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  1. Article ; Online: The insights from SARS-CoV-2 antibody treatment for future emerging infectious diseases.

    Wang, Yeming / Cao, Bin

    The Lancet. Infectious diseases

    2023  Volume 24, Issue 1, Page(s) 2–3

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Communicable Diseases, Emerging/drug therapy ; Middle East Respiratory Syndrome Coronavirus ; Antibodies, Viral/therapeutic use
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00454-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
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  2. Article ; Online: Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19. Reply.

    Wang, Yeming / Hu, Honglin / Cao, Bin

    The New England journal of medicine

    2024  Volume 390, Issue 16, Page(s) 1534–1535

    MeSH term(s) Adult ; Humans ; Administration, Oral ; Antiviral Agents/administration & dosage ; Antiviral Agents/therapeutic use ; COVID-19/therapy ; COVID-19/virology ; COVID-19 Drug Treatment ; SARS-CoV-2 ; Viral Load
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2402378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The efficacy of extracted Tanshinone compounds for infantile hemangiomas of the skin: results from a pilot study.

    Huang, Yingying / Li, Chao / Wang, Rui / Wu, Yeming

    Translational pediatrics

    2024  Volume 13, Issue 1, Page(s) 137–145

    Abstract: Background: Infantile hemangiomas (IHs) on skin are conventionally treated with beta blockers, pulsed dye laser (PDL), or surgery, either invasive or limited to clinical conditions. Our preclinical studies suggested that Tanshinone, extracted from : ... ...

    Abstract Background: Infantile hemangiomas (IHs) on skin are conventionally treated with beta blockers, pulsed dye laser (PDL), or surgery, either invasive or limited to clinical conditions. Our preclinical studies suggested that Tanshinone, extracted from
    Methods: The single-armed pilot study included a total of 29 infants diagnosed with IHs. Thrice daily (at an interval of 6-8 hours) topical applications of Tanshinone were used for each patient. The primary response was the skin erythema index assessed by investigators using SkinColorCatch colorimeter instrument (Delfin). The Achauer score and the satisfaction of parents were also evaluated.
    Results: A total of 29 infants, 22 females (76%) and 7 males (24%), with a median age of 60 days (interquartile range, 45 to 99 days) were included. The position of IHs was distributed in the trunk (44.8%), head (34.5%), and limbs (20.7%). After 6 months of IHs treatment, the decrease in skin erythema index (baseline: 566.79±854.67
    Conclusions: The topical use of Tanshinone compounds might be a potentially effective and noninvasive therapy in treating IHs.
    Language English
    Publishing date 2024-01-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-23-555
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  4. Article ; Online: 68

    Qu, Bin / Li, Xianjun / Ma, Yuze / Wang, Yanzhi / Han, Yeming / Hou, Guihua / Gao, Feng

    Dalton transactions (Cambridge, England : 2003)

    2024  

    Abstract: The absence of better biomarkers currently limits early diagnosis and treatment of triple-negative breast cancer (TNBC). Our previously published study reported that the cyclic-peptide SD01 exhibited specific binding to EphA2 (Ephrin type-A receptor 2) ... ...

    Abstract The absence of better biomarkers currently limits early diagnosis and treatment of triple-negative breast cancer (TNBC). Our previously published study reported that the cyclic-peptide SD01 exhibited specific binding to EphA2 (Ephrin type-A receptor 2) on TNBC. To develop a novel PET imaging agent, we prepared gallium-68 (
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d4dt00837e
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  5. Article ; Online: Analysis of the Reform Effectiveness of Vocational Skill Identification Based on the New Social Training Model in the New Era under Deep Learning Assessment

    Yeming Wang / Yong Ran

    Applied Bionics and Biomechanics, Vol

    2022  Volume 2022

    Abstract: In order to be able to make full use of domain knowledge to improve the performance of skill word extraction, this paper proposes a skill word extraction method based on a combination of deep learning and corpus features. Skill word extraction is ... ...

    Abstract In order to be able to make full use of domain knowledge to improve the performance of skill word extraction, this paper proposes a skill word extraction method based on a combination of deep learning and corpus features. Skill word extraction is transformed into a sequence annotation problem, and based on the basic model of sequence annotation, Bi-LSTM-CRF, corpus features are added to the input layer, and the output of the input layer is connected with the Bi-LSTM output as the input of the CRF layer. The experimental results show timely updating of the question bank, paying attention to the quality of vocational skill identification, and strictly managing the issuance of vocational qualification false certificates.
    Keywords Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Analysis of the Reform Effectiveness of Vocational Skill Identification Based on the New Social Training Model in the New Era under Deep Learning Assessment.

    Wang, Yeming / Ran, Yong

    publication RETRACTED

    Applied bionics and biomechanics

    2022  Volume 2022, Page(s) 1676355

    Abstract: In order to be able to make full use of domain knowledge to improve the performance of skill word extraction, this paper proposes a skill word extraction method based on a combination of deep learning and corpus features. Skill word extraction is ... ...

    Abstract In order to be able to make full use of domain knowledge to improve the performance of skill word extraction, this paper proposes a skill word extraction method based on a combination of deep learning and corpus features. Skill word extraction is transformed into a sequence annotation problem, and based on the basic model of sequence annotation, Bi-LSTM-CRF, corpus features are added to the input layer, and the output of the input layer is connected with the Bi-LSTM output as the input of the CRF layer. The experimental results show timely updating of the question bank, paying attention to the quality of vocational skill identification, and strictly managing the issuance of vocational qualification false certificates.
    Language English
    Publishing date 2022-03-20
    Publishing country Egypt
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2179924-6
    ISSN 1754-2103 ; 1176-2322
    ISSN (online) 1754-2103
    ISSN 1176-2322
    DOI 10.1155/2022/1676355
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  7. Article: Yokenella Regensburgei Infection in an Immunocompetent Patient.

    Huang, Luxin / Chen, Yeming / Wang, Xue

    Clinical laboratory

    2023  Volume 70, Issue 3

    Abstract: Background: Yokenella regensburgei is a gram-negative, opportunistic pathogen that is ubiquitous in natural environments. It commonly affects immunocompromised patients.: Methods: The patient was a 71-year-old female with skin and soft tissue wound ... ...

    Abstract Background: Yokenella regensburgei is a gram-negative, opportunistic pathogen that is ubiquitous in natural environments. It commonly affects immunocompromised patients.
    Methods: The patient was a 71-year-old female with skin and soft tissue wound caused by trauma. The surgical debridement and abscess drainage were performed by surgeons. The specie of infected organism was identified by the D2Mini semi-automated system and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF).
    Results: The result of bacterium culture showed gram-negative bacillus was moist, grey-white, semitransparent, and regular shape. Then the D2Mini semi-automated system and MALDI-TOF revealed that the colonies are Y. regensburgei. According to the result for drug sensitivity, antibiotic therapy was switched to cefoperazone/sulbac-tam and levofloxacin.
    Conclusions: Cooperation between clinical microbiology laboratories and surgeons is essential for the infected patient without typical symptoms. Agricultural activities and stab wounds may be related to Y. regensburgei infection.
    MeSH term(s) Female ; Humans ; Aged ; Enterobacteriaceae ; Enterobacteriaceae Infections/microbiology ; Anti-Bacterial Agents/therapeutic use ; Laboratories ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-09-22
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2023.230916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.170: Show issues Location:
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    Zs.MO 25: Show issues

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  8. Article ; Online: Exploring the pharmacological and adverse reaction mechanism of a drug by network pharmacology strategy: Using colchicine to treat Behcet syndrome as an example.

    Li, Shizhe / Wang, Lei / Wang, Yeming / Zhang, Chaoqun

    Medicine

    2023  Volume 102, Issue 14, Page(s) e33486

    Abstract: Colchicine (COLC) is a natural alkaloid used to treat Behcet syndrome (BS), but its adverse reactions limit its clinical application in treating BS. However, the adverse reaction mechanism of COLC in the treatment of BS remains unclear. Herein, a network ...

    Abstract Colchicine (COLC) is a natural alkaloid used to treat Behcet syndrome (BS), but its adverse reactions limit its clinical application in treating BS. However, the adverse reaction mechanism of COLC in the treatment of BS remains unclear. Herein, a network pharmacology-based strategy was designed to analyze the pharmacological and adverse reaction mechanism of COLC in treating BS. The biological functions of COLC and BS pathogenesis were analyzed through a series of network construction and analysis. The data above predicted the pharmacological and adverse reaction mechanism of COLC in BS treatment. The pharmacological mechanism of COLC against BS was predicted to control inflammatory responses. Interleukin-8, interleukin-18, integrin alpha-4, integrin beta-2, and tubulin targets are crucial in treating BS. The adverse reactions of COLC in BS treatment were predicted as neurotoxicity and hepatotoxicity. The mechanism of hepatotoxicity may be related to the decrease of cytochrome P450 family 3 subfamily A activity caused by various factors, such as poor hepatic function, the dosage of COLC, and combination with inhibitors. The mechanism of neurotoxicity may be related to the disruption of microtubules in the nervous system by COLC transport across the blood-brain barrier. This study provided basic evidence for the medication safety management of COLC used in treating BS. Moreover, this study demonstrated that it is feasible to analyze the adverse reaction mechanisms of drugs using a network pharmacology strategy, which facilitates systematic drug safety management and evaluation.
    MeSH term(s) Humans ; Behcet Syndrome ; Colchicine/adverse effects ; Network Pharmacology ; Chemical and Drug Induced Liver Injury/complications ; Integrins ; Drugs, Chinese Herbal/therapeutic use
    Chemical Substances Colchicine (SML2Y3J35T) ; Integrins ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000033486
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    Ua VI Zs.171: Show issues Location:
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  9. Article ; Online: Mechanism of the Anomalous Dependence between Spin-Orbit Coupling and Dimensionality in Lead Halide Perovskites.

    Xian, Yeming / Wang, Xiaoming / Yan, Yanfa

    The journal of physical chemistry letters

    2023  Volume 14, Issue 39, Page(s) 8811–8819

    Abstract: The spin-orbit coupling (SOC) effect of lead (Pb) atoms is a consequential attribute of the unique optoelectronic and defect properties of lead halide perovskites (LHPs). It has been found that the SOC effect varies significantly as the structural ... ...

    Abstract The spin-orbit coupling (SOC) effect of lead (Pb) atoms is a consequential attribute of the unique optoelectronic and defect properties of lead halide perovskites (LHPs). It has been found that the SOC effect varies significantly as the structural dimensionality changes with an anomalous dependence; i.e., while the SOC strength monotonically decreases as structural dimensionality decreases from three-dimensional (3D) to two-dimensional (2D) and then to one-dimensional (1D), the zero-dimensional (0D) SOC strength is greater than the 1D SOC strength. The underlying mechanism of such a SOC dimensionality dependence anomaly remains elusive. In this work, we show that Pb 6p energy splitting increases from 3D to 2D and to 1D LHPs due to the increased degree of distortion, leading to a reduced SOC strength. However, the degree of distortion decreases for the 1D to 0D transformation, resulting in reverse SOC enhancement. The mechanism described in this work can be employed to regulate the SOC effect in the design of perovskite materials.
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c02161
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  10. Article ; Online: Characterization of mung bean endogenous proteases and globulins and their effects on the production of mung bean protein.

    Zhou, Qianqian / Wang, Lili / Zhang, Yaowen / Zhang, Caimeng / Kong, Xiangzhen / Hua, Yufei / Chen, Yeming

    Food chemistry

    2024  Volume 442, Page(s) 138477

    Abstract: Mung bean protein possesses several health benefits, and aqueous processing methods are used for its production. However, mung bean protein yields are different with different methods, which are actually different in conditions (e.g., pH, temperature, ... ...

    Abstract Mung bean protein possesses several health benefits, and aqueous processing methods are used for its production. However, mung bean protein yields are different with different methods, which are actually different in conditions (e.g., pH, temperature, and time). Herein, liquid chromatography tandem mass spectrometry identified 28 endopeptidases and exopeptidases in mung bean protein extract, and the positions of 8S and 11S globulins on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) gel were confirmed in our experimental conditions. The SDS-PAGE, trichloroacetic acid-nitrogen solubility index, and free amino acid analysis revealed that (1) 8S globulins showed strong resistance to the endopeptidases (optimal at pH 5 and 50 °C) at pH 3-9, and 11S globulin exhibit strong resistance expect at pH 3-3.5; (2) the exopeptidases (optimal at pH 6 and 50 °C) preferred to liberate methionine and tryptophan. These proteases negatively affected protein yield, and short production time and low temperature were recommended.
    MeSH term(s) Vigna/chemistry ; Peptide Hydrolases ; Fabaceae/chemistry ; Globulins/chemistry ; Endopeptidases ; Exopeptidases
    Chemical Substances Peptide Hydrolases (EC 3.4.-) ; Globulins ; Endopeptidases (EC 3.4.-) ; Exopeptidases (EC 3.4.-)
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.138477
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