Renin Cleavage Site of Human Angiotensinogen Do Not Affect Blood Pressure and Atherosclerosis in Mice-Brief Report.

    Wu, Chia-Hua / Wu, Congqing / Howatt, Deborah A / Moorleghen, Jessica J / Cassis, Lisa A / Daugherty, Alan / Lu, Hong S

    Arteriosclerosis, thrombosis, and vascular biology

    2020  Band 40, Heft 9, Seite(n) 2108–2113

    Abstract: Objective: Renin cleavage of angiotensinogen has species specificity. As the residues at positions 11 and 12 are different between human angiotensinogen and mouse angiotensinogen, we determined whether these 2 residues in angiotensinogen affect renin ... ...

    Abstract Objective: Renin cleavage of angiotensinogen has species specificity. As the residues at positions 11 and 12 are different between human angiotensinogen and mouse angiotensinogen, we determined whether these 2 residues in angiotensinogen affect renin cleavage and angiotensin II-mediated blood pressure regulation and atherosclerosis using an adenoassociated viral approach for manipulating angiotensinogen in vivo. Approach and Results: Hepatocyte-specific angiotensinogen deficient (hepAGT
    Conclusions: Replacement of L11 and Y12 to V11 and I12, respectively, in mouse angiotensinogen does not affect renin cleavage, blood pressure, and atherosclerosis in LDL receptor-deficient mice.
    Mesh-Begriff(e) Amino Acid Substitution ; Angiotensin II/metabolism ; Angiotensinogen/deficiency ; Angiotensinogen/genetics ; Angiotensinogen/metabolism ; Animals ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Blood Pressure ; Disease Models, Animal ; Female ; Hepatocytes/metabolism ; Humans ; Hypertension/genetics ; Hypertension/metabolism ; Hypertension/physiopathology ; Male ; Mice, Knockout ; Plaque, Atherosclerotic ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Renin/metabolism ; Species Specificity
    Chemische Substanzen AGT protein, human ; Agt protein, mouse ; Receptors, LDL ; Angiotensinogen (11002-13-4) ; Angiotensin II (11128-99-7) ; Renin (EC 3.4.23.15)
    Sprache Englisch
    Erscheinungsdatum 2020-07-09
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.120.314048
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  8. Artikel ; Online: Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation.

    Sawada, Hisashi / Kukida, Masayoshi / Chen, Xiaofeng / Howatt, Deborah A / Moorleghen, Jessica J / Balakrishnan, Anju / Wu, Congqing / Daugherty, Alan / Lu, Hong S

    Circulation journal : official journal of the Japanese Circulation Society

    2020  Band 84, Heft 5, Seite(n) 825–829

    Abstract: Background: Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE in endothelial and smooth muscle cells in aortic aneurysms.Methods and Results:AngI infusion ... ...

    Abstract Background: Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE in endothelial and smooth muscle cells in aortic aneurysms.Methods and Results:AngI infusion led to thoracic and abdominal aortic aneurysms in low-density lipoprotein receptor-deficient mice, which were ablated by ACE inhibition. Endothelial or smooth muscle cell-specific ACE deletion resulted in reduction of AngI-induced thoracic, but not abdominal, aortic dilatation.
    Conclusions: AngI infusion causes thoracic and abdominal aortic aneurysms in mice. ACE in aortic resident cells has differential effects on AngI-induced thoracic and abdominal aortic aneurysms.
    Mesh-Begriff(e) Angiotensin I ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Aorta, Abdominal/drug effects ; Aorta, Abdominal/enzymology ; Aorta, Abdominal/pathology ; Aorta, Thoracic/drug effects ; Aorta, Thoracic/enzymology ; Aorta, Thoracic/pathology ; Aortic Aneurysm, Abdominal/chemically induced ; Aortic Aneurysm, Abdominal/enzymology ; Aortic Aneurysm, Abdominal/pathology ; Aortic Aneurysm, Abdominal/prevention & control ; Aortic Aneurysm, Thoracic/chemically induced ; Aortic Aneurysm, Thoracic/enzymology ; Aortic Aneurysm, Thoracic/pathology ; Aortic Aneurysm, Thoracic/prevention & control ; Dilatation, Pathologic ; Disease Models, Animal ; Endothelial Cells/enzymology ; Endothelial Cells/pathology ; Mice, Knockout ; Myocytes, Smooth Muscle/enzymology ; Myocytes, Smooth Muscle/pathology ; Peptidyl-Dipeptidase A/deficiency ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Receptors, LDL/deficiency ; Receptors, LDL/genetics
    Chemische Substanzen Angiotensin-Converting Enzyme Inhibitors ; Receptors, LDL ; Angiotensin I (9041-90-1) ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Sprache Englisch
    Erscheinungsdatum 2020-03-31
    Erscheinungsland Japan
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-19-0955
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: A mini-review on quantification of atherosclerosis in hypercholesterolemic mice.

    Chen, Hui / Howatt, Deborah A / Franklin, Michael K / Amioka, Naofumi / Sawada, Hisashi / Daugherty, Alan / Lu, Hong S

    Global translational medicine

    2022  Band 1, Heft 1

    Abstract: Atherosclerosis is a leading cause of morbidity and mortality in many countries. Mice are the most frequently used animal model to study the pathogenesis and molecular mechanisms of atherosclerosis. ...

    Abstract Atherosclerosis is a leading cause of morbidity and mortality in many countries. Mice are the most frequently used animal model to study the pathogenesis and molecular mechanisms of atherosclerosis.
    Sprache Englisch
    Erscheinungsdatum 2022-06-14
    Erscheinungsland Singapore
    Dokumenttyp Journal Article
    DOI 10.36922/gtm.v1i1.76
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Renal Proximal Tubule Cell-specific Megalin Deletion Induces Tubulointerstitial Nephritis in Mice Fed Western Diet.

    Amioka, Naofumi / Franklin, Michael K / Kukida, Masayoshi / Sawada, Hisashi / Moorleghen, Jessica J / Howatt, Deborah A / Katsumata, Yuriko / Mullick, Adam E / Yanagita, Motoko / Martinez-Irizarry, Michelle M / Sandoval, Ruben M / Dunn, Kenneth W / Lu, Hong S / Daugherty, Alan

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Pharmacological inhibition of megalin (also known as low-density lipoprotein receptor-related protein 2: LRP2) attenuates atherosclerosis in hypercholesterolemic mice. Since megalin is abundant in renal proximal tubule cells (PTCs), PTC-LRP2 +/+ and -/- ... ...

    Abstract Pharmacological inhibition of megalin (also known as low-density lipoprotein receptor-related protein 2: LRP2) attenuates atherosclerosis in hypercholesterolemic mice. Since megalin is abundant in renal proximal tubule cells (PTCs), PTC-LRP2 +/+ and -/- littermates in an LDL receptor -/- background were generated and fed a Western diet to determine effects of PTC- derived megalin on atherosclerosis. PTC-specific megalin deletion did not attenuate atherosclerosis in LDL receptor -/- mice in either sex. Serendipitously, we discovered that PTC-specific megalin deletion led to interstitial infiltration of CD68+ cells and tubular atrophy. The pathology was only evident in male PTC-LRP2 -/- mice fed the Western diet, but not in mice fed a normal laboratory diet. Renal pathologies were also observed in male PTC-LRP2 -/- mice in an LDL receptor +/+ background fed the same Western diet, demonstrating that the renal pathologies were dependent on diet and not hypercholesterolemia. By contrast, female PTC-LRP2 -/- mice had no apparent renal pathologies. In vivo multiphoton microscopy demonstrated that PTC-specific megalin deletion dramatically diminished albumin accumulation in PTCs within 10 days of Western diet feeding. RNA sequencing analyses demonstrated the upregulation of inflammation-related pathways in kidney. Overall, PTC- specific megalin deletion leads to tubulointerstitial nephritis in mice fed Western diet, with severe pathologies in male mice.
    Sprache Englisch
    Erscheinungsdatum 2024-05-14
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.05.11.592234
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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