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  1. Article ; Online: #Stayathome If You Have a Cold: High SARS-CoV-2 Salivary Viral Loads in Pediatric Patients with Nasopharyngeal Symptoms.

    Monzani, Alice / Borgogna, Cinzia / Ferrante, Daniela / Ciacchini, Benedetta / Felici, Enrico / Gariglio, Marisa / Rabbone, Ivana

    Viruses

    2022  Volume 15, Issue 1

    Abstract: The choice of the best SARS-CoV-2 detection approach is crucial to predict which children with SARS-CoV-2 are at high risk of spreading the virus in order to manage public health measures and policies. In this prospective observational study of 35 ... ...

    Abstract The choice of the best SARS-CoV-2 detection approach is crucial to predict which children with SARS-CoV-2 are at high risk of spreading the virus in order to manage public health measures and policies. In this prospective observational study of 35 children admitted to the Pediatric Emergency Departments of two tertiary hospitals in Northern Italy who tested positive for SARS-CoV-2 by standard RT-PCR in nasopharyngeal swab (NPS), we evaluated their presenting symptoms according to their salivary viral load (SVL) determined by droplet digital PCR (ddPCR). Despite an overall low concordance between SARS-CoV-2 detected by salivary ddPCR and NPS RT-PCR (54.3%), when only patients with nasopharyngeal symptoms were analyzed, the sensitivity of ddPCR in saliva specimens increased to 71.4%, and over half of these patients had high SVL (>105 copies/mL), which was significantly more frequent than in children without nasopharyngeal symptoms (57.1% vs. 14.3%, OR = 8, CI 95% 1.28−50.03, p = 0.03). All asymptomatic children had low SVL values. Our findings support the hypothesis that children with nasopharyngeal symptoms are at higher risk of spreading SARS-CoV-2 due to their high SVL and, conversely, asymptomatic children are unlikely to spread the virus due to their low SVL, regardless of their NPS positivity.
    MeSH term(s) Humans ; Child ; SARS-CoV-2/genetics ; COVID-19/diagnosis ; Viral Load ; Real-Time Polymerase Chain Reaction ; Nasopharynx ; Saliva ; Specimen Handling
    Language English
    Publishing date 2022-12-28
    Publishing country Switzerland
    Document type Observational Study ; Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15010081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multisystemic Increment of Cortical Thickness in Congenital Blind Children.

    Inuggi, Alberto / Pichiecchio, Anna / Ciacchini, Benedetta / Signorini, Sabrina / Morelli, Federica / Gori, Monica

    Cerebral cortex communications

    2020  Volume 1, Issue 1, Page(s) tgaa071

    Abstract: It has been shown that the total or partial lack of visual experience is associated with a plastic reorganization at the brain level, more prominent in congenital blind. Cortical thickness (CT) studies, to date involving only adult subjects, showed that ... ...

    Abstract It has been shown that the total or partial lack of visual experience is associated with a plastic reorganization at the brain level, more prominent in congenital blind. Cortical thickness (CT) studies, to date involving only adult subjects, showed that only congenital blind have a thicker cortex than age-matched sighted population while late blind do not. This was explained as a deviation from the physiological mechanism of initial neural growth followed by a pruning mechanism that, in congenital blind children, might be reduced by their visual deprivation, thus determining a thicker cortex. Since those studies involved only adults, it is unknown when these changes may appear and whether they are related to impairment degree. To address this question, we compared the CT among 28 children, from 2 to 12 years, with congenital visual impairments of different degree and an age-matched sighted population. Vertex-wise analysis showed that blind children, but not low vision one, had a thicker cortical surface in few clusters located in occipital, superior parietal, anterior-cingular, orbito-frontal, and mesial precentral regions. Our data suggest that the effect of visual impairment on determining thicker cortex is an early phenomenon, is multisystemic, and occurs only when blindness is almost complete.
    Language English
    Publishing date 2020-10-09
    Publishing country United States
    Document type Journal Article
    ISSN 2632-7376
    ISSN (online) 2632-7376
    DOI 10.1093/texcom/tgaa071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reluctance to seek pediatric care during the COVID-19 pandemic and the risks of delayed diagnosis.

    Ciacchini, Benedetta / Tonioli, Francesco / Marciano, Cinzia / Faticato, Maria Grazia / Borali, Elena / Pini Prato, Alessio / Felici, Enrico

    Italian journal of pediatrics

    2020  Volume 46, Issue 1, Page(s) 87

    Abstract: Since the outbreak of COVID-19 pandemic, the number of cases registered worldwide has risen to over 3 million. While COVID-19 per se does not seem to represent a significant threat to the pediatric population, which generally presents a benign course and ...

    Abstract Since the outbreak of COVID-19 pandemic, the number of cases registered worldwide has risen to over 3 million. While COVID-19 per se does not seem to represent a significant threat to the pediatric population, which generally presents a benign course and a low lethality, the current emergency might negatively affect the care of pediatric patients and overall children welfare. In particular, the fear of contracting COVID-19 may determine a delayed access to pediatric emergency facilities. Present report focuses on the experience of The Children Hospital in Alessandria (northern Italy). The authors document a drop in the number of admissions to the emergency department (A&E) during the lock-down. They will also focus on four emblematic cases of pediatric patients who were seen to our A&E in severe conditions. All these cases share a significant diagnostic delay caused by the parents' reluctance to seek medical attention, seen as a potential risk factor for COVID-19 contagion. None was found positive to all COVID-19 swab or immunologic testing. All in all, our data strongly support the importance of promoting a direct and timely interaction between patients and medical staff, to prevent the fear of COVID-19 from causing more harm than the virus itself.
    MeSH term(s) COVID-19 ; Child ; Child Welfare ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Delayed Diagnosis/statistics & numerical data ; Emergencies/epidemiology ; Emergency Service, Hospital/statistics & numerical data ; Female ; Hospitals, Pediatric ; Humans ; Infection Control/organization & administration ; Italy/epidemiology ; Male ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Patient Admission/statistics & numerical data ; Pediatrics/organization & administration ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Program Development ; Risk Assessment
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country England
    Document type Letter
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-020-00849-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Reluctance to seek pediatric care during the COVID-19 pandemic and the risks of delayed diagnosis

    Ciacchini, Benedetta / Tonioli, Francesco / Marciano, Cinzia / Faticato, Maria Grazia / Borali, Elena / Pini Prato, Alessio / Felici, Enrico

    Italian Journal of Pediatrics

    2020  Volume 46, Issue 1

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-020-00849-w
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1961: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  5. Article ; Online: Reluctance to seek pediatric care during the COVID-19 pandemic and the risks of delayed diagnosis

    Benedetta Ciacchini / Francesco Tonioli / Cinzia Marciano / Maria Grazia Faticato / Elena Borali / Alessio Pini Prato / Enrico Felici

    Italian Journal of Pediatrics, Vol 46, Iss 1, Pp 1-

    2020  Volume 4

    Abstract: Abstract Since the outbreak of COVID-19 pandemic, the number of cases registered worldwide has risen to over 3 million. While COVID-19 per se does not seem to represent a significant threat to the pediatric population, which generally presents a benign ... ...

    Abstract Abstract Since the outbreak of COVID-19 pandemic, the number of cases registered worldwide has risen to over 3 million. While COVID-19 per se does not seem to represent a significant threat to the pediatric population, which generally presents a benign course and a low lethality, the current emergency might negatively affect the care of pediatric patients and overall children welfare. In particular, the fear of contracting COVID-19 may determine a delayed access to pediatric emergency facilities. Present report focuses on the experience of The Children Hospital in Alessandria (northern Italy). The authors document a drop in the number of admissions to the emergency department (A&E) during the lock-down. They will also focus on four emblematic cases of pediatric patients who were seen to our A&E in severe conditions. All these cases share a significant diagnostic delay caused by the parents’ reluctance to seek medical attention, seen as a potential risk factor for COVID-19 contagion. None was found positive to all COVID-19 swab or immunologic testing. All in all, our data strongly support the importance of promoting a direct and timely interaction between patients and medical staff, to prevent the fear of COVID-19 from causing more harm than the virus itself.
    Keywords COVID-19 ; Delayed diagnosis ; Pediatric emergency ; Pediatrics ; RJ1-570 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Reluctance to seek pediatric care during the COVID-19 pandemic and the risks of delayed diagnosis

    Ciacchini, Benedetta / Tonioli, Francesco / Marciano, Cinzia / Faticato, Maria Grazia / Borali, Elena / Pini Prato, Alessio / Felici, Enrico

    Ital J Pediatr

    Abstract: Since the outbreak of COVID-19 pandemic, the number of cases registered worldwide has risen to over 3 million. While COVID-19 per se does not seem to represent a significant threat to the pediatric population, which generally presents a benign course and ...

    Abstract Since the outbreak of COVID-19 pandemic, the number of cases registered worldwide has risen to over 3 million. While COVID-19 per se does not seem to represent a significant threat to the pediatric population, which generally presents a benign course and a low lethality, the current emergency might negatively affect the care of pediatric patients and overall children welfare. In particular, the fear of contracting COVID-19 may determine a delayed access to pediatric emergency facilities. Present report focuses on the experience of The Children Hospital in Alessandria (northern Italy). The authors document a drop in the number of admissions to the emergency department (A&E) during the lock-down. They will also focus on four emblematic cases of pediatric patients who were seen to our A&E in severe conditions. All these cases share a significant diagnostic delay caused by the parents' reluctance to seek medical attention, seen as a potential risk factor for COVID-19 contagion. None was found positive to all COVID-19 swab or immunologic testing. All in all, our data strongly support the importance of promoting a direct and timely interaction between patients and medical staff, to prevent the fear of COVID-19 from causing more harm than the virus itself.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #617355
    Database COVID19

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