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  1. Book ; Online: Drought index from tree-rings in Kongton Mountains, China, supplementary data to: Fang, Keyan; Gou, Xiaohua; Chen, Fahu; Changzhi, Liu; Davi, Nicole; Li, Jinbao; Zhao, Zhiqian; Li, Yingjun (2011): Tree-ring based reconstruction of drought variability (1615-2009) in the Kongtong Mountain area, northern China. (PDI-633), Global and Planetary Change, in press

    Fang, Keyan / Changzhi, Liu / Chen, Fahu / Davi, Nicole / Gou, Xiaohua / Li, Jinbao / Li, Yingjun / Zhao, Zhiqian

    2011  

    Abstract: The Kongtong Mountain area is a marginal area of the Asian summer monsoon and is sensitive to monsoon dynamics. The sensitivity highlights the need to establishing long-term climate records there and evaluating links with the Asian monsoon. Using "signal- ...

    Abstract The Kongtong Mountain area is a marginal area of the Asian summer monsoon and is sensitive to monsoon dynamics. The sensitivity highlights the need to establishing long-term climate records there and evaluating links with the Asian monsoon. Using "signal-free" methods, we developed a tree-ring chronology based 52 ring-width series from 23 Pinus tabulaeformis and Pinus armandidi trees in the Kongtong Mountain, northern China. Tree growth is highly correlated (0.844) with the Palmer Drought Severity Index (PDSI) from May to July, demonstrating the strength of PDSI in modeling drought conditions in this region. We therefore developed a robust May-July PDSI reconstruction spanning 1615-2009, which explained 71.2% of the instrumental variance for the period 1951-2005. Extremely dry epochs are found in periods of 1723-1727 and 1928-1932, and significant wet conditions are seen from 1696-1700, 1753-1757 and 1963-1969. These persistent dry and wet epochs were also found in northeastern Mongolia, suggesting similar drought regimes between these two regions. The dryness that occurred in the 1920s-1930s was the most severe and was concurrent with a warming period. This warming/drying relationship of the 1920s-1930s may be an analog to the current drying trend in northern China.
    Language English
    Dates of publication 2011-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    DOI 10.1594/PANGAEA.770741
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Book ; Online: Use of Patented Traditional Chinese Medicine against COVID-19 : A Practical Manual

    Zhai, Huaqiang / Wang, Yanping / Yang, Yiheng / Li, Xiaodong / Shao, Yingjun

    2021  

    Keywords MED004000 ; MED022090 ; MED115000 ; MX ; Chinese Patent Medicine; COVID-19; Guidance
    Size 1 electronic resource (188 pages)
    Publisher World Scientific Publishing Company
    Publishing place Singapore
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021051680
    ISBN 9789811227899 ; 9811227896
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Apoptotic extracellular vesicles restore homeostasis of the articular microenvironment for the treatment of rheumatoid arthritis.

    Li, Xian / Li, Shichun / Fu, Xiaoling / Wang, Yingjun

    Bioactive materials

    2024  Volume 35, Page(s) 564–576

    Abstract: Rheumatoid arthritis (RA) is a severe autoimmune disease with symptoms including synovial inflammation, cartilage erosion, and bone loss in RA lesions, which eventually lead to joint deformity and function loss. Most current treatments fail to achieve ... ...

    Abstract Rheumatoid arthritis (RA) is a severe autoimmune disease with symptoms including synovial inflammation, cartilage erosion, and bone loss in RA lesions, which eventually lead to joint deformity and function loss. Most current treatments fail to achieve satisfying therapeutic outcomes with some adverse effects. Extracellular vesicles derived from apoptotic cells (apoEVs) have emerged as important mediators in intercellular communication regulating diverse physiological and pathological processes. In this study, we investigated the therapeutic efficacy of macrophage-derived and osteoclast-derived apoEVs (Mφ-apoEVs and OC-apoEVs) on RA. The
    Language English
    Publishing date 2024-03-04
    Publishing country China
    Document type Journal Article
    ISSN 2452-199X
    ISSN (online) 2452-199X
    DOI 10.1016/j.bioactmat.2023.11.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Appraising the causal role of smoking in idiopathic pulmonary fibrosis: a Mendelian randomization study.

    Zhu, Jiahao / Zhou, Dan / Yu, Min / Li, Yingjun

    Thorax

    2024  Volume 79, Issue 2, Page(s) 179–181

    Abstract: Smoking has been considered a risk factor for idiopathic pulmonary fibrosis (IPF) in observational studies. To assess whether smoking plays a causal role in IPF, we performed a Mendelian randomization study using genetic association data of 10 382 cases ... ...

    Abstract Smoking has been considered a risk factor for idiopathic pulmonary fibrosis (IPF) in observational studies. To assess whether smoking plays a causal role in IPF, we performed a Mendelian randomization study using genetic association data of 10 382 cases with IPF and 968 080 controls. We found that genetic predisposition to smoking initiation (based on 378 variants) and lifetime smoking (based on 126 variants) were associated with a higher risk of IPF. Our study suggests a potential causal effect of smoking on increasing IPF risk from a genetic perspective.
    MeSH term(s) Humans ; Genome-Wide Association Study ; Idiopathic Pulmonary Fibrosis/genetics ; Mendelian Randomization Analysis ; Risk Factors ; Smoking/adverse effects
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2023-220012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Passive immunotherapy for Alzheimer's disease.

    Guo, Xiaoyi / Yan, Li / Zhang, Denghong / Zhao, Yingjun

    Ageing research reviews

    2024  Volume 94, Page(s) 102192

    Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by cognitive impairment with few therapeutic options. Despite many failures in developing AD treatment during the past 20 years, significant advances have been achieved ... ...

    Abstract Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by cognitive impairment with few therapeutic options. Despite many failures in developing AD treatment during the past 20 years, significant advances have been achieved in passive immunotherapy of AD very recently. Here, we review characteristics, clinical trial data, and mechanisms of action for monoclonal antibodies (mAbs) targeting key players in AD pathogenesis, including amyloid-β (Aβ), tau and neuroinflammation modulators. We emphasized the efficacy of lecanemab and donanemab on cognition and amyloid clearance in AD patients in phase III clinical trials and discussed factors that may contribute to the efficacy and side effects of anti-Aβ mAbs. In addition, we provided important information on mAbs targeting tau or inflammatory regulators in clinical trials, and indicated that mAbs against the mid-region of tau or pathogenic tau have therapeutic potential for AD. In conclusion, passive immunotherapy targeting key players in AD pathogenesis offers a promising strategy for effective AD treatment.
    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Neurodegenerative Diseases/drug therapy ; Amyloid beta-Peptides ; Antibodies, Monoclonal/therapeutic use ; Immunization, Passive ; Immunotherapy ; tau Proteins ; Antibodies, Monoclonal, Humanized
    Chemical Substances donanemab ; Amyloid beta-Peptides ; Antibodies, Monoclonal ; tau Proteins ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-01-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2024.102192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effects of chlorogenic acid on growth, metabolism, antioxidation, immunity, and intestinal flora of crucian carp (

    Jin, Xuexia / Su, Mengyuan / Liang, Yunxiang / Li, Yingjun

    Frontiers in microbiology

    2023  Volume 13, Page(s) 1084500

    Abstract: In recent years, with the harm caused by the abuse of antibiotics and the increasing demand for green and healthy food, people gradually began to look for antibiotic alternatives for aquaculture. As a Chinese herbal medicine, leaf extract chlorogenic ... ...

    Abstract In recent years, with the harm caused by the abuse of antibiotics and the increasing demand for green and healthy food, people gradually began to look for antibiotic alternatives for aquaculture. As a Chinese herbal medicine, leaf extract chlorogenic acid (CGA) of
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1084500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Incorporation of Shewanella oneidensis MR-1 and goethite stimulates anaerobic Sb(III) oxidation by the generation of labile Fe(III) intermediate.

    Sheng, Huamin / Liu, Wenjing / Wang, Yingjun / Ye, Li / Jing, Chuanyong

    Environmental pollution (Barking, Essex : 1987)

    2024  , Page(s) 124008

    Abstract: Dissimilatory iron-reducing bacteria (DIRB) affect the geochemical cycling of redox-sensitive pollutants in anaerobic environments by controlling the transformation of Fe morphology. The anaerobic oxidation of antimonite (Sb(III)) driven by DIRB and Fe( ... ...

    Abstract Dissimilatory iron-reducing bacteria (DIRB) affect the geochemical cycling of redox-sensitive pollutants in anaerobic environments by controlling the transformation of Fe morphology. The anaerobic oxidation of antimonite (Sb(III)) driven by DIRB and Fe(III) oxyhydroxides interactions has been previously reported. However, the oxidative species and mechanisms involved remain unclear. In this study, both biotic phenomenon and abiotic verification experiments were conducted to explore the formed oxidative intermediates and related processes that lead to anaerobic Sb(III) oxidation accompanied during dissimilatory iron reduction. Sb(V) up to 2.59 μmol L
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2024.124008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hypolipidemic and Antithrombotic Effect of 6'-

    Wu, Boxiao / Li, Churan / Kan, Huan / Zhang, Yingjun / Rao, Xiaoping / Liu, Yun / Zhao, Ping

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 4

    Abstract: Vaccinium ... ...

    Abstract Vaccinium dunalianum
    MeSH term(s) Animals ; Arbutin/analogs & derivatives ; Caffeic Acids ; Drugs, Chinese Herbal ; Fibrinolytic Agents/pharmacology ; Hyperlipidemias/drug therapy ; Molecular Docking Simulation ; Network Pharmacology ; Thrombosis/drug therapy ; Zebrafish
    Chemical Substances 6'-O-caffeoylarbutin ; Arbutin (C5INA23HXF) ; Caffeic Acids ; Drugs, Chinese Herbal ; Fibrinolytic Agents
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29040780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Primary goose kidney tubular epithelial cells for goose astrovirus genotype 2 infection: establishment and RNA sequencing analysis.

    Guo, Zixuan / Zhu, Ming / Li, Xinyang / Xu, Haoran / Lv, Yingjun

    Poultry science

    2024  Volume 103, Issue 7, Page(s) 103774

    Abstract: Goose astrovirus genotype 2 (GAstV-2) mainly causes gout in goslings; therefore, it is a major pathogen threatening to goose flocks. However, the mechanisms underlying host-GAstV-2 interactions remain unclear because host cells suitable for GAstV-2 ... ...

    Abstract Goose astrovirus genotype 2 (GAstV-2) mainly causes gout in goslings; therefore, it is a major pathogen threatening to goose flocks. However, the mechanisms underlying host-GAstV-2 interactions remain unclear because host cells suitable for GAstV-2 replication have been unavailable. We previously noted that GAstV-2 is primarily located in goose renal epithelial cells, where it causes kidney damage. Therefore, here, we derived goose primary renal tubular epithelial (RTE) cells (GRTE cells) from the kidneys of goose embryos after collagenase I digestion. After culture in Dulbecco's modified Eagle medium/Nutrient mixture F-12 with 10% fetal bovine serum (FBS), the isolated cells had polygonal with roadstone-like morphology; they were identified to be epithelial cells based on the presence of cytokeratin 18 expression detected through immunofluorescence assay (IFA). GAstV-2 infection in GRTE cells led to no obvious cytopathic effects; the maximum amounts of infectious virions were observed 48 h post infection through IFA and quantitative PCR. Next, RNA-seq was performed to identify and map post-GAstV-2 infection differentially expressed genes. The downregulated pathways were mainly related to metabolism, including tryptophan metabolism, drug metabolism by cytochrome P450, xenobiotic metabolism by cytochrome P450, retinol metabolism, butanoate metabolism, starch and sucrose metabolism, ascorbate and aldarate metabolism, and drug metabolism by other enzymes and peroxisome. In contrast, the upregulated pathways were mostly related to the host cell defense and proliferation, including extracellular matrix-receptor interaction, complement and coagulation cascades, phagosome, PI3K-Akt signaling pathway, human T-lymphotropic virus 1 infection, lysosome, and tumor necrosis factor signaling pathway. In conclusion, we developed a GRTE cell line for GAstV-2 replication and analyzed the potential host-GAstV-2 interactions through RNA-seq; our results may aid in further investigating the pathogenic mechanisms underlying GAstV-2 infection and provide strategies for its prevention and control.
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2024.103774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Total Synthesis of (-)-Levesquamide.

    Jiang, Yingjun / Liu, Xiaoyu / Li, Wenxuan / Jiao, Xiaozhen / Xie, Ping

    The Journal of organic chemistry

    2023  Volume 88, Issue 6, Page(s) 3981–3986

    Abstract: The total synthesis of levesquamide, a natural product with an unprecedented pentasubstituted pyridine-isothiazolinone skeleton, has been accomplished from kojic acid for the first time. The key features of the synthesis include a Suzuki coupling ... ...

    Abstract The total synthesis of levesquamide, a natural product with an unprecedented pentasubstituted pyridine-isothiazolinone skeleton, has been accomplished from kojic acid for the first time. The key features of the synthesis include a Suzuki coupling reaction between bromopyranone and oxazolyl borate fragments, a copper-mediated introduction of a thioether, a mild hydrolysis of a pyridine 2-
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c03066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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