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Article: Corrigendum to: Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male.

Pham, Khanh / Gottesdiener, Lee / Simon, Matthew S / Trzebucki, Alex / Maldarelli, Grace A / Cisse, Babacar / Lieberman, Joshua / DeHaan, Elliot / Pisapia, David

Open forum infectious diseases

2022 Volume 9, Issue 1, Page(s) ofab635

Abstract: This corrects the article DOI: 10.1093/ofid/ofab455.]. ...

Abstract	[This corrects the article DOI: 10.1093/ofid/ofab455.].
Language	English
Publishing date	2022-01-12
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofab635
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Article ; Online: The gut microbiome regulates the clinical efficacy of sulfasalazine therapy for IBD-associated spondyloarthritis.

Lima, Svetlana F / Pires, Silvia / Rupert, Amanda / Oguntunmibi, Seun / Jin, Wen-Bing / Marderstein, Andrew / Funez-dePagnier, Gabriela / Maldarelli, Grace / Viladomiu, Monica / Putzel, Gregory / Yang, Wei / Tran, Nancy / Xiang, Grace / Grier, Alex / Guo, Chun-Jun / Lukin, Dana / Mandl, Lisa A / Scherl, Ellen J / Longman, Randy S

Cell reports. Medicine

2024 Volume 5, Issue 3, Page(s) 101431

Abstract: Sulfasalazine is a prodrug known to be effective for the treatment of inflammatory bowel disease (IBD)-associated peripheral spondyloarthritis (pSpA), but the mechanistic role for the gut microbiome in regulating its clinical efficacy is not well ... ...

Abstract	Sulfasalazine is a prodrug known to be effective for the treatment of inflammatory bowel disease (IBD)-associated peripheral spondyloarthritis (pSpA), but the mechanistic role for the gut microbiome in regulating its clinical efficacy is not well understood. Here, treatment of 22 IBD-pSpA subjects with sulfasalazine identifies clinical responders with a gut microbiome enriched in Faecalibacterium prausnitzii and the capacity for butyrate production. Sulfapyridine promotes butyrate production and transcription of the butyrate synthesis gene but in F. prausnitzii in vitro, which is suppressed by excess folate. Sulfasalazine therapy enhances fecal butyrate production and limits colitis in wild-type and gnotobiotic mice colonized with responder, but not non-responder, microbiomes. F. prausnitzii is sufficient to restore sulfasalazine protection from colitis in gnotobiotic mice colonized with non-responder microbiomes. These findings reveal a mechanistic link between the efficacy of sulfasalazine therapy and the gut microbiome with the potential to guide diagnostic and therapeutic approaches for IBD-pSpA.
MeSH term(s)	Humans ; Mice ; Animals ; Sulfasalazine/pharmacology ; Sulfasalazine/therapeutic use ; Gastrointestinal Microbiome ; Inflammatory Bowel Diseases/drug therapy ; Colitis ; Treatment Outcome ; Butyrates
Chemical Substances	Sulfasalazine (3XC8GUZ6CB) ; Butyrates
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2024.101431
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Remdesivir Treatment for Severe COVID-19 in Third-Trimester Pregnancy: Case Report and Management Discussion.

Maldarelli, Grace A / Savage, Megan / Mazur, Shawn / Oxford-Horrey, Corrina / Salvatore, Mirella / Marks, Kristen M

Open forum infectious diseases

2020 Volume 7, Issue 9, Page(s) ofaa345

Abstract: We report a case of COVID-19 in third-trimester pregnancy, who required support in an intensive care unit and received remdesivir. After discharge, she had an uncomplicated vaginal delivery at term. COVID-19 in pregnancy may be managed without emergent ... ...

Abstract	We report a case of COVID-19 in third-trimester pregnancy, who required support in an intensive care unit and received remdesivir. After discharge, she had an uncomplicated vaginal delivery at term. COVID-19 in pregnancy may be managed without emergent delivery; a multispecialty team is critical in caring for these patients.
Keywords	covid19
Language	English
Publishing date	2020-08-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofaa345
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Article: Meningovascular Syphilis Presenting as a Brain Mass in an Immunocompetent Male.

Pham, Khanh / Gottesdiener, Lee / Simon, Matthew S / Trzebucki, Alex / Maldarelli, Grace A / Cisse, Babacar / Lieberman, Joshua / DeHaan, Elliot / Pisapia, David

Open forum infectious diseases

2021 Volume 8, Issue 9, Page(s) ofab455

Abstract: We present a case of a human immunodeficiency virus-negative man with syphilitic meningovascular disease with subjacent involvement of brain parenchyma leading to a mass-forming inflammatory lesion that was pathologically distinct from a typical gumma. ... ...

Abstract	We present a case of a human immunodeficiency virus-negative man with syphilitic meningovascular disease with subjacent involvement of brain parenchyma leading to a mass-forming inflammatory lesion that was pathologically distinct from a typical gumma. Syphilis was diagnosed after tissue obtained from a brain biopsy demonstrated spirochetes consistent with
Language	English
Publishing date	2021-08-31
Publishing country	United States
Document type	Case Reports
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofab455
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Article: Remdesivir treatment for severe COVID-19 in third-trimester pregnancy: Case report and management discussion

Maldarelli, Grace A. / Savage, Megan / Mazur, Shawn / Oxford-Horrey, Corrina / Salvatore, Mirella / Marks, Kristen M.

Open Forum Infectious Diseases

Abstract: We report a case of COVID-19 in third trimester pregnancy, who required support in an intensive care unit and received remdesivir After discharge, she had an uncomplicated vaginal delivery at term COVID-19 in pregnancy may be managed without emergent ... ...

Abstract	We report a case of COVID-19 in third trimester pregnancy, who required support in an intensive care unit and received remdesivir After discharge, she had an uncomplicated vaginal delivery at term COVID-19 in pregnancy may be managed without emergent delivery;a multispecialty team is critical in caring for these patients
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #729188
Database	COVID19

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Article ; Online: Remdesivir Treatment for Severe COVID-19 in Third-Trimester Pregnancy

Maldarelli, Grace A / Savage, Megan / Mazur, Shawn / Oxford-Horrey, Corrina / Salvatore, Mirella / Marks, Kristen M

Open Forum Infectious Diseases

Case Report and Management Discussion

2020 Volume 7, Issue 9

Abstract: Abstract We report a case of COVID-19 in third-trimester pregnancy, who required support in an intensive care unit and received remdesivir. After discharge, she had an uncomplicated vaginal delivery at term. COVID-19 in pregnancy may be managed without ... ...

Abstract	Abstract We report a case of COVID-19 in third-trimester pregnancy, who required support in an intensive care unit and received remdesivir. After discharge, she had an uncomplicated vaginal delivery at term. COVID-19 in pregnancy may be managed without emergent delivery; a multispecialty team is critical in caring for these patients.
Keywords	Oncology ; Clinical Neurology ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofaa345
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Safety, tolerability, and clinical outcomes of hydroxychloroquine for hospitalized patients with coronavirus 2019 disease.

Satlin, Michael J / Goyal, Parag / Magleby, Reed / Maldarelli, Grace A / Pham, Khanh / Kondo, Maiko / Schenck, Edward J / Rennert, Hanna / Westblade, Lars F / Choi, Justin J / Safford, Monika M / Gulick, Roy M

PloS one

2020 Volume 15, Issue 7, Page(s) e0236778

Abstract: Background: Severe acute respiratory coronavirus 2 (SARS-CoV-2) has caused a devastating worldwide pandemic. Hydroxychloroquine (HCQ) has in vitro activity against SARS-CoV-2, but clinical data supporting HCQ for coronavirus disease 2019 (COVID-19) are ... ...

Abstract	Background: Severe acute respiratory coronavirus 2 (SARS-CoV-2) has caused a devastating worldwide pandemic. Hydroxychloroquine (HCQ) has in vitro activity against SARS-CoV-2, but clinical data supporting HCQ for coronavirus disease 2019 (COVID-19) are limited. Methods: This was a retrospective cohort study of hospitalized patients with COVID-19 who received ≥1 dose of HCQ at two New York City hospitals. We measured incident Grade 3 or 4 blood count and liver test abnormalities, ventricular arrhythmias, and vomiting and diarrhea within 10 days after HCQ initiation, and the proportion of patients who completed HCQ therapy. We also describe changes in Sequential Organ Failure Assessment hypoxia scores between baseline and day 10 after HCQ initiation and in-hospital mortality. Results: None of the 153 hospitalized patients with COVID-19 who received HCQ developed a sustained ventricular tachyarrhythmia. Incident blood count and liver test abnormalities occurred in <15% of patients and incident vomiting or diarrhea was rare. Eighty-nine percent of patients completed their HCQ course and three patients discontinued therapy because of QT prolongation. Fifty-two percent of patients had improved hypoxia scores 10 days after starting HCQ. Thirty-one percent of patients who were receiving mechanical ventilation at the time of HCQ initiation died during their hospitalization, compared to 18% of patients who were receiving supplemental oxygen but not requiring mechanical ventilation, and 8% of patients who were not requiring supplemental oxygen. Co-administration of azithromycin was not associated with improved outcomes. Conclusions: HCQ appears to be reasonably safe and tolerable in most hospitalized patients with COVID-19. However, nearly one-half of patients did not improve with this treatment, highlighting the need to evaluate HCQ and alternate therapies in randomized trials.
MeSH term(s)	Adult ; Aged ; Azithromycin/therapeutic use ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Female ; Humans ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/therapeutic use ; Male ; Middle Aged ; New York City ; Pandemics ; Pneumonia, Viral/drug therapy ; Retrospective Studies ; SARS-CoV-2 ; Treatment Outcome
Chemical Substances	Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
Keywords	covid19
Language	English
Publishing date	2020-07-23
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, N.I.H., Extramural
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0236778
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pilin Vaccination Stimulates Weak Antibody Responses and Provides No Protection in a C57Bl/6 Murine Model of Acute

Maldarelli, Grace A / Matz, Hanover / Gao, Si / Chen, Kevin / Hamza, Therwa / Yfantis, Harris G / Feng, Hanping / Donnenberg, Michael S

Journal of vaccines & vaccination

2016 Volume 7, Issue 3

Abstract: Clostridium ... ...

Abstract	Clostridium difficile
Language	English
Publishing date	2016-05-27
Publishing country	United States
Document type	Journal Article
ISSN	2157-7560
ISSN	2157-7560
DOI	10.4172/2157-7560.1000321
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Safety, tolerability, and clinical outcomes of hydroxychloroquine for hospitalized patients with coronavirus 2019 disease.

Michael J Satlin / Parag Goyal / Reed Magleby / Grace A Maldarelli / Khanh Pham / Maiko Kondo / Edward J Schenck / Hanna Rennert / Lars F Westblade / Justin J Choi / Monika M Safford / Roy M Gulick

PLoS ONE, Vol 15, Iss 7, p e

2020 Volume 0236778

Abstract: Background Severe acute respiratory coronavirus 2 (SARS-CoV-2) has caused a devastating worldwide pandemic. Hydroxychloroquine (HCQ) has in vitro activity against SARS-CoV-2, but clinical data supporting HCQ for coronavirus disease 2019 (COVID-19) are ... ...

Abstract	Background Severe acute respiratory coronavirus 2 (SARS-CoV-2) has caused a devastating worldwide pandemic. Hydroxychloroquine (HCQ) has in vitro activity against SARS-CoV-2, but clinical data supporting HCQ for coronavirus disease 2019 (COVID-19) are limited. Methods This was a retrospective cohort study of hospitalized patients with COVID-19 who received ≥1 dose of HCQ at two New York City hospitals. We measured incident Grade 3 or 4 blood count and liver test abnormalities, ventricular arrhythmias, and vomiting and diarrhea within 10 days after HCQ initiation, and the proportion of patients who completed HCQ therapy. We also describe changes in Sequential Organ Failure Assessment hypoxia scores between baseline and day 10 after HCQ initiation and in-hospital mortality. Results None of the 153 hospitalized patients with COVID-19 who received HCQ developed a sustained ventricular tachyarrhythmia. Incident blood count and liver test abnormalities occurred in <15% of patients and incident vomiting or diarrhea was rare. Eighty-nine percent of patients completed their HCQ course and three patients discontinued therapy because of QT prolongation. Fifty-two percent of patients had improved hypoxia scores 10 days after starting HCQ. Thirty-one percent of patients who were receiving mechanical ventilation at the time of HCQ initiation died during their hospitalization, compared to 18% of patients who were receiving supplemental oxygen but not requiring mechanical ventilation, and 8% of patients who were not requiring supplemental oxygen. Co-administration of azithromycin was not associated with improved outcomes. Conclusions HCQ appears to be reasonably safe and tolerable in most hospitalized patients with COVID-19. However, nearly one-half of patients did not improve with this treatment, highlighting the need to evaluate HCQ and alternate therapies in randomized trials.
Keywords	Medicine ; R ; Science ; Q ; covid19
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification, immunogenicity, and cross-reactivity of type IV pilin and pilin-like proteins from Clostridium difficile.

Maldarelli, Grace A / De Masi, Leon / von Rosenvinge, Erik C / Carter, Mihaela / Donnenberg, Michael S

Pathogens and disease

2014 Volume 71, Issue 3, Page(s) 302–314

Abstract: The Gram-positive anaerobe Clostridium difficile is the major cause of nosocomial diarrhea; manifestations of infection include diarrhea, pseudomembranous colitis, and death. Genes for type IV pili, a bacterial nanofiber often involved in colonization ... ...

Abstract	The Gram-positive anaerobe Clostridium difficile is the major cause of nosocomial diarrhea; manifestations of infection include diarrhea, pseudomembranous colitis, and death. Genes for type IV pili, a bacterial nanofiber often involved in colonization and until relatively recently described only in Gram-negatives, are present in all members of the Clostridiales. We hypothesized that any pilins encoded in the C. difficile genome would be immunogenic, as has been shown with pilins from Gram-negative organisms. We describe nine pilin or pilin-like protein genes, for which we introduce a coherent nomenclature, in the C. difficile R20291 genome. The nine predicted pilin or pilin-like proteins have relatively conserved N-terminal hydrophobic regions, but diverge at their C-termini. Analysis of synonymous and nonsynonymous substitutions revealed evidence of diversifying selective pressure in two pilin genes. Six of the nine identified proteins were purified and used to immunize mice. Immunization of mice with each individual protein generated antibody responses that varied in titer and cross-reactivity, a notable result given the low amino acid sequence identity among the pilins. Further studies in other small mammals mirrored our results in mice. Our results illuminate components of the C. difficile type IV pilus and help identify targets for an anti-C. difficile vaccine.
MeSH term(s)	Animals ; Antibodies, Bacterial/blood ; Antigens, Bacterial/genetics ; Antigens, Bacterial/immunology ; Bacterial Vaccines/administration & dosage ; Bacterial Vaccines/immunology ; Clostridioides difficile/genetics ; Clostridioides difficile/immunology ; Evolution, Molecular ; Fimbriae Proteins/genetics ; Fimbriae Proteins/immunology ; Genetic Variation ; Guinea Pigs ; Mice ; Mutation ; Rabbits ; Selection, Genetic ; Vaccines, Subunit/administration & dosage ; Vaccines, Subunit/immunology
Chemical Substances	Antibodies, Bacterial ; Antigens, Bacterial ; Bacterial Vaccines ; Vaccines, Subunit ; Fimbriae Proteins (147680-16-8)
Language	English
Publishing date	2014-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2049-632X
ISSN (online)	2049-632X
DOI	10.1111/2049-632X.12137
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