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  1. Book: Pharmakokinetik kompakt

    Derendorf, Hartmut

    Grundlagen und Praxisrelevanz ; mit 29 Tabellen

    (Reihe Kompakt-Lehrbuch)

    2011  

    Author's details Hartmut Derendorf
    Series title Reihe Kompakt-Lehrbuch
    Keywords Pharmacokinetics ; Pharmakokinetik
    Subject Klinische Pharmakokinetik ; Toxikokinetik
    Language German
    Size XIV, 378 S. : Ill., graph. Darst.
    Edition 3., völlig neu bearb. und erw. Aufl.
    Publisher Wiss. Verl.-Ges
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    Old title 2. Aufl. u.d.T. Pharmakokinetik
    HBZ-ID HT016527276
    ISBN 978-3-8047-2450-1 ; 3-8047-2450-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 5662 order for loan Magazin

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  2. Book: Fundamentals of antimicrobial pharmacokinetics and pharmacodynamics

    Vinks, Alexander A. / Derendorf, Hartmut / Mouton, Johan W.

    2014  

    Author's details Alexander A. Vinks ; Hartmut Derendorf ; Johan W. Mouton ed
    Keywords Anti-infective agents--Pharmacokinetics ; Anti-infective agents--Dose-response relationship
    Subject code 615.7922
    Language English
    Size IX, 466 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018118457
    ISBN 978-0-387-75612-7 ; 0-387-75612-4 ; 9780387756134 ; 0387756132
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 34 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin.

    Derendorf, Hartmut

    International journal of antimicrobial agents

    2020  Volume 55, Issue 6, Page(s) 106007

    Abstract: A recent report identified significant reductions or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin. The present communication discusses some common pharmacokinetic properties of these two ... ...

    Abstract A recent report identified significant reductions or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin. The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of action for these antiviral effects. The physicochemical properties of both hydroxychloroquine and azithromycin are consistent with particularly high affinity for the intracellular lysosomal space, which has been implicated as a target site for antiviral activity. The properties of both drugs predict dramatic accumulation in lysosomes, with calculated lysosomal drug concentrations that exceed cytosolic and extracellular concentrations by more than 50 000-fold. These predictions are consistent with previously reported experimentally measured cellular and extracellular concentrations of azithromycin. This is also reflected in the very large volumes of distribution of these drugs, which are among the highest of all drugs currently in use. The combination of hydroxychloroquine and azithromycin produces very high local concentrations in lysosomes. The clinical significance of this observation is unclear; however, the magnitude of this mechanism of drug accumulation via ion-trapping in lysosomes could be an important factor for the pharmacodynamic effects of this drug combination.
    MeSH term(s) Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Azithromycin/pharmacokinetics ; Azithromycin/pharmacology ; Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Humans ; Hydroxychloroquine/pharmacokinetics ; Hydroxychloroquine/pharmacology ; Lysosomes/drug effects ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; Viral Load/drug effects
    Chemical Substances Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2020.106007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3368: Show issues Location:
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    Zs.MO 500: Show issues

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  4. Article: Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin

    Derendorf, Hartmut

    Int J Antimicrob Agents

    Abstract: A recent report identified significant reductions or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin. The present communication discusses some common pharmacokinetic properties of these two ... ...

    Abstract A recent report identified significant reductions or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin. The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of action for these antiviral effects. The physicochemical properties of both hydroxychloroquine and azithromycin are consistent with particularly high affinity for the intracellular lysosomal space, which has been implicated as a target site for antiviral activity. The properties of both drugs predict dramatic accumulation in lysosomes, with calculated lysosomal drug concentrations that exceed cytosolic and extracellular concentrations by more than 50 000-fold. These predictions are consistent with previously reported experimentally measured cellular and extracellular concentrations of azithromycin. This is also reflected in the very large volumes of distribution of these drugs, which are among the highest of all drugs currently in use. The combination of hydroxychloroquine and azithromycin produces very high local concentrations in lysosomes. The clinical significance of this observation is unclear; however, the magnitude of this mechanism of drug accumulation via ion-trapping in lysosomes could be an important factor for the pharmacodynamic effects of this drug combination.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #197691
    Database COVID19

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  5. Article ; Online: One Giant Leap for Pharmacology.

    Eyal, Sara / Derendorf, Hartmut

    Pharmaceutical research

    2020  Volume 37, Issue 3, Page(s) 62

    MeSH term(s) Astronauts ; Biological Availability ; Drug Therapy/methods ; Humans ; Medication Therapy Management ; Pharmaceutical Research/methods ; Space Flight ; Spacecraft ; Weightlessness
    Language English
    Publishing date 2020-03-02
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 843063-9
    ISSN 1573-904X ; 0724-8741 ; 0739-0742
    ISSN (online) 1573-904X
    ISSN 0724-8741 ; 0739-0742
    DOI 10.1007/s11095-020-02788-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1937: Show issues Location:
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  6. Article ; Online: Roger W. Jelliffe, M.D. (1929-2020).

    Derendorf, Hartmut / Peloquin, Charles

    Clinical pharmacokinetics

    2020  Volume 59, Issue 9, Page(s) 1063

    Language English
    Publishing date 2020-08-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 197627-8
    ISSN 1179-1926 ; 0312-5963
    ISSN (online) 1179-1926
    ISSN 0312-5963
    DOI 10.1007/s40262-020-00928-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1246: Show issues Location:
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  7. Book: Handbook of pharmacokinetic pharmacodynamic correlation

    Derendorf, Hartmut

    (Handbooks of pharmacology and toxicology)

    1995  

    Title variant Pharmacokinetic pharmacodynamic correlation
    Author's details ed. by Harmut Derendorf
    Series title Handbooks of pharmacology and toxicology
    Keywords Pharmacokinetics ; Pharmacology ; Dose-Response Relationship, Drug ; Models, Theoretical ; Pharmakokinetik ; Arzneimittel ; Dosis-Wirkungs-Beziehung
    Subject Fertigarzneimittel ; Therapeutikum ; Medikament ; Medukamente ; Pharmakon ; Pharmaka ; Arzneistoff ; Arzneimittelwirkstoff ; Arznei ; Pharmazeutikum ; Pharmazeutika ; Pharmazeutischer Wirkstoff ; Arzneidroge ; Klinische Pharmakokinetik ; Toxikokinetik
    Language English
    Size 483 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT007104928
    ISBN 0-8493-8303-X ; 978-0-8493-8303-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 2348 order for loan Magazin

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  8. Article ; Online: Medications in Space: In Search of a Pharmacologist's Guide to the Galaxy.

    Eyal, Sara / Derendorf, Hartmut

    Pharmaceutical research

    2019  Volume 36, Issue 10, Page(s) 148

    Abstract: Medications have been used during space missions for more than half a century, yet our understanding of the effects of spaceflight on drug pharmacokinetics and pharmacodynamics is poor. The space environment induces time-dependent alterations in human ... ...

    Abstract Medications have been used during space missions for more than half a century, yet our understanding of the effects of spaceflight on drug pharmacokinetics and pharmacodynamics is poor. The space environment induces time-dependent alterations in human physiology that include fluid shifts, cardiovascular deconditioning, bone and muscle density loss, and impaired immunity. This review presents the current knowledge on the physiological effects of spaceflight that can translate into altered drug disposition and activity and eventually to inadequate treatment. It describes findings from studies in astronauts along with mechanistic studies in animal models and in vitro systems. Future missions into deeper space and the emergence of commercial spaceflight will require a more detailed understanding of space pharmacology to optimize treatment in astronauts and space travelers.
    MeSH term(s) Aerospace Medicine ; Animals ; Astronauts ; Gravitation ; Humans ; Pharmaceutical Preparations/administration & dosage ; Pharmaceutical Preparations/metabolism ; Pharmacokinetics ; Space Flight ; Weightlessness/adverse effects
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2019-08-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 843063-9
    ISSN 1573-904X ; 0724-8741 ; 0739-0742
    ISSN (online) 1573-904X
    ISSN 0724-8741 ; 0739-0742
    DOI 10.1007/s11095-019-2679-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1937: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Book: Arzneimittelkunde

    Derendorf, Hartmut

    mit 8 Tab

    (Der pharmazeutisch-technische Assistent ; 2)

    1988  

    Series title Der pharmazeutisch-technische Assistent ; 2
    Collection
    Keywords Pharmacology ; Pharmazie ; Lehrbuch
    Subject Kompendium ; Arzneikunde ; Arzneimittelkunde
    Size 286 S. : Ill., graph. Darst.
    Edition 4., überarb. u. erg. Aufl.
    Publisher Deutscher Apotheker-Verl
    Publishing place Stuttgart
    Document type Book
    HBZ-ID HT003293879
    ISBN 3-7692-1129-4 ; 978-3-7692-1129-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1988 A 1923 -2- order for loan Magazin

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  10. Article: Model-based drug approval - the rubber hits the road.

    Derendorf, Hartmut

    International journal of clinical pharmacology and therapeutics

    2012  Volume 50, Issue 9, Page(s) 621

    MeSH term(s) Adrenergic beta-2 Receptor Agonists/administration & dosage ; Bronchodilator Agents/administration & dosage ; Drug Discovery/methods ; Drug Dosage Calculations ; Humans ; Indans/administration & dosage ; Lung/drug effects ; Models, Theoretical ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Quinolones/administration & dosage
    Chemical Substances Adrenergic beta-2 Receptor Agonists ; Bronchodilator Agents ; Indans ; Quinolones ; indacaterol (8OR09251MQ)
    Language English
    Publishing date 2012-09-18
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 124384-6
    ISSN 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
    ISSN 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
    DOI 10.5414/cpp50621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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