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Article ; Online: Process matters: Emerging concepts underlying impaired natriuretic peptide system function in heart failure.

Dries, Daniel L

2011 Volume 4, Issue 2, Page(s) 107–110

MeSH term(s)	Atrial Natriuretic Factor/blood ; Biomarkers/blood ; Cyclic GMP/blood ; Down-Regulation ; Heart Failure/blood ; Heart Failure/physiopathology ; Humans ; Natriuretic Peptide, Brain/blood ; Prognosis ; Serine Endopeptidases/blood ; Severity of Illness Index ; Stroke Volume ; Ventricular Function
Chemical Substances	Biomarkers ; Natriuretic Peptide, Brain (114471-18-0) ; Atrial Natriuretic Factor (85637-73-6) ; CORIN protein, human (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-) ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2011-03
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	2429459-7
ISSN	1941-3297 ; 1941-3289
ISSN (online)	1941-3297
ISSN	1941-3289
DOI	10.1161/CIRCHEARTFAILURE.111.960948
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Article ; Online: Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption.

Haigis, Ann-Cathrin / Vergauwen, Lucia / LaLone, Carlie A / Villeneuve, Daniel L / O'Brien, Jason M / Knapen, Dries

Toxicological sciences : an official journal of the Society of Toxicology

2023 Volume 195, Issue 1, Page(s) 1–27

Abstract: Thyroid hormone system disrupting compounds are considered potential threats for human and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone system disruption (THSD) are being developed in different taxa. Combining these ... ...

Abstract	Thyroid hormone system disrupting compounds are considered potential threats for human and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone system disruption (THSD) are being developed in different taxa. Combining these AOPs results in a cross-species AOP network for THSD which may provide an evidence-based foundation for extrapolating THSD data across vertebrate species and bridging the gap between human and environmental health. This review aimed to advance the description of the taxonomic domain of applicability (tDOA) in the network to improve its utility for cross-species extrapolation. We focused on the molecular initiating events (MIEs) and adverse outcomes (AOs) and evaluated both their plausible domain of applicability (taxa they are likely applicable to) and empirical domain of applicability (where evidence for applicability to various taxa exists) in a THSD context. The evaluation showed that all MIEs in the AOP network are applicable to mammals. With some exceptions, there was evidence of structural conservation across vertebrate taxa and especially for fish and amphibians, and to a lesser extent for birds, empirical evidence was found. Current evidence supports the applicability of impaired neurodevelopment, neurosensory development (eg, vision) and reproduction across vertebrate taxa. The results of this tDOA evaluation are summarized in a conceptual AOP network that helps prioritize (parts of) AOPs for a more detailed evaluation. In conclusion, this review advances the tDOA description of an existing THSD AOP network and serves as a catalog summarizing plausible and empirical evidence on which future cross-species AOP development and tDOA assessment could build.
MeSH term(s)	Animals ; Humans ; Adverse Outcome Pathways ; Thyroid Hormones ; Fishes ; Reproduction ; Risk Assessment/methods ; Mammals
Chemical Substances	Thyroid Hormones
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1420885-4
ISSN	1096-0929 ; 1096-6080
ISSN (online)	1096-0929
ISSN	1096-6080
DOI	10.1093/toxsci/kfad063
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Zs.A 1709: Show issues

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Article ; Online: Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish.

Van Dingenen, Imke / Vergauwen, Lucia / Haigis, Ann-Cathrin / Blackwell, Brett R / Stacy, Emma / Villeneuve, Daniel L / Knapen, Dries

Aquatic toxicology (Amsterdam, Netherlands)

2023 Volume 261, Page(s) 106632

Abstract: ... development that is impacted by deiodinase inhibition. Zebrafish embryos were exposed to 6 mg/L iopanoic acid ...

Abstract	Thyroid hormone system disruption (THSD) negatively affects multiple developmental processes and organs. In fish, inhibition of deiodinases, which are enzymes crucial for (in)activating thyroid hormones (THs), leads to impaired swim bladder inflation. Until now, the underlying mechanism has remained largely unknown. Therefore, the objective of this study was to identify the process during swim bladder development that is impacted by deiodinase inhibition. Zebrafish embryos were exposed to 6 mg/L iopanoic acid (IOP), a model deiodinase inhibitor, during 8 different exposure windows (0-60, 60-120, 24-48, 48-72, 72-96, 96-120, 72-120 and 0-120 h post fertilization (hpf)). Exposure windows were chosen based on the three stages of swim bladder development: budding (24-48 hpf), pre-inflation, i.e., the formation of the swim bladder tissue layers (48-72 hpf), and inflation phase (72-120 hpf). Exposures prior to 72 hpf, during either the budding or pre-inflation phase (or both), impaired swim bladder inflation, while exposure during the inflation phase did not. Based on our results, we hypothesize that DIO inhibition before 72 hpf leads to a local decrease in T3 levels in the developing swim bladder. Gene transcript analysis showed that these TH level alterations disturb both Wnt and hedgehog signaling, known to be essential for swim bladder formation, eventually resulting in impaired development of the swim bladder tissue layers. Improper development of the swim bladder impairs swim bladder inflation, leading to reduced swimming performance. This study demonstrates that deiodinase inhibition impacts processes underlying the formation of the swim bladder and not the inflation process, suggesting that these processes primarily rely on maternal rather than endogenously synthetized THs since TH measurements showed that THs were not endogenously synthetized during the sensitive period.
MeSH term(s)	Animals ; Zebrafish/physiology ; Iodide Peroxidase/genetics ; Urinary Bladder ; Hedgehog Proteins/genetics ; Water Pollutants, Chemical/toxicity ; Thyroid Hormones ; Embryonic Development ; Embryo, Nonmammalian/physiology
Chemical Substances	Iodide Peroxidase (EC 1.11.1.8) ; Hedgehog Proteins ; Water Pollutants, Chemical ; Thyroid Hormones
Language	English
Publishing date	2023-07-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782699-0
ISSN	1879-1514 ; 0166-445X
ISSN (online)	1879-1514
ISSN	0166-445X
DOI	10.1016/j.aquatox.2023.106632
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Zs.A 4376: Show issues

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Article ; Online: Genetic ancestry, population admixture, and the genetic epidemiology of complex disease.

Dries, Daniel L

Circulation. Cardiovascular genetics

2009 Volume 2, Issue 6, Page(s) 540–543

MeSH term(s)	Disease/genetics ; Evolution, Molecular ; Gene Frequency ; Genetics, Population ; Humans ; Molecular Epidemiology
Language	English
Publishing date	2009-12
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	2477394-3
ISSN	1942-3268 ; 1942-325X
ISSN (online)	1942-3268
ISSN	1942-325X
DOI	10.1161/CIRCGENETICS.109.922898
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Zs.A 6731: Show issues

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Article: Natriuretic peptides and the genomics of left-ventricular hypertrophy.

Dries, Daniel L

Heart failure clinics

2009 Volume 6, Issue 1, Page(s) 55–64

Abstract: Left-ventricular hypertrophy (LVH) is one of the strongest independent predictors of cardiovascular morbidity and mortality in the general population. Although hypertension and obesity are well-established, independent risk factors for the development of ...

Abstract	Left-ventricular hypertrophy (LVH) is one of the strongest independent predictors of cardiovascular morbidity and mortality in the general population. Although hypertension and obesity are well-established, independent risk factors for the development of LVH, they explain less than 25% to 50% of the variance of left ventricular mass (LVM) in humans. A substantial body of evidence suggests that there is a genetic basis to the observed inter-individual variability in the susceptibility to the development of LVH. Given the continuous relationship between LVM and cardiovascular morbidity and mortality, elucidating the genetic determinants of inter-individual differences in the susceptibility to LVH is of considerable public health importance. It promises the opportunity to identify high-risk individuals for targeted intervention and may identify novel therapeutic targets for improved prevention and treatment strategies.
MeSH term(s)	African Americans/genetics ; Antihypertensive Agents/therapeutic use ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/mortality ; Genetic Variation ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypertrophy, Left Ventricular/drug therapy ; Hypertrophy, Left Ventricular/epidemiology ; Hypertrophy, Left Ventricular/genetics ; Hypertrophy, Left Ventricular/mortality ; Natriuretic Peptides/genetics ; Natriuretic Peptides/physiology ; Risk Assessment ; Serine Endopeptidases/genetics ; United States/epidemiology
Chemical Substances	Antihypertensive Agents ; Natriuretic Peptides ; CORIN protein, human (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-)
Language	English
Publishing date	2009-04-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2212019-1
ISSN	1551-7136
ISSN	1551-7136
DOI	10.1016/j.hfc.2009.08.007
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Zs.A 6554: Show issues

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Article ; Online: Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish

Van Dingenen, Imke / Vergauwen, Lucia / Haigis, Ann-Cathrin / Blackwell, Brett R. / Stacy, Emma / Villeneuve, Daniel L. / Knapen, Dries

Elsevier B.V. Aquatic Toxicology. 2023 July 07, p.106632-

2023 , Page(s) 106632–

Abstract: ... development that is impacted by deiodinase inhibition. Zebrafish embryos were exposed to 6 mg/L iopanoic acid ...

Abstract	Thyroid hormone system disruption (THSD) negatively affects multiple developmental processes and organs. In fish, inhibition of deiodinases, which are enzymes crucial for (in)activating thyroid hormones (THs), leads to impaired swim bladder inflation. Until now, the underlying mechanism has remained largely unknown. Therefore, the objective of this study was to identify the process during swim bladder development that is impacted by deiodinase inhibition. Zebrafish embryos were exposed to 6 mg/L iopanoic acid (IOP), a model deiodinase inhibitor, during 8 different exposure windows (0-60, 60-120, 24-48, 48-72, 72-96, 96-120, 72-120 and 0-120 hours post fertilization (hpf)). Exposure windows were chosen based on the three stages of swim bladder development: budding (24-48 hpf), pre-inflation, i.e., the formation of the swim bladder tissue layers (48-72 hpf), and inflation phase (72-120 hpf). Exposures prior to 72 hpf, during either the budding or pre-inflation phase (or both), impaired swim bladder inflation, while exposure during the inflation phase did not. Based on our results, we hypothesize that DIO inhibition before 72 hpf leads to a local decrease in T3 levels in the developing swim bladder. Gene transcript analysis showed that these TH level alterations disturb both Wnt and hedgehog signaling, known to be essential for swim bladder formation, eventually resulting in impaired development of the swim bladder tissue layers. Improper development of the swim bladder impairs swim bladder inflation, leading to reduced swimming performance. This study demonstrates that deiodinase inhibition impacts processes underlying the formation of the swim bladder and not the inflation process, suggesting that these processes primarily rely on maternal rather than endogenously synthetized THs since TH measurements showed that THs were not endogenously synthetized during the sensitive period.
Keywords	Danio rerio ; Erinaceidae ; embryogenesis ; inflation ; messenger RNA ; swim bladder ; thyroid hormones ; Thyroid hormone system disruption ; iopanoic acid ; swim bladder development ; zebrafish embryo ; Wnt/hedgehog signaling ; deiodinase inhibition
Language	English
Dates of publication	2023-0707
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	782699-0
ISSN	1879-1514 ; 0166-445X
ISSN (online)	1879-1514
ISSN	0166-445X
DOI	10.1016/j.aquatox.2023.106632
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Relevance of molecular forms of brain natriuretic peptide for natriuretic peptide research.

Dries, Daniel L

Hypertension (Dallas, Tex. : 1979)

2007 Volume 49, Issue 5, Page(s) 971–973

MeSH term(s)	Animals ; Biological Assay ; Biomedical Research ; Cardiac Output, Low/metabolism ; Cardiac Output, Low/physiopathology ; Cross Reactions ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Natriuretic Peptide, Brain/chemistry ; Natriuretic Peptide, Brain/immunology ; Natriuretic Peptides/metabolism ; Natriuretic Peptides/physiology ; Protein Isoforms
Chemical Substances	Natriuretic Peptides ; Protein Isoforms ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2007-05
Publishing country	United States
Document type	Comment ; Editorial ; Review
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.107.087254
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Zs.A 1488: Show issues

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Article ; Online: Single-Color Isomer-Resolved Spectroscopy.

Abma, Grite L / Kleuskens, Dries / Wang, Siwen / Balster, Michiel / Roij, Andre van / Janssen, Niek / Horke, Daniel A

The journal of physical chemistry. A

2022 Volume 126, Issue 23, Page(s) 3811–3815

Abstract: Structural isomers, such as conformers or tautomers, are of significant importance across chemistry and biology, as they can have different functionalities. In gas-phase experiments using molecular beams, formation of many different isomers cannot be ... ...

Abstract	Structural isomers, such as conformers or tautomers, are of significant importance across chemistry and biology, as they can have different functionalities. In gas-phase experiments using molecular beams, formation of many different isomers cannot be prevented, and their presence significantly complicates the assignment of spectral lines. Current isomer-resolved spectroscopic techniques heavily rely on theoretical calculations or make use of elaborate double-resonance schemes. We show here that isomer-resolved spectroscopy can also be performed using a single tunable laser. In particular, we demonstrate single-color isomer-resolved spectroscopy by utilizing electrostatic deflection to spatially separate the isomers. We show that for 3-aminophenol we can spatially separate the
MeSH term(s)	Isomerism ; Spectrophotometry, Infrared ; Spectrophotometry, Ultraviolet ; Static Electricity
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.2c02277
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Article ; Online: Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish.

Stinckens, Evelyn / Vergauwen, Lucia / Blackwell, Brett R / Ankley, Gerald T / Villeneuve, Daniel L / Knapen, Dries

Environmental science & technology

2020 Volume 54, Issue 10, Page(s) 6213–6223

Abstract: A set of adverse outcome pathways (AOPs) linking inhibition of thyroperoxidase and deiodinase to impaired swim bladder inflation in fish has recently been developed. These AOPs help to establish links between these thyroid hormone (TH) disrupting ... ...

Abstract	A set of adverse outcome pathways (AOPs) linking inhibition of thyroperoxidase and deiodinase to impaired swim bladder inflation in fish has recently been developed. These AOPs help to establish links between these thyroid hormone (TH) disrupting molecular events and adverse outcomes relevant to aquatic ecological risk assessment. Until now, very little data on the effects of TH disruption on inflation of the anterior chamber (AC) of the swim bladder were available. The present study used zebrafish exposure experiments with three model compounds with distinct thyroperoxidase and deiodinase inhibition potencies (methimazole, iopanoic acid, and propylthiouracil) to evaluate this linkage. Exposure to all three chemicals decreased whole body triiodothyronine (T3) concentrations, either through inhibition of thyroxine (T4) synthesis or through inhibition of Dio mediated conversion of T4 to T3. A quantitative relationship between reduced T3 and reduced AC inflation was established, a critical key event relationship linking impaired swim bladder inflation to TH disruption. Reduced inflation of the AC was directly linked to reductions in swimming distance compared to controls as well as to chemical-exposed fish whose ACs inflated. Together the data provide compelling support for AOPs linking TH disruption to impaired AC inflation in fish.
MeSH term(s)	Animals ; Embryo, Nonmammalian ; Iodide Peroxidase ; Thyroxine ; Triiodothyronine ; Urinary Bladder ; Water Pollutants, Chemical ; Zebrafish
Chemical Substances	Water Pollutants, Chemical ; Triiodothyronine (06LU7C9H1V) ; Iodide Peroxidase (EC 1.11.1.8) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2020-04-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.9b07204
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Article ; Online: Evolution of a self-renewing, participant-centered workshop series in BMB assessment.

Tyler, Ludmila / Kennelly, Peter J / Engelman, Shelly / Block, Kirsten F / Bobenko, Jennifer C / Catalano, Jaclyn / Jones, Jesica A / Kanipes-Spinks, Margaret I / Lim, Yang Mooi / Loertscher, Jennifer / Olafimihan, Tejiri / Reiss, Hailey / Upchurch-Poole, Territa L / Wei, Yufeng / Linenberger Cortes, Kimberly J / Moore, Victoria Del Gaizo / Dries, Daniel R

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

2023 Volume 52, Issue 1, Page(s) 58–69

Abstract: We present as a case study the evolution of a series of participant-centered workshops designed to meet a need in the life sciences education community-the incorporation of best practices in the assessment of student learning. Initially, the ICABL ( ... ...

Abstract	We present as a case study the evolution of a series of participant-centered workshops designed to meet a need in the life sciences education community-the incorporation of best practices in the assessment of student learning. Initially, the ICABL (Inclusive Community for the Assessment of Biochemistry and Molecular Biology/BMB Learning) project arose from a grass-roots effort to develop material for a national exam in biochemistry and molecular biology. ICABL has since evolved into a community of practice in which participants themselves-through extensive peer review and reflection-become integral stakeholders in the workshops. To examine this evolution, this case study begins with a pilot workshop supported by seed funding and thoughtful programmatic assessment, the results of which informed evidence-based changes that, in turn, led to an improved experience for the community. Using participant response data, the case study also reveals critical features for successful workshops, including participant-centered activities and the value of frequent peer review of participants' products. Furthermore, we outline a train-the-trainer model for creating a self-renewing community by bringing new perspectives and voices into an existing core leadership team. This case study, then, offers a blueprint for building a thriving, evolving community of practice that not only serves the needs of individual scientist-educators as they seek to enhance student learning, but also provides a pathway for elevating members to positions of leadership.
MeSH term(s)	Humans ; Students ; Biochemistry/education ; Molecular Biology/education ; Learning ; Physicians
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2039717-3
ISSN	1539-3429 ; 1470-8175
ISSN (online)	1539-3429
ISSN	1470-8175
DOI	10.1002/bmb.21789
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