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Article ; Online: San-wei-tan-xiang capsule attenuates atherosclerosis by increasing lysosomal activity in adipose tissue macrophages.

Ye, Heng / Wang, Gang / Wang, Xuchao / Wang, Lin / Ni, Wei / Chen, Linjian / Zhu, Yifan / Zhao, Longshan / Xiong, Zhili / Wang, Yan / Dai, Cuilian / Liu, Binbin

Journal of ethnopharmacology

2023 Volume 312, Page(s) 116444

Abstract: ... of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule ...

Abstract	Ethnopharmacological relevance: Dyslipidemia is the leading risk factor of atherosclerosis (AS). Adipose tissue macrophages (ATMs) can regulate postprandial cholesterol levels via uptake and hydrolyzation of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts clinical benefits in patients with atherosclerotic cardiovascular diseases. Aim of the study: This work is aimed to evaluate the chemical ingredients and mechanisms of SWTX in anti-AS. Materials and methods: The chemical ingredients of SWTX identified by liquid chromatography coupled with tandem mass spectrometry were used for network pharmacological analysis. The atheroprotective function of SWTX was evaluated in ApoE Results: The chemical ingredients identified in SWTX were predicated to be important for lipid metabolism and AS. Animals studies suggested that SWTX effectively attenuated the atherosclerotic plaque growth, elevated postprandial HDL cholesterol levels, elevated the proportion of Tim4 and CD36-expressed ATMs, and upregulated the uptake of lipid and lysosomal activity in ATMs. SWTX-induced elevation of postprandial HDL cholesterol levels was dependent on increased lysosomal activity, since chloroquine, an inhibitor of lysosomal function, blocked the effect of SWTX. Lastly, some predicated bioactive compounds in SWTX can elevate lysosomal activity in vitro. Conclusion: SWTX could attenuate atherosclerotic plaque formation by elevating lysosomal activity and enhancing MCE in ATMs.
MeSH term(s)	Mice ; Animals ; Plaque, Atherosclerotic/metabolism ; Cholesterol, HDL ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Atherosclerosis/etiology ; Macrophages ; Cholesterol/metabolism ; Lysosomes/metabolism ; Apolipoproteins E
Chemical Substances	Cholesterol, HDL ; Cholesterol (97C5T2UQ7J) ; Apolipoproteins E
Language	English
Publishing date	2023-04-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116444
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Article ; Online: San-wei-tan-xiang capsule attenuates atherosclerosis by increasing lysosomal activity in adipose tissue macrophages

Ye, Heng / Wang, Gang / Wang, Xuchao / Wang, Lin / Ni, Wei / Chen, Linjian / Zhu, Yifan / Zhao, Longshan / Xiong, Zhili / Wang, Yan / Dai, Cuilian / Liu, Binbin

Journal of Ethnopharmacology. 2023 Aug., v. 312 p.116444-

2023

Abstract: ... of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts ...

Abstract	Dyslipidemia is the leading risk factor of atherosclerosis (AS). Adipose tissue macrophages (ATMs) can regulate postprandial cholesterol levels via uptake and hydrolyzation of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts clinical benefits in patients with atherosclerotic cardiovascular diseases. This work is aimed to evaluate the chemical ingredients and mechanisms of SWTX in anti-AS. The chemical ingredients of SWTX identified by liquid chromatography coupled with tandem mass spectrometry were used for network pharmacological analysis. The atheroprotective function of SWTX was evaluated in ApoE⁻/⁻ mice fed a cholesterol-enriched diet. The chemical ingredients identified in SWTX were predicated to be important for lipid metabolism and AS. Animals studies suggested that SWTX effectively attenuated the atherosclerotic plaque growth, elevated postprandial HDL cholesterol levels, elevated the proportion of Tim4 and CD36-expressed ATMs, and upregulated the uptake of lipid and lysosomal activity in ATMs. SWTX-induced elevation of postprandial HDL cholesterol levels was dependent on increased lysosomal activity, since chloroquine, an inhibitor of lysosomal function, blocked the effect of SWTX. Lastly, some predicated bioactive compounds in SWTX can elevate lysosomal activity in vitro. SWTX could attenuate atherosclerotic plaque formation by elevating lysosomal activity and enhancing MCE in ATMs.
Keywords	Oriental traditional medicine ; adipose tissue ; atherosclerosis ; chloroquine ; diet ; high density lipoprotein cholesterol ; hyperlipidemia ; lipid metabolism ; liquid chromatography ; macrophages ; risk factors ; tandem mass spectrometry ; Adipose tissue macrophage ; Lysosomal activity ; Postprandial cholesterol level ; San-wei-tan-xiang capsule
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116444
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Article ; Online: Wei-fu-chun tablet halted gastric intestinal metaplasia and dysplasia associated with inflammation by regulating the NF-κB pathway.

Xie, Dong / Wu, Chao / Wang, Dan / Nisma Lena, Bahaji Azami / Liu, Ningning / Ye, Guan / Sun, Mingyu

Journal of ethnopharmacology

2023 Volume 318, Issue Pt B, Page(s) 117020

Abstract: Ethnopharmacological relevance: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis ( ... ...

Abstract	Ethnopharmacological relevance: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous lesions in China clinically. This study aimed to investigate the efficacy and potential mechanism of WFC in treating Gastric intestinal metaplasia (GIM) and Gastric dysplasia (GDys). Materials and methods: Rat GIM and GDys established by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) combined with hot paste, ethanol injury, and intermittent fasting were intervened by WFC. Body weight, histopathology, pH of gastric acid, pepsin activity, intestinal metaplasia index and inflammation were detected. Rat bone marrow derived macrophages (BMDMs) pretreated with WFC were stimulated by LPS. Inflammatory factors and the nuclear factor-kappa B (NF-κB) pathway were assessed. GES-1 cells pretreated by WFC were stimulated by MNNG and TNF-α, intestinal metaplasia index, the NF-κB pathway and interaction between P65 and CDX2 were detected. Results: WFC improved rat body weight, histopathology, pH value of gastric acid, activity of gastric pepsin, intestinal metaplasia (CDX2), inflammation (IL-1β, IL-6 and TNF-α), macrophage aggregation (CD68) in gastric mucosa in rat GIM and GDys. WFC inhibited inflammation (IL-1β and TNF-α) by inactivating the NF-κB pathway. WFC reduced the expression of CDX2 by inhibiting the binding of CDX2 promoter TSS upstream region with p65. Conclusion: WFC blocked GIM and GDys associated with inflammation by regulating the NF-κB pathway.
MeSH term(s)	Rats ; Animals ; NF-kappa B/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Methylnitronitrosoguanidine ; Pepsin A/metabolism ; Inflammation/pathology ; Precancerous Conditions/drug therapy ; Hyperplasia/pathology ; Stomach Neoplasms/pathology ; Metaplasia/metabolism ; Metaplasia/pathology ; Gastric Mucosa/pathology
Chemical Substances	NF-kappa B ; Tumor Necrosis Factor-alpha ; Methylnitronitrosoguanidine (12H3O2UGSF) ; Pepsin A (EC 3.4.23.1)
Language	English
Publishing date	2023-08-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117020
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Article ; Online: Retraction: He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis.

Song, Zehai / Chang, Hang / Han, Na / Liu, Zhihui / Liu, Ye / Wang, Hui / Shao, Jingxuan / Wang, Zhonglin / Gao, Hao / Yin, Jun

RSC advances

2023 Volume 13, Issue 18, Page(s) 12276

Abstract: This retracts the article DOI: 10.1039/C7RA02830J.]. ...

Abstract	[This retracts the article DOI: 10.1039/C7RA02830J.].
Language	English
Publishing date	2023-04-19
Publishing country	England
Document type	Retraction of Publication
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra90036c
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Article: Chinese herbal medicine Jia Wei Jing Xie Yin (JWJXY) ameliorates psoriasis via suppressing the Th17 cell response.

Yang, Dengke / Guo, Yiyu / Wu, Jun / Qin, Jianping / Wu, Jie / Lu, Yu / Xiao, Yan / Zhang, Xiaolin / Ye, Jianzhou

Annals of translational medicine

2022 Volume 10, Issue 6, Page(s) 332

Abstract: ... advantages. The Chinese herbal medicine Jia Wei Jing Xie Yin (JWJXY) has its origins in Jing Xie Yin ...

Abstract	Background: Psoriasis is a chronic autoimmune disease. At present, it is very difficult to treat; however, clinical trials have shown that the traditional Chinese medicine (TCM) treatment of psoriasis has certain advantages. The Chinese herbal medicine Jia Wei Jing Xie Yin (JWJXY) has its origins in Jing Xie Yin, a medicine created by the TCM doctor Wu Jun. Previous studies have shown that JWJXY has good clinical efficacy for patients with blood-heat type psoriasis, but its mechanism is unknown. Methods: This paper aimed to further study the therapeutic effect and mechanism of JWJXY on an imiquimod (IMQ)-induced, psoriasis-like mouse model (0.4 mL, i.g., 6 days). The histopathological skin changes were observed by hematoxylin and eosin (HE) staining, the infiltration of cluster of differentiation 11B (CD11b) and cluster of differentiation 4 (CD4) cells was observed by immunohistochemistry, lymphocyte subsets were detected by flow cytometry, T helper (Th)17 cell expression was perceived by flow cytometry, and Th17 cell-related gene expression was detected by real-time quantitative polymerase chain reaction (qPCR). Results: JWJXY significantly reduced the skin thickness of the IMQ-induced model mouse. Compared with that in the vehicle group, the skin tissue of the mice in the JWJXY group showed significantly reduced infiltration of CD11b Conclusions: The study confirmed the therapeutic effect of JWJXY on psoriasis. Its mechanism of action might be to inhibit the Th17 cell response but not the Th1 and Treg response.
Language	English
Publishing date	2022-04-01
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-22-967
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Article: A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Effective Substances and Mechanisms of Wei-Fu-Chun Tablet in the Treatment of Precancerous Lesions of Gastric Cancer.

Wang, Huijun / Wu, Ruoming / Xie, Dong / Ding, Liqin / Lv, Xing / Bian, Yanqin / Chen, Xi / Nisma Lena, Bahaji Azami / Wang, Shunchun / Li, Kun / Chen, Wei / Ye, Guan / Sun, Mingyu

Frontiers in pharmacology

2020 Volume 11, Page(s) 558471

Abstract: Wei-Fu-Chun (WFC) tablet is a commercial medicinal product approved by China ...

Abstract	Wei-Fu-Chun (WFC) tablet is a commercial medicinal product approved by China Food and Drug Administration, which is made of
Language	English
Publishing date	2020-11-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.558471
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Article ; Online: Wei-fu-chun tablet halted gastric intestinal metaplasia and dysplasia associated with inflammation by regulating the NF-κB pathway

Xie, Dong / Wu, Chao / Wang, Dan / Nisma Lena, Bahaji Azami / Liu, Ningning / Ye, Guan / Sun, Mingyu

Journal of Ethnopharmacology. 2023 Aug. 09, p.117020-

2023 , Page(s) 117020–

Abstract: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous ... ...

Abstract	Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous lesions in China clinically. This study aimed to investigate the efficacy and potential mechanism of WFC in treating Gastric intestinal metaplasia (GIM) and Gastric dysplasia (GDys). Rat GIM and GDys established by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) combined with hot paste, ethanol injury, and intermittent fasting were intervened by WFC. Body weight, histopathology, pH of gastric acid, pepsin activity, intestinal metaplasia index and inflammation were detected. Rat bone marrow derived macrophages (BMDMs) pretreated with WFC were stimulated by LPS. Inflammatory factors and the nuclear factor-kappa B (NF-κB) pathway were assessed. GES-1 cells pretreated by WFC were stimulated by MNNG and TNF-α, intestinal metaplasia index, the NF-κB pathway and interaction between P65 and CDX2 were detected. WFC improved rat body weight, histopathology, pH value of gastric acid, activity of gastric pepsin, intestinal metaplasia (CDX2), inflammation (IL-1β, IL-6 and TNF-α), macrophage aggregation (CD68) in gastric mucosa in rat GIM and GDys. WFC inhibited inflammation (IL-1β and TNF-α) by inactivating the NF-κB pathway. WFC reduced the expression of CDX2 by inhibiting the binding of CDX2 promoter TSS upstream region with p65. WFC blocked GIM and GDys associated with inflammation by regulating the NF-κB pathway.
Keywords	Food and Drug Administration ; body weight ; bone marrow ; ethanol ; fasting ; gastric acid ; gastric mucosa ; gastritis ; herbal medicines ; histopathology ; inflammation ; interleukin-6 ; intestines ; macrophages ; metaplasia ; pH ; pepsin ; rats ; traditional medicine ; transcription factor NF-kappa B ; China ; Wei-fu-chun tablet ; Gastric intestinal metaplasia ; Gastric dysplasia ; NF-κB pathway
Language	English
Dates of publication	2023-0809
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117020
Database	NAL-Catalogue (AGRICOLA)

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Article: A research on the mechanism of NSAID-related gastric ulcer treated by jia wei wu qi san based on the p38mapk signal pathway.

Zheng, Liang / Wang, Pei / Wang, Yuan-Yuan / Li, Zhen / Tian, Ye

Pakistan journal of pharmaceutical sciences

2021 Volume 34, Issue 2, Page(s) 585–589

Abstract: This study aims to explore the mechanism of NSAID-related gastric ulcer treated by JIA WEI WU QI ... was given rabeprazole (2mg/kg), and group D was administered with JIA WEI WU QI SAN (2g/kg ... D (P<0.05). (4) The expression of p-P38MAPK decreased in group D (P<0.05). JIA WEI WU QI SAN has ...

Abstract	This study aims to explore the mechanism of NSAID-related gastric ulcer treated by JIA WEI WU QI SAN. Clean-grade SD rats were randomly divided into four groups. Group A was assigned as the control group. Groups B, C and D were intragastrically administered with 2.5mg/kg of indomethacin solution QD after 48 hours. After 15 days of treatment, group B was administered with 0.9% sodium chloride, group C was given rabeprazole (2mg/kg), and group D was administered with JIA WEI WU QI SAN (2g/kg). Abdominal aorta sampling was performed, and gastric tissues were isolated on the 29th day. The protein expression of p-P38MAPK and COX-2 were detected by western blot, while the concentration of PGE2 and IL-1 were determined by ELISA. (1) The expression of IL-1ingroup B dramatically declined in group D (P<0.01). (2)The expression of PGE-2dramatically increased in group D(P<0.01). (3) The expression of COX-2 increased in group D (P<0.05). (4) The expression of p-P38MAPK decreased in group D (P<0.05). JIA WEI WU QI SAN has multiple functions, including the activation of the p-P38MAPK signaling pathway, which promote the activation of COX-2, induce the arachidonic acid to increase the level of PG, and decrease the concentration of IL-1, thereby inducing an inflammatory reaction, and promote gastric mucosa repair.
MeSH term(s)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Arachidonic Acid/metabolism ; Cyclooxygenase 2/drug effects ; Cyclooxygenase 2/metabolism ; Dinoprostone/metabolism ; Drugs, Chinese Herbal/pharmacology ; Indomethacin/adverse effects ; Interleukin-1/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Stomach/drug effects ; Stomach/metabolism ; Stomach Ulcer/chemically induced ; Stomach Ulcer/metabolism ; p38 Mitogen-Activated Protein Kinases/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Drugs, Chinese Herbal ; Interleukin-1 ; Arachidonic Acid (27YG812J1I) ; Cyclooxygenase 2 (EC 1.14.99.1) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Dinoprostone (K7Q1JQR04M) ; Indomethacin (XXE1CET956)
Language	English
Publishing date	2021-07-19
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Xiao Tan He Wei Decoction reverses MNNG-induced precancerous lesions of gastric carcinoma in vivo and vitro: Regulation of apoptosis through NF-κB pathway.

Xu, Jingyu / Shen, Wei / Pei, Bei / Wang, Xiaowei / Sun, Dazhi / Li, Yongjin / Xiu, LiJuan / Liu, Xuan / Lu, Ye / Zhang, Xuan / Yue, XiaoQiang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2018 Volume 108, Page(s) 95–102

Abstract: ... the relationship between Chinese traditional medicine (Xiao Tan He Wei Decoction) and gastric cancer in the PLGC ... proliferation, invasion and metastasis ability. Our research founds that Xiao Tan He Wei Decoction could inhibit ... Furthermore, Xiao Tan He Wei Decoction could inhibit nuclear factor kappa-light-chain-enhancer (NF-kB ...

Abstract	In recent years, Chinese medicine has played an important role in the prognosis of gastric cancer. Precancerous lesions of gastric carcinoma (PLGC) is a class of gastric cancer which is closely related to the gastric mucosal pathology changes in the role of carcinogenic incentives, and plays key role in the progression of normal gastric mucosal cells into gastric cancerous cells. In current experiment, we explore the relationship between Chinese traditional medicine (Xiao Tan He Wei Decoction) and gastric cancer in the PLGC rat animal models and epithelial-mesenchymal transitioned GES-1 cells which were induced useing 1- Methyl-3-nitro-1-nitrosoguanidine (MNNG). PLGC rat model showed significant deterioration in the gastric mucosa with terrible growth rate in body weight and more atypical hyperplasia in gastric mucosa. MC cells, MNNG induced GES-1 cells which epithelial- mesenchymal-transition (EMT)-related proteins have a great change compare with normal GES-1 cells. The cells had characteristics of malignant cells including proliferation, invasion and metastasis ability. Our research founds that Xiao Tan He Wei Decoction could inhibit cell proliferation and increased apoptosis by increase the level of pro-apoptotic proteins like Bax and caspase-3 and decreased the level of anti-apoptotic protein Bcl-2, block the cells in G0/G1 phase simultaneously. Furthermore, Xiao Tan He Wei Decoction could inhibit nuclear factor kappa-light-chain-enhancer (NF-kB) activity and inhibit its transfer from the cytoplasm to the nucleus. However, when we incubated with NF-κB activator PMA, the effect of Xiao Tan He Wei Decoction was reversed. These results suggested that Xiao Tan He Wei Decoction could be used as a method for the treatment of gastric precancerous lesions, and possibly provide a theoretical basis for the clinical treatment of gastric cancer and gastric precancerous lesions.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cell Transformation, Neoplastic/drug effects ; Cell Transformation, Neoplastic/pathology ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Epithelial-Mesenchymal Transition/drug effects ; Humans ; Hyperplasia ; Methylnitronitrosoguanidine ; NF-kappa B/metabolism ; Precancerous Conditions/drug therapy ; Precancerous Conditions/pathology ; Rats, Wistar ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Tetradecanoylphorbol Acetate/pharmacology
Chemical Substances	Drugs, Chinese Herbal ; NF-kappa B ; Methylnitronitrosoguanidine (12H3O2UGSF) ; Tetradecanoylphorbol Acetate (NI40JAQ945)
Language	English
Publishing date	2018-09-12
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2018.09.012
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Article ; Online: Xiao Tan He Wei Decoction reverses MNNG-induced precancerous lesions of gastric carcinoma in vivo and vitro

Jingyu Xu / Wei Shen / Bei Pei / Xiaowei Wang / Dazhi Sun / Yongjin Li / LiJuan Xiu / Xuan Liu / Ye Lu / Xuan Zhang / XiaoQiang Yue

Biomedicine & Pharmacotherapy, Vol 108, Iss , Pp 95-

Regulation of apoptosis through NF-κB pathway

2018 Volume 102

Abstract	In recent years, Chinese medicine has played an important role in the prognosis of gastric cancer. Precancerous lesions of gastric carcinoma (PLGC) is a class of gastric cancer which is closely related to the gastric mucosal pathology changes in the role of carcinogenic incentives, and plays key role in the progression of normal gastric mucosal cells into gastric cancerous cells. In current experiment, we explore the relationship between Chinese traditional medicine (Xiao Tan He Wei Decoction) and gastric cancer in the PLGC rat animal models and epithelial-mesenchymal transitioned GES-1 cells which were induced useing 1- Methyl-3-nitro-1-nitrosoguanidine (MNNG). PLGC rat model showed significant deterioration in the gastric mucosa with terrible growth rate in body weight and more atypical hyperplasia in gastric mucosa. MC cells, MNNG induced GES-1 cells which epithelial- mesenchymal-transition (EMT)-related proteins have a great change compare with normal GES-1 cells. The cells had characteristics of malignant cells including proliferation, invasion and metastasis ability. Our research founds that Xiao Tan He Wei Decoction could inhibit cell proliferation and increased apoptosis by increase the level of pro-apoptotic proteins like Bax and caspase-3 and decreased the level of anti-apoptotic protein Bcl-2, block the cells in G0/G1 phase simultaneously. Furthermore, Xiao Tan He Wei Decoction could inhibit nuclear factor kappa-light-chain-enhancer (NF-kB) activity and inhibit its transfer from the cytoplasm to the nucleus. However, when we incubated with NF-κB activator PMA, the effect of Xiao Tan He Wei Decoction was reversed. These results suggested that Xiao Tan He Wei Decoction could be used as a method for the treatment of gastric precancerous lesions, and possibly provide a theoretical basis for the clinical treatment of gastric cancer and gastric precancerous lesions.
Keywords	Chinese traditional medicine ; Xian Tan He Wei Decoction ; Gastric cancer ; Gastric precancerous lesions ; NF-kB ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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