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  1. Article ; Online: Remdesivir: A giant step, or a tiptoe?

    Dickinson, Gordon M

    Clinics in dermatology

    2020  Volume 38, Issue 6, Page(s) 773–774

    Keywords covid19
    Language English
    Publishing date 2020-05-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2020.05.015
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  3. Article ; Online: A research note on the benefit of patient and public involvement in research: The experience of prostate cancer patients regarding information in radiotherapy.

    Gordon, L / Dickinson, A / Offredy, M / Smiddy, J

    Radiography (London, England : 1995)

    2017  Volume 23, Issue 2, Page(s) 167–170

    Abstract: Aim: To explore the inclusion of patient and public involvement (PPI) in a qualitative study on the experiences of men with prostate cancer regarding information in radiotherapy.: Method: The application of PPI to one doctoral research study is ... ...

    Abstract Aim: To explore the inclusion of patient and public involvement (PPI) in a qualitative study on the experiences of men with prostate cancer regarding information in radiotherapy.
    Method: The application of PPI to one doctoral research study is explored with respect to two perspectives: firstly, involvement of a patient reference group who informed the research design and materials, and secondly, the involvement of a public involvement in research group (PIRg) in advising the researcher during the design process.
    Discussion: PPI is recognised as an important component of contemporary health research. PPI is becoming a common and essential requirement for high quality research projects and yet literature exploring or reporting the involvement and influence of PPI is sparse. Consideration is given to the national PPI landscape that has shaped public involvement in health research.
    Conclusion: The contribution of PPI to this study appears to have been beneficial to the development and evaluation of the study design, the self-worth of the reference group participants and demonstrates that the value of PPI in health research should not be underestimated.
    MeSH term(s) Biomedical Research ; Community Participation ; Cooperative Behavior ; Humans ; Male ; Patient Participation ; Prostatic Neoplasms/radiotherapy ; Qualitative Research ; Research Design
    Language English
    Publishing date 2017-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1289102-2
    ISSN 1532-2831 ; 1078-8174
    ISSN (online) 1532-2831
    ISSN 1078-8174
    DOI 10.1016/j.radi.2017.02.004
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  4. Article ; Online: The early use of Pasteur's rabies vaccine in the United States.

    Hoenig, Leonard J / Jackson, Alan C / Dickinson, Gordon M

    Vaccine

    2018  Volume 36, Issue 30, Page(s) 4578–4581

    Abstract: Louis Pasteur's vaccine against rabies was introduced in France during 1885. A year later it became available within the United States. This article tells the story of the first use of the Pasteur vaccine in America and describes the early history of the ...

    Abstract Louis Pasteur's vaccine against rabies was introduced in France during 1885. A year later it became available within the United States. This article tells the story of the first use of the Pasteur vaccine in America and describes the early history of the vaccine's production and distribution across the country by Pasteur Institutes established for this purpose. Highlights of Pasteur's landmark studies on rabies are presented: research which pioneered the field of virology and the use of immunization to prevent infectious diseases.
    MeSH term(s) History, 19th Century ; Humans ; Rabies/prevention & control ; Rabies Vaccines/history ; Rabies Vaccines/therapeutic use ; United States
    Chemical Substances Rabies Vaccines
    Language English
    Publishing date 2018-06-18
    Publishing country Netherlands
    Document type Historical Article ; Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2018.05.016
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  5. Article ; Online: A Highly Unusual V1 Region of Env in an Elite Controller of HIV Infection.

    Silver, Zachary A / Dickinson, Gordon M / Seaman, Michael S / Desrosiers, Ronald C

    Journal of virology

    2019  Volume 93, Issue 10

    Abstract: HIV elite controllers represent a remarkable minority of patients who maintain normal ... ...

    Abstract HIV elite controllers represent a remarkable minority of patients who maintain normal CD4
    MeSH term(s) Amino Acid Sequence ; Antibodies, Monoclonal/metabolism ; Antibodies, Neutralizing/immunology ; Epitopes/immunology ; Glycosylation ; HIV Antibodies/immunology ; HIV Envelope Protein gp120/genetics ; HIV Envelope Protein gp120/immunology ; HIV Envelope Protein gp120/metabolism ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/immunology ; HIV-1/pathogenicity ; Humans ; Immune Evasion/immunology ; Neutralization Tests ; Peptide Fragments/genetics ; Peptide Fragments/immunology ; Polysaccharides/metabolism ; env Gene Products, Human Immunodeficiency Virus/genetics ; env Gene Products, Human Immunodeficiency Virus/immunology
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing ; Epitopes ; HIV Antibodies ; HIV Envelope Protein gp120 ; HIV envelope protein gp120 (135-148) ; Peptide Fragments ; Polysaccharides ; env Gene Products, Human Immunodeficiency Virus
    Language English
    Publishing date 2019-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00094-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 609: Show issues Location:
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  6. Article ; Online: Information in radiotherapy for men with localised prostate cancer: An integrative review.

    Gordon, Lynne / Dickinson, Angela / Offredy, Maxine

    European journal of cancer care

    2019  Volume 28, Issue 3, Page(s) e13085

    Abstract: Introduction: Men with prostate cancer may receive radiotherapy as part of their management. They encounter a range of information related to radiotherapy, and a crucial role for therapeutic radiographers and other healthcare practitioners is ensuring ... ...

    Abstract Introduction: Men with prostate cancer may receive radiotherapy as part of their management. They encounter a range of information related to radiotherapy, and a crucial role for therapeutic radiographers and other healthcare practitioners is ensuring patients receive appropriate information related to their treatment. This integrative review aims to identify, synthesise and analyse literature reporting experiences of men with localised prostate cancer related to information in radiotherapy.
    Methods: A systematic literature search encompassing database and hand searches was carried out between February and March 2017 with date limits of 2000-2017 applied. Initially, 4,954 articles were identified. Systematic screening and detailed examination identified that 33 met the inclusion criteria. Data were synthesised and analysed thematically.
    Results: Few studies explicitly addressed the issue of information in radiotherapy for men with localised prostate cancer. Themes that emerged and were explored are information needs, information regarding adverse effects, information and time, information preferences, satisfaction with information related to radiotherapy and patient experience related to radiotherapy information.
    Conclusion: This review suggests that although several aspects related to information for men with localised prostate cancer have been documented, few were explored in detail with respect to radiotherapy indicating that further research in this area is warranted.
    MeSH term(s) Brachytherapy ; Humans ; Male ; Needs Assessment ; Patient Education as Topic ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Radiotherapy, Intensity-Modulated
    Language English
    Publishing date 2019-05-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1303114-4
    ISSN 1365-2354 ; 0961-5423 ; 1360-5801
    ISSN (online) 1365-2354
    ISSN 0961-5423 ; 1360-5801
    DOI 10.1111/ecc.13085
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    Zs.A 3347: Show issues Location:
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  7. Article ; Online: Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies.

    Silver, Zachary A / Antonopoulos, Aristotelis / Haslam, Stuart M / Dell, Anne / Dickinson, Gordon M / Seaman, Michael S / Desrosiers, Ronald C

    Cell reports

    2020  Volume 30, Issue 6, Page(s) 1862–1869.e4

    Abstract: Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on Env. ... ...

    Abstract Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on Env. Here we show that a subset of patient-derived HIV-1 isolates contain O-linked carbohydrate on the variable 1 (V1) domain of Env gp120. We demonstrate the presence of this O-glycosylation both on virions and on gp120 expressed as a secreted protein. Further, we establish that these O-linked glycans can confer a more than 1,000-fold decrease in neutralization sensitivity (IC
    MeSH term(s) Broadly Neutralizing Antibodies/metabolism ; HIV Antibodies/immunology ; HIV-1/immunology ; Humans
    Chemical Substances Broadly Neutralizing Antibodies ; HIV Antibodies
    Language English
    Publishing date 2020-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2020.01.056
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  8. Article ; Online: Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies

    Zachary A. Silver / Aristotelis Antonopoulos / Stuart M. Haslam / Anne Dell / Gordon M. Dickinson / Michael S. Seaman / Ronald C. Desrosiers

    Cell Reports, Vol 30, Iss 6, Pp 1862-1869.e

    2020  Volume 4

    Abstract: Summary: Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on ...

    Abstract Summary: Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on Env. Here we show that a subset of patient-derived HIV-1 isolates contain O-linked carbohydrate on the variable 1 (V1) domain of Env gp120. We demonstrate the presence of this O-glycosylation both on virions and on gp120 expressed as a secreted protein. Further, we establish that these O-linked glycans can confer a more than 1,000-fold decrease in neutralization sensitivity (IC50) to V3-glycan broadly neutralizing antibodies. These findings uncover a structural modification to the HIV-1 Env and suggest a functional role in promoting viral escape from one category of broadly neutralizing antibodies. : Silver et al. demonstrate that certain HIV-1 isolates possess O-linked carbohydrate on their Envelope glycoprotein. These sugars allow the virus to evade V3-glycan broadly neutralizing antibodies. This work identifies a post-translational modification to the HIV-1 Envelope and sheds light on its role in shielding against the host antibody response. Keywords: HIV-1, Envelope, gp120, V1 domain, O-glycosylation, broadly neutralizing antibodies, immune evasion, escape mechanism
    Keywords Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: The early use of Pasteur’s rabies vaccine in the United States

    Hoenig, Leonard J / Dickinson, Gordon M / Jackson, Alan C

    Elsevier Ltd Vaccine. 2018 July 16, v. 36, no. 30

    2018  

    Abstract: Louis Pasteur’s vaccine against rabies was introduced in France during 1885. A year later it became available within the United States. This article tells the story of the first use of the Pasteur vaccine in America and describes the early history of the ...

    Abstract Louis Pasteur’s vaccine against rabies was introduced in France during 1885. A year later it became available within the United States. This article tells the story of the first use of the Pasteur vaccine in America and describes the early history of the vaccine’s production and distribution across the country by Pasteur Institutes established for this purpose. Highlights of Pasteur’s landmark studies on rabies are presented: research which pioneered the field of virology and the use of immunization to prevent infectious diseases.
    Keywords immunization ; rabies ; Rabies virus ; vaccines ; virology ; United States
    Language English
    Dates of publication 2018-0716
    Size p. 4578-4581.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2018.05.016
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Acute crystalline arthritis in an artificial knee.

    Hunte, Tai C / Bernstein, Henry M / Dickinson, Gordon M

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2012  Volume 18, Issue 4, Page(s) 203–204

    MeSH term(s) Acute Disease ; Anti-Bacterial Agents/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Arthroplasty, Replacement, Knee ; Calcium Pyrophosphate/isolation & purification ; Chondrocalcinosis/diagnosis ; Chondrocalcinosis/etiology ; Chondrocalcinosis/therapy ; Debridement ; Humans ; Indomethacin/therapeutic use ; Inflammation/etiology ; Male ; Middle Aged ; Pneumonia/complications ; Pneumonia/drug therapy ; Postoperative Complications ; Synovial Fluid/chemistry ; Vancomycin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Vancomycin (6Q205EH1VU) ; Calcium Pyrophosphate (X69NU20D19) ; Indomethacin (XXE1CET956)
    Language English
    Publishing date 2012-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0b013e318258b582
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