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Article: Religious education and the new cosmology

Faller, Paul

Journal of Religious Education

Abstract: James Michael Lee (in Forging a better religious education in the third millennium, Religious Education Press, Birmingham, AL, 2000, p 3) suggests that “religious education visions a broad sweeping future and then makes that future happen earlier than it ...

Abstract	James Michael Lee (in Forging a better religious education in the third millennium, Religious Education Press, Birmingham, AL, 2000, p 3) suggests that “religious education visions a broad sweeping future and then makes that future happen earlier than it would have happened if religious education were not there ” Religious Education thus has a prophetic role to play in society The current generation is between stories—the religious and the scientific How might religious education be developed in the Catholic school to reflect the growing convergence in theological discourse of the Christian Story with the New Universe Story? How might it energise young students with images that empower them to develop a prophetic stance towards their future and the future of humanity? We first consider the need for a paradigm shift in the way we tell the Christian Story Then, taking our lead from the theology of Karl Rahner which allows us to take a cosmic view of Christian religious experience, and from various writers who apply such a view to different areas of Christian life, we attempt a synthesis of current theological thought Lastly, we suggest how this shift might be applied to the religious education curriculum in order to provide an answer to the questions posed above
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #617354
Database	COVID19

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Article ; Online: Pupil-linked arousal correlates with neural activity prior to sensorimotor decisions.

Koorathota, Sharath / Ma, Jia Li / Faller, Josef / Hong, Linbi / Lapborisuth, Pawan / Sajda, Paul

Journal of neural engineering

2023 Volume 20, Issue 6

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Pupil ; Visual Cortex ; Arousal ; Prefrontal Cortex ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2170901-4
ISSN	1741-2552 ; 1741-2560
ISSN (online)	1741-2552
ISSN	1741-2560
DOI	10.1088/1741-2552/ad1055
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Article ; Online: Regulation of arousal via online neurofeedback improves human performance in a demanding sensory-motor task.

Faller, Josef / Cummings, Jennifer / Saproo, Sameer / Sajda, Paul

Proceedings of the National Academy of Sciences of the United States of America

2019 Volume 116, Issue 13, Page(s) 6482–6490

Abstract: Our state of arousal can significantly affect our ability to make optimal decisions, judgments, and actions in real-world dynamic environments. The Yerkes-Dodson law, which posits an inverse-U relationship between arousal and task performance, suggests ... ...

Abstract	Our state of arousal can significantly affect our ability to make optimal decisions, judgments, and actions in real-world dynamic environments. The Yerkes-Dodson law, which posits an inverse-U relationship between arousal and task performance, suggests that there is a state of arousal that is optimal for behavioral performance in a given task. Here we show that we can use online neurofeedback to shift an individual's arousal from the right side of the Yerkes-Dodson curve to the left toward a state of improved performance. Specifically, we use a brain-computer interface (BCI) that uses information in the EEG to generate a neurofeedback signal that dynamically adjusts an individual's arousal state when they are engaged in a boundary-avoidance task (BAT). The BAT is a demanding sensory-motor task paradigm that we implement as an aerial navigation task in virtual reality and which creates cognitive conditions that escalate arousal and quickly results in task failure (e.g., missing or crashing into the boundary). We demonstrate that task performance, measured as time and distance over which the subject can navigate before failure, is significantly increased when veridical neurofeedback is provided. Simultaneous measurements of pupil dilation and heart-rate variability show that the neurofeedback indeed reduces arousal. Our work demonstrates a BCI system that uses online neurofeedback to shift arousal state and increase task performance in accordance with the Yerkes-Dodson law.
MeSH term(s)	Adult ; Arousal/physiology ; Brain-Computer Interfaces ; Electroencephalography ; Female ; Heart Rate ; Humans ; Male ; Neurofeedback/methods ; New York City ; Psychomotor Performance/physiology ; Pupil Disorders ; Task Performance and Analysis ; Young Adult
Language	English
Publishing date	2019-03-12
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1817207116
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Book ; Online ; Thesis: Eine deutschsprachige Variante des Functioning Assessment Short Test (FAST): Übereinstimmung zwischen Selbsteinschätzung und Fremdeinschätzung

Riegler, Christoph Paul [Verfasser] / Heuschmann, Peter U. [Gutachter] / Störk, Stefan [Gutachter] / Faller, Hermann [Gutachter] / Berger, Klaus [Gutachter]

2022

Author's details	Christoph Paul Riegler ; Gutachter: Peter U. Heuschmann, Stefan Störk, Hermann Faller, Klaus Berger
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universität Würzburg
Publishing place	Würzburg
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Spatiospectral brain networks reflective of improvisational experience.

Faller, Josef / Goldman, Andrew / Lin, Yida / McIntosh, James R / Sajda, Paul

NeuroImage

2021 Volume 242, Page(s) 118458

Abstract: Musical improvisers are trained to categorize certain musical structures into functional classes, which is thought to facilitate improvisation. Using a novel auditory oddball paradigm (Goldman et al., 2020) which enables us to disassociate a deviant (i.e. ...

Abstract	Musical improvisers are trained to categorize certain musical structures into functional classes, which is thought to facilitate improvisation. Using a novel auditory oddball paradigm (Goldman et al., 2020) which enables us to disassociate a deviant (i.e. musical chord inversion) from a consistent functional class, we recorded scalp EEG from a group of musicians who spanned a range of improvisational and classically trained experience. Using a spatiospectral based inter and intra network connectivity analysis, we found that improvisers showed a variety of differences in connectivity within and between large-scale cortical networks compared to classically trained musicians, as a function of deviant type. Inter-network connectivity in the alpha band, for a time window leading up to the behavioural response, was strongly linked to improvisation experience, with the default mode network acting as a hub. Spatiospectral networks post response were substantially different between improvisers and classically trained musicians, with greater inter-network connectivity (specific to the alpha and beta bands) seen in improvisers whereas those with more classical training had largely reduced inter-network activity (mostly in the gamma band). More generally, we interpret our findings in the context of network-level correlates of expectation violation as a function of subject expertise, and we discuss how these may generalize to other and more ecologically valid scenarios.
MeSH term(s)	Acoustic Stimulation ; Adult ; Auditory Perception/physiology ; Brain/physiology ; Brain Mapping/methods ; Creativity ; Electroencephalography ; Female ; Humans ; Male ; Music ; Young Adult
Language	English
Publishing date	2021-08-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2021.118458
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Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Survival Outcomes and Treatment Patterns in Patients With NFE2L2 and/or KEAP1 Mutation-Positive Advanced Squamous Cell NSCLC Using a Real-World Clinico-Genomic Database.

Wu, Yanyu / Yin, Yu / Crossland, Victoria / Vincent, Sylvie / Paik, Paul K / Lineberry, Neil / Faller, Douglas V

Clinical lung cancer

2022 Volume 23, Issue 6, Page(s) 487–497

Abstract: Background: NFE2L2 and/or KEAP1 mutations are associated with worse prognosis in all non-small cell lung cancer (NSCLC). We determined real-world survival outcomes and treatment patterns among patients with advanced squamous cell NSCLC by NFE2L2 and ... ...

Abstract	Background: NFE2L2 and/or KEAP1 mutations are associated with worse prognosis in all non-small cell lung cancer (NSCLC). We determined real-world survival outcomes and treatment patterns among patients with advanced squamous cell NSCLC by NFE2L2 and KEAP1 mutation status. Patients and methods: A retrospective study (January 2011-December 2018) was conducted using a de-identified US-based clinico-genomic database. Adult patients with advanced squamous cell NSCLC with ≥ 2 in-network visits and comprehensive genomic profiling during the study period were included. Outcomes included real-world progression free survival (rwPFS) by line of therapy and overall survival (OS). The real-world effectiveness of anti-PD-1/PD-L1 first-line therapy was also evaluated in patients with a NFE2L2 and/or KEAP1 mutation. Results: Of 703 patients included (median age: 70.0 years), 31.6% had a NFE2L2 and/or KEAP1 mutation. The most common first- and second-line treatments regardless of mutation status were platinum-based chemotherapies and anti-PD-1/PD-L1 therapies. The most common third-line treatment was anti-PD-1/PD-L1 therapy in patients with a NFE2L2 and/or KEAP1 mutation and single-agent chemotherapy in patients with wild-type disease. Patients with a NFE2L2 and/or KEAP1 mutation versus wild-type disease had significantly shorter rwPFS (4.54 vs. 6.25 months; P = .003) following first- but not second- or third-line therapy and shorter median OS (13.59 vs. 17.37 months; P = .4105). No survival differences were observed in patients with a NFE2L2 and/or KEAP1 mutation receiving first-line anti-PD-1/PD-L1 therapies versus other therapies. Conclusions: Patients with advanced squamous cell NSCLC with a NFE2L2 and/or KEAP1 mutation have poor real-world survival, highlighting the need for a genotype-directed therapeutic strategy in this population.
MeSH term(s)	Adult ; Aged ; B7-H1 Antigen/metabolism ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/genetics ; Epithelial Cells/metabolism ; Genomics ; Humans ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Mutation/genetics ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/therapeutic use ; Retrospective Studies
Chemical Substances	B7-H1 Antigen ; KEAP1 protein, human ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; NFE2L2 protein, human
Language	English
Publishing date	2022-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2022.05.008
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Zs.A 5893: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Demand Response Model for Optimized Use of Renewable Energies in Production

Clemens Faller / Sonja Podjawerschek / Armin Co / Markus Dannehl / Moritz Paul Heimbach / Sory Ibrahima Nadiaye

TH Wildau Engineering and Natural Sciences Proceedings, Vol

2021 Volume 1

Abstract: A demand-response model was developed in the Automation Technology Laboratory at the Velbert/Heiligenhaus Campus (CVH) of Bochum University of Applied Sciences, in which energy users in the manufacturing sector are networked with a smart grid via a cloud ...

Abstract	A demand-response model was developed in the Automation Technology Laboratory at the Velbert/Heiligenhaus Campus (CVH) of Bochum University of Applied Sciences, in which energy users in the manufacturing sector are networked with a smart grid via a cloud platform in order to control production based on the supply of renewable energies.
Keywords	Demand-Response ; Smart-Grid ; Cloud-Platform ; IOT ; Industry 4.0 ; Environmental engineering ; TA170-171 ; Science (General) ; Q1-390
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	TIB Open Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Biomarkers predict the efficacy of closed-loop rTMS treatment for refractory depression.

Sun, Xiaoxiao / Doose, Jayce / Faller, Josef / McIntosh, James R / Saber, Golbarg T / Huffman, Sarah / Pantazatos, Spiro P / Yuan, Han / Goldman, Robin I / Brown, Truman R / George, Mark S / Sajda, Paul

Research square

2023

Abstract: Transcranial magnetic stimulation (TMS) is a non-invasive FDA-approved therapy for major depressive disorder (MDD), specifically for treatment-resistant depression (TRD). Though offering promise for those with TRD, its effectiveness is less than one in ... ...

Abstract	Transcranial magnetic stimulation (TMS) is a non-invasive FDA-approved therapy for major depressive disorder (MDD), specifically for treatment-resistant depression (TRD). Though offering promise for those with TRD, its effectiveness is less than one in two patients (i.e., less than 50%). Limits on efficacy may be due to individual patient variability, but to date, there are no established biomarkers or measures of target engagement that can predict efficacy. Additionally, TMS efficacy is typically not assessed until a six-week treatment ends, precluding interim re-evaluations of the treatment. Here, we report results using a closed-loop phase-locked repetitive TMS (rTMS) treatment that synchronizes the delivery of rTMS based on the timing of the pulses relative to a patient's individual electroencephalographic (EEG) prefrontal alpha oscillation indexed by functional magnetic resonance imaging (fMRI). Among responders, synchronized rTMS produces two systematic changes in brain dynamics: a reduction in global cortical excitability and enhanced phase entrainment of cortical dynamics. These effects predict clinical outcomes in the synchronized treatment group but not in an active-treatment unsynchronized control group. The systematic decrease in excitability and increase in entrainment correlated with treatment efficacy at the endpoint and intermediate weeks during the synchronized treatment. Specifically, we show that weekly biomarker tracking enables efficacy prediction and dynamic adjustments through a treatment course, improving the overall response rates. This innovative approach advances the prospects of individualized medicine in MDD and holds potential for application in other neuropsychiatric disorders.
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3496521/v1
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Article: Increased entrainment and decreased excitability predict efficacious treatment of closed-loop phase-locked rTMS for treatment-resistant depression.

medRxiv : the preprint server for health sciences

2023

Abstract: Transcranial magnetic stimulation (TMS) is an FDA-approved therapy for major depressive disorder (MDD), specifically for patients who have treatment-resistant depression (TRD). However, TMS produces response or remission in about 50% of patients but is ... ...

Abstract	Transcranial magnetic stimulation (TMS) is an FDA-approved therapy for major depressive disorder (MDD), specifically for patients who have treatment-resistant depression (TRD). However, TMS produces response or remission in about 50% of patients but is ineffective for the other 50%. Limits on efficacy may be due to individual patient variability, but to date, there are no good biomarkers or measures of target engagement. In addition, TMS efficacy is typically not assessed until a six-week treatment ends, precluding the evaluation of intermediate improvements during the treatment duration. Here, we report on results using a closed-loop phase-locked repetitive TMS (rTMS) treatment that synchronizes the delivery of rTMS based on the timing of the pulses relative to a patient's individual electroencephalographic (EEG) prefrontal alpha oscillation informed by functional magnetic resonance imaging (fMRI). We find that, in responders, synchronized delivery of rTMS produces two systematic changes in brain dynamics. The first change is a decrease in global cortical excitability, and the second is an increase in the phase entrainment of cortical dynamics. These two effects predict clinical outcomes in the synchronized treatment group but not in an active-treatment unsynchronized control group. The systematic decrease in excitability and increase in entrainment correlated with treatment efficacy at the endpoint and intermediate weeks during the synchronized treatment. Specifically, we show that weekly tracking of these biomarkers allows for efficacy prediction and potential of dynamic adjustments through a treatment course, improving the overall response rates.
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.09.23296751
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Article ; Online: The timing of transcranial magnetic stimulation relative to the phase of prefrontal alpha EEG modulates downstream target engagement.

Pantazatos, Spiro P / Mclntosh, James R / Saber, Golbarg T / Sun, Xiaoxiao / Doose, Jayce / Faller, Josef / Lin, Yida / Teves, Joshua B / Blankenship, Aidan / Huffman, Sarah / Goldman, Robin I / George, Mark S / Sajda, Paul / Brown, Truman R

Brain stimulation

2023 Volume 16, Issue 3, Page(s) 830–839

Abstract: Background: The communication through coherence model posits that brain rhythms are synchronized across different frequency bands and that effective connectivity strength between interacting regions depends on their phase relation. Evidence to support ... ...

Abstract	Background: The communication through coherence model posits that brain rhythms are synchronized across different frequency bands and that effective connectivity strength between interacting regions depends on their phase relation. Evidence to support the model comes mostly from electrophysiological recordings in animals while evidence from human data is limited. Methods: Here, an fMRI-EEG-TMS (fET) instrument capable of acquiring simultaneous fMRI and EEG during noninvasive single pulse TMS applied to dorsolateral prefrontal cortex (DLPFC) was used to test whether prefrontal EEG alpha phase moderates TMS-evoked top-down influences on subgenual, rostral and dorsal anterior cingulate cortex (ACC). Six runs (276 total trials) were acquired in each participant. Phase at each TMS pulse was determined post-hoc using single-trial sorting. Results were examined in two independent datasets: healthy volunteers (HV) (n = 11) and patients with major depressive disorder (MDD) (n = 17) collected as part of an ongoing clinical trial. Results: In both groups, TMS-evoked functional connectivity between DLPFC and subgenual ACC (sgACC) depended on the EEG alpha phase. TMS-evoked DLPFC to sgACC fMRI-derived effective connectivity (EC) was modulated by EEG alpha phase in healthy volunteers, but not in the MDD patients. Top-down EC was inhibitory for TMS pulses during the upward slope of the alpha wave relative to TMS timed to the downward slope of the alpha wave. Prefrontal EEG alpha phase dependent effects on TMS-evoked fMRI BOLD activation of the rostral anterior cingulate cortex were detected in the MDD patient group, but not in the healthy volunteer group. Discussion: Results demonstrate that TMS-evoked top-down influences vary as a function of the prefrontal alpha rhythm, and suggest potential clinical applications whereby TMS is synchronized to the brain's internal rhythms in order to more efficiently engage deep therapeutic targets.
MeSH term(s)	Animals ; Humans ; Transcranial Magnetic Stimulation ; Depressive Disorder, Major ; Brain ; Alpha Rhythm ; Dorsolateral Prefrontal Cortex ; Prefrontal Cortex ; Electroencephalography ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-05-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2394410-9
ISSN	1876-4754 ; 1935-861X
ISSN (online)	1876-4754
ISSN	1935-861X
DOI	10.1016/j.brs.2023.05.007
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