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  1. Article ; Online: Anosmia (smell failure) and dysgeusia (taste distortion) in COVID-19: it is genetic.

    Hendaus, Mohamed A

    Journal of biomolecular structure & dynamics

    2022  Volume 41, Issue 7, Page(s) 3162–3165

    Abstract: The COVID-19 pandemic is a very contagious respiratory illness with has affected millions of individuals worldwide. In addition to the well-known symptoms of any respiratory virus, COVID-19 can present with anosmia (failure to smell) and dysgeusia ( ... ...

    Abstract The COVID-19 pandemic is a very contagious respiratory illness with has affected millions of individuals worldwide. In addition to the well-known symptoms of any respiratory virus, COVID-19 can present with anosmia (failure to smell) and dysgeusia (distortion of the sense of taste). It appears to be a genetic link to the biological mechanisms underlying COVID-19-related anosmia and dysgeusia. Significant locus in the vicinity of the UGT2A1 and UGT2A2 genes are currently considered as the main culprit of the symptoms. However, more studies are needed to delineate a clear pathophysiology.Communicated by Ramaswamy H. Sarma.
    MeSH term(s) Humans ; COVID-19 ; Dysgeusia/diagnosis ; Dysgeusia/epidemiology ; Smell ; Taste ; Anosmia ; Pandemics ; SARS-CoV-2 ; Olfaction Disorders/diagnosis ; Olfaction Disorders/epidemiology ; Glucuronosyltransferase
    Chemical Substances UGT2A1 protein, human (EC 2.4.1.17) ; Glucuronosyltransferase (EC 2.4.1.17)
    Language English
    Publishing date 2022-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2022.2039773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Letter to the Editor: COVID-19 utilization of ACE-2 receptor to enter the host cell.

    Hendaus, Mohamed A

    Journal of biomolecular structure & dynamics

    2021  Volume 40, Issue 19, Page(s) 9576

    Abstract: Communicated by Ramaswamy H. Sarma. ...

    Abstract Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2021-04-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2021.1917174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Remdesivir in the treatment of coronavirus disease 2019 (COVID-19): a simplified summary.

    Hendaus, Mohamed A

    Journal of biomolecular structure & dynamics

    2020  Volume 39, Issue 10, Page(s) 3787–3792

    Abstract: The pandemic of COVID-19 (Coronavirus Disease-2019) is an extremely contagious respiratory illness due to a novel coronavirus, SARS-CoV-2. Certain drugs have several protein targets and many illnesses share overlapping molecular paths. In such cases, ... ...

    Abstract The pandemic of COVID-19 (Coronavirus Disease-2019) is an extremely contagious respiratory illness due to a novel coronavirus, SARS-CoV-2. Certain drugs have several protein targets and many illnesses share overlapping molecular paths. In such cases, reusing drugs for more than one objective and finding their novice uses can considerably decrease the time in finding new cures for unforeseen diseases. Remdesivir has been recently a strong candidate for the treatment of Covid-19. In this commentary, we have portrayed the structure of the coronavirus in a simple way as well as the site where remdesivir acts. We have also displayed the ongoing clinical trials, as well as a published study that was conducted on compassionate base. The covid-19 pandemic might wean down by the end of summer 2020, but the risk of seasonality exists. Therefore, future disposal of agents such as remdesivir might be crucial for ensuring an efficient treatment, decrease mortality and allow early discharge.Communicated by Ramaswamy H. Sarma.
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Antiviral Agents/therapeutic use ; Humans ; Pandemics ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1767691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Why Are Children With Bronchiolitis At Risk Of Urinary Tract Infections?

    Hendaus, Mohamed A

    Risk management and healthcare policy

    2019  Volume 12, Page(s) 251–254

    Abstract: Viral respiratory infections are frequently eliminated from human bodies without any sequelae. Secondary serious bacterial infection (SBI) in children with acute bronchiolitis has been an apprehension expressed by health care providers. Several published ...

    Abstract Viral respiratory infections are frequently eliminated from human bodies without any sequelae. Secondary serious bacterial infection (SBI) in children with acute bronchiolitis has been an apprehension expressed by health care providers. Several published studies have shown an association between acute bronchiolitis and secondary bacterial infection, including urinary tract infections (UTI). However, the proposed mechanism by which a virus can induce UTIs is not yet known. The aim of this commentary is to update the current evidence of risk of UTI in children with bronchiolitis. We present several clinical studies related to the topic as well as a brief review of the potential pathophysiology of secondary infections that could present with viral respiratory illness.
    Keywords covid19
    Language English
    Publishing date 2019-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2495128-6
    ISSN 1179-1594
    ISSN 1179-1594
    DOI 10.2147/RMHP.S222470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: mRNA Vaccines for COVID-19: A Simple Explanation.

    Hendaus, Mohamed A / Jomha, Fatima A

    Qatar medical journal

    2021  Volume 2021, Issue 1, Page(s) 7

    Language English
    Publishing date 2021-02-18
    Publishing country Qatar
    Document type Journal Article
    ZDB-ID 3031075-1
    ISSN 2227-0426 ; 0253-8253
    ISSN (online) 2227-0426
    ISSN 0253-8253
    DOI 10.5339/qmj.2021.07
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  6. Article ; Online: COVID-19 vector-based vaccine causing thrombosis.

    Hendaus, Mohamed A / Jomha, Fatima A

    Journal of biomolecular structure & dynamics

    2021  Volume 40, Issue 19, Page(s) 9568–9570

    Abstract: The number of people affected by COVID-19 is staggering and countries are rushing and competing to vaccinate their populations. However, there has been a concern about the association between COVID-19 vector-based vaccines and thrombosis. The proposed ... ...

    Abstract The number of people affected by COVID-19 is staggering and countries are rushing and competing to vaccinate their populations. However, there has been a concern about the association between COVID-19 vector-based vaccines and thrombosis. The proposed mechanism by which a COVID-19 vector-based vaccine can cause thrombosis is called vaccine-induced immune thrombotic thrombocytopenia (VITT). This commentary will provide an easy sketch of VITT as well as presentation of thrombosis after COVID-19 vaccines and proposed treatment.Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2021-05-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2021.1927847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Can virus-virus interactions impact the dynamics of the covid-19 pandemic?

    Hendaus, Mohamed A / Jomha, Fatima A

    Journal of biomolecular structure & dynamics

    2021  Volume 40, Issue 19, Page(s) 9571–9575

    Abstract: Viral respiratory infections can occur in pandemics and can spread rapidly within communities resulting in health concerns globally. Several respiratory viruses co-circulate at one specific time. However, interface between different viruses has not been ... ...

    Abstract Viral respiratory infections can occur in pandemics and can spread rapidly within communities resulting in health concerns globally. Several respiratory viruses co-circulate at one specific time. However, interface between different viruses has not been clearly established. This interaction is crucial to delineate, especially during pandemics, including the one relate to covid-19. This commentary will provide a brief description of how respiratory viruses interact and the outcome of this interaction on a pandemic.Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2021-05-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2021.1926327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
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  8. Article: Delta variant of COVID-19: A simple explanation.

    Hendaus, Mohamed A / Jomha, Fatima A

    Qatar medical journal

    2021  Volume 2021, Issue 3, Page(s) 49

    Abstract: Severe acute respiratory syndrome coronavirus 2, the virus that causes coronavirus disease (COVID-19), has undergone numerous mutations since its initial identification, leading to challenges in controlling the pandemic. Till date, several variants of ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2, the virus that causes coronavirus disease (COVID-19), has undergone numerous mutations since its initial identification, leading to challenges in controlling the pandemic. Till date, several variants of concern have been identified. However, currently, the Delta variant (B.1.617.2) is the most dreaded one owing to its enhanced transmissibility and increased virulence. In addition, this variant can potentially facilitate fusion of the spike protein to cells or inhibit antibodies from binding to it. In this commentary, we have simplified the complexity of the nomenclature of variants related to COVID-19, concentrating on the Delta variant including its transmissibility, response to vaccines, and prevention.
    Language English
    Publishing date 2021-10-05
    Publishing country Qatar
    Document type Journal Article
    ZDB-ID 3031075-1
    ISSN 2227-0426 ; 0253-8253
    ISSN (online) 2227-0426
    ISSN 0253-8253
    DOI 10.5339/qmj.2021.49
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Remdesivir in the treatment of coronavirus disease 2019 (COVID-19)

    Hendaus, Mohamed A.

    Journal of Biomolecular Structure and Dynamics

    a simplified summary

    2020  , Page(s) 1–6

    Keywords Molecular Biology ; Structural Biology ; General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1767691
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Remdesivir in the treatment of coronavirus disease 2019 (COVID-19): a simplified summary

    Hendaus, Mohamed A

    J Biomol Struct Dyn

    Abstract: The pandemic of COVID-19 (Coronavirus Disease-2019) is an extremely contagious respiratory illness due to a novel coronavirus, SARS-CoV-2. Certain drugs have several protein targets and many illnesses share overlapping molecular paths. In such cases, ... ...

    Abstract The pandemic of COVID-19 (Coronavirus Disease-2019) is an extremely contagious respiratory illness due to a novel coronavirus, SARS-CoV-2. Certain drugs have several protein targets and many illnesses share overlapping molecular paths. In such cases, reusing drugs for more than one objective and finding their novice uses can considerably decrease the time in finding new cures for unforeseen diseases. Remdesivir has been recently a strong candidate for the treatment of Covid-19. In this commentary, we have portrayed the structure of the coronavirus in a simple way as well as the site where remdesivir acts. We have also displayed the ongoing clinical trials, as well as a published study that was conducted on compassionate base. The covid-19 pandemic might wean down by the end of summer 2020, but the risk of seasonality exists. Therefore, future disposal of agents such as remdesivir might be crucial for ensuring an efficient treatment, decrease mortality and allow early discharge.Communicated by Ramaswamy H. Sarma.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #245039
    Database COVID19

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