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  1. Article ; Online: Letter by Lei Wang and Yun-Tao Zhao Regarding Article, "Young Male With Incessantly Wide Complex Tachycardia: What Is the Substrate of the Arrhythmia?"

    Wang, Lei / Zhao, Yun-Tao

    Circulation

    2018  Volume 138, Issue 2, Page(s) 211

    MeSH term(s) Arrhythmias, Cardiac ; Humans ; Male ; Tachycardia
    Language English
    Publishing date 2018-07-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.118.034580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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  2. Article ; Online: ST-T Alternans in Acute Myocardial Infarction as a Risk Predictor for Fatal Ventricular Arrhythmia.

    Zhao, Yun-Tao / Wang, Lei

    JAMA internal medicine

    2024  Volume 184, Issue 3, Page(s) 335–336

    MeSH term(s) Humans ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/etiology ; Electrocardiography
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2023.7720
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    Ua VI Zs.119: Show issues Location:
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  3. Article ; Online: Serum irisin levels are negatively associated with blood pressure in dialysis patients.

    Wang, Pei-Xin / Fan, Zheng-Jia / Wu, Lei-Yun / Wang, Shi-Yuan / Zhang, Jia-Ling / Dong, Xing-Tong / Zhang, Ai-Hua

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 12, Page(s) 2738–2745

    Abstract: Elevated blood pressure is highly prevalent among dialysis patients and is associated with high mortality. Irisin is a newly found myokine that has been indicated to be related to blood pressure regulation in animal experiments. Data regarding the effect ...

    Abstract Elevated blood pressure is highly prevalent among dialysis patients and is associated with high mortality. Irisin is a newly found myokine that has been indicated to be related to blood pressure regulation in animal experiments. Data regarding the effect of serum irisin levels on blood pressure in dialysis patients are limited. To identify the association between serum irisin levels and blood pressure and examine determinant factors of systolic blood pressure in dialysis patients, we recruited 300 dialysis patients at Xuanwu Hospital Capital Medical University. Serum irisin levels were assessed by enzyme-linked immunosorbent assay kits. Blood pressure was self-measured on 7 consecutive days by an automated sphygmomanometer. The Pearson correlation test showed that the natural logarithm of irisin was negatively correlated with systolic blood pressure (r = -0.462, P < 0.001) and pulse pressure (r = -0.487, P < 0.001), but not correlated with diastolic blood pressure (r = -0.022, P = 0.709). Multivariate analysis revealed that the natural logarithm of irisin (β = -0.336, P < 0.001), lean tissue mass (β = 0.164, P = 0.005), diabetes mellitus (β = 0.165, P = 0.003) and serum calcium (β = -0.135, P = 0.019) were significant determinant factors for systolic blood pressure. This study is the first to demonstrate that serum irisin levels are significantly negatively associated with blood pressure in dialysis patients. Further studies are needed to provide possible mechanisms. We demonstrated that serum irisin levels were negatively associated with blood pressure in dialysis patients, which may provide a new target for antihypertensive treatment.
    MeSH term(s) Humans ; Blood Pressure ; Diabetes Mellitus ; Fibronectins ; Hypertension ; Renal Dialysis
    Chemical Substances Fibronectins ; FNDC5 protein, human
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01449-x
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    Zs.A 3898: Show issues Location:
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  4. Article ; Online: Characterization the prognosis role and effects of snoRNAs in melanoma patients.

    Wang, Lei-Yun / Song, Jia-Nan / Chen, Yi-Xuan / Zhu, Ying / Ren, Hui-Li / Li, Qiu-Qi / Zhang, Shao-Hui

    Experimental dermatology

    2023  Volume 33, Issue 1, Page(s) e14944

    Abstract: Melanoma is a melanocyte-derived malignant cancer and is known for its early metastasis and high mortality rates. It is a highly cutaneous tumour disease that could be related to the abnormal immune microenvironment, and the identification of reliable ... ...

    Abstract Melanoma is a melanocyte-derived malignant cancer and is known for its early metastasis and high mortality rates. It is a highly cutaneous tumour disease that could be related to the abnormal immune microenvironment, and the identification of reliable diagnostic and prognostic markers is crucial for improving patient outcomes. In the search for biomarkers, various types of RNAs have been discovered and recognized as reliable prognostic markers. Among these, small nucleolar RNAs (snoRNAs) have emerged as a promising avenue for studying early diagnosis and prognostic markers in tumours due to their widespread presence in tissues, tumour specificity and stability. In our study, we analysed snoRNAs data from melanoma samples in the TCGA-SKCM cohort and developed a prognostic model comprising 12 snoRNAs (SNORD9, SNORA31, SNORD14E, SNORA14A, SNORA5A, SNORD83A, SNORA75, AL096855, AC007684, SNORD14A, SNORA65 and AC004839). This model exhibited unique prognostic accuracy and demonstrated a significant correlation with the immune infiltration tumour microenvironment. Additionally, analysis of the GSE213145 dataset, which explored the sensitivity and resistance of immune checkpoint inhibitors, further supported the potential of snoRNAs as prognostic markers for immunotherapy. Overall, our study contributes reliable prognostic and immune-related biomarkers for melanoma patients. These findings can offer valuable insights for the future discovery of novel melanoma treatment strategies and hold promise for improving clinical outcomes in melanoma patients.
    MeSH term(s) Humans ; Melanoma/genetics ; RNA, Small Nucleolar/genetics ; Prognosis ; Skin Neoplasms/genetics ; Biomarkers ; Tumor Microenvironment
    Chemical Substances RNA, Small Nucleolar ; Biomarkers
    Language English
    Publishing date 2023-09-29
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14944
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    Zs.A 3508: Show issues Location:
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  5. Article ; Online: The role of CSDE1 in translational reprogramming and human diseases.

    Guo, Ao-Xiang / Cui, Jia-Jia / Wang, Lei-Yun / Yin, Ji-Ye

    Cell communication and signaling : CCS

    2020  Volume 18, Issue 1, Page(s) 14

    Abstract: CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming, which determines the fate of a number of RNAs during biological processes. Interestingly, the role of CSDE1 is bidirectional. It not only promotes and represses the ... ...

    Abstract CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming, which determines the fate of a number of RNAs during biological processes. Interestingly, the role of CSDE1 is bidirectional. It not only promotes and represses the translation of RNAs but also increases and decreases the abundance of RNAs. However, the mechanisms underlying this phenomenon are still unknown. In this review, we propose a "protein-RNA connector" model to explain this bidirectional role and depict its three versions: sequential connection, mutual connection and facilitating connection. As described in this molecular model, CSDE1 binds to RNAs and cooperates with other protein regulators. CSDE1 connects with different RNAs and their regulators for different purposes. The triple complex of CSDE1, a regulator and an RNA reprograms translation in different directions for each transcript. Meanwhile, a number of recent studies have found important roles for CSDE1 in human diseases. This model will help us to understand the role of CSDE1 in translational reprogramming and human diseases. Video Abstract.
    MeSH term(s) Animals ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Disease/genetics ; Humans ; Protein Biosynthesis ; RNA/genetics ; RNA/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
    Chemical Substances CSDE1 protein, human ; DNA-Binding Proteins ; RNA-Binding Proteins ; RNA (63231-63-0)
    Language English
    Publishing date 2020-01-27
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1478-811X
    ISSN (online) 1478-811X
    DOI 10.1186/s12964-019-0496-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A New Way to Discover IRESs in Pathology or Stress Conditions? Harnessing Latest High-Throughput Technologies.

    Wang, Lei-Yun / Cui, Jia-Jia / Guo, Cheng-Xian / Yin, Ji-Ye

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2020  Volume 42, Issue 3, Page(s) e1900180

    Abstract: The cellular internal ribosomal entry site (IRES) is one of the most important elements to mediate cap-independent translational initiation, especially under conditions of stress and pathology. However, a high-throughput method to discover IRESs in these ...

    Abstract The cellular internal ribosomal entry site (IRES) is one of the most important elements to mediate cap-independent translational initiation, especially under conditions of stress and pathology. However, a high-throughput method to discover IRESs in these conditions is still lacking. Here, a possible way IRES long-read sequencing based on the latest high-throughput technologies is proposed to solve this problem. Based on this design, diversity and integrity of the transcriptome from original samples can be kept. The micro-environment that stimulates or inhibits IRES activity can also be mimicked. By using long read-length sequencing technology, additional experiments that are essential for ruling out the cryptic promoters or splicing events in routine IRES identification processes can be circumvented. It is hoped that this proposed methodology may be adopted for IRES element discovery, hence uncovering the full extent of the role of IRESs in disease, development, and stress. Also see the video abstract here https://youtu.be/JuWBbMzWXS8.
    MeSH term(s) Alternative Splicing/genetics ; Animals ; Genes, Reporter ; Genetic Variation ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Internal Ribosome Entry Sites/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; Promoter Regions, Genetic ; Protein Biosynthesis/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism ; Transcriptome
    Chemical Substances Internal Ribosome Entry Sites ; RNA, Messenger
    Language English
    Publishing date 2020-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.201900180
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    Zs.A 2024: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Childhood Obesity and Risk of Stroke: A Mendelian Randomisation Analysis.

    Zou, Xue-Lun / Wang, Sai / Wang, Lei-Yun / Xiao, Lin-Xiao / Yao, Tian-Xing / Zeng, Yi / Zhang, Le

    Frontiers in genetics

    2021  Volume 12, Page(s) 727475

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.727475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The role of CSDE1 in translational reprogramming and human diseases

    Ao-Xiang Guo / Jia-Jia Cui / Lei-Yun Wang / Ji-Ye Yin

    Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-

    2020  Volume 12

    Abstract: Abstract CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming, which determines the fate of a number of RNAs during biological processes. Interestingly, the role of CSDE1 is bidirectional. It not only promotes and ... ...

    Abstract Abstract CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming, which determines the fate of a number of RNAs during biological processes. Interestingly, the role of CSDE1 is bidirectional. It not only promotes and represses the translation of RNAs but also increases and decreases the abundance of RNAs. However, the mechanisms underlying this phenomenon are still unknown. In this review, we propose a “protein-RNA connector” model to explain this bidirectional role and depict its three versions: sequential connection, mutual connection and facilitating connection. As described in this molecular model, CSDE1 binds to RNAs and cooperates with other protein regulators. CSDE1 connects with different RNAs and their regulators for different purposes. The triple complex of CSDE1, a regulator and an RNA reprograms translation in different directions for each transcript. Meanwhile, a number of recent studies have found important roles for CSDE1 in human diseases. This model will help us to understand the role of CSDE1 in translational reprogramming and human diseases. Video Abstract Graphical abstract
    Keywords CSDE1 ; UNR ; Reprogramming ; Translation initiation ; RNA binding protein ; Cancer ; Medicine ; R ; Cytology ; QH573-671
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Editorial: Novel diagnostic and therapeutic strategies for retinal diseases, volume II.

    Fang, Dong / Wang, Yun / Lei, Hetian / Zhang, Shaochong

    Frontiers in medicine

    2023  Volume 10, Page(s) 1234119

    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1234119
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  10. Article: 

    Su, Fan / Qin, Xiao-Wei / Wang, Yun-Lei / Wang, Ren-Fen / Hao, Chao-Yun / Tan, Ke

    PhytoKeys

    2023  Volume 232, Page(s) 59–66

    Abstract: ... ...

    Abstract Staurantherafloribunda
    Language English
    Publishing date 2023-09-07
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2579891-1
    ISSN 1314-2003 ; 1314-2011
    ISSN (online) 1314-2003
    ISSN 1314-2011
    DOI 10.3897/phytokeys.232.108996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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