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  1. Article ; Online: How do we enhance protective immunity to COVID-19 in lung transplant recipients?

    Griffin, David W J / McMahon, James H

    The European respiratory journal

    2023  Volume 61, Issue 1

    MeSH term(s) Humans ; COVID-19 ; COVID-19 Vaccines ; Transplant Recipients ; Cohort Studies ; Lung
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01723-2022
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    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  2. Article ; Online: Meningococcal Vaccine in Mali and Gambia.

    Griffin, David W J / Hoy, Jennifer F / McMahon, James H

    The New England journal of medicine

    2023  Volume 389, Issue 6, Page(s) 577

    MeSH term(s) Humans ; Meningococcal Vaccines ; Gambia ; Mali/epidemiology ; Vaccines, Conjugate
    Chemical Substances Meningococcal Vaccines ; Vaccines, Conjugate
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2307375
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    Ua VI Zs.34: Show issues Location:
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  3. Article ; Online: Long-acting cabotegravir PrEP: a time for cautious optimism.

    Griffin, David Wj / Hoy, Jennifer F / McMahon, James H

    The lancet. HIV

    2023  Volume 10, Issue 12, Page(s) e756–e757

    MeSH term(s) Humans ; HIV Infections/prevention & control ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Pyridones/therapeutic use ; Pre-Exposure Prophylaxis
    Chemical Substances cabotegravir (HMH0132Z1Q) ; Anti-HIV Agents ; Pyridones
    Language English
    Publishing date 2023-11-09
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(23)00294-1
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  4. Article ; Online: Assessing understandings and perceptions of HIV cure among peer navigators and treatment officers in Australia.

    Lau, Jillian S Y / Clifton, Brent / Rule, John / Ellard, Jeanne / McMahon, James H

    HIV research & clinical practice

    2024  Volume 25, Issue 1, Page(s) 2330751

    Abstract: HIV community peer navigators and treatment officers are important sources of information and guidance for people living with HIV. We conducted an anonymous online survey with members of the treatment outreach network of the Australian National ... ...

    Abstract HIV community peer navigators and treatment officers are important sources of information and guidance for people living with HIV. We conducted an anonymous online survey with members of the treatment outreach network of the Australian National Association of People Living with HIV. The survey explored understandings and acceptance of HIV cure research and was disseminated before and following an interactive workshop on HIV cure. We demonstrated an improvement in understandings of HIV cure science and increased willingness to participate in interventional clinical trials after the workshop. Concerns around interrupting HIV treatment and detrimental impacts on health were identified as barriers to participation. Altruism was a motivator to enrol in HIV cure trials, along with endorsement from a trusted member of community.
    MeSH term(s) Humans ; Animals ; Australia ; Altruism ; Coleoptera ; Peer Group ; HIV Infections/drug therapy
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ISSN 2578-7470
    ISSN (online) 2578-7470
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  5. Article ; Online: Early Outpatient Treatment of SARS-CoV-2 (COVID-19): A Comment.

    Korman, Tony M / McMahon, James H

    The American journal of medicine

    2021  Volume 134, Issue 3, Page(s) e220–e221

    MeSH term(s) Ambulatory Care ; COVID-19 ; Humans ; Outpatients ; SARS-CoV-2
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2020.08.044
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    Ua VI Zs.289: Show issues Location:
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  6. Article ; Online: Immunogenicity, effectiveness, and safety of SARS-CoV-2 vaccination in people with HIV.

    Griffin, David W J / Pai Mangalore, Rekha / Hoy, Jennifer F / McMahon, James H

    AIDS (London, England)

    2023  Volume 37, Issue 9, Page(s) 1345–1360

    Abstract: Objectives: People with HIV (PWH) experience a greater risk of morbidity and mortality following COVID-19 infection, and poorer immunological responses to several vaccines. We explored existing evidence regarding the immunogenicity, effectiveness, and ... ...

    Abstract Objectives: People with HIV (PWH) experience a greater risk of morbidity and mortality following COVID-19 infection, and poorer immunological responses to several vaccines. We explored existing evidence regarding the immunogenicity, effectiveness, and safety of SARS-CoV-2 vaccines in PWH compared with controls.
    Methods: We conducted a systematic search of electronic databases from January 2020 until June 2022, in addition to conference databases, to identify studies comparing clinical, immunogenicity, and safety in PWH and controls. We compared results between those with low (<350 cells/μl) and high (>350 cells/μl) CD4 + T-cell counts where possible. We performed a meta-analysis of seroconversion and neutralization responses to calculate a pooled risk ratio as the measure of effect.
    Results: We identified 30 studies, including four reporting clinical effectiveness, 27 immunogenicity, and 12 reporting safety outcomes. PWH were 3% [risk ratio 0.97, 95% confidence interval (95% CI) 0.95-0.99] less likely to seroconvert and 5% less likely to demonstrate neutralization responses (risk ratio 0.95, 95% CI 0.91-0.99) following a primary vaccine schedule. Having a CD4 + T-cell count less than 350 cells/μl (risk ratio 0.91, 95% CI 0.83-0.99) compared with a CD4 + T-cell count more than 350 cells/μl, and receipt of a non-mRNA vaccine in PWH compared with controls (risk ratio 0.86, 95% CI 0.77-0.96) were associated with reduced seroconversion. Two studies reported worse clinical outcomes in PWH.
    Conclusion: Although vaccines appear well tolerated in PWH, this group experience poorer immunological responses following vaccination than controls, particularly with non-mRNA vaccines and low CD4 + T-cell counts. PWH should be prioritized for mRNA COVID-19 vaccines, especially PWH with more advanced immunodeficiency.
    MeSH term(s) Humans ; Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; HIV Infections/complications ; SARS-CoV-2 ; Vaccination
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Editorial
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003579
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    Zs.A 2228: Show issues Location:
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  7. Article ; Online: Remdesivir for the Treatment of Covid-19 - Preliminary Report.

    McMahon, James H / Udy, Andrew / Peleg, Anton Y

    The New England journal of medicine

    2020  Volume 383, Issue 10, Page(s) 992–993

    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2020-07-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2022236
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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: Updated Australian guidance for health care providers about "undetectable = untransmittable" for HIV.

    McMahon, James H / Allan, Brent / Grace, Daniel / Holas, Nic

    The Medical journal of Australia

    2021  Volume 215, Issue 5, Page(s) 201–202.e1

    MeSH term(s) Anti-HIV Agents/therapeutic use ; Australia ; HIV Infections/drug therapy ; HIV Infections/transmission ; Health Knowledge, Attitudes, Practice ; Health Personnel ; Humans ; Viral Load
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2021-08-02
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.51211
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    Ua VI Zs.398: Show issues Location:
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  10. Article ; Online: Bringing evidence from press release to the clinic in the era of COVID-19.

    McMahon, James H / Lydeamore, Michael J / Stewardson, Andrew J

    The Journal of antimicrobial chemotherapy

    2020  Volume 76, Issue 3, Page(s) 547–549

    Abstract: The urgent need to develop effective therapeutics and disseminate information from clinical studies has led to data from clinical trials being made available by alternate methods prior to peer-reviewed publication, including press releases, social media ... ...

    Abstract The urgent need to develop effective therapeutics and disseminate information from clinical studies has led to data from clinical trials being made available by alternate methods prior to peer-reviewed publication, including press releases, social media and pre-print papers. While this allows clinicians more open access to these data, a trust has to be placed with the investigators releasing these data without the availability of scientifically rigorous peer review. The examples of results from trials studying dexamethasone and hydroxychloroquine for treatment of COVID-19 have had contrasting outcomes, including the potential for significant numbers of lives saved with the early release of results from the RECOVERY trial studying dexamethasone contrasting with unsubstantiated data being presented from trials studying hydroxychloroquine. Clinicians and researchers must maintain a healthy scepticism when reviewing results prior to peer-reviewed publication, but also consider when these opportunities may allow for early implementation of potentially lifesaving interventions for people infected with COVID-19.
    MeSH term(s) COVID-19/epidemiology ; Clinical Trials as Topic/methods ; Dexamethasone/therapeutic use ; Evidence-Based Medicine/trends ; Humans ; Hydroxychloroquine/therapeutic use ; Peer Review/trends ; Social Media/trends ; COVID-19 Drug Treatment
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2020-12-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkaa506
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    Zs.MO 124: Show issues

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