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  1. Book ; Online ; E-Book: Male osteoporosis

    Ferlin, Alberto / Migliaccio, Silvia

    gender differences in pathophysiology, clinical aspects, diagnosis and treatment

    (Trends in andrology and sexual medicine)

    2020  

    Abstract: This book represents a comprehensive, clinically oriented text covering all aspects of male osteoporosis, from the basic concepts of bone physiology and regulation of bone remodeling in men, the causes and pathophysiological mechanisms responsible for ... ...

    Author's details Alberto Ferlin, Silvia Migliaccio, editors
    Series title Trends in andrology and sexual medicine
    Abstract This book represents a comprehensive, clinically oriented text covering all aspects of male osteoporosis, from the basic concepts of bone physiology and regulation of bone remodeling in men, the causes and pathophysiological mechanisms responsible for the most frequent causes of osteoporosis, to diagnostic and screening protocols, as well as prevention and treatment approaches. It offers a broad overview of male osteoporosis by specialists involved in research and clinical practice and discusses the practical issues encountered. Filling a gap in the literature, this volume is a valuable resource for general practitioners, clinical endocrinologists, geriatricians and experts in osteoporosis. .
    Keywords Osteoporosis ; Osteoporosis/Pathophysiology ; Osteoporosis/Treatment
    Subject code 616.716
    Language English
    Size 1 online resource (VIII, 224 p. 20 illus., 14 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-319-96376-7 ; 3-319-96375-9 ; 978-3-319-96376-1 ; 978-3-319-96375-4
    DOI 10.1007/978-3-319-96376-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Strategies to improve early diagnosis of Klinefelter syndrome.

    Ferlin, Alberto

    Expert review of endocrinology & metabolism

    2020  Volume 15, Issue 6, Page(s) 375–378

    MeSH term(s) Early Diagnosis ; Humans ; Klinefelter Syndrome/diagnosis
    Language English
    Publishing date 2020-10-14
    Publishing country England
    Document type Editorial
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1080/17446651.2020.1831912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Guideline for unexplained couple infertility: misunderstandings on the approach to the male factor.

    Grande, Giuseppe / Graziani, Andrea / Ferlin, Alberto

    Human reproduction (Oxford, England)

    2024  Volume 39, Issue 4, Page(s) 859–860

    MeSH term(s) Humans ; Male ; Infertility/diagnosis ; Infertility/therapy ; Infertility, Male/diagnosis ; Infertility, Male/therapy
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/deae032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Re: Taylor P. Kohn, Jaden R. Kohn, Ryan C. Owen, R. Matthew Coward. The Prevalence of Y-chromosome Microdeletions in Oligozoospermic Men: A Systematic Review and Meta-analysis of European and North American Studies. Eur Urol 2019;76:626-36: Indication for Y Chromosome Microdeletion Analysis in Infertile Men Should Not be Based Merely on Sperm Concentration.

    Ferlin, Alberto

    European urology

    2020  Volume 77, Issue 4, Page(s) e96–e97

    MeSH term(s) Chromosome Deletion ; Chromosomes, Human, Y ; Humans ; Infertility, Male ; Male ; Prevalence ; Sex Chromosome Aberrations ; Sex Chromosome Disorders of Sex Development ; Spermatozoa ; United States
    Language English
    Publishing date 2020-01-21
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.01.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Testis cancer: Genes, environment, hormones

    Foresta, Carlo / Ferlin, Alberto

    2015  

    Abstract: Testicular cancer (TC) is the most common cancer in males aged 20-40 years, with a worldwide incidence of 7.5 per 100,000, but the rates vary considerably between countries and ethnic groups and there is evidence also for an increasing incidence in last ... ...

    Abstract Testicular cancer (TC) is the most common cancer in males aged 20-40 years, with a worldwide incidence of 7.5 per 100,000, but the rates vary considerably between countries and ethnic groups and there is evidence also for an increasing incidence in last decades. About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It is generally assumed that the development of TGCT is under endocrine control. In particular, unbalanced androgen/estrogen levels and/or activity are believed to represent the key events for TGCT development and progression. Furthermore, recent evidence has suggested genetic association of TGCT with variations in genes involved in hypothalamic-pituitary-testicular axis and steroidogenic enzymes.-

    This recent evidence expands the current knowledge on the role of genetic contribution in testicular cancer susceptibility, and supports the hypothesis that variations in hormone metabolism genes might change the hormonal environment implicated in testicular carcinogenesis. Therefore, hormonal carcinogenesis is an important and controversial area of current research in TGCT, and further attention is given to genetic factors influencing hormone-related cancer risk. The genetic component to TGCT is in general strong. In fact, although environmental factors clearly contribute to TGCT development (and probably to its increasing incidence in some geographical areas), the proportion of TGCT susceptibility accounted for by the genetic effects is estimated at 25%.-

    TGCT has high familial risks compared with most other cancer types that are generally no more than two-fold: brothers of individuals with TGCT have an 8- to 12-fold increased risk of disease, and sons of affected individuals have a 4- to 6-fold increased risk. Despite this strong familial relative risk, early results from linkage studies identified a limited relationship with genetic factors, suggesting that TGCT is a genetically complex trait. However, more recently, four genome-wide association studies (GWAS) from the UK and USA have reported association of TGCTs with six new loci (KITLG, SPRY4, BAK1, DMRT1, TERT, and ATF7IP). The strongest association for TGCT susceptibility was found for SNPs in KITLG (ligand for the membrane-bound receptor tyrosine kinase KIT) gene with a greater than 2.5-fold increased risk of disease per major allele, which is the highest reported for any cancer to date.-
    Keywords Medicine (General) ; Diseases of the endocrine glands. Clinical endocrinology
    Size 1 electronic resource (86 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020091856
    ISBN 9782889196722 ; 2889196720
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: Proteomics for the identification of peripheral markers in pituitary disease.

    Grande, Giuseppe / Graziani, Andrea / DE Toni, Luca / Ferlin, Alberto

    Minerva endocrinology

    2024  

    Abstract: Although precision medicine moved its first steps from genomic medicine, it has gone far beyond genomics, considering the full complexity of cellular physiology. Therefore, the present time might be considered as the "post-genomic era." In detail, ... ...

    Abstract Although precision medicine moved its first steps from genomic medicine, it has gone far beyond genomics, considering the full complexity of cellular physiology. Therefore, the present time might be considered as the "post-genomic era." In detail, proteomics captures the overall protein profile of an analyzed sample. The goals of proteomic analysis are to perform a global analysis of protein expression and function, to systematically define the role proteins in physiological and pathological condition, to increase mechanistic understanding of the biological processes and to discover new biomarkers and therapeutic targets. In this narrative mini-review, the role of proteomics is discussed with a particular focus on the few attempts of the application of proteomic platforms for the identification of new biomarkers in pituitary diseases, namely in acromegaly, GH deficiency and male secondary hypogonadism.
    Language English
    Publishing date 2024-04-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062786-2
    ISSN 2724-6116
    ISSN (online) 2724-6116
    DOI 10.23736/S2724-6507.23.04075-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Sperm DNA fragmentation testing as a diagnostic and prognostic parameter of couple infertility.

    Ferlin, Alberto

    Translational andrology and urology

    2017  Volume 6, Issue Suppl 4, Page(s) S618–S620

    Language English
    Publishing date 2017-08-19
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau.2017.06.10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The complex relation between obstructive sleep apnoea syndrome, hypogonadism and testosterone replacement therapy.

    Graziani, Andrea / Grande, Giuseppe / Ferlin, Alberto

    Frontiers in reproductive health

    2023  Volume 5, Page(s) 1219239

    Abstract: Obstructive sleep apnoea syndrome (OSAS) is an under-recognized medical disease. The main risk factors for OSAS are male sex, older age, obesity, and metabolic syndrome, that are also associated with male hypogonadism (MH). Therefore, obesity has been ... ...

    Abstract Obstructive sleep apnoea syndrome (OSAS) is an under-recognized medical disease. The main risk factors for OSAS are male sex, older age, obesity, and metabolic syndrome, that are also associated with male hypogonadism (MH). Therefore, obesity has been classically identified as the most evident link between OSAS and MH. However, OSAS is
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-3153
    ISSN (online) 2673-3153
    DOI 10.3389/frph.2023.1219239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Protein and Peptide Markers in Endocrine Diseases.

    Ferlin, Alberto / Grande, Giuseppe

    Protein and peptide letters

    2020  Volume 27, Issue 12, Page(s) 1179–1180

    MeSH term(s) Biomarkers ; Endocrine System Diseases ; Humans ; Peptides ; Proteins
    Chemical Substances Biomarkers ; Peptides ; Proteins
    Language English
    Publishing date 2020-12-09
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 1280776-x
    ISSN 1875-5305 ; 0929-8665
    ISSN (online) 1875-5305
    ISSN 0929-8665
    DOI 10.2174/092986652712201202094908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Gender Differences in Soft Tissue and Bone Sarcoma: A Narrative Review.

    Cosci, Ilaria / Del Fiore, Paolo / Mocellin, Simone / Ferlin, Alberto

    Cancers

    2023  Volume 16, Issue 1

    Abstract: Sarcomas, uncommon malignancies, stem from mesenchymal tissues, distinct from epithelial tissues, originating in the embryonic mesodermal layer. These sarcomas have been categorized as either bone or soft tissue sarcomas, depending on their originating ... ...

    Abstract Sarcomas, uncommon malignancies, stem from mesenchymal tissues, distinct from epithelial tissues, originating in the embryonic mesodermal layer. These sarcomas have been categorized as either bone or soft tissue sarcomas, depending on their originating tissue. The majority of sarcomas occur sporadically with their etiology being unknown, but there are several, well-established genetic predisposition syndromes and some environmental exposures associated with specific sarcomas. Recently, many studies have shown that sarcomas, in analogy with colorectal, skin, head and neck, esophageal, lung, and liver carcinomas, also have a male sex predilection. Significant gender differences have already been observed in childhood sarcomas. Among the tumors strongly associated with the male sex, childhood sarcomas have been identified as being particularly sensitive to the biological differences between the sexes, with special regard to soft tissue sarcomas. As the biological mechanisms underlying the sex differences in the incidence of soft tissue sarcomas remain largely unexplored, this review aims to highlight the factors underlying these differences to inform prevention and treatment.
    Language English
    Publishing date 2023-12-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16010201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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